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Cited by 28Child Nutrition and Water AccessBirth, Development, and HealthFatty Acid Research and Health

Maternal Spirulina supplementation during pregnancy and lactation partially prevents oxidative stress, glial activation and neuronal damage in protein malnourished F1 progeny

Sinha, Shrstha, Patro, Nisha, Tiwari, P.K., Patro, Ishan K.·2020·Neurochemistry International
DOI 10.1016/j.neuint.2020.104877
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Abstract

Protein malnutrition (PMN) is a global health issue but most prevalent in Africa and Asia. It exerts detrimental effect on structural and physiological aspects of hippocampal circuitry. Despite accumulating evidence for PMN induced changes in nervous system, relatively very little is known about how maternal nutritional supplementation during malnutrition affects glial cells and neurons. Herein, we aimed to investigate the effects of maternal Spirulina supplementation against PMN induced oxidative stress, reactive gliosis and neuronal damage in hippocampus of F1 progeny. Three months old healthy Sprague Dawley females (n=24) were shifted to normoprotein (NC; 20% protein) and low protein (LP; 8% protein) diets 15 days before conception. The NC and LP group females were subdivided into two groups according to Spirulina supplementation (400 mg/kg/b.wt. orally throughout gestation and lactation period): normal control with Spirulina (NC SPI) and low protein with Spirulina supplemented group (LP SPI). F1 progeny born were used in present study. Thus, building on earlier results of ameliorated neurobehavioral and cognitive abilities in Spirulina supplemented protein deprived rats, the present study incorporates neurochemical and morphometric analysis of glial cells and neurons and revealed that maternal Spirulina consumption partially prevented the PMN associated neuropathological alterations in terms of attenuated oxidative brain damage, reduced reactive gliosis and apoptotic cell population, improved dendritic branch complexity with few damaged neurons and enhanced mushroom shaped spine density. The results suggest that cellular changes in hippocampus after PMN are partially restored after maternal Spirulina supplementation and one could envision intervention approaches using Spirulina against malnutrition.

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Crossref · 10.1016/j.neuint.2020.104877

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  • Maternal dietary supplementation with Spirulina during pregnancy and lactation to protein-malnourished rats reduced astrocytic and microglial activation in F1 progeny.

    “In another study, Sinha et al. observed that maternal dietary supplementation with Spirulina during pregnancy, and lactation to protein-malnourished (PMN) rats reduced astrocytic and microglial activation in F1 progeny.”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [64]

  • Spirulina caused a reduction of CR3 and MHC II expression on microglia cells.

    “In addition, it was reported that Spirulina caused a reduction of CR3 and MHC II expression on microglia cells that lose the typical shape of activated phagocytic cells.”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [64]

  • Spirulina prevented PMN-induced astrogliosis by reducing the astrocytic population labeled with GFAP and S100β.

    “In particular, Spirulina prevented PMN-induced astrogliosis by effectively reducing the astrocytic population labeled with glial fibrillary acidic protein (GFAP) and S100β, and with enlarged cell body and thick processes, a morphology that characterizes activated astrocytes.”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [64]

  • Spirulina treatment enhanced behavioral and cognitive functions in PMN rats.

    “thus enhancing behavioral and cognitive functions [64].”

    From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [64]

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Authors
Sinha, S., Patro, N., Tiwari, P. K., & Patro, I. K.
Affiliations
Jiwaji University (IN)
Corresponding author
Patro, Ishan K.
ORCID
Venue
Neurochemistry International
Publisher
Elsevier BV
Published
2020-12
Volume
141
Pages
104877
ISSN
0197-0186 (ISSN-L)
DOI
10.1016/j.neuint.2020.104877
OpenAlex
W3091792857
Semantic Scholar
0ef297b8f9c878d21709c26f7f553e466127d2d6
Cited by
28
References
119
Citations by year
2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 3 · 2018: 1
FWCI
2.37
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurochemistry International (publishedVersion)
  • PubMed (publishedVersion)
Funders
Department of Science and Technology, Ministry of Science and Technology, India
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
spirulina supplementation, protein malnutrition, maternal nutrition, pregnancy, lactation, oxidative stress, reactive gliosis, neuronal injury, hippocampus, dendritic spine density, dendritic morphology, apoptosis, F1 progeny, low-protein diet, neuroprotection
MeSH terms
Animals, Behavior, Animal, Female, Gliosis, Hippocampus, Lactation, Macrophage Activation, Neuroglia, Neurons, Pregnancy, Protein-Energy Malnutrition, Rats, Sprague-Dawley, Oxidative Stress, Dietary Supplements, Rats, Spirulina

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