Serum anti-PDIK1L autoantibody as a novel marker for endometriosis
Open accessAbstract
Objective To establish a novel serum marker for endometriosis, serum autoantibodies (autoAbs) were investigated using a proteomic approach.Design Retrospective study.Setting Departments of Molecular Pathology and Obstetrics and Gynecology in Ehime University and University Hospital.Patient(s) Sixty-nine patients with endometriosis, 38 disease control patients without endometriosis, and 44 healthy volunteers.Intervention(s) Autoantibodies in sera of endometriotic patients and healthy controls were investigated using a human fibroblast cell line, two-dimensional gel electrophoresis, and Western blotting. Proteins in reacted spots were identified using MALDI time of flight mass spectrometry with MASCOT analysis. ELISAs were established using recombinant proteins, and autoAb-titers were estimated in sera of endometriotic patients and controls.Main outcome measure(s) Identification of serum autoAb useful for diagnosis of endometriosis.Result(s) Several autoAbs were identified. ELISAs were established and serum autoAb titers were estimated. Among those identified, anti-PDIK1L-autoAb levels were significantly elevated in endometriotic patients. Sensitivity (59.4%) and accuracy (72.8%) of serum anti-PDIK1L-autoAb assay were better than those of serum CA125 levels (36.2% and 62.9%, respectively) in diagnosis of endometriosis. Additionally, anti-PDIK1L-autoAb could detect endometriotic patients in early stages.Conclusion(s) Serum anti-PDIK1L-autoAb can be a new serum marker for the diagnosis of endometriosis. This study validates further clinical evaluation of this novel marker.
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Serum anti-PDIK1L and anti-syntaxin 5 autoantibodies were reported elevated in endometriosis patients.
“Additionally, serum anti-PDIK1L [77] and anti-syntaxin 5 autoantibodies [78] were reported elevated in endometriosis patients.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [77]
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Self-citation
- Authors
- Nabeta, M., Abe, Y., Haraguchi, R., Kito, K., Kusanagi, Y., & Ito, M.
- Affiliations
- Ehime University (JP)
- Corresponding author
- Abe, Yasuhito
- ORCID
- Haraguchi, Ryuma
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 94
- Issue
- 7
- Pages
- 2552-2557.e1
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2144434711
- Cited by
- 22
- References
- 27
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- endometriosis, serum autoantibodies, serum biomarkers, endometriosis diagnosis, CA125
- MeSH terms
- Adolescent, Adult, Autoantibodies, Carcinoma, Cells, Cultured, Endometriosis, Female, Humans, Leiomyoma, Middle Aged, Ovarian Neoplasms, Retrospective Studies, Uterine Diseases, Uterine Neoplasms, Biomarkers, Case-Control Studies, Protein Serine-Threonine Kinases, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Young Adult
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