Functional Properties of Bioactive Compounds from Spirulina spp.: Current Status and Future Trends
Open accessAbstract
Functional foods show non-toxic bioactive compounds that offer health benefits beyond their nutritional value and beneficially modulate one or more target functions in the body. In recent decades, there has been an increase in the trend toward consuming foods rich in bioactive compounds, less industrialized, and with functional properties. Spirulina, a cyanobacterium considered blue microalgae, widely found in South America, stands out for its rich composition of bioactive compounds, as well as unsaturated fatty acids and essential amino acids, which contribute to basic human nutrition and can be used as a protein source for diets free from animal products. In addition, they have colored compounds, such as chlorophylls, carotenoids, phycocyanins, and phenolic compounds which can be used as corants and natural antioxidants. In this context, this review article presents the main biological activities of spirulina as an anticancer, neuroprotective, probiotic, anti-inflammatory, and immune system stimulating effect. Furthermore, an overview of the composition of spirulina, its potential for different applications in functional foods, and its emerging technologies are covered in this review.
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Microalgae produce a wide range of bioactive compounds that exhibit diverse biological properties, including antioxidant, anticoagulant, anti-inflammatory, antimicrobial, anticancer, and neuroprotective effects.
“Microalgae produce a wide range of bioactive compounds that exhibit diverse biological properties, including antioxidant, anticoagulant, anti-inflammatory, antimicrobial, anticancer, and neuroprotective effects among others.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [93]
The Biological effects and Neuroprotective effects sections report antioxidant, anti-inflammatory, antibacterial, anticancer, and neuroprotective activities of Spirulina compounds. The Anti-inflammatory properties section reports inhibition of platelet aggregation, but does not establish anticoagulant activity. The review focuses on Spirulina, so it does not establish that the full range of effects applies to microalgae generally; page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe potential applications of bioactive compounds derived from microalgae have attracted considerable attention, given their prospective uses across a variety of sectors such as food, animal feed, cosmetics, and pharmaceuticals.
“The potential applications of these bioactive compounds derived from microalgae have attracted considerable attention, given their prospective uses across a variety of sectors such as food, animal feed, cosmetics, and pharmaceuticals [57,93,94,95].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [93]
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- Authors
- Bortolini, D. G., Maciel, G. M., Fernandes, I. D. A. A., Pedro, A. C., Rubio, F. T. V., Branco, I. G., & Haminiuk, C. W. I.
- Affiliations
- Universidade Federal do Paraná (BR)
- Universidade Tecnológica Federal do Paraná (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Haminiuk, Charles Windson Isidoro
- ORCID
- Venue
- Food Chemistry: Molecular Sciences
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 5
- Pages
- 100134
- ISSN
- 2666-5662 (ISSN-L)
- PMC
- PMC9513730
- OpenAlex
- W4296260796
- Cited by
- 201
- References
- 69
- Citations by year
- 2026: 27 · 2025: 78 · 2024: 64 · 2023: 31 · 2022: 1
- FWCI
- 29.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Food Chemistry Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88882.381635/2019-01, 88882.381652/2019-01)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (304978/2016-7)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Keywords
- Spirulina, cyanobacteria, bioactive compounds, functional foods, phycocyanin, chlorophyll, carotenoids, phenolic compounds, unsaturated fatty acids, essential amino acids, anticancer activity, neuroprotection, probiotic activity, anti-inflammatory activity, immunostimulation, natural antioxidants, natural colorants, functional food applications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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