Cited by 198Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsTreatment of Major Depression

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide

Hashioka, Sadayuki, Klegeris, Andis, Monji, Akira, Kato, Takahiro, Sawada, Makoto, McGeer, Patrick L., Kanba, Shigenobu·2007·Experimental Neurology

DOI 10.1016/j.expneurol.2007.03.022

Open this paper in CoChat — free account

Abstract

Circumstantial evidence has suggested that activated microglia may be associated with the pathogenesis of depression. Pro-inflammatory cytokines may also be involved. Therefore, we examined the effects of various types of antidepressants, as well as the mood-stabilizer lithium chloride, on interferon-gamma (IFN-gamma)-induced microglial production of the pro-inflammatory mediators interleukin-6 (IL-6) and nitric oxide (NO). Treatment of the murine microglial 6-3 cells with 100 U/ml of IFN-gamma resulted in an eightfold increase in IL-6 and a tenfold increase in NO into the culture medium. Pretreatment with the selective serotonin reuptake inhibitor fluvoxamine, the relatively selective noradrenaline reuptake inhibitor reboxetine, or the non-selective monoaminergic reuptake inhibitor imipramine, significantly inhibited IL-6 and NO production in a dose-dependent manner. These inhibitions were reversed significantly by SQ 22536, a cyclic adenosine monophosphate (cAMP) inhibitor, and, except for reboxetine, by the protein kinase A (PKA) inhibitor Rp-adenosine3',5'-cyclic monophosphorothioate triethylammonium salt (Rp-3',5'-cAMPS). Lithium chloride, which is believed to act by inhibiting the calcium-dependent release of noradrenaline, had a different spectrum of action on microglial 6-3 cells. It enhanced IFN-gamma-stimulated IL-6 production and inhibited NO production. The inhibitory effect of lithium chloride was not reversed by either SQ 22536 or Rp-3',5'-cAMPS. These results suggest that antidepressants have inhibitory effects on IFN-gamma-activated microglia and these effects are, at least partially, mediated by the cAMP-dependent PKA pathway. On the other hand, the mood stabilizer and anti-manic agent lithium chloride has mixed effects on IFN-gamma-induced microglial activation.

Integrity signals

Registry

Crossref · 10.1016/j.expneurol.2007.03.022

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940
Self-citation
The macrophage theory of depression
Smith, R. S. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90272-z · Cited by 931
Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791
Depression: a case of neuronal life and death?
Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.033 · Cited by 630
Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6
Vallières, L., Campbell, I. L., Gage, F. H., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00486.2002 · Cited by 608

Show all 42 references

Sorted by citations

Interleukin-6, a Major Cytokine in the Central Nervous System
Erta, M., Quintana, A., & Hidalgo, J. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4679 · Cited by 1,093
Depression as a Microglial Disease
Yirmiya, R., Rimmerman, N., & Reshef, R. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.001 · Cited by 944
Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
Kreisel, T., Frank, M. G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M. V., Maier, S. F., & Yirmiya, R. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.155 · Cited by 663
In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression
Kubera, M., Obuchowicz, E., Goehler, L., Brzeszcz, J., & Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.08.026 · Cited by 443
Inflammation and depression: a causal or coincidental link to the pathophysiology?
Leonard, B. E. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.69 · Cited by 409
A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia
Tynan, R. J., Weidenhofer, J., Hinwood, M., Cairns, M. J., Day, T. A., & Walker, F. R. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.12.011 · Cited by 382
Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
Beurel, E., Michalek, S. M., & Jope, R. S. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.09.007 · Cited by 378
Neurobiology of depression, fibromyalgia and neuropathic pain
Maletic, V. (2009) · Frontiers in bioscience · doi:10.2741/3598 · Cited by 384
A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder
Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350
Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function
Walker, F. R., Nilsson, M., & Jones, K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990208 · Cited by 336
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325
Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome
Cruz-Pereira, J. S., Rea, K., Nolan, Y. M., O'Leary, O. F., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-122216-011613 · Cited by 320
Microglial Dysregulation in Psychiatric Disease
Frick, L. R., Williams, K., & Pittenger, C. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/608654 · Cited by 299
Inflammation, Glutamate, and Glia in Depression:A Literature Review
McNally, L., Bhagwagar, Z., & Hannestad, J. (2008) · CNS Spectrums · doi:10.1017/s1092852900016734 · Cited by 289
Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies
Loftis, J. M., Huckans, M. S., & Morasco, B. J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.015 · Cited by 259
Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases
Lee, M., Cho, T., Jantaratnotai, N., Wang, Y. T., McGeer, E. G., & McGeer, P. L. (2010) · The FASEB Journal · doi:10.1096/fj.09-149997 · Cited by 239
Self-citation
A psychoneuroimmunological review on cytokines involved in antidepressant treatment response
Janssen, D. G. A., Caniato, R. N., Verster, J. C., & Baune, B. T. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1103 · Cited by 240
Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells
Liu, D., Wang, Z., Liu, S., Wang, F., Zhao, S., & Hao, A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.033 · Cited by 221
Effects of Lithium on Inflammation
Nassar, A., & Azab, A. N. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500038f · Cited by 230
Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder
Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205
Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies
Suzuki, H., Ohgidani, M., Kuwano, N., Chrétien, F., Lorin de la Grandmaison, G., Onaya, M., Tominaga, I., Setoyama, D., Kang, D., Mimura, M., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00031 · Cited by 198
Self-citation
Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants
Hwang, J., Zheng, L. T., Ock, J., Lee, M. G., Kim, S.-H., Lee, H.-W., Lee, W.-H., Park, H.-C., & Suk, K. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.045 · Cited by 181
Causes, consequences, and cures for neuroinflammation mediated via the locus coeruleus: noradrenergic signaling system
Feinstein, D. L., Kalinin, S., & Braun, D. J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13447 · Cited by 185
A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: Do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression?
Walker, F. R. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.10.002 · Cited by 175
Depression: A repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition?
Wager‐Smith, K., & Markou, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.010 · Cited by 153
The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder
Foster, J. A., Baker, G. B., & Dursun, S. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.721126 · Cited by 161
Impact of inflammation on neurotransmitter changes in major depression: An insight into the action of antidepressants
Leonard, B. E. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.018 · Cited by 129
Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium
Horikawa, H., Kato, T. A., Mizoguchi, Y., Monji, A., Seki, Y., Ohkuri, T., Gotoh, L., Yonaha, M., Ueda, T., Hashioka, S., et al. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.015 · Cited by 118
Self-citation
Immunomodulation mechanism of antidepressants: interactions between serotonin/norepinephrine balance and Th1/Th2 balance
Martino, M., Rocchi, G., Escelsior, A., & Fornaro, M. (2012) · Current Neuropharmacology · doi:10.2174/157015912800604542 · Cited by 111
Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors
Ramírez, K., & Sheridan, J. F. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.05.008 · Cited by 111
Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance
Ramirez, K., Shea, D. T., McKim, D. B., Reader, B. F., & Sheridan, J. F. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.016 · Cited by 108
A neuroimmunological perspective on anxiety disorders
Hou, R. H., & Baldwin, D. S. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1259 · Cited by 113
Hydrogen sulfide‐releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation
Lee, M., Sparatore, A., Soldato, P. D., McGeer, E. G., & McGeer, P. L. (2009) · Glia · doi:10.1002/glia.20905 · Cited by 104
Self-citation
Putative neuroprotective agents in neuropsychiatric disorders
Dodd, S., Maes, M. H. J., Anderson, G., Dean, O. M., Moylan, S., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.007 · Cited by 105
Effect of Antidepressants on the Course of Disability Following Stroke
Mikami, K., Jorge, R. E., Adams, H. P., Davis, P. H., Leira, E. C. C., Jang, M., & Robinson, R. G. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31821181b0 · Cited by 103
Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application
Watkins, C. C., Sawa, A., & Pomper, M. G. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.119 · Cited by 100
Growth inhibition and coordinated physiological regulation of zebrafish (Danio rerio) embryos upon sublethal exposure to antidepressant amitriptyline
Yang, M., Qiu, W., Chen, J., Zhan, J., Pan, C., Lei, X., & Wu, M. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.12.029 · Cited by 100
Melancholic and atypical major depression—Connection between cytokines, psychopathology and treatment
Dunjic-Kostic, B., Ivkovic, M., Radonjic, N. V., Petronijevic, N. D., Pantovic, M., Damjanovic, A., Poznanovic, S. T., Jovanovic, A., Nikolic, T., & Jasovic-Gasic, M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.009 · Cited by 99
Nitric oxide involvement in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test
Ghasemi, M., Sadeghipour, H., Mosleh, A., Sadeghipour, H. R., Mani, A. R., & Dehpour, A. R. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.07.011 · Cited by 96
Review: the role of inflammation in depression.
Patel, A. J. (2013) · PubMed · Cited by 96
A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95
Modulation of microglial activation by antidepressants
Mariani, N., Everson, J., Pariante, C. M., & Borsini, A. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811211069110 · Cited by 92
Tryptophan: The key to boosting brain serotonin synthesis in depressive illness
Badawy, A. A. ‐. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113499209 · Cited by 94
Magnesium sulfate provides neuroprotection in lipopolysaccharide-activated primary microglia by inhibiting NF-κB pathway
Gao, F., Baozhong, D., Zhou, L., Gao, X., Guo, H., & Xu, H. Y. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.03.034 · Cited by 90
Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort
Black, C. N., Bot, M., Scheffer, P. G., & Penninx, B. W. J. H. (2016) · Psychological Medicine · doi:10.1017/s0033291716002828 · Cited by 90
The antidepressant venlafaxine ameliorates murine experimental autoimmune encephalomyelitis by suppression of pro-inflammatory cytokines
Vollmar, P., Nessler, S., Kalluri, S. R., Hartung, H., & Hemmer, B. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009425 · Cited by 87
The role of macrophages in anti-inflammatory activity of antidepressant drugs
Nazimek, K., Strobel, S. D., Bryniarski, P., Kozlowski, M., Filipczak-Bryniarska, I., & Bryniarski, K. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.07.001 · Cited by 91
Quercetin, not caffeine, is a major neuroprotective component in coffee
Lee, M., McGeer, E. G., & McGeer, P. L. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.06.015 · Cited by 86
Self-citation
An Overview on Chemotherapy-induced Cognitive Impairment and Potential Role of Antidepressants
Das, A., Ranadive, N., Kinra, M., Nampoothiri, M., Arora, D. S., & Mudgal, J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200221113842 · Cited by 87
Regulation by glycogen synthase kinase-3 of inflammation and T cells in CNS diseases
Beurel, E. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00018 · Cited by 82
Implications of Systemic Inflammation and Periodontitis for Major Depression
Hashioka, S., Inoue, K., Hayashida, M., Wake, R., Oh‐Nishi, A., & Miyaoka, T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00483 · Cited by 85
Self-citation
Update on the Relationship Between Depression and Neuroendocrine Metabolism
Qiu, W., Cai, X., Zheng, C., Qiu, S., Ke, H., & Huang, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.728810 · Cited by 90
Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
Gallego‐Landin, I., García-Baos, A., Castro‐Zavala, A., & Valverde, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762738 · Cited by 85
Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro
Su, F., Yi, H., Xu, L., & Zhang, Z. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.028 · Cited by 82
Astrocytes and Microglia: Responses to Neuropathological Conditions
Singh, S., Swarnkar, S., Goswami, P., & Nath, C. (2011) · International Journal of Neuroscience · doi:10.3109/00207454.2011.598981 · Cited by 77
The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium
Ghasemi, M., & Dehpour, A. R. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.03.006 · Cited by 77
Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges
Visentin, A. P. V., Colombo, R., Scotton, E., Fracasso, D. S., Rosa, A. R., Branco, C. S., & Salvador, M. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2972968 · Cited by 77
Fluoxetine and citalopram decrease microglial release of glutamate and d-serine to promote cortical neuronal viability following ischemic insult
Dhami, K., Churchward, M. A., Baker, G. B., & Todd, K. G. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.07.006 · Cited by 76
Artemisinin Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Inhibiting NF-κB Pathway in Microglia Cells
Zhu, C., Xiong, Z., Chen, X., Peng, F., Hu, X., Chen, Y., & Wang, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035125 · Cited by 74
Inhibiting p53 pathways in microglia attenuates microglial‐evoked neurotoxicity following exposure to Alzheimer peptides
Davenport, C. M., Sevastou, I. G., Hooper, C., & Pocock, J. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06485.x · Cited by 67
Increasing CNS Noradrenaline Reduces EAE Severity
Simonini, M. V., Polak, P. E., Sharp, A. J., McGuire, S. O., Galea, E., & Feinstein, D. L. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9182-2 · Cited by 69
Mitochondria-Related Gene Expression Changes Are Associated With Fatigue in Patients With Nonmetastatic Prostate Cancer Receiving External Beam Radiation Therapy
Hsiao, C., Wang, D., Kaushal, A., & Saligan, L. N. (2012) · Cancer Nursing · doi:10.1097/ncc.0b013e318263f514 · Cited by 69
NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders
Lee, M., McGeer, E. G., Kodela, R., Kashfi, K., & McGeer, P. L. (2013) · Glia · doi:10.1002/glia.22553 · Cited by 69
Self-citation
Imipramine and fluoxetine inhibit LPS-induced activation and affect morphology of microglial cells in the rat glial culture
Obuchowicz, E., Bielecka, A., Paul-Samojedny, M., Pudełko, A., & Kowalski, J. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2013.08.002 · Cited by 68
Brain-Derived Neurotrophic Factor Induces Sustained Elevation of Intracellular Ca2+ in Rodent Microglia
Mizoguchi, Y., Monji, A., Kato, T. A., Seki, Y., Gotoh, L., Horikawa, H., Suzuki, S. O., Iwaki, T., Yonaha, M., Hashioka, S., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901326 · Cited by 68
Self-citation
Distinct non-inflammatory signature of microglia in post-mortem brain tissue of patients with major depressive disorder
Snijders, G. J. L., Sneeboer, M. A. M., Fernández-Andreu, A., Udine, E., (NBB-Psy), P. D. P. O. T. N. B. B., Boks, M. P., Ormel, P. R., van Berlekom, A. B., van Mierlo, H. C., Böttcher, C., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00896-z · Cited by 66
Mind and body: how the health of the body impacts on neuropsychiatry
Renoir, T., Hasebe, K., & Gray, L. J. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00158 · Cited by 65
Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation
Rimmerman, N., Verdiger, H., Goldenberg, H., Naggan, L., Robinson, E., Kozela, E., Gelb, S., Reshef, R., Ryan, K. M., Ayoun, L., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01338-0 · Cited by 62
Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection
Creeden, J. F., Imami, A. S., Eby, H. M., Gillman, C., Becker, K. N., Reigle, J., Andari, E., Pan, Z. K., O’Donovan, S. M., McCullumsmith, R. E., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111437 · Cited by 61
A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue
Elsayed, M., & Magistretti, P. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00468 · Cited by 62
Gut Bacteria and Neuropsychiatric Disorders
Dicks, L. M. T., Hurn, D., & Hermanus, D. (2021) · Microorganisms · doi:10.3390/microorganisms9122583 · Cited by 63
Lithium modulates the production of peripheral and cerebral cytokines in an animal model of mania induced by dextroamphetamine
Valvassori, S. S., Tonin, P. T., Varela, R. B., Carvalho, A. F., Mariot, E., Amboni, R. T., Bianchini, G., Andersen, M. L., & Quevedo, J. (2015) · Bipolar Disorders · doi:10.1111/bdi.12299 · Cited by 58
Noradrenergic Regulation of Glial Activation: Molecular Mechanisms and Therapeutic Implications
Braun, D. J., Madrigal, J. L. M., & Feinstein, D. L. (2014) · Current Neuropharmacology · doi:10.2174/1570159x12666140828220938 · Cited by 56
Role of nitric oxide in obsessive–compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice
Umathe, S. N., Bhutada, P., Jain, N. S., Mundhada, Y. R., Borkar, S. S., & Dhumal, B. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.07.001 · Cited by 54
Neuroimmune endocrine effects of antidepressants
Carvalho, L. A. (2012) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s16409 · Cited by 52
A role for nitrergic system in the antidepressant-like effects of chronic lithium treatment in the mouse forced swimming test
Ghasemi, M., Sadeghipour, H., Poorheidari, G., & Dehpour, A. R. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.032 · Cited by 51
Fluoxetine reverses behavior changes in socially isolated rats: role of the hippocampal GSH-dependent defense system and proinflammatory cytokines
Perić, I., Stanisavljević, A., Gass, P., & Filipović, D. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0807-9 · Cited by 51
Cyclooxygenase‐2 deficiency modifies the neurochemical effects, motor impairment and co‐morbid anxiety provoked by paraquat administration in mice
Litteljohn, D., Mangano, E. N., & Hayley, S. P. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06371.x · Cited by 52
Nitric oxide: Antidepressant mechanisms and inflammation
Ghasemi, M. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.04.004 · Cited by 50
Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases
Lee, M., McGeer, E. G., & McGeer, P. L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0488-8 · Cited by 50
Self-citation
Histamine H3receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion
Iida, T., Yoshikawa, T., Matsuzawa, T., Naganuma, F., Nakamura, T., Miura, Y., Mohsen, A. S., Harada, R., Iwata, R., & Yanai, K. (2015) · Glia · doi:10.1002/glia.22812 · Cited by 50
Sex Differences in the Inflammatory Consequences of Stress: Implications for Pharmacotherapy
Martínez-Muñiz, G. A., & Wood, S. K. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266205 · Cited by 53
Microglia under psychosocial stressors along the aging trajectory: Consequences on neuronal circuits, behavior, and brain diseases
Tian, L., Hui, C. W., Bisht, K., Tan, Y., Sharma, K. P., Chen, S., Zhang, X., & Tremblay, M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.01.007 · Cited by 52
Modulation of neuroimmune cytokine networks by antidepressants: implications in mood regulation
Nava, R. G., Adri, A. S., Filgueiras, I. S., Nóbile, A. L., Barcelos, P. M., Corrêa, Y. L. G., de Oliveira, S. F., Cabral‐Miranda, G., Dias, H. D., Schimke, L. F., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03532-y · Cited by 53
The effect of different antidepressant drugs of oxidative stress after lipopolysaccharide administration in mice
Abdel‐Salam, O. M. E., Morsy, S., & Sleem, A. A. (2012) · Europe PMC (PubMed Central) · doi:10.17877/de290r-5131 · Cited by 46
Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology
Litteljohn, D., Cummings, A., Brennan, A., Gill, A., Chunduri, S., Anisman, H., & Hayley, S. P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.12.001 · Cited by 48
Increase in IL-6 levels among major depressive disorder patients after a 6-week treatment with duloxetine 60 mg/day: a preliminary observation
Fornaro, M., Martino, M., Battaglia, F., Colicchio, & Perugi, G. (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s16382 · Cited by 46
Early effects of Staphylococcus aureus biofilm secreted products on inflammatory responses of human epithelial keratinocytes
Tankersley, A. N., Frank, M. B., Bebak, M., & Brennan, R. E. (2014) · Journal of Inflammation · doi:10.1186/1476-9255-11-17 · Cited by 44
Reduction of Iba1-expressing microglial process density in the hippocampus following electroconvulsive shock
Jinno, S., & Kosaka, T. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.028 · Cited by 42
Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells
Kim, E.-A. L., Han, A. R., Choi, J.-Y., Ahn, J., Choi, S. Y., & Cho, S. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.06.022 · Cited by 42
Serum cytokines-based biomarkers in the diagnosis and monitoring of therapeutic response in patients with major depressive disorder
Xu, Y., Liang, J., Sun, Y., Zhang, Y., Shan, F., Ge, J., & Xia, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110108 · Cited by 41
The possible immunoregulatory and anti-inflammatory effects of selective serotonin reuptake inhibitors in coronavirus disease patients
Hamed, M. G. M., & Hagag, R. S. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110140 · Cited by 42
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-κB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells
Yang, J., Rui, B.-B., Chen, C., Chen, H., Xu, T., Xu, W. P., & Wei, W. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.016 · Cited by 41
Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia
Kato, T. A., Hayakawa, K., Monji, A., & Kanba, S. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00053 · Cited by 43
Self-citation
Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain
Liu, Y., Zhu, S., Wang, K., Feng, Z.-Y., & Chen, Q.-L. (2008) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b0820039 · Cited by 39
Preventing neurodegeneration by adrenergic astroglial excitation
Zorec, R., Parpura, V., & Verkhratsky, A. (2018) · FEBS Journal · doi:10.1111/febs.14456 · Cited by 40
Tianeptine exerts neuroprotective effects in the brain tissue of rats exposed to the chronic stress model
Della, F. P., Abelaira, H. M., Réus, G. Z., Antunes, A. R., dos Santos, M. A. B., Zappellini, G., Steckert, A. V., Vuolo, F. S., Galant, L. S., Dal‐Pizzol, F., et al. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.09.018 · Cited by 39
Fluoxetine induces vasodilatation of cerebral arterioles by co‐modulating NO /muscarinic signalling
Ofek, K., Schoknecht, K., Melamed‐Book, N., Heinemann, U., Friedman, A., & Soreq, H. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01596.x · Cited by 37
DHA effects in Parkinson disease depression
Pomponi, M., Loria, G., Salvati, S., Biase, A. D., Conte, G. L., Villella, C., Righino, E., Ciciarelli, C., Bria, P., Torre, G. L., et al. (2014) · Basal Ganglia · doi:10.1016/j.baga.2014.03.004 · Cited by 37
Pathologic role of nitrergic neurotransmission in mood disorders
Ghasemi, M., Claunch, J. D., & Niu, K. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.002 · Cited by 37

Authors: Hashioka, S., Klegeris, A., Monji, A., Kato, T., Sawada, M., McGeer, P. L., & Kanba, S.
Affiliations: Kyushu University (JP)
University of British Columbia (CA)
Research Institute of Environmental Medicine, Nagoya University (JP)
Corresponding author: Hashioka, Sadayuki
Monji, Akira
ORCID: Hashioka, Sadayuki
Klegeris, Andis
Monji, Akira
Kato, Takahiro
Sawada, Makoto
McGeer, Patrick L.
Venue: Experimental Neurology
Publisher: Elsevier BV
Published: 2007-07
Volume: 206
Issue: 1
Pages: 33-42
ISSN: 0014-4886 (ISSN-L)
DOI: 10.1016/j.expneurol.2007.03.022
OpenAlex: W1970022478
Cited by: 198
References: 42
Citations by year: 2026: 3 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 5 · 2017: 7 · 2016: 18 · 2015: 16 · 2014: 18 · 2013: 14 · 2012: 18
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: antidepressants, microglia, interferon-gamma, interleukin-6, nitric oxide, fluvoxamine, reboxetine, imipramine, lithium chloride, cAMP signaling, protein kinase A, microglial activation, depression, inflammatory cytokines, mood stabilizers
MeSH terms: Cyclic AMP, Animals, Antidepressive Agents, Antiviral Agents, Brain, Cell Line, Depressive Disorder, Dose-Response Relationship, Drug, Enzyme Inhibitors, Interferon-gamma, Mice, Inbred C57BL, Nitric Oxide, Neurotransmitter Uptake Inhibitors, Interleukin-6, Up-Regulation, Microglia, Cyclic AMP-Dependent Protein Kinases, Lithium Chloride, Antimanic Agents, MAP Kinase Signaling System, Mice, Cyclic AMP-Dependent Protein Kinase Type II

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks