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The logic of TGFβ signaling
Abstract
The identification of the TGFβ cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses – the cell cycle arrest response – into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.
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Metadata
- Authors
- Massagué, J., & Gomis, R. R.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-04-21
- Volume
- 580
- Issue
- 12
- Pages
- 2811-2820
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2074629755
- Cited by
- 721
- References
- 109
- FWCI
- 25.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
