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Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease

Beauquis, Juan, Pavía, Patricio, Pomilio, Carlos, Vinuesa, Angeles, Podlutskaya, Natalia, Galvan, Verónica, Saravia, Flavia·2013·Experimental Neurology
DOI 10.1016/j.expneurol.2012.09.009
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that affects neurons and glial cells and leads to dementia. Growing evidence shows that glial changes may precede neuronal alterations and behavioral impairment in the progression of the disease. The modulation of these changes could be addressed as a potential therapeutic strategy. Environmental enrichment has been classically associated to effects on neuronal morphology and function but less attention has been paid to the modulation of glia. We thus characterized astroglial changes in the hippocampus of adult PDAPP-J20 transgenic mice, a model of AD, exposed for 3 months to an enriched environment, from 5 to 8 months of age. Using confocal microscopy, three-dimensional reconstruction and Sholl analysis, we evaluated the morphology of two distinct populations of astrocytes: those associated to amyloid β plaques and those that were not. We found that plaque-associated astrocytes in PDAPP-J20 mice had an increased volume and process ramification than control astrocytes. Non-plaque-associated astrocytes showed a decrease in volume and an increase in the ramification of GFAP+ processes as compared with control astrocytes. Environmental enrichment prevented these alterations and promoted a cellular morphology similar to that found in control mice. Morphological changes in non-plaque-associated astrocytes were found also at 5 months of age, before amyloid β deposition in the hippocampus. These results suggest that glial alter…

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Metadata

Authors
Beauquis, J., Pavía, P., Pomilio, C., Vinuesa, A., Podlutskaya, N., Galvan, V., & Saravia, F.
Venue
Experimental Neurology
Publisher
Elsevier BV
Published
2013-01
Volume
239
Pages
28-37
ISSN
0014-4886
DOI
10.1016/j.expneurol.2012.09.009
Cited by
148
References
12
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
Agencia Nacional de Promoción de Ciencia y Tecnología of Argentina (PICT 2011, #1012)

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