Identification biomarkers of eutopic endometrium in endometriosis using artificial neural networks and protein fingerprinting
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Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) protein chip array technology was used to detect biomarkers of eutopic endometrium in endometriosis patients. Five potential biomarkers (6,898 m/z, 5,891 m/z, 5,385 m/z, 6,448 m/z, and 5,425 m/z) were found.
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Wang et al. identified five differentially expressed peptide peaks (5.385 m/z, 5.425 m/z, 5.891 m/z, 6.448 m/z, and 6.898 m/z) in endometrium from 13 women with and 13 women without endometriosis that collectively showed 91.7% sensitivity and 90% specificity in the diagnosis of endometriosis.
“Wang et al. performed proteomic profiling of endometrium from 13 women with and 13 women without endometriosis identifying five differentially expressed peptide peaks (5.385 m/z, 5.425 m/z, 5.891 m/z, 6.448 m/z, and 6.898 m/z) that collectively showed 91.7% sensitivity and 90% specificity in the diagnosis of endometriosis [132].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [132]
Menstrual cycle phase of endometrial samples was not specified in several of the studies.
“Specifically, menstrual cycle phase of endometrial samples was not specified in several of the studies [132, 135], and only one randomly divided endometrial samples into training and test sets [131].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [132]
Several groups have reported unique proteomic profiles using the SELDI-TOF MS platform in eutopic endometrial specimens from women with and without endometriosis.
“Several groups have reported unique proteomic profiles using the SELDI-TOF MS platform in eutopic endometrial specimens from women with and without endometriosis [131, 132].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [132]
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- Authors
- Wang, L., Zheng, W., Ding, X.-Y., Yu, J.-K., Jiang, W.-Z., & Zhang, S.-Z.
- Affiliations
- Second Affiliated Hospital of Zhejiang University (CN)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 93
- Issue
- 7
- Pages
- 2460-2462
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2126964060
- Cited by
- 30
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Keywords
- endometriosis, eutopic endometrium, biomarkers, SELDI-TOF-MS, protein fingerprinting, artificial neural networks
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Middle Aged, Peptide Mapping, Uterine Diseases, Biomarkers, Case-Control Studies, Neural Networks, Computer, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Array Analysis, Early Diagnosis, Young Adult
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