Reelin-deficient mice show impaired neurogenesis and increased stroke size
Abstract
Reelin (Reln) is a protein involved in migration of newborn neurons during development. Reln mutations produce the reeler phenotype in mice, which is characterized by a defect in brain lamination, and autosomal recessive lissencephaly in humans. Reln expression persists in adult brain, but little is known about its function. We used reeler mice to investigate the effects of Reln deficiency on neurogenesis and the response to injury in the adult brain. Newborn neurons were decreased in number in the dentate gyrus and rostral migratory stream of reeler, compared to wild-type, mice. This was due, at least in part, to impaired cell migration. In addition, reeler mice showed increased susceptibility to ischemic brain injury. Cerebral infarcts from middle cerebral artery occlusion were larger in reeler than in wild-type mice, and associated neurobehavioral abnormalities were more severe. The brains of reeler mice also showed larger excitotoxic lesions after the intracerebral injection of N-methyl-D-aspartate. Finally, despite the fact that reeler mice had larger cerebral infarcts, the ischemia-induced enhancement of neurogenesis observed in wild-type mice was attenuated. These findings suggest that, in addition to its neurodevelopmental effects, Reln deficiency continues to influence neurogenesis and ischemic neuronal injury in the adult brain.
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In the adult mouse hippocampus, reelin deficiency reduces neurogenesis, while reelin overexpression increases neurogenesis.
“In the adult mouse hippocampus, reelin deficiency reduces neurogenesis (Won et al., 2006), while reelin overexpression increases neurogenesis (Pujadas et al., 2010) (Figure 3A).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Won et al., 2006
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- Authors
- Won, S. J., Kim, S. H., Xie, L., Wang, Y., Mao, X. O., Jin, K., & Greenberg, D. A.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Greenberg, David A.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 198
- Issue
- 1
- Pages
- 250-259
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W1990864995
- Cited by
- 84
- References
- 49
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG021980, AG21980)
- National Institute of Neurological Disorders and Stroke (R01NS044921, NS 44921)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- reelin, reeler mice, neurogenesis, ischemic brain injury, stroke, cerebral infarct size, neuronal migration, dentate gyrus, rostral migratory stream, excitotoxic lesions, NMDA, neurobehavioral abnormalities, adult neurogenesis
- MeSH terms
- Doublecortin Domain Proteins, Reelin Protein, Animals, Bromodeoxyuridine, Cell Count, Cerebral Infarction, Disease Models, Animal, Gene Expression Regulation, Immunohistochemistry, Mice, Neurologic Mutants, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, Neuropeptides, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Gene Expression, Extracellular Matrix Proteins, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Stroke, Mice, Calbindins, S100 Calcium Binding Protein G
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