An Integration Study of Microalgae Bioactive Retention: From Microalgae Biomass to Microalgae Bioactives Nanoparticle
Abstract
Microalgae metabolites include biologically active compounds with therapeutic effects such as anticancer, anti-inflammatory and immunomodulation effects. One of the most recent focuses is on utilizing microalgae lipid-based biologically active compounds in food applications. However, most microalgae biological active compounds in their natural forms have common drawbacks like low solubility, low physicochemical stability and strong susceptibility to degradation, which significantly limits their application in foods, therefore, it is important to find solutions to retain their functional properties. In the present work, a comprehensive review on multi-product biorefinery was carried out from upstream processing stage to downstream processing stage, and identify critical processes and factors that impact bioactive material acquisition and retention. Furthermore, since nanoencapsulation technology emerges as an effective solution for microalgae nutraceutical product's retention, this work also focus on the nanoparticle perspective and comprehensively reviews the current nanoencapsulation solutions of the microalgae bioactive extract products. The aim is to depict advances in the formulations of microalage bioactive nanoparticles and provide a critical analysis of the reported nanoparticle formation. Overall, through the investigation of microalgae from biomass to bioactive nanoparticles, we aim to facilitate microalgae nutraceuticals incorporation as high value-added ingredients in more functional food that can improve human health.
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Biochemical content of microalgae is affected by light, humidity, pH, and high temperature, making them unstable.
“The biochemical content of microalgae is affected by light, humidity, pH, and high temperature, i.e., they are quite unstable [151].”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [151]
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- Authors
- Cai, Y., Lim, H. R., Khoo, K. S., Ng, H.-S., Cai, Y., Wang, J., Tak-Yee Chan, A., & Show, P. L.
- Affiliations
- University of Nottingham (GB)
- University of Nottingham Malaysia Campus (MY)
- UCSI University (MY)
- Dongguan University of Technology (CN)
- Corresponding author
- Khoo, Kuan Shiong
- Show, Pau Loke
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 158
- Pages
- 112607
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W3206015401
- Cited by
- 37
- References
- 90
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 11 · 2022: 7
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Keywords
- microalgae, bioactive compounds, nanoencapsulation, bioactive nanoparticles, microalgal lipids, functional foods, bioactive retention, downstream processing, anticancer agents, anti-inflammatory agents, immunomodulation
- MeSH terms
- Biological Products, Drug Compounding, Humans, Biomass, Dietary Supplements, Nanoparticles, Functional Food, Biofuels, Microalgae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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