Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis
Open accessAbstract
Objective Since endometriosis is a persistent disease with substantial gene dysregulation, there must be cellular memory of some sort that constitutes a unique cell identity for endometriotic cells. Epigenetic regulation, especially through DNA methylation, is a flexible, yet stable, mechanism for maintaining such a cellular memory. The aim of this study was to determine gene expression levels of DNMT1, DNMT3A, and DNMT3B, the three genes coding for DNA methyltransferases that are responsible for methylation.Design Cross-sectional measurements of gene expression levels of DNMT1, DNMT3A, and DNMT3B on endometriotic tissue.Setting Academic.Patient(s) Seventeen patients with laparoscopically confirmed endometriosis and 8 healthy women who underwent tubal sterilization who were free of endometriosis were recruited for the study.Intervention(s) Epithelial cells were harvested from tissue samples by laser capture microdissection and messenger RNA abundance was measured by quantitative real-time reverse transcription-polymerase chain reaction.Main outcome measure(s) The expression levels of these genes in epithelial cells from 13 ectopic endometrial tissue samples, 10 eutopic endometrial tissue samples taken from women with endometriosis, and 8 normal endometrial tissue samples from women without endometriosis.Result(s) The genes DNMT1, DNMT3A, and DNMT3B were over-expressed in the ectopic endometrium as compared with normal control subjects or the eutopic endometrium of women with endometriosis, and their expression levels were correlated positively with each other.Conclusion(s) The aberrant expression of these genes suggests that aberrant methylation may be rampant in endometriosis. This also provides a strong piece of evidence that endometriosis ultimately may be an epigenetic disease.
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High levels of expression of DNMTs can lead to transcriptional activation or silencing of critical genes involved in regulating cell growth and apoptosis, thereby resulting in the survival of endometrial cells.
“High levels of expression of DNMTs can lead to transcriptional activation or silencing of critical genes involved in regulating cell growth and apoptosis, respectively, thereby resulting in the survival of endometrial cells.30”
From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [30]
DNA methyltransferases (DNMT1, DNMT3a, and DNMT3b) are highly expressed in endometrial lesions.
“DNA methyltransferases (DNMT1, DNMT3a, and DNMT3b) are highly expressed in endometrial lesions.”
From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [30]
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Cites
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works
The fundamental role of epigenetic events in cancer
Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648 · see citing works
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777 · see citing works
Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166 · see citing works
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078 · see citing works
DNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864 · see citing works
Rw, N., Hertig, A. T., & Rock, J. A. (1950) · Fertility and Sterility · doi:10.1016/s0015-0282(16)30062-0 · Cited by 2,854 · see citing works
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
Rhee, I. P., Bachman, K. E., Park, B. H., Jair, K.-W., Yen, R.-W. C., Schuebel, K. E., Cui, H., Feinberg, A. P., Christoph Lengauer, C., Kinzler, K. W., et al. (2002) · Nature · doi:10.1038/416552a · Cited by 1,243 · see citing works
DNA methylation in health and disease
Robertson, K. D., & Wolffe, A. P. (2000) · Nature Reviews Genetics · doi:10.1038/35049533 · Cited by 1,056 · see citing works
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816 · see citing works
DNA methylation, methyltransferases, and cancer
Robertson, K. D. (2001) · Oncogene · doi:10.1038/sj.onc.1204341 · Cited by 732 · see citing works
Kao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696 · see citing works
Aromatase expression in endometriosis.
Noble, L. S., Simpson, E. R., Johns, A., & Bulun, S. E. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.1.8550748 · Cited by 566 · see citing works
ABERRANT DNA METHYLATION AS A CANCER-INDUCING MECHANISM
Esteller, M. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095832 · Cited by 549 · see citing works
Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis
Attia, G. R. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2897 · Cited by 488 · see citing works
The Role of Laparoscopy in Chronic Pelvic Pain: Promise and Pitfalls
HOWARD, F. M. (1993) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199306000-00001 · Cited by 434 · see citing works
HOX gene expression is altered in the endometrium of women with endometriosis
Taylor, H. S. (1999) · Human Reproduction · doi:10.1093/humrep/14.5.1328 · Cited by 372 · see citing works
Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.
Girault, I., Tozlu, S., Lidereau, R., & Bièche, I. (2003) · PubMed · Cited by 358 · see citing works
Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Endometriosis
Wu, Y., Strawn, E., Basir, Z., Halverson, G., & Guo, S. (2006) · Epigenetics · doi:10.4161/epi.1.2.2766 · Cited by 323 · see citing works
Self-citationEndometriosis and Subfertility: Is the Relationship Resolved?
D’Hooghe, T. M., Debrock, S., Hill, J. A., & Meuleman, C. (2003) · Seminars in Reproductive Medicine · doi:10.1055/s-2003-41330 · Cited by 320 · see citing works
Zeitoun, K., Takayama, K., Sasano, H., Suzuki, T., Moghrabi, N., Andersson, S., Johns, A., Meng, L., Putman, M., Carr, B., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5301 · Cited by 308 · see citing works
Expression of various genes is controlled by DNA methylation during mammalian development
Ehrlich, M. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10464 · Cited by 287 · see citing works
Wu, Y., Halverson, G., Basir, Z., Strawn, E., Yan, P., & Guo, S.-W. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.01.034 · Cited by 283 · see citing works
Self-citationProgestins for symptomatic endometriosis: a critical analysis of the evidence
Vercellini, P., Cortesi, I., & Crosignani, P. G. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00193-3 · Cited by 229 · see citing works
Transcriptional characterizations of differences between eutopic and ectopic endometrium
Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W. (2006) · Endocrinology · doi:10.1210/en.2005-0426 · Cited by 208 · see citing works
Self-citationAberrant methylations in cancer cells: Where do they come from?
Ushijima, T., & Okochi‐Takada, E. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00035.x · Cited by 184 · see citing works
Matsuzaki, S., Canis, M. J., Vaurs‐Barrière, C., Boespflug‐Tanguy, O., Dastugue, B., & Mage, G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.041 · Cited by 151 · see citing works
Matrix Metalloproteinases and Endometriosis
Osteen, K. G., Yeaman, G. R., & Bruner‐Tran, K. L. (2003) · Seminars in Reproductive Medicine · doi:10.1055/s-2003-41322 · Cited by 150 · see citing works
Diagnostic and Therapeutic Applications of Epigenetics
Miyamoto, K., & Ushijima, T. (2005) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyi088 · Cited by 149 · see citing works
Xiong, Y., Dowdy, S. C., Podratz, K. C., Jin, F., Attewell, J. R., Eberhardt, N. L., & Jiang, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2843 · Cited by 139 · see citing works
Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis.
Arimoto, T., Katagiri, T., Oda, K., Tsunoda, T., Yasugi, T., Osuga, Y., Yoshikawa, H., Nishii, O., Yano, T., Taketani, Y., et al. (2003) · PubMed · Cited by 125 · see citing works
DNA methylation 40 years later: Its role in human health and disease
Scarano, M. I., Strazzullo, M., Matarazzo, M. R., & D'Esposito, M. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20280 · Cited by 120 · see citing works
Matsuzaki, S., Canis, M. J., Vaurs‐Barrière, C., Pouly, J.-L., Boespflug‐Tanguy, O., Penault-Llorca, F. M., Dechelotte, P., Dastugue, B., Okamura, K., & Mage, G. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah097 · Cited by 117 · see citing works
Kitawaki, J., Ishihara, H., Koshiba, H., Kiyomizu, M., Teramoto, M., Kitaoka, Y., & Honjo, H. (2005) · Human Reproduction · doi:10.1093/humrep/deh890 · Cited by 112 · see citing works
Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization
Gogusev, J., Joliniere, J. B. D., Telvi, L., Doussau, M., du Manoir, S., Stojkoski, A., & Levardon, M. (1999) · Human Genetics · doi:10.1007/s004390051129 · Cited by 93 · see citing works
The reproducibility of the revised American Fertility Society classification of endometriosis
Hornstein, M. D., Gleason, R. E., Orav, E. J., Haas, S. T., Friedman, A. J., Rein, M. S., Hill, J. A., & Barbieri, R. L. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55921-4 · Cited by 92 · see citing works
Bischoff, F. Z., Heard, M., & Simpson, J. L. (2002) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(01)00131-0 · Cited by 82 · see citing works
DNMT cooperativity—the developing links between methylation, chromatin structure and cancer
El‐Osta, A. (2003) · BioEssays · doi:10.1002/bies.10345 · Cited by 80 · see citing works
Aberrant DNA Methylation in Cutaneous Malignancies
van Doorn, R., Gruis, N. A., Willemze, R., van der Velden, P. A., & Tensen, C. P. (2005) · Seminars in Oncology · doi:10.1053/j.seminoncol.2005.07.001 · Cited by 73 · see citing works
Increased heterogeneity of chromosome 17 aneuploidy in endometriosis
Kosugi, Y., Elias, S., Malinak, L. R., Nagata, J., Isaka, K., Takayama, M., Simpson, J. L., & Bischoff, F. Z. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70649-6 · Cited by 72 · see citing works
Goumenou, A. G., Arvanitis, D. A., Matalliotakis, I., Koumantakis, E. E., & Spandidos, D. A. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01663-0 · Cited by 71 · see citing works
Up-regulation of DNA methyltransferase 3B expression in endometrial cancers
Jin, F., Dowdy, S. C., Xiong, Y., Eberhardt, N. L., Podratz, K. C., & Jiang, S. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.10.039 · Cited by 67 · see citing works
Shin, J.-C., Ross, H. L., Elias, S., Nguyen, D. D., Mitchell‐Leef, D., Simpson, J. L., & Bischoff, F. Z. (1997) · Human Genetics · doi:10.1007/s004390050524 · Cited by 59 · see citing works
Xiong, Y., Dowdy, S. C., Xue, A., Shujuan, J., Eberhardt, N. L., Podratz, K. C., & Jiang, S. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.11.047 · Cited by 59 · see citing works
Endometriosis and Infertility: Is There a Cause and Effect Relationship?
Witz, C. A., & Burns, W. N. (2002) · Gynecologic and Obstetric Investigation · doi:10.1159/000049418 · Cited by 52 · see citing works
Wieser, F., Vigne, J., Ryan, I. P., Hornung, D., Djalali, S., & Taylor, R. N. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0972 · Cited by 52 · see citing works
MATSUZAKI, S., CANIS, M., DARCHA, C., FUKAYA, T., YAJIMA, A., & BRUHAT, M. A. (1998) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1998.tb00420.x · Cited by 50 · see citing works
Genomic alterations in the endometrium may be a proximate cause for endometriosis
Guo, S., Wu, Y., Strawn, E., Basir, Z., Wang, Y., Halverson, G., Montgomery, K., & Kajdacsy-Balla, A. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.02.004 · Cited by 46 · see citing works
Self-citationUp-regulation of DNA methyltransferases DNMT1, 3A, and 3B in myelodysplastic syndrome
Länger, F. P., Dingemann, J., Kreipe, H. H., & Lehmann, U. (2004) · Leukemia Research · doi:10.1016/j.leukres.2004.08.004 · Cited by 43 · see citing works
Expression of steroid hormone receptors, proliferation and apoptotic markers in primate endometrium
Narkar, M., Kholkute, S. D., Chitlange, S., & Nandedkar, T. D. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.029 · Cited by 30 · see citing works
Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization
Gogusev, J., Joliniere, J. B. D., Telvi, L., et al. (1999) · Human Genetics · doi:10.1007/s004399900174 · Cited by 29 · see citing works
Mammalian DNA Methyltransferase 1: Inspiration for New Directions
Ting, A. H., Jair, K.-W., Suzuki, H., Yen, R.-W. C., Baylin, S. B., & Schuebel, K. E. (2004) · Cell Cycle · doi:10.4161/cc.3.8.1070 · Cited by 28 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Zeitoun K, Takayama K, Sasano H, Suzuki T, Moghrabi N, Andersson S, et al. Deficient 17beta-hydroxysteroid dehydrogenase type 2 expres- sion in endometriosis: failure to metabolize 17beta-estradiol. J Clin Endocrinol Metab 1998;83:4474 -80.
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Baylin, S. B., & Jones, P. A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019505 · Cited by 1,363 · see citing works
Cancer Genetics and Epigenetics: Two Sides of the Same Coin?
You, J. S., & Jones, P. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.06.008 · Cited by 1,163 · see citing works
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights
Laganà, A. S., Garzon, S., Götte, M., Viganò, P., Franchi, M. P., Ghezzi, F., & Martin, D. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225615 · Cited by 492 · see citing works
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Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328 · see citing works
Self-citationEndometriosis-associated infertility: From pathophysiology to tailored treatment
Bonavina, G., & Taylor, H. S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1020827 · Cited by 359 · see citing works
Bromer, J. G., Zhou, Y., Taylor, M. B., Doherty, L. F., & Taylor, H. S. (2010) · The FASEB Journal · doi:10.1096/fj.09-140533 · Cited by 303 · see citing works
The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and FertilityPreprint
Du, H., & Taylor, H. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a023002 · Cited by 252 · see citing works
Structural and molecular features of the endomyometrium in endometriosis and adenomyosis
Benagiano, G., Brosens, I., & Habiba, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt052 · Cited by 246 · see citing works
Endometrial alterations in endometriosis: a systematic review of putative biomarkers
May, K. E., Villar, J., Kirtley, S., Kennedy, S. H., & Becker, C. M. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr013 · Cited by 237 · see citing works
Dyson, M. T., Roqueiro, D., Monsivais, D., Ercan, C. M., Pavone, M. E., Brooks, D. C., Kakinuma, T., Ono, M., Jafari, N., Dai, Y., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004158 · Cited by 211 · see citing works
Lee, B., Du, H., & Taylor, H. S. (2009) · Biology of Reproduction · doi:10.1095/biolreprod.108.070391 · Cited by 204 · see citing works
Bromer, J. G., Wu, J., Zhou, Y., & Taylor, H. S. (2009) · Endocrinology · doi:10.1210/en.2009-0071 · Cited by 189 · see citing works
Peter, A. W., Adamson, G. D., Al‐Jefout, M., Becker, C. M., D’Hooghe, T. M., Dunselman, G. A. J., Fazleabas, A. T., Giudice, L. C., Horne, A. W., Hull, M. L., et al. (2016) · Reproductive Sciences · doi:10.1177/1933719116654991 · Cited by 188 · see citing works
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Gupta, D., Hull, M. L., Fraser, I. S., Miller, L., Bossuyt, P. M., JOHNSON, N. P., & Nisenblat, V. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012165 · Cited by 174 · see citing works
Filigheddu, N., Gregnanin, I., Porporato, P. E., Surico, D., Perego, B., Galli, L., Patrignani, C., Graziani, A., & Surico, N. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/369549 · Cited by 162 · see citing works
Yamagata, Y., Asada, H., Tamura, I., Lee, L., Maekawa, R., Taniguchi, K., Taketani, T., Matsuoka, A., Tamura, H., & Sugino, N. (2009) · Human Reproduction · doi:10.1093/humrep/dep015 · Cited by 151 · see citing works
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Self-citationGuo, S. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000096047 · Cited by 140 · see citing works
Self-citationProgesterone Resistance in Endometriosis: Current Evidence and Putative Mechanisms
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Cellular and molecular basis for endometriosis-associated infertility
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Lu, Y., Nie, J., Liu, X., Zheng, Y., & Guo, S. (2010) · Human Reproduction · doi:10.1093/humrep/dep472 · Cited by 111 · see citing works
Self-citationCakmak, H., & Taylor, H. (2010) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1242996 · Cited by 105 · see citing works
Insufficient maintenance DNA methylation is associated with abnormal embryonic development
Yin, L., Zhang, Y., Lv, P., He, W., Wu, Y., Liu, A.-X., Ding, G., Dong, M.-Y., Qu, F., Xu, C., et al. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-26 · Cited by 105 · see citing works
Self-citationWu, Y., Starzinski‐Powitz, A., & Guo, S. (2007) · Reproductive Sciences · doi:10.1177/1933719107302913 · Cited by 104 · see citing works
Self-citationDNA methylation in endometriosis (Review)
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Borghese, B., Barbaux, S., Mondon, F., Santulli, P., Pierre, G., Vinci, G., Chapron, C., & Vaiman, D. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0160 · Cited by 97 · see citing works
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Self-citationWu, Y., Starzinski‐Powitz, A., & Guo, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.008 · Cited by 73 · see citing works
Self-citationThe Endometrium in Adenomyosis
Benagiano, G., & Brosens, I. A. (2012) · Women s Health · doi:10.2217/whe.12.8 · Cited by 73 · see citing works
Genome-wide DNA methylation profiling in cultured eutopic and ectopic endometrial stromal cells
Yamagata, Y., Nishino, K., Takaki, E., Sato, S., Maekawa, R., Nakai, A., & Sugino, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083612 · Cited by 70 · see citing works
Liu, M.-H., Liu, X., Zhang, Y., & Guo, S. (2012) · Reproductive Sciences · doi:10.1177/1933719111424453 · Cited by 68 · see citing works
Self-citationEpigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity
Szukiewicz, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943839 · Cited by 64 · see citing works
Aberrant histone acetylation and methylation levels in woman with endometriosis
Xia, X., Zhao, M., Ma, J., & Xiaoling, F. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2591-0 · Cited by 66 · see citing works
van Kaam, K. J. A. F., Delvoux, B., Romano, A., D’Hooghe, T., Dunselman, G. A. J., & Groothuis, P. G. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.031 · Cited by 64 · see citing works
Machine Learning Classifiers for Endometriosis Using Transcriptomics and Methylomics Data
Akter, S., Xu, D. H., Nagel, S. C., Bromfield, J. J., Pelch, K. E., Wilshire, G., & Joshi, T. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00766 · Cited by 64 · see citing works
Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis
Guo, S. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12221 · Cited by 58 · see citing works
Self-citationThe impact of epigenomics on future drug design and new therapies
Hamm, C. A., & Costa, F. F. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.04.007 · Cited by 59 · see citing works
Genomic Alterations in Ectopic and Eutopic Endometria of Women with Endometriosis
Wu, Y., Strawn, E., Basir, Z., Wang, Y., Halverson, G., Jailwala, P., & Guo, S. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000093130 · Cited by 58 · see citing works
Self-citationFunamizu, A., Fukui, A., Kamoi, M., Fuchinoue, K., Yokota, M., Fukuhara, R., & Mizunuma, H. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12206 · Cited by 58 · see citing works
Szczepańska, M., Wirstlein, P. K., Łuczak, M. W., Jagodziński, P. P., & Skrzypczak, J. (2010) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2010.09.012 · Cited by 57 · see citing works
The elusive and controversial roles of estrogen and progesterone receptors in human endometriosis.
Shao, R., Cao, S., Wang, X., Feng, Y., & Billig, H. (2014) · Europe PMC (PubMed Central) · Cited by 55 · see citing works
Ponsuksili, S., Muráni, E., Schwerin, M., Schellander, K., Tesfaye, D., & Wimmers, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042402 · Cited by 55 · see citing works
Stilley, J. A. W., Woods-Marshall, R., Sutovsky, M., Šutovský, P., & Sharpe-Timms, K. L. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.108.073411 · Cited by 55 · see citing works
Expression and regulation of DNA methyltransferases in human endometrium
Vincent, Z. L., Farquhar, C. M., Mitchell, M. D., & Ponnampalam, A. P. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.09.030 · Cited by 55 · see citing works
Wang, D., Chen, Q., Zhang, C., Ren, F., & Li, T. (2012) · European journal of medical research · doi:10.1186/2047-783x-17-12 · Cited by 53 · see citing works
Logan, P. C., Yango, P., & Tran, N. D. (2017) · Reproductive Sciences · doi:10.1177/1933719117704905 · Cited by 54 · see citing works
The effect of DNA methylation inhibitor 5-Aza-2′-deoxycytidine on human endometrial stromal cells
Logan, P. C., Ponnampalam, A. P., Rahnama, F., Lobie, P. E., & Mitchell, M. D. (2010) · Human Reproduction · doi:10.1093/humrep/deq238 · Cited by 50 · see citing works
A system-wide analysis of differentially expressed genes in ectopic and eutopic endometrium
Wren, J. D., Wu, Y., & Guo, S. (2007) · Human Reproduction · doi:10.1093/humrep/dem129 · Cited by 50 · see citing works
Self-citationArosh, J. A., Lee, J., Starzinski‐Powitz, A., & Banu, S. K. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.03.023 · Cited by 49 · see citing works
Imesch, P., Fink, D. A., & Fedier, A. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.04.052 · Cited by 47 · see citing works
MEYER, J. L., ZIMBARDI, D., PODGAEC, S., AMORIM, R. L., ABRÃO, M. S., & RAINHO, C. A. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1637 · Cited by 47 · see citing works
Logan, P. C., Ponnampalam, A. P., STEINER, M. C., & Mitchell, M. D. (2012) · Molecular Human Reproduction · doi:10.1093/molehr/gas062 · Cited by 46 · see citing works
Shen, F., Wang, Y., Lu, Y., Yuan, L., Liu, X., & Guo, S. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.04.040 · Cited by 44 · see citing works
Self-citationYuan, C., Zhang, Y., Liu, Y., Zhang, T., & Wang, Z. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2016.07.015 · Cited by 44 · see citing works
Wu, Y., & Guo, S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.04.012 · Cited by 44 · see citing works
Self-citationThe growing role of gene methylation on endocrine function
García-Carpizo, V., Ruiz-Llorente, L., Fraga, M. F., & Aranda, A. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0059 · Cited by 42 · see citing works
Aberrant Immunoreactivity of Deoxyribonucleic Acid Methyltransferases in Adenomyosis
Liu, X., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000337718 · Cited by 41 · see citing works
Self-citationMicroRNA expression pattern differs depending on endometriosis lesion type†
Haikalis, M. E., Wessels, J. M., Leyland, N. A., Agarwal, S. K., & Foster, W. G. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy019 · Cited by 41 · see citing works
The Interplay between T Cells and Cancer: The Basis of Immunotherapy
Chen, C., Liu, X., Chang, C., Wang, H. Y., & Wang, R. (2023) · Genes · doi:10.3390/genes14051008 · Cited by 39 · see citing works
Yuan, C., Wang, L., Zhu, L., Ran, B., Xue, X., & Wang, Z. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.02.035 · Cited by 38 · see citing works
Dyson, M. T., Kakinuma, T., Pavone, M. E., Monsivais, D., Navarro, A., Malpani, S. S., Ono, M., & Bulun, S. E. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.06.046 · Cited by 37 · see citing works
Mortlock, S., Houshdaran, S., Kosti, I., Rahmioğlu, N., NEZHAT, C. R., Vitonis, A. F., Andrews, S. V., Grosjean, P., Paranjpe, M. D., Horne, A. W., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05070-z · Cited by 38 · see citing works
Current Knowledge on Endometriosis Etiology: A Systematic Review of Literature
Михалева, Л. М., Radzinsky, V. E., Orazov, M. R., Николаевна, Х. Т., Sorokina, A. V., Александрович, М. С., Владимировна, В. С., Shustova, V. B., & Sinelnikov, M. Y. (2021) · International Journal of Women s Health · doi:10.2147/ijwh.s306135 · Cited by 37 · see citing works
A role for vimentin in Crohn disease
Henderson, P., Wilson, D. C., Satsangi, J. J., & Stevens, C. (2012) · Autophagy · doi:10.4161/auto.21690 · Cited by 36 · see citing works
Wang, L., Zhao, J., Li, Y., Wang, Z., & Kang, S. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23127 · Cited by 33 · see citing works
Zhou, Y., Gu, B., Brichant, G., Singh, J. P., Yang, H., Chang, H., Zhao, Y., Cheng, C., Liu, Z., Alderman, M. H., et al. (2022) · BMC Biology · doi:10.1186/s12915-022-01293-4 · Cited by 31 · see citing works
Włodarczyk, M., Ciebiera, M., Nowicka, G., Łoziński, T., Ali, M. K., & Al-Hendy, A. A. (2024) · Nutrients · doi:10.3390/nu16040559 · Cited by 31 · see citing works
The Endometriotic Tissue Lining the Internal Surface of Endometrioma
Sanchez, A., Viganò, P., Somigliana, E., Cioffi, R., Panina-Bordignon, P., & Candiani, M. (2015) · Reproductive Sciences · doi:10.1177/1933719114529374 · Cited by 23 · see citing works
Cao, Y. (2015) · Frontiers of Medicine · doi:10.1007/s11684-015-0406-y · Cited by 29 · see citing works
The Present and the Future of Medical Therapies for Adenomyosis: A Narrative Review
Moawad, G., Youssef, Y., Fruscalzo, A., Faysal, H., Kheil, M. H., Pirtea, P., Guani, B., Ayoubi, J. M., & Féki, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12196130 · Cited by 28 · see citing works
Risk of carcinoma in women with ovarian endometrioma
Kobayashi, H. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e267 · Cited by 28 · see citing works
A DNA Methylation Perspective on Infertility
Shacfe, G., Turko, R., Syed, H., Masoud, I., Tahmaz, Y., Samhan, L. M., AlKattan, K. M., Shafqat, A., & Yaqinuddin, A. (2023) · Genes · doi:10.3390/genes14122132 · Cited by 28 · see citing works
Ding, D., Liu, X., & Guo, S. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.11.033 · Cited by 28 · see citing works
Self-citationGattazzo, C., Teramo, A., Miorin, M., Scquizzato, E., Cabrelle, A., Balsamo, M. L., Agostini, C., Vendrame, E., Facco, M., Albergoni, M. P., et al. (2010) · Haematologica · doi:10.3324/haematol.2010.023358 · Cited by 28 · see citing works
Recent Advances in Gene Therapy of Endometriosis
Shubina, A., Egorova, A., Баранов, В. С., & Kiselev, A. (2014) · Recent Patents on DNA & Gene Sequences · doi:10.2174/18722156113079990021 · Cited by 28 · see citing works
Borghese, B., Santulli, P., Héquet, D., Pierre, G., de Ziegler, D., Vaiman, D., & Chapron, C. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.01.009 · Cited by 26 · see citing works
Epigenetic control of embryo–uterine crosstalk at peri-implantation
Kong, S., Zhou, C., Bao, H., Ni, Z., Liu, M., He, B., Huang, L., Sun, Y., Wang, H., & Lu, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03245-8 · Cited by 27 · see citing works
Epigenetic dysregulation of endometriosis susceptibility genes (Review)
Koike, N., Higashiura, Y., Akasaka, J., Uekuri, C., Ito, F., & Kobayashi, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3635 · Cited by 25 · see citing works
The endometrial epigenome and its response to steroid hormones.
Guo, S.-W. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.10.025 · Cited by 24 · see citing works
Self-citationLogan, P. C., Mitchell, M. D., & Lobie, P. E. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00265 · Cited by 25 · see citing works
Molecular aspects of endometriosis
Adamyan, L. V., & Aznaurova, Y. B. (2015) · Russian Journal of Human Reproduction · doi:10.17116/repro201521266-77 · Cited by 25 · see citing works
Emerging drugs for endometriosis
Guo, S. (2008) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210802548360 · Cited by 25 · see citing works
Self-citationYuan, C., Zhang, Y., Liu, Y., Wang, S., & Wang, Z. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.12.098 · Cited by 24 · see citing works
Various types of adenomyosis and endometriosis: in search of optimal management
Guo, S. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.03.021 · Cited by 24 · see citing works
Self-citationWu, Y., Starzinski‐Powitz, A., & Guo, S. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000279324 · Cited by 23 · see citing works
Self-citation
- Authors
- Wu, Y., Strawn, E., Basir, Z., Halverson, G., & Guo, S.-W.
- Affiliations
- Medical College of Wisconsin (US)
- Corresponding author
- Guo, Sun-Wei
- ORCID
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 87
- Issue
- 1
- Pages
- 24-32
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2095392967
- Cited by
- 193
- References
- 52
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 21 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 8 · 2012: 18
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
- Keywords
- endometriosis, DNA methyltransferases, DNMT1, DNMT3A, DNMT3B, DNA methylation, epigenetic regulation, ectopic endometrium, eutopic endometrium, gene expression, cellular memory, epigenetic disorders
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3A, DNA Methyltransferase 3B, Adult, DNA (Cytosine-5-)-Methyltransferases, Endometriosis, Endometrium, Female, Humans, Middle Aged, Tissue Distribution, Gene Expression
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