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Calorie restriction and prevention of age‐associated chronic disease

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Omodei, Daniela, Fontana, Luigi·2011·FEBS Letters

DOI 10.1016/j.febslet.2011.03.015PMC PMC3439843

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Abstract

Life expectancy in the world has increased dramatically during the last century; the number of older adults is expected to rise while the number of youths will decline in the near future. This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases. Calorie restriction (CR) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents. In non‐human and human primates, CR with adequate nutrition protects against abdominal obesity, diabetes, hypertension and cardiovascular diseases. Cancer morbidity and mortality are also diminished in CR monkeys, and data obtained from individuals practicing long‐term CR show a reduction of metabolic and hormonal factors associated with increased cancer risk.

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Postscript
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Exercise, 1930–1939
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Introduction
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Conclusion
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Authors: Omodei, D., & Fontana, L.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Fontana, Luigi
ORCID: Omodei, Daniela
Fontana, Luigi
Venue: FEBS Letters
Publisher: Wiley
Published: 2011-03-12
Volume: 585
Issue: 11
Pages: 1537-1542
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2011.03.015
PMC: PMC3439843
OpenAlex: W2054879507
Cited by: 293
References: 95
Citations by year: 2026: 5 · 2025: 10 · 2024: 12 · 2023: 19 · 2022: 13 · 2021: 14 · 2020: 39 · 2019: 17 · 2018: 20 · 2017: 21 · 2016: 20 · 2015: 19 · 2014: 21 · 2013: 36 · 2012: 21
FWCI: 2.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Funders: National Center for Research Resources (UL1 RR024992)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341)
Istituto Superiore di Sanità/National Institutes of Health Collaboration Program, Ministero della Salute
Longer Life Foundation
Bakewell Foundation
Scott and Annie Appleby Charitable Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords: caloric restriction, aging, disease prevention, dietary intervention, obesity, diabetes mellitus, hypertension, cardiovascular disease, cancer risk, metabolic factors, hormonal factors, non-human primates, rodents
MeSH terms: Aging, Animals, Cardiovascular Diseases, Chronic Disease, Humans, Neoplasms, Caloric Restriction

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Calorie restriction and prevention of age‐associated chronic disease

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