Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?

Myonectin deletion promotes adipose fat storage and reduces liver steatosis

Little, H. C., Rodriguez, S., Lei, X., Tan, S. Y., Stewart, A. N., Sahagun, A., Sarver, D. C., & William Wong, G. (2019) · The FASEB Journal · doi:10.1096/fj.201900520r · Cited by 78

Age‐Related Modifications in Circulating IL‐15 Levels in Humans

Gangemi, S., Basile, G., Monti, D., Merendino, R. A., Pasquale, G. D., Bisignano, U., Nicita-Mauro, V., & Franceschi, C. (2005) · Mediators of Inflammation · doi:10.1155/mi.2005.245 · Cited by 77

Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice

Bae, J. Y. (2018) · BioMed Research International · doi:10.1155/2018/6283932 · Cited by 77

Skeletal muscle and aging

Navarro, A. (2001) · Frontiers in bioscience · doi:10.2741/navarro · Cited by 75

Are declining testosterone levels a major risk factor for ill-health in aging men?

Yeap, B. B. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.60 · Cited by 75

Myonectin Predicts the Development of Type 2 Diabetes

Li, K., Liao, X., Wang, K., Mi, Q., Zhang, T., Jia, Y., Xu, X., Luo, X., Zhang, C., Liu, H., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01604 · Cited by 73

Effects of IL-10 and age on IL-6, IL-1β, and TNF-α responses in mouse skeletal and cardiac muscle to an acute inflammatory insult

Meador, B. M., Krzyszton, C. P., Johnson, R. W., & Huey, K. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01079.2007 · Cited by 72

Decorin is a secreted protein associated with obesity and type 2 diabetes

Bolton, K. A., Segal, D., McMillan, J. S., Jowett, J. B. M., Heilbronn, L. K., Abberton, K. M., Zimmet, P., Chisholm, D. J., Collier, G. R., & Walder, K. R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.41 · Cited by 71

Effect of Obesity and Exercise Training on Plasma Amino Acids and Amino Metabolites in American Indian Adolescents

Short, K. R., Chadwick, J. Q., Teague, A. M., Tullier, M. A., WOLBERT, L. D., COLEMAN, C. L., & Copeland, K. C. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02698 · Cited by 71

An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity

Babaknejad, N., Nayeri, H., Hemmati, R., Bahrami, S., & Esmaillzadeh, A. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0623-2909 · Cited by 70

Metabolic Health—The Role of Adipo-Myokines

Gräf, C., & Ferrari, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246159 · Cited by 70

Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2

Lieu, S., Hansen, E., Dedini, R. D., Behonick, D. J., Werb, Z., Miclau, T., Marcucio, R., & Colnot, C. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.006304 · Cited by 69

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines

Seldin, M. M., & Wong, G. W. (2012) · Adipocyte · doi:10.4161/adip.20877 · Cited by 69

Serum and muscle interleukin-15 levels decrease in aging mice: Correlation with declines in soluble interleukin-15 receptor alpha expression

Quinn, L. S., Anderson, B. G., Strait‐Bodey, L., & Wolden‐Hanson, T. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.012 · Cited by 68

Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance

Dağdeviren, S., Jung, D. Y., Lee, E., Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N., Tsitsilianos, A. V., Tran, D. A., et al. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00181-16 · Cited by 68

Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice

Re Cecconi, A. D., Forti, M., Chiappa, M., Zhu, Z., Zingman, L. V., Cervo, L., Beltrame, L., Marchini, S., & Piccirillo, R. (2019) · Cancers · doi:10.3390/cancers11101541 · Cited by 66

Interval exercise training increases LIF expression and prevents myocardial infarction-induced skeletal muscle atrophy in rats

Jia, D., Cai, M., Xi, Y., Du, S., & Tian, Z. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.009 · Cited by 65

Therapeutic potential of interleukin-15: a myokine involved in muscle wasting and adiposity

Argilés, J. M. A., López-Soriano, F. J., & Busquets, S. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.10.010 · Cited by 64

The relationship between plasma interleukin-15 levels and sarcopenia in outpatient older people

Yalçın, A., Sılay, K., Balik, A. R., Avcıoğlu, G., & Şenat, A. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0848-y · Cited by 64

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis

Pérez-Sotelo, D., Roca-Rivada, A., de la Torre, I. B., Baltar, J., Castro, A. I., Domínguez, E., Collado, M., Casanueva, F. F., & Pardo, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16602-z · Cited by 59

Insulin resistance and mitochondrial function in skeletal muscle

Dela, F., & Helge, J. W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.09.019 · Cited by 57

Inhibition of the myostatin/Smad signaling pathway by short decorin-derived peptides

Shafey, N. E., Guesnon, M., Simon, F., Deprez, E., Cosette, J., Stockholm, D., Scherman, D., Bigey, P., & Kichler, A. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.01.019 · Cited by 57

Secreted protein acidic and rich in cysteine and bioenergetics: Extracellular matrix, adipocytes remodeling and skeletal muscle metabolism

Ghanemi, A., Melouane, A., Yoshioka, M., & St‐Amand, J. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105627 · Cited by 57

Fatty Liver Index Associates with Relative Sarcopenia and GH/ IGF- 1 Status in Obese Subjects

Poggiogalle, E., Lubrano, C., Gnessi, L., Mariani, S., Lenzi, A., & Donini, L. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145811 · Cited by 56

Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α Pathway

Liu, X., Wang, Y., Hou, L., Xiong, Y., & Zhao, S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25735 · Cited by 56

Autocrine and immune cell‐derived BDNF in human skeletal muscle: implications for myogenesis and tissue regeneration

Colombo, E., Bedogni, F., Lorenzetti, I., Landsberger, N., Previtali, S. C., & Farina, C. (2013) · The Journal of Pathology · doi:10.1002/path.4228 · Cited by 54

Elevated plasma levels of SPARC in patients with newly diagnosed type 2 diabetes mellitus

Wu, D., Li, L., Yang, M., Liu, H., & Yang, G. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0131 · Cited by 51

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

Sabaratnam, R., Pedersen, A. J. T., Kristensen, J. M., Handberg, A., Wojtaszewski, J. F. P., & Højlund, K. (2018) · Physiological Reports · doi:10.14814/phy2.13723 · Cited by 50

Regenerative Medicine Approaches for Age-Related Muscle Loss and Sarcopenia: A Mini-Review

Naranjo, J. D., Dziki, J. L., & Badylak, S. F. (2017) · Gerontology · doi:10.1159/000479278 · Cited by 49

Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes

Du, Y., Ye, X., Lu, A., Zhao, D., Liu, J., Cheng, J., & Yang, T. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108068 · Cited by 49

Loss of the adipokine lipocalin-2 impairs satellite cell activation and skeletal muscle regeneration

Rebalka, I. A., Monaco, C. M. F., Varah, N. E., Berger, T., D’Souza, D. M., Zhou, S., Mak, T. W., & Hawke, T. J. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2017 · Cited by 48

Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle

Vassilakos, G., & Barton, E. R. (2018) · Comprehensive physiology · doi:10.1002/cphy.c180010 · Cited by 48

Overexpression of interleukin-15 in mice promotes resistance to diet-induced obesity, increased insulin sensitivity, and markers of oxidative skeletal muscle metabolism

Quinn, L., Anderson, Conner, Pistilli, & Wolden-Hanson (2011) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s19007 · Cited by 47

The Splicing of the IGF-I Gene to Yield Different Muscle Growth Factors

Goldspink, G., & Yang, S. Y. (2004) · Advances in genetics · doi:10.1016/s0065-2660(04)52002-3 · Cited by 46

Irisin treatment improves healing of dystrophic skeletal muscle

Reza, M. M., Sim, C. M., Subramaniyam, N., Ge, X., Sharma, M., Kambadur, R., & McFarlane, C. (2017) · Oncotarget · doi:10.18632/oncotarget.21636 · Cited by 45

Age-related resistance of skeletal muscle-derived progenitor cells to SPARC may explain a shift from myogenesis to adipogenesis

Nakamura, S. K., Nakano, S., Miyoshi, T., Yamanouchi, K., Matsuwaki, T., & Nishihara, M. (2012) · Aging · doi:10.18632/aging.100426 · Cited by 44

Skeletal muscle ceramides and daily fat oxidation in obesity and diabetes

Broskey, N. T., Obanda, D. N., Burton, J. H., Cefalu, W. T., & Ravussin, É. (2018) · Metabolism · doi:10.1016/j.metabol.2017.12.012 · Cited by 44

Association of the Myostatin Gene with Obesity, Abdominal Obesity and Low Lean Body Mass and in Non-Diabetic Asian Indians in North India

Bhatt, S. P., Nigam, P., Misra, A., Guleria, R., Luthra, K., Jain, S. K., & Pasha, M. A. Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040977 · Cited by 43

Deficient leukemia inhibitory factor signaling in muscle precursor cells from patients with type 2 diabetes

Broholm, C., Brandt, C., Schultz, N. S., Nielsen, A. R., Pedersen, B. K., & Schéele, C. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2011 · Cited by 43

A Role for SPARC in the Moderation of Human Insulin Secretion

Harries, L. W., McCulloch, L. J., Holley, J. E., Rawling, T. J., Welters, H. J., & Kos, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068253 · Cited by 42

Excessive secretion of IL-8 by skeletal muscle in type 2 diabetes impairs tube growth: potential role of PI3K and the Tie2 receptor

Levy, Y. A., Ciaraldi, T. P., Mudaliar, S. R. D., Phillips, S. A., & Henry, R. R. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2014 · Cited by 42

Plasma levels of myonectin but not myostatin or fibroblast-derived growth factor 21 are associated with insulin resistance in adult humans without diabetes mellitus

Toloza, F. J. K., Mantilla-Rivas, J. O., Pérez-Matos, M. C., Ricardo-Silgado, M. L., Morales-Alvarez, M. C., Pinzón-Cortés, J. A., Pérez-Mayorga, M., Arévalo-Garcia, M. L., Tolosa-González, G., & Mendivil, C. O. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00005 · Cited by 42

The impact of sarcopenic obesity on inflammation, lean body mass, and muscle strength in elderly women

Nascimento, D. D. C., Oliveira, S. D. C., Vieira, D. C. L., Funghetto, S. S., Silva, A. D. O., Valduga, R., Schoenfeld, B. J., & Prestes, J. (2018) · International Journal of General Medicine · doi:10.2147/ijgm.s187285 · Cited by 42

SPARC Interacts with Actin in Skeletal Muscle in Vitro and in Vivo

Jørgensen, L. H., Jepsen, P. L., Boysen, A., Dalgaard, L. B., Hvid, L. G., Ørtenblad, N., Ravn, D., Sellathurai, J., Møller‐Jensen, J., Lochmüller, H., et al. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.10.013 · Cited by 41

SPARC is up-regulated during skeletal muscle regeneration and inhibits myoblast differentiation.

Petersson, S. J., Jørgensen, L. H., Andersen, D. C., Nørgaard, R. C., Jensen, C. H., & Schrøder, H. D. (2013) · PubMed · doi:10.14670/hh-28.1451 · Cited by 40

MG53: Biological Function and Potential as a Therapeutic Target

Zhang, Y., Wu, H., Lv, F., & Xiao, R. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.108241 · Cited by 40

Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle

Fujimoto, T., Sugimoto, K., Takahashi, T., Yasunobe, Y., Keyu, X., Tanaka, M., Ohnishi, Y., Yoshida, S., Kurinami, H., Akasaka, H., et al. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.01.024 · Cited by 40

Increased circulating myostatin in patients with type 2 diabetes mellitus

Wang, F., Liao, Y., Li, X., Ren, C., Cheng, C., & Ren, Y. (2012) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-012-0092-9 · Cited by 39

Adipokines in healthy skeletal muscle and metabolic disease

Coles, C. A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-27511-6_6 · Cited by 39

Nuclear matrix metalloproteinase-2 in the cardiomyocyte and the ischemic-reperfused heart

Baghirova, S., Hughes, B. G., Poirier, M., Kondo, M. Y., & Schulz, R. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.04.004 · Cited by 38

Effects of exercise‐induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats

Son, J. S., Kim, H., Son, Y., Lee, H., Chae, S. A., Seong, J. K., & Song, W. J. (2017) · Muscle & Nerve · doi:10.1002/mus.25596 · Cited by 38

Influence of skeletal muscle mass and fat mass on the metabolic and inflammatory profile in sarcopenic and non-sarcopenic overfat elderly

Rossi, F. E., Lira, F. S., Silva, B. S. D. A., Freire, A. P. C. F., Ramos, E. M. C., & Gobbo, L. A. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-018-1029-3 · Cited by 38

Brain derived neurotrophic factor in newly diagnosed diabetes and prediabetes

Liu, W., Han, X., Zhou, X., Zhang, S., Cai, X., Zhang, L., Li, Y., Li, M., Gong, S., & Ji, L. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.04.002 · Cited by 36

Positive association between musclin and insulin resistance in obesity: evidence of a human study and an animal experiment

Chen, W.-J., Liu, Y., Sui, Y.-B., Yang, H., Chang, J.-R., Tang, C., Qi, Y., Zhang, J., & Yin, X. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0199-x · Cited by 36

Deficiency of fibroblast growth factor 21 aggravates obesity-induced atrophic responses in skeletal muscle

Kim, C.-S., Joe, Y., Choi, H., Back, S. H., Park, J. W., Chung, H., Roh, E., Kim, M., Ha, T. Y., & Yu, R. (2019) · Journal of Inflammation · doi:10.1186/s12950-019-0221-3 · Cited by 36

Leukemia inhibitory factor increases glucose uptake in mouse skeletal muscle

Brandt, N., O’Neill, H. M., Kleinert, M., Schjerling, P., Vernet, E., Steinberg, G. R., Richter, E. A., & Jørgensen, S. B. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00313.2014 · Cited by 35

Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice

Svärd, J., Røst, T. H., Sommervoll, C. E. N., Haugen, C., Gudbrandsen, O. A., Mellgren, A. E. C., Rødahl, E., Fernø, J., Dankel, S. N., Sagen, J. V., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37501-x · Cited by 35

Intracellular MMP‐2 Activity in Skeletal Muscle Is Associated With Type II Fibers

Hadler‐Olsen, E., Solli, A. I., Hafstad, A. D., Winberg, J., & Uhlin‐Hansen, L. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24694 · Cited by 33

Muscle-specific inflammation induced by MCP-1 overexpression does not affect whole-body insulin sensitivity in mice

Evers-van Gogh, I. J. A., Oteng, A.-B., Alex, S., Hamers, N., Catoire, M., Stienstra, R., Kalkhoven, E., & Kersten, S. (2016) · Diabetologia · doi:10.1007/s00125-015-3822-2 · Cited by 33

Attenuated strength gains during prolonged resistance exercise training in older adults with high inflammatory status

Hangelbroek, R., Knuiman, P., Tieland, M., & de Groot, C. P. G. M. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.02.008 · Cited by 32

Role of serum myostatin in the association between hyperinsulinemia and muscle atrophy in Japanese obese patients

Tanaka, M., Masuda, S., Yamakage, H., Inoue, T., Ohue‐Kitano, R., Yokota, S., Kusakabe, T., Wada, H., Sanada, K., Ishii, K., et al. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.05.041 · Cited by 32

Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy

Welc, S. S., Flores, I., Wehling‐Henricks, M., Ramos, J. N., Wang, Y., Bertoni, C., & Tidball, J. G. (2019) · Nature Communications · doi:10.1038/s41467-019-10614-1 · Cited by 32

The Role of Leukemia Inhibitory Factor Receptor Signaling in Skeletal Muscle Growth, Injury and Disease.

Hunt, L., & White, J. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-27511-6_3 · Cited by 31

Distribution and activation of matrix metalloproteinase-2 in skeletal muscle fibers

Ren, X., Lamb, G. D., & Murphy, R. M. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00113.2019 · Cited by 31

Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients

Chen, W.-J., Liu, Y., Sui, Y.-B., Zhang, B., Zhang, X., & Yin, X. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164116675493 · Cited by 30

New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus

Catalina, M. O., Redondo, P. C., Granados, M. P., Cantonero, C., Sánchez-Collado, J., Albarrán, L., & López, J. J. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867325666171205162248 · Cited by 30

Dual function of MG53 in membrane repair and insulin signaling

Tan, T., Ko, Y., & Ma, J. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.8.079 · Cited by 28

Kalirin, a GEF for Rac1, plays an important role in FSTL-1-mediated glucose uptake in skeletal muscle cells

Lee, H. J., Lee, J. O., Lee, Y. W., Kim, S. A., Park, S. H., & Kim, H. S. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.10.013 · Cited by 28

The small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes

Bolton, K. A., Segal, & Walder (2012) · Biologics · doi:10.2147/btt.s27925 · Cited by 27

Role of Angptl4/Fiaf in exercise-induced skeletal muscle AMPK activation

Chang, H., Kwon, O., Shin, M.-S., Kang, G. M., Leem, Y. H., Lee, C. H., Kim, S. J., Roh, E., Kim, H.-K., Youn, B., et al. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00984.2016 · Cited by 27

Insulin‐like growth factor‐I E peptides: implications for ageing skeletal muscle

Velloso, C. P., & Harridge, S. D. R. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.00997.x · Cited by 26

Secreted protein acidic and rich in cysteine internalization and its age‐related alterations in skeletal muscle progenitor cells

Nakamura, K., Yamanouchi, K., & Nishihara, M. (2013) · Aging Cell · doi:10.1111/acel.12168 · Cited by 26

Effect of Treadmill Running on Apelin and APJ Expression in Adipose Tissue and Skeletal Muscle in Rats Fed a High-fat Diet

Yang, H., Zhao, L., Zhang, J., Tang, C., Qi, Y., & Zhang, J. (2015) · International Journal of Sports Medicine · doi:10.1055/s-0034-1398653 · Cited by 22

Circulating myokine levels in different stages of glucose intolerance

Park, K., Ahn, C. W., Park, J. S., Kim, Y.-S., & Nam, J. S. (2020) · Medicine · doi:10.1097/md.0000000000019235 · Cited by 22

The manifold role of the mitochondria in skeletal muscle insulin resistance

Cade, W. T. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000480 · Cited by 21

ANGPTL4 — the link binding obesity and glucose intolerance

Morris, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.35 · Cited by 20

Lower insulin sensitivity is related to lower relative muscle cross-sectional area, lower muscle density and lower handgrip force in young and middle aged non-diabetic men.

Gysel, T., Tonoli, C., Pardaens, S., Cambier, D. C., Kaufman, J.-M., Zmierczak, H.-G., Goemaere, S., Lapauw, B., & Calders, P. (2016) · Europe PMC (PubMed Central) · Cited by 18

Exercise-induced SPARC prevents tumorigenesis of colon cancer

Liu, Y., & Hsiao, M. (2012) · Gut · doi:10.1136/gutjnl-2012-303235 · Cited by 16

Effect of resistance ladder training on sparc expression in skeletal muscle of hindlimb immobilized rats

Son, J. S., Kim, J. H., Kim, H.-J., Yoon, D. H., Kim, J., Song, H. S., & Song, W. J. (2015) · Muscle & Nerve · doi:10.1002/mus.24940 · Cited by 16

Myostatin as a Biomarker for Diagnosis or Prognosis of Frailty and Sarcopenia: Current Knowledge

Arrieta, H., Rodriguez‐Larrad, A., & Irazusta, J. (2019) · Gerontology · doi:10.1159/000496469 · Cited by 14

Myostatin: A Powerful Biomarker for Sarcopenia and Frailty?

Laurent, M. R., Dupont, J., Dejaeger, M., & Gielen, E. (2019) · Gerontology · doi:10.1159/000495839 · Cited by 12

Role of myokines in the maintenance of whole-body metabolic homeostasis.

Kostrominova, T. Y. (2016) · PubMed · Cited by 11

Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines

Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 269

Deciphering the “obesity paradox” in the elderly: A systematic review and meta‐analysis of sarcopenic obesity

Liu, C., Wong, P. Y., Chung, Y. L., Chow, S. K., Cheung, W. H., Law, S. W., Chan, J. C. N., & Wong, R. M. Y. (2023) · Obesity Reviews · doi:10.1111/obr.13534 · Cited by 247

Skeletal muscle energy metabolism in obesity

Mengeste, A. M., Rustan, A. C., & Lund, J. (2021) · Obesity · doi:10.1002/oby.23227 · Cited by 141

Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors

Alizadeh Pahlavani, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.811751 · Cited by 145

Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk

Scisciola, L., Fontanella, R. A., Surina, S., Cataldo, V., Paolisso, G., & Barbieri, M. (2021) · Life · doi:10.3390/life11020173 · Cited by 153

Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines

Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 269

Beyond body mass index: phenotypic and circulating biomarkers for the identification and characterization of sarcopenic obesity

Turki, M. A. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1930821

The Potential of MicroRNAs in the Context of Sarcopenic Obesity

Chobolová, N., Švagera, Z., Stejskal, D., & Bužga, M. (2025) · Physiological Research · doi:10.33549/physiolres.935755

State-of-the-art insights into myokines as biomarkers of sarcopenia: a literature review

Moussaoui, O. R. (2025) · International Journal of Physiology Pathophysiology and Pharmacology · doi:10.62347/rneq8696 · Cited by 4

The role of genes and myokines of developing sarcopenia: A review

Valeeva, F. V., Rodygina, Z. A., & Yilmaz, T. S. (2024) · Consilium Medicum · doi:10.26442/20751753.2024.4.202735