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Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT)
Abstract
Recent evidence indicates that curcumin (CUR), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors. The aim of the present study was to examine the modulating impacts of CUR against cognitive deficits and oxidative damage in intracerebroventricular-streptozotocin (ICV-STZ) infused rats. Rats were injected bilaterally with ICV-STZ (3 mg/kg), while sham rats received the same volume of vehicle and then supplemented with CUR (80 mg/kg) for three weeks. After two weeks of ICV-STZ infusion, rats were tested for cognitive performance using passive avoidance and water maze tasks and then sacrificed for biochemical and histopathological assays. ICV-STZ rats showed significant cognitive deficits, which were significantly improved by CUR supplementation. CUR supplementation significantly augmented increased 4-hydroxynonenal (4-HNE) and malonaldehyde (MDA), thiobarbituric reactive substances (TBARS), hydrogen peroxide (H2O2), protein carbonyl (PC) and oxidized glutathione (GSSG); decreased levels of reduced glutathione (GSH) and its dependent enzymes (Glutathione peroxidase [GPx] and glutathione reductase [GR]) in the hippocampus and cerebral cortex; and increased choline acetyltransferase (ChAT) activity in the hippocampus of ICV-STZ rats. The study suggests that CUR is effective in preventing cognitive deficits, and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT).
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“Another experimental study showed that curcumin treatment restored learning and memory functions in the STZ model of AD by reducing the oxidative stress, enhancing ChAT activity and restoring insulin receptor protein [117,118].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [118]
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Metadata
- Authors
- Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., Ahmad, A., & Islam, F.
- Affiliations
- Emory University (US)
- Jamia Hamdard (IN)
- University of Pittsburgh (US)
- Corresponding author
- Islam, Fakhrul
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 19
- Issue
- 9
- Pages
- 636-647
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2028376455
- Cited by
- 230
- References
- 71
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 22 · 2019: 15 · 2018: 22 · 2017: 19 · 2016: 17 · 2015: 10 · 2014: 14 · 2013: 14 · 2012: 19
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health and Family Welfare
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, cognitive impairment, neurodegeneration, streptozotocin-induced neurotoxicity, oxidative stress, antioxidant activity, hippocampus, cerebral cortex, choline acetyltransferase, glutathione, lipid peroxidation, neuroprotection
- MeSH terms
- Alzheimer Disease, Animals, Brain, Cerebral Cortex, Choline O-Acetyltransferase, Cognition, Curcumin, Disease Models, Animal, Hippocampus, Injections, Intraventricular, Male, Nerve Degeneration, Streptozocin, Time Factors, Rats, Wistar, Reactive Oxygen Species, Neuroprotective Agents, Rats
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