mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

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TOR signaling in growth and metabolism

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

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Metformin and reduced risk of cancer in diabetic patients

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A mammalian protein targeted by G1-arresting rapamycin–receptor complex

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

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Hypothalamic mTOR Signaling Regulates Food Intake

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

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Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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The LKB1 tumor suppressor negatively regulates mTOR signaling

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Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

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Hepatocellular carcinoma: Recent trends in the United States

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Mammalian TOR: a homeostatic ATP sensor

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GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

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Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma

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Plasma Amino Acid Levels and Insulin Secretion in Obesity

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

Shah, O. J., Wang, Z., & Hunter, T. R. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.026 · Cited by 800 · see citing works

Overweight as an avoidable cause of cancer in Europe

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

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Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

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Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study

Davila, J. A., Morgan, R. O., Shaib, Y. H., McGlynn, K. A., & El‐Serag, H. B. (2005) · Gut · doi:10.1136/gut.2004.052167 · Cited by 703 · see citing works

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

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Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis

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mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

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Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

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The NF1 tumor suppressor critically regulates TSC2 and mTOR

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndromePreprint

Corradetti, M. N., Inoki, K., Bardeesy, N. M., DePinho, R. A., & Guan, K. (2004) · Genes & Development · doi:10.1101/gad.1199104 · Cited by 560 · see citing works

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

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hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

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Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

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The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation

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Rheb fills a GAP between TSC and TOR

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Phase II Study of Temsirolimus (CCI-779), a Novel Inhibitor of mTOR, in Heavily Pretreated Patients With Locally Advanced or Metastatic Breast Cancer

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Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

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Akt-dependent transformation: there is more to growth than just surviving

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PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR

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The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses

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Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

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Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin

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A Novel Method for Measurement of Submembrane ATP Concentration

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Nutrition, Insulin, Insulin-like Growth Factors and Cancer

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Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1

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L ‐type amino acid transporter 1 as a potential molecular target in human astrocytic tumors

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Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors

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Obesity and risk of cancer in Japan

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The amino acid sensitive TOR pathway from yeast to mammals

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Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

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Splanchnic glucose and amino acid metabolism in obesity.

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dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

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Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signalingPreprint

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Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis

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Characterization of the expression pattern of p63α and δnp63α in benign and malignant oral epithelial lesions

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The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

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Imatinib and Regression of Type 2 Diabetes

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Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

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A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

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Imatinib Mesylate May Improve Fasting Blood Glucose in Diabetic Ph+ Chronic Myelogenous Leukemia Patients Responsive to Treatment

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Cancer Targets in the Ras PathwayPreprint

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hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

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Diabetes Mellitus and Risk of Large Bowel Cancer

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G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation

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Nutrient sensor links obesity with diabetes risk

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Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent Regulation

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Overexpression of LAT1/CD98 Light Chain Is Sufficient to Increase System l-Amino Acid Transport Activity in Mouse Hepatocytes but Not Fibroblasts

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Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells.

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Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells

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Mammalian Target of Rapamycin Inhibitors in Combination with Letrozole in Breast Cancer

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Improvement of Type 2 Diabetes in a Lung Cancer Patient Treated With Erlotinib

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Are Plasma Amino Acid Levels Elevated in Obesity?

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Nutrition, energy balance and colon cancer risk: the role of insulin and insulin-like growth factor-I.

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Rapamycin together with herceptin significantly increased anti‐tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells

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Molecular mechanisms of mTOR-mediated translational control

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Chronic high fat feeding attenuates load‐induced hypertrophy in mice

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Metformin for treatment of fragile X syndrome and other neurological disorders

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Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors

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Chapter 11 Monitoring Mammalian Target of Rapamycin (mTOR) Activity

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