Amino acid sensing in skeletal muscle

Sarcopenia: European consensus on definition and diagnosis

Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works

Sestrin2 is a leucine sensor for the mTORC1 pathway

Wolfson, R. L., Chantranupong, L., Saxton, R. A., Shen, K., Scaria, S. M., Cantor, J. R., & Sabatini, D. M. (2016) · Science · doi:10.1126/science.aab2674 · Cited by 1,306 · see citing works

Coping with stress: eIF2 kinases and translational control

Wek, R. C., Jiang, H.-Y., & Anthony, T. G. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340007 · Cited by 1,290 · see citing works

Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · see citing works

Mixed muscle protein synthesis and breakdown after resistance exercise in humans

Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132 · see citing works

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

Bodine, S. C., & Baehr, L. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00204.2014 · Cited by 1,117 · see citing works

Muscle wasting in disease: molecular mechanisms and promising therapies

Cohen, S., Nathan, J. A., & Goldberg, A. L. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4467 · Cited by 1,089 · see citing works

A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly

Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923 · see citing works

Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults

Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846 · see citing works

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Chantranupong, L., Scaria, S. M., Saxton, R. A., Gygi, M. P., Shen, K., Wyant, G. A., Wang, T., Harper, J. W., Gygi, S. P., & Sabatini, D. M. (2016) · Cell · doi:10.1016/j.cell.2016.02.035 · Cited by 843 · see citing works

Dietary protein recommendations and the prevention of sarcopenia

Paddon-Jones, D., & Rasmussen, B. B. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831cef8b · Cited by 823 · see citing works

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

Wang, S., Tsun, Z., Wolfson, R. L., Shen, K., Wyant, G., Plovanich, M. E., Yuan, E. D., Jones, T. D., Chantranupong, L., Comb, W. C., et al. (2015) · Science · doi:10.1126/science.1257132 · Cited by 772 · see citing works

Protein Ingestion to Stimulate Myofibrillar Protein Synthesis Requires Greater Relative Protein Intakes in Healthy Older Versus Younger Men

Moore, D. R., Churchward-Venne, T. A., Witard, O., Breen, L., Burd, N. A., Tipton, K. D., & Phillips, S. M. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu103 · Cited by 770 · see citing works

Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men

Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740 · see citing works

Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: A randomized controlled trial

Smith, G. I., Atherton, P., Reeds, D. N., Mohammed, B. S., Rankin, D., Rennie, M. J., & Mittendorfer, B. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005611 · Cited by 665 · see citing works

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585 · see citing works

Activating transcription factor 4

Ameri, K., & Harris, A. L. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.020 · Cited by 557 · see citing works

Coping with stress: eIF2 kinases and translational control

Jiang, H.-Y., Wek, R. C., & Anthony, T. G. (2005) · Biochemical Society Transactions · doi:10.1042/bst20060007 · Cited by 522 · see citing works

Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids

Katsanos, C. S., Kobayashi, H., Sheffield‐Moore, M., Aarsland, A. A., & Wolfe, R. R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1065 · Cited by 500 · see citing works

Amino acid ingestion improves muscle protein synthesis in the young and elderly

Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467 · see citing works

The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly¹

Volpi, E., Mittendorfer, B., Rasmussen, B. B., & Wolfe, R. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7021 · Cited by 464 · see citing works

Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis

Drummond, M. J., Fry, C. S., Glynn, E. L., Dreyer, H. C., Dhanani, S., Timmerman, K. L., Volpi, E., & Rasmussen, B. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163816 · Cited by 439 · cited 2× · see citing works

Dietary protein distribution positively influences 24-h muscle protein synthesis in healthy adults

Mamerow, M. M., Mettler, J. A., English, K. L., Casperson, S. L., Arentson-Lantz, E., Sheffield-Moore, M., Layman, D. K., & Paddon-Jones, D. (2014) · The Journal of Nutrition · doi:10.3945/jn.113.185280 · Cited by 438 · see citing works

Basal Muscle Amino Acid Kinetics and Protein Synthesis in Healthy Young and Older Men

Volpi, E. (2001) · JAMA · doi:10.1001/jama.286.10.1206 · Cited by 416 · see citing works

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

Glover, E. I., Phillips, S. M., Oates, B. R., Tang, J. E., Tarnopolsky, M. A., Selby, A., Smith, K., & Rennie, M. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160333 · Cited by 414 · see citing works

Insulin resistance of muscle protein metabolism in aging

Rasmussen, B. B., Fujita, S., Wolfe, R. R., Mittendorfer, B., Roy, M., Rowe, V. L., & Volpi, E. (2006) · The FASEB Journal · doi:10.1096/fj.05-4607fje · Cited by 402 · see citing works

Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men

Fry, C. S., Glynn, E. L., Drummond, M. J., Timmerman, K. L., Fujita, S., Abe, T., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01266.2009 · Cited by 402 · see citing works

Two Weeks of Reduced Activity Decreases Leg Lean Mass and Induces “Anabolic Resistance” of Myofibrillar Protein Synthesis in Healthy Elderly

Breen, L., Stokes, K. A., Churchward-Venne, T. A., Moore, D. R., Baker, S. K., Smith, K., Atherton, P. J., & Phillips, S. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1502 · Cited by 395 · see citing works

Is the optimal level of protein intake for older adults greater than the recommended dietary allowance?

Volpi, E., Campbell, W., Dwyer, J., Johnson, M., Jensen, G., Morley, J., & Wolfe, R. (2013) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/gls229 · Cited by 361 · see citing works

Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion

Wall, B. T., Gorissen, S. H., Pennings, B., Koopman, R., Groen, B. B. L., Verdijk, L. B., & van Loon, L. J. C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140903 · Cited by 352 · see citing works

Aging impairs contraction-induced human skeletal muscle mtorc1 signaling and protein synthesis

Fry, C. S., Drummond, M. J., Glynn, E. L., Dickinson, J. M., Gundermann, D. M., Timmerman, K. L., Walker, D. K., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-11 · Cited by 351 · see citing works

mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass

Kunkel, S. D., Suneja, M., Ebert, S. M., Bongers, K. S., Fox, D. K., Malmberg, S. E., Alipour, F., Shields, R. K., & Adams, C. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.020 · Cited by 345 · cited 2× · see citing works

Nutrient signalling in the regulation of human muscle protein synthesis

Fujita, S., Dreyer, H. C., Drummond, M. J., Glynn, E. L., Cadenas, J. G., Yoshizawa, F., Volpi, E., & Rasmussen, B. B. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.134593 · Cited by 339 · see citing works

Mammalian Target of Rapamycin Complex 1 Activation Is Required for the Stimulation of Human Skeletal Muscle Protein Synthesis by Essential Amino Acids1–3

Dickinson, J. M., Fry, C. S., Drummond, M. J., Gundermann, D. M., Walker, D. K., Glynn, E. L., Timmerman, K. L., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2011) · The Journal of Nutrition · doi:10.3945/jn.111.139485 · Cited by 282 · see citing works

Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers

Tipton, K. (1999) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(98)00087-4 · Cited by 231 · see citing works

An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle.

Drummond, M., Glynn, E., Fry, C., Timmerman, K., Volpi, E., & Rasmussen, B. (2010) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00690.2009 · Cited by 231 · see citing works

Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling

Fujita, S., Rasmussen, B. B., Cadenas, J. G., Drummond, M. J., Glynn, E. L., Sattler, F. R., & Volpi, E. (2007) · Diabetes · doi:10.2337/db06-1566 · Cited by 224 · see citing works

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

Drummond, M. J., Dickinson, J. M., Fry, C. S., Walker, D. K., Gundermann, D. M., Reidy, P. T., Timmerman, K. L., Markofski, M. M., Paddon‐Jones, D., Rasmussen, B. B., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00603.2011 · Cited by 224 · see citing works

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

Ebert, S. M., Dyle, M. C., Kunkel, S. D., Bullard, S. A., Bongers, K. S., Fox, D. K., Dierdorff, J. M., Foster, E. D., & Adams, C. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374777 · Cited by 221 · see citing works

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Kunkel, S. D., Elmore, C., Bongers, K. S., Ebert, S. M., Fox, D. K., Dyle, M. C., Bullard, S. A., & Adams, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039332 · Cited by 220 · see citing works

Regulation of Muscle Protein Synthesis and the Effects of Catabolic States

Gordon, B. S., Kelleher, A., & Kimball, S. (2013) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2013.05.039 · Cited by 195 · see citing works

Low-intensity resistance training with blood flow restriction improves vascular endothelial function and peripheral blood circulation in healthy elderly people

Shimizu, R., Hotta, K., Yamamoto, S., Matsumoto, T., Kamiya, K., Kato, M., Hamazaki, N., Kamekawa, D., Akiyama, A., Kamada, Y., et al. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3328-8 · Cited by 187 · see citing works

Insulin Stimulates Human Skeletal Muscle Protein Synthesis via an Indirect Mechanism Involving Endothelial-Dependent Vasodilation and Mammalian Target of Rapamycin Complex 1 Signaling

Timmerman, K. L., Lee, J. L., Dreyer, H. C., Dhanani, S., Glynn, E. L., Fry, C. S., Drummond, M. J., Sheffield‐Moore, M., Rasmussen, B. B., & Volpi, E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2696 · Cited by 180 · see citing works

Supraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism

Fujita, S., Glynn, E. L., Timmerman, K. L., Rasmussen, B. B., & Volpi, E. (2009) · Diabetologia · doi:10.1007/s00125-009-1430-8 · Cited by 164 · see citing works

Interactions Between Nitric Oxide and Endothelin in the Regulation of Vascular Tone of Human Resistance Vessels In Vivo

Cardillo, C., Kilcoyne, C. M., Cannon, R. O., & Panza, J. A. (2000) · Hypertension · doi:10.1161/01.hyp.35.6.1237 · Cited by 164 · see citing works

Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise

Bukhari, S. S. I., Phillips, B. E., Wilkinson, D. J., Limb, M. C., Rankin, D., Mitchell, W. K., Kobayashi, H., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00481.2014 · Cited by 162 · see citing works

Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

Markofski, M., Dickinson, J., Drummond, M., Fry, C., Fujita, S., Gundermann, D., Glynn, E., Jennings, K., Paddon-Jones, D., Reidy, P., et al. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.02.015 · Cited by 155 · see citing works

Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults

Timmerman, K. L., Lee, J. L., Fujita, S., Dhanani, S., Dreyer, H. C., Fry, C. S., Drummond, M. J., Sheffield-Moore, M., Rasmussen, B. B., & Volpi, E. (2010) · Diabetes · doi:10.2337/db10-0415 · Cited by 149 · see citing works

Systems-Based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., Bullard, S. A., Dierdorff, J. M., & Adams, C. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556241 · Cited by 138 · see citing works

A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults

Timmerman, K. L., Dhanani, S., Glynn, E. L., Fry, C. S., Drummond, M. J., Jennings, K., Rasmussen, B. B., & Volpi, E. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.020800 · Cited by 138 · see citing works

You're Only as Old as Your Arteries: Translational Strategies for Preserving Vascular Endothelial Function with Aging

Seals, D. R., Kaplon, R. E., Gioscia‐Ryan, R. A., & LaRocca, T. J. (2014) · Physiology · doi:10.1152/physiol.00059.2013 · Cited by 138 · see citing works

Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnoverThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

Rennie, M. J. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-012 · Cited by 135 · see citing works

The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting

Ebert, S. M., Monteys, A. M., Fox, D. K., Bongers, K. S., Shields, B. E., Malmberg, S. E., Davidson, B. L., Suneja, M., & Adams, C. M. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0345 · Cited by 130 · see citing works

Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise–Induced Muscle Protein Anabolism

Reidy, P. T., & Rasmussen, B. B. (2016) · The Journal of Nutrition · doi:10.3945/jn.114.203208 · Cited by 128 · see citing works

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

Ebert, S. M., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., Murry, D. J., Fox, D. K., Bongers, K. S., Lira, V. A., Meyerholz, D. K., Talley, J. J., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.681445 · Cited by 120 · see citing works

Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise

Drummond, M. J., Fry, C. S., Glynn, E. L., Timmerman, K. L., Dickinson, J. M., Walker, D. K., Gundermann, D. M., Volpi, E., & Rasmussen, B. B. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01408.2010 · Cited by 120 · see citing works

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

Fox, D. K., Ebert, S. M., Bongers, K. S., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., Kunkel, S. D., & Adams, C. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2014 · Cited by 119 · see citing works

Leucine-Enriched Amino Acid Ingestion after Resistance Exercise Prolongs Myofibrillar Protein Synthesis and Amino Acid Transporter Expression in Older Men

Dickinson, J. M., Gundermann, D. M., Walker, D. K., Reidy, P. T., Borack, M. S., Drummond, M. J., Arora, M., Volpi, E., & Rasmussen, B. B. (2014) · Journal of Nutrition · doi:10.3945/jn.114.198671 · Cited by 101 · see citing works

Anabolic resistance in critically ill patients

Rennie, M. J. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6ec1f · Cited by 90 · see citing works

Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise

Dickinson, J. M., Drummond, M. J., Coben, J. R., Volpi, E., & Rasmussen, B. B. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.07.009 · Cited by 86 · see citing works

Effects of Dietary Omega-3 Fatty Acid Supplementation on Endothelium-Dependent Vasodilation in Patients With Chronic Heart Failure

Morgan, D. R., Dixon, L., Hanratty, C. G., El-Sherbeeny, N. A., Hamilton, P., McGrath, L. T., Leahey, W. J., Johnston, G., & McVeigh, G. E. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.08.075 · Cited by 72 · see citing works

Ursolic acid-induced elevation of serum irisin augments muscle strength during resistance training in men

Bang, H. S., Seo, D. Y., Chung, Y. M., Oh, K.-M., Park, J. J., Arturo, F., Jeong, S.-H., Kim, N., & Han, J. (2014) · The Korean Journal of Physiology & Pharmacology · doi:10.4196/kjpp.2014.18.5.441 · Cited by 69 · see citing works

Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle.

Kimball, S. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.068387 · Cited by 46 · see citing works

Muscle protein metabolism responds similarly to exogenous amino acids in healthy younger and older adults during NO-induced hyperemia

Dillon, E. L., Casperson, S. L., Durham, W. J., Randolph, K. M., Urban, R. J., Volpi, E., Ahmad, M., Kinsky, M. P., & Sheffield‐Moore, M. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00211.2011 · Cited by 41 · see citing works

Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue

Sheffield‐Moore, M., Wiktorowicz, J. E., Soman, K. V., Danesi, C. P., Kinsky, M. P., Dillon, E. L., Randolph, K. M., Casperson, S. L., Gore, D. C., Horstman, A. M. H., et al. (2013) · Clinical and Translational Science · doi:10.1111/cts.12121 · Cited by 39 · see citing works

In vivo muscle amino acid transport involves two distinct processes

Miller, S. L., Chinkes, D. L., MacLean, D. A., Gore, D. C., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00092.2004 · Cited by 37 · see citing works

Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy

Adams, C. M., Ebert, S. M., & Dyle, M. C. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000159 · Cited by 20 · see citing works

Amino acid infusion fails to stimulate skeletal muscle protein synthesis up to 1 year after injury in children with severe burns

Porter, C. C., Cotter, M., Diaz, E. C., Jennings, K., Herndon, D. N., & Børsheim, E. (2013) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3182921651 · Cited by 20 · see citing works

The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans

Wilkinson, D. J., Piasecki, M., & Atherton, P. J. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.005 · Cited by 885 · see citing works

Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities

Migliavacca, E., Tay, S. K. H., Patel, H. P., Sonntag, T., Civiletto, G., McFarlane, C., Forrester, T., Barton, S. J., Leow, M. K., Antoun, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13694-1 · Cited by 365 · see citing works

Regulation of Skeletal Muscle Function by Amino Acids

Kamei, Y., Hatazawa, Y., Uchitomi, R., Yoshimura, R., & Miura, S. (2020) · Nutrients · doi:10.3390/nu12010261 · Cited by 254 · see citing works

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

Ham, D. J., Börsch, A., Lin, S., Thürkauf, M., Weihrauch, M., Reinhard, J. R., Delezie, J., Battilana, F., Wang, X., Kaiser, M. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18140-1 · Cited by 178 · see citing works

The Importance of Resistance Exercise Training to Combat Neuromuscular Aging

Lavin, K. M., Roberts, B. M., Fry, C. S., Moro, T., Rasmussen, B. B., & Bamman, M. M. (2019) · Physiology · doi:10.1152/physiol.00044.2018 · Cited by 131 · see citing works

Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism

Nunn, E., Jaiswal, N., Gavin, M., Uehara, K., Stefkovich, M., Drareni, K., Calhoun, R., Lee, M., Holman, C. D., Baur, J. A., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101880 · Cited by 126 · see citing works

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

Rong, S., Wang, L., Peng, Z., Liao, Y., Li, D., Yang, X., Nussler, A. K., Liu, L., Bao, W., & Yang, W. Q. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12536 · Cited by 104 · see citing works

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

Ham, D. J., Börsch, A., Chojnowska, K., Lin, S., Leuchtmann, A. B., Ham, A. S., Thürkauf, M., Delezie, J., Furrer, R., Bürri, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29714-6 · Cited by 102 · see citing works

Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen

Ali, A. M., & Kunugi, H. (2020) · Foods · doi:10.3390/foods9101362 · Cited by 99 · see citing works

Obesity Alters the Muscle Protein Synthetic Response to Nutrition and Exercise

Beals, J. W., Burd, N. A., Moore, D. R., & van Vliet, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00087 · Cited by 88 · see citing works

Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults

Moro, T., Brightwell, C. R., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00723.2019 · Cited by 85 · see citing works

The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans

Trommelen, J., van Lieshout, G. A. A., Nyakayiru, J., Holwerda, A. M., Smeets, J. S. J., Hendriks, F. K., van Kranenburg, J. M. X., Zorenc, A. H., Senden, J. M., Goessens, J. P. B., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101324 · Cited by 82 · see citing works

Role of dietary protein and muscular fitness on longevity and aging

Strasser, B., Volaklis, K., Fuchs, D., & Burtscher, M. (2018) · Aging and Disease · doi:10.14336/ad.2017.0202 · Cited by 78 · see citing works

Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training.

Moro, T., Brightwell, C. R., Deer, R., Graber, T. G., Galvan, E., Fry, C., Volpi, E., & Rasmussen, B. (2018) · Journal of NutriLife · doi:10.1093/jn/nxy064 · Cited by 58 · see citing works

The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties

Bailly, C. (2021) · Steroids · doi:10.1016/j.steroids.2021.108933 · Cited by 66 · see citing works

Acute sprint exercise transcriptome in human skeletal muscle

Rundqvist, H., Montelius, A., Österlund, T., Norman, B., Esbjörnsson, M., & Jansson, E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223024 · Cited by 62 · see citing works

Apigenin Enhances Skeletal Muscle Hypertrophy and Myoblast Differentiation by Regulating Prmt7

Jang, Y. J., Son, H. J., Choi, Y. M., Ahn, J., Jung, C. H., & Ha, T. Y. (2017) · Oncotarget · doi:10.18632/oncotarget.20962 · Cited by 59 · see citing works

Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy

Ninomiya, S., Nakamura, N., Nakamura, H., Mizutani, T., Kaneda, Y., Yamaguchi, K., Matsumoto, T., Kitagawa, J., Kanemura, N., Shiraki, M., et al. (2020) · Nutrients · doi:10.3390/nu12040978 · Cited by 57 · see citing works

Sarcopenia, Aging and Prospective Interventional Strategies

Waltz, T. B., Fivenson, E. M., Morevati, M., Li, C., Becker, K. G., Bohr, V. A., & Fang, E. F. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170801095850 · Cited by 54 · see citing works

Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol

Kimball, S. R., & Lang, C. H. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064642 · Cited by 53 · see citing works

Amino acids and amino acid sensing: implication for aging and diseases

Dato, S., Hoxha, E., Crocco, P., Iannone, F., Passarino, G., & Rose, G. (2018) · Biogerontology (Dordrecht) · doi:10.1007/s10522-018-9770-8 · Cited by 44 · see citing works

Post-absorptive muscle protein turnover affects resistance training hypertrophy

Reidy, P., Borack, M. S., Markofski, M., Dickinson, J., Fry, C., Deer, R., Volpi, E., & Rasmussen, B. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3566-4 · Cited by 49 · see citing works

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category

Omura, T., & Araki, A. (2022) · Geriatrics & Gerontology International · doi:10.1111/ggi.14339 · Cited by 47 · see citing works

Whey Protein Hydrolysate Increases Amino Acid Uptake, mTORC1 Signaling, and Protein Synthesis in Skeletal Muscle of Healthy Young Men in a Randomized Crossover Trial.

Moro, T., Brightwell, C. R., Velarde, B., Fry, C., Nakayama, K., Sanbongi, C., Volpi, E., & Rasmussen, B. (2019) · Journal of NutriLife · doi:10.1093/jn/nxz053 · Cited by 44 · see citing works

Improvement of cognitive functions in response to a regular Nordic walking training in elderly women – A change dependent on the training experience

Gmiat, A., Jaworska, J., Micielska, K., Kortas, J. A., Prusik, K., Prusik, K., Lipowski, M., Radulska, A., Szupryczyńska, N., Antosiewicz, J., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.02.006 · Cited by 46 · see citing works

Isoleucine increases muscle mass through promoting myogenesis and intramyocellular fat deposition

Liu, S., Sun, Y., Zhao, R., Wang, Y., Zhang, W., & Pang, W. (2020) · Food & Function · doi:10.1039/d0fo02156c · Cited by 44 · see citing works

Inflammation and metabolism: the role of adiposity in sarcopenic obesity

Lynch, G. M., Murphy, C. H., Castro, E. D. M., & Roche, H. M. (2020) · Proceedings of the Nutrition Society · doi:10.1017/s0029665120007119 · Cited by 41 · see citing works

Nutritional Support for Bariatric Surgery Patients: The Skin beyond the Fat

Toninello, P., Montanari, A., Bassetto, F., Vindigni, V., & Paoli, A. (2021) · Nutrients · doi:10.3390/nu13051565 · Cited by 43 · see citing works

Protein metabolism and related body function: mechanistic approaches and health consequences

Tomé, D., Benoit, S., & Azzout‐Marniche, D. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120007880 · Cited by 39 · see citing works

Leucine-rich diet alters the 1H-NMR based metabolomic profile without changing the Walker-256 tumour mass in rats

Viana, L. R., Canevarolo, R. R., Luiz, A. C. P., Soares, R. F., Lubaczeuski, C., Zeri, A. C. D. M., & Gomes‐Marcondes, M. C. C. (2016) · BMC Cancer · doi:10.1186/s12885-016-2811-2 · Cited by 37 · see citing works

Metabolic derangements of skeletal muscle from a murine model of glioma cachexia

Cui, P., Shao, W., Huang, C., Wu, C., Jiang, B., & Lin, D. (2019) · Skeletal Muscle · doi:10.1186/s13395-018-0188-4 · Cited by 35 · see citing works

Osteopontin - The stirring multifunctional regulatory factor in multisystem aging

Du, Y., Mao, L., Wang, Z., Yan, K., Zhang, L., & Zou, J. T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1014853 · Cited by 32 · see citing works

Association of plasma FGF21 levels with muscle mass and muscle strength in a national multicentre cohort study: Korean Frailty and Aging Cohort Study

Roh, E., Hwang, S. Y., Yoo, H. J., Baik, S. H., Cho, B., Park, Y. S., Kim, H. J., Lee, S., Kim, B., Jang, H. C., et al. (2021) · Age and Ageing · doi:10.1093/ageing/afab178 · Cited by 31 · see citing works

α-Lactalbumin: Functional properties and potential health benefits

Ge, X., Zhang, J., Regenstein, J. M., Liu, D., Huang, Y., Qiao, Y., & Zhou, P. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104371 · Cited by 30 · see citing works

GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice

Biagetti, B., & Simó, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010415 · Cited by 29 · see citing works

LAT1 Protein Content Increases Following 12 Weeks of Resistance Exercise Training in Human Skeletal Muscle

Roberson, P. A., Mobley, C. B., Romero, M. A., Haun, C. T., Osburn, S. C., Mumford, P. W., Vann, C. G., Greer, R. A., Ferrando, A. A., & Roberts, M. D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.628405 · Cited by 28 · see citing works

Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia

Cruz, B., de Oliveira, A. G., Viana, L. R., Lopes‐Aguiar, L., Canevarolo, R. R., Colombera, M. C., Valentim, R. R., Garcia-Fóssa, F., de Sousa, L. M., Castelucci, B. G., et al. (2020) · Cancers · doi:10.3390/cancers12071880 · Cited by 26 · see citing works

Low‐Grade Systemic Inflammation Interferes with Anabolic and Catabolic Characteristics of the Aged Human Skeletal Muscle

Draganidis, D., Jamurtas, A. Z., Chondrogianni, N., Mastorakos, G. P., Jung, T., Grune, T., Papadopoulos, C., Παπανικολάου, Κ., Papassotiriou, I., Papaevgeniou, N., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8376915 · Cited by 25 · see citing works

Not Only Protein: Dietary Supplements to Optimize the Skeletal Muscle Growth Response to Resistance Training: The Current State of Knowledge

Paoli, A., Cerullo, G., Bianco, A., Neri, M., Gennaro, F., Charrier, D., & Moro, T. (2024) · Journal of Human Kinetics · doi:10.5114/jhk/186660 · Cited by 27 · see citing works

Metabolomics‐driven discovery of therapeutic targets for cancer cachexia

Cui, P., Li, X., Huang, C., & Lin, D. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13465 · Cited by 21 · see citing works

The association between inflammatory cytokines and sarcopenia-related traits: a bi-directional Mendelian randomization study

Wang, J., Xiang, Y., Wu, L., Zhang, C., Han, B., Cheng, Y., Tong, Y., Yan, D., & Wang, L. (2024) · European Journal of Clinical Nutrition · doi:10.1038/s41430-024-01486-w · Cited by 22 · see citing works

Association of endothelial dysfunction and peripheral arterial disease with sarcopenia in chronic kidney disease

Hsu, B., Wang, C., Lai, Y., Kuo, C., & Lin, Y. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13471 · Cited by 21 · see citing works

Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target

Renzini, A., Riera, C. S., Minic, I., D’Ercole, C., Lozanoska‐Ochser, B., Cedola, A., Gigli, G., Moresi, V., & Madaro, L. (2021) · Metabolites · doi:10.3390/metabo11080517 · Cited by 20 · see citing works

A Transcriptomic Regulatory Network among miRNAs, lncRNAs, circRNAs, and mRNAs Associated with L-leucine-induced Proliferation of Equine Satellite Cells

Xing, J., Qi, X., Liu, G., Li, X., Gao, X., Bou, G., Bai, D., Zhao, Y., Du, M., Dugarjaviin, M., et al. (2023) · Animals · doi:10.3390/ani13020208 · Cited by 20 · see citing works

Age-Dependent Changes in Plasma Amino Acids Contribute to Alterations in Glycoxidation Products

Foroumandi, E., Alizadeh, M., & Kheirouri, S. (2018) · Journal of Medical Biochemistry · doi:10.1515/jomb-2017-0065 · Cited by 17 · see citing works

Regulatory Roles of GADD45α in Skeletal Muscle and Adipocyte

You, W., Xu, Z., & Shan, T. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190624143503 · Cited by 16 · see citing works

Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

Zhao, M., Danneskiold‐Samsøe, N. B., Uličná, L., Nguyen, Q., Coassolo, L., Lee, D. E., White, J. P., Jiang, Z., Cuthbert, N., Paramasivam, S., et al. (2022) · eLife · doi:10.7554/elife.80014 · Cited by 16 · see citing works

The effect of Nannochloropsis oceanica feed inclusion on rabbit muscle proteome

Ribeiro, D. M., Bandarrinha, J., Nanni, P., Alves, S. P., Martins, C. F., Bessa, R. J. B., Falcão-e-Cunha, L., & de Almeida, A. M. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103783 · Cited by 16 · see citing works

Glucagon and energy expenditure; Revisiting amino acid metabolism and implications for weight loss therapy

Hope, D. C. D., & Tan, T. M.-M. (2023) · Peptides · doi:10.1016/j.peptides.2023.170962 · Cited by 16 · see citing works

Association of endothelial dysfunction with sarcopenia and muscle function in a relatively young cohort of kidney transplant recipients

Khoo, S.-B., Lin, Y., Ho, G., Lee, M., & Hsu, B. (2021) · PeerJ · doi:10.7717/peerj.12521 · Cited by 14 · see citing works

The Plateau in Muscle Growth with Resistance Training: An Exploration of Possible Mechanisms

Kataoka, R., Hammert, W. B., Yamada, Y., Song, J. S., Seffrin, A., Kang, A., Spitz, R. W., Wong, V. H. Y., & Loenneke, J. P. (2023) · Sports Medicine · doi:10.1007/s40279-023-01932-y · Cited by 16 · see citing works

The Specific Judo Training Program Combined With the Whole Body Cryostimulation Induced an Increase of Serum Concentrations of Growth Factors and Changes in Amino Acid Profile in Professional Judokas

Jaworska, J., Laskowski, R., Ziemann, E., Żuczek, K., Lombardi, G., Antosiewicz, J., & Żurek, P. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.627657 · Cited by 14 · see citing works

Physiological and Molecular Adaptations to Strength Training

Ahtiainen, J. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-75547-2_5 · Cited by 15 · see citing works

ATF4 Is a Fundamental Regulator of Nutrient Sensing and Protein Turnover

Rasmussen, B. B., & Adams, C. M. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa067 · Cited by 13 · see citing works

Mitochondrial Alpha-Keto Acid Dehydrogenase Complexes: Recent Developments on Structure and Function in Health and Disease

Szabó, E., Nagy, B., Czajlik, A., Komlódi, T., Ozohanics, O., Tretter, L., & Ambrus, A. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-58843-3_13 · Cited by 13 · see citing works

Glyoxylic Acid, an α-Keto Acid Metabolite Derived from Glycine, Promotes Myogenesis in C2C12 Cells

Norikura, T., Sasaki, Y., Kojima‐Yuasa, A., & Kon, A. (2023) · Nutrients · doi:10.3390/nu15071763 · Cited by 12 · see citing works

The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle‐aged women is not caused by leucine alone

van Vliet, S., Smith, G. I., Porter, L. C., Ramaswamy, R. S., Reeds, D. N., Okunade, A. L., Yoshino, J., Klein, S., & Mittendorfer, B. (2018) · The Journal of Physiology · doi:10.1113/jp276504 · Cited by 12 · see citing works

Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef bulls

Wang, J., Shen, C., Zhao, G., Hanigan, M. D., & Li, M. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.04.028 · Cited by 12 · see citing works

Distinct impacts of fat and fructose on the liver, muscle, and adipose tissue metabolome: An integrated view

Meneses, M. J., Sousa‐Lima, I., Jarak, I., Raposo, J. F., Alves, M. G., & Macedo, M. P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.898471 · Cited by 11 · see citing works

Amino acids contribute to adaptive thermogenesis. New insights into the mechanisms of action of recent drugs for metabolic disorders are emerging

Ruocco, C., Malavazos, A. E., Ragni, M., Carruba, M. O., Valerio, A., Iacobellis, G., & Nisoli, E. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106892 · Cited by 10 · see citing works

Korean Mint (Agastache rugosa) Extract and Its Bioactive Compound Tilianin Alleviate Muscle Atrophy via the PI3K/Akt/FoxO3 Pathway in C2C12 Myotubes

Woo, Y. K., Kang, M., Kim, C., & Hwang, J. (2024) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2024.29.2.154 · Cited by 10 · see citing works

A reliable LC-MS/MS method for the quantification of natural amino acids in human plasma and its application in clinic

Lin, J., Song, Y., Zhang, Y., Ke, T., Ou, F., Zeng, K., He, D., Li, L., & Yu, L.-S. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.116672 · Cited by 8 · see citing works

Mechanism of exercise-derived circulating exosomes as a target for sarcopenia management

Wang, X., Huang, H., Chen, J., Zhang, Q., Yuan, Z., Yin, M., Peng, C., & liu, S. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2025.1680485 · Cited by 7 · see citing works

Acute effects of low-load resistance exercise with different rest periods on muscle swelling in healthy young men

Hirono, T., Ikezoe, T., Nakamura, M., Tanaka, H., Umehara, J., & Ichihashi, N. (2019) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.8.165 · Cited by 5 · see citing works

The effect of resistance and endurance training with ursolic acid on atrophy‐related biomarkers in muscle tissue of diabetic male rats induced by streptozotocin and a high‐fat diet

Zolfaghari, M., Faramarzi, M., Hedayati, M., & Ghaffari, M. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14202 · Cited by 7 · see citing works

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal musclePreprint

Ham, D. J., Börsch, A., Chojnowska, K., Lin, S., Leuchtmann, A. B., Ham, A. S., Thürkauf, M., Delezie, J., Furrer, R., Bürri, D., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.28.446097 · Cited by 7 · see citing works

Dietary intake of micronized avian eggshell membrane in aged mice reduces circulating inflammatory markers, increases microbiota diversity, and attenuates skeletal muscle aging

Rønning, S. B., Carlsen, H., Rocha, S. D. C., Rud, I., Solberg, N. T., Høst, V., Veiseth-Kent, E., Arnesen, H., Bergum, S. K., Kirkhus, B., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1336477 · Cited by 5 · see citing works

Combined Effects of Ketogenic Diet and Aerobic Exercise on Skeletal Muscle Fiber Remodeling and Metabolic Adaptation in Simulated Microgravity Mice

Chen, J., Li, W., Liang, Y., Zhang, B., Li, Z., Peng, Z., Bai, D., Dai, X., & Wang, Q. (2025) · Metabolites · doi:10.3390/metabo15040270 · Cited by 5 · see citing works

CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity.

Liu, C., Zhang, Y., Wang, Y., Wu, M., Li, Y.-C., Wei, J., Shi, J., Wang, R., Su, L., Yang, T., et al. (2026) · Molecules and Cells · doi:10.1016/j.molcel.2025.12.016 · Cited by 6 · see citing works

Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes

Figueroa, A., Dillon, K. N., Levitt, D. E., & Kang, Y. (2025) · Nutrients · doi:10.3390/nu17172790 · Cited by 5 · see citing works

Effects of day-time feeding on murine skeletal muscle growth and synthesis

Aoyama, S., Kojima, S., Sasaki, K., Shimoda, T., Takahashi, K., Hirooka, R., Tahara, Y., & Shibata, S. (2019) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2019.100099 · Cited by 4 · see citing works

Association of serum intact parathyroid hormone levels with sarcopenia in patients undergoing peritoneal dialysis

Hsu, B., Wang, C., Tsai, J., Chen, Y.-H., Hung, S., & Lin, Y. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1487449 · Cited by 4 · see citing works

Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue

Kang, J.-H., Kim, J. Y., Jung, Y., Kim, S. U., Lee, E. Y., & Cho, J. (2022) · Metabolites · doi:10.3390/metabo12101004 · Cited by 4 · see citing works

Analysis of the Stimulative Effect of Arginine on Translation Initiation of Protein Synthesis in Skeletal Muscle

Suzuki, D., Takami, Y., Sato, Y., Toyoshima, Y., & Yoshizawa, F. (2025) · Nutrients · doi:10.3390/nu17182981 · Cited by 3 · see citing works

Circulating Amino Acid Concentration after the Consumption of Pea or Whey Proteins in Young and Older Adults Affects Protein Synthesis in C2C12 Myotubes

Salles, J., Gueugneau, M., Laleg, K., Giraudet, C., Sanchez, P., Blot, A., Richard, R., Neveux, N., Lefranc‐Millot, C., Perreau, C., et al. (2024) · Nutrients · doi:10.3390/nu16172870 · Cited by 4 · see citing works

Leucine and Its Importance for Cell Signalling Pathways in Cancer Cachexia-Induced Muscle Wasting

de Oliveira, A. G., Cruz, B., de Oliveira, S. C. P., Viana, L. R., Miyaguti, N. A. D. S., Ramos, L., Valentim, R. R., & Gomes‐Marcondes, M. C. C. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.78990 · Cited by 3 · see citing works

mTORC1 signalling and protein synthesis are elevated in response to amino acids in human myotubes obtained from young, old, and old trained men

Gagnon, S. D., Qian, J., Belhac, V., & Martin, N. R. W. (2025) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-025-01041-2 · Cited by 1 · see citing works

Integrated transcriptomic and metabolomic profiling reveals sex-specific regulation of breast muscle development during sexual maturation in Huanglang chicken

Ouyang, Q., Song, Y., Li, J., Xiao, J., Song, Z., Zhang, H., & He, X. (2026) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2026.100366 · Cited by 1 · see citing works

Nutrition for Older Adults: Perspectives on Dietary Guidance for Healthy Aging

Booth, S. L., Campbell, W. W., Volpi, E., Ferrucci, L., Starke-Reed, P. E., Bailey, R. L., Bales, C. W., Barbey, A. K., Choi, I., Houston, D. K., et al. (2026) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2026.107658 · Cited by 3 · see citing works

The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration

Dominikowski, A., Rękoś, Z., Olejarz, M., Szczepanek‐Parulska, E., Domin, R., & Ruchała, M. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1822475 · Cited by 1 · see citing works

Nonpharmacologic intervention for osteosarcopenia

Waters, D. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-820088-9.00007-x · Cited by 1 · see citing works

Синдром персистирующего воспаления, иммуносупрессии и катаболизма: механизмы саркопении и пути коррекции

Чуклін, С. М., Chuklin, S. S., & Shershen, G. (2021) · EMERGENCY MEDICINE · doi:10.22141/2224-0586.16.7-8.2020.223712

β-hydroxy-β-methylbutyrate: role and prospects applications in gerontology

Nikitina, E., Orlova, S., Pigareva, Y., & Магомедова, Х. А. (2021) · Medical alphabet · doi:10.33667/2078-5631-2021-21-94-100

Peer Review #1 of "Association of endothelial dysfunction with sarcopenia and muscle function in a relatively young cohort of kidney transplant recipients (v0.2)"

(2021) · PeerJ · doi:10.7287/peerj.12521v0.2/reviews/1

Peer Review #1 of "Association of endothelial dysfunction with sarcopenia and muscle function in a relatively young cohort of kidney transplant recipients (v0.1)"

(2021) · PeerJ · doi:10.7287/peerj.12521v0.1/reviews/1

Peer Review #2 of "Association of endothelial dysfunction with sarcopenia and muscle function in a relatively young cohort of kidney transplant recipients (v0.1)"

(2021) · PeerJ · doi:10.7287/peerj.12521v0.1/reviews/2

The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover

Counts, B. R. (2021) · doi:10.21007/etd.cghs.2021.0559

Nutrition and Aging: Nutrition Balance and Dietary Protein Needs

Strasser, B. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_130

Nutrition and Aging: Nutrition Balance and Dietary Protein Needs

Strasser, B. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_130-1

Effects of Age on Exercise Metabolism

Hinkley, J. M., Coen, P. M., & Goodpaster, B. H. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-94305-9_14

Nutritional aspects in the sportsman’s functional rehabilitation program

Fondi, A., D’Angelo, A., Bartoletti, A., Giacinto, G. D., & Ripari, P. (2023) · Journal of Cardiovascular Medicine and Cardiology · doi:10.17352/2455-2976.000196

Nutritional and Exercise Approaches for Prevention of Sarcopenia

Fujita, S. (2023) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.76.297

Dietary Protein Re-Alimentation Following Restriction Improves Protein Deposition Via Changing Amino Acid Metabolism and Transcriptional Profiling of Muscle Tissue in Growing Beef CattlePreprint

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