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Phycocyanobilin reduces brain injury after endothelin-1- induced focal cerebral ischaemia

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Sustainable Production of Pigments from Cyanobacteria

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The Neuroprotective Role of Cyanobacteria with Focus on the Anti-Inflammatory and Antioxidant Potential: Current Status and Perspectives

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Progress on the Extraction, Separation, Biological Activity, and Delivery of Natural Plant Pigments

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Phycobiliproteins in Microalgae: Occurrence, Distribution, and Biosynthesis

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Natural Bioactive Compounds from Macroalgae and Microalgae for the Treatment of Alzheimer’s Disease: A Review

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The powerful phycobiliproteins-phycocyanin and phycoerythrin: Pleiotropic applications and biofunctional uses

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The Radiant World of Cyanobacterial Phycobiliproteins: Examining Their Structure, Functions, and Biomedical Potentials

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The Effect of C-Phycocyanin on Microglia Activation Is Mediated by Toll-like Receptor 4

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Cyanobacterial Metabolites as Promising Neuroprotective Agents by Targeting Phosphoglycerate Kinase 1: Dynamic In Silico Approaches

Prabhu, S., Kalaimathi, K., Jayasree, S., Ayyanar, M., Kadaikunnan, S., Thiruvengadam, M., Amalraj, S., Ceasar, S. A., Alharbi, N. S. H. A., Sanjeevi, S. B., et al. (2024) · Journal of Computational Biophysics and Chemistry · doi:10.1142/s2737416524500133 · Cited by 23 · see citing works

Nostoc sphaeroides Cyanobacteria: a review of its nutritional characteristics and processing technologies

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Swimming Exercise Ameliorates Symptoms of MOG-Induced Experimental Autoimmune Encephalomyelitis by Inhibiting Inflammation and Demyelination in Rats

Kim, J., Yi, E.-S., Lee, H., Kim, J., Jee, Y., Kim, S., Kim, C., & Ko, I. (2020) · International Neurourology Journal · doi:10.5213/inj.2040156.078 · Cited by 19 · see citing works

Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis

Marín‐Prida, J., Fuentes, N. P., Lagumersindez-Denis, N., Camacho, H., García-Soca, A. M., Sarduy-Chávez, R. D. L. C., Vieira, É. L. M., Tavares, J. C., Falcón‐Cama, V., Fernández, J. R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1036200 · Cited by 18 · see citing works

Development of pH-Sensitive hydrogel for advanced wound Healing: Graft copolymerization of locust bean gum with acrylamide and acrylic acid

Alka, Singh, P., Pal, R. R., Mishra, N., Singh, N., Verma, A., & Saraf, S. A. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124450 · Cited by 17 · see citing works

An insight into the potential antioxidant, anticancer and antimicrobial activities of Geitlerinema sp. C-phycocyanin extracts

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Phycocyanobilin from Arthrospira platensis: A potential photodynamic anticancer agent

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Report on the Symposium “Molecular Mechanisms Involved in Neurodegeneration”

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Covalent binding of food-derived blue pigment phycocyanobilin to bovine β-lactoglobulin under physiological conditions

Minic, S. L., Radomirović, M., Savkovic, N., Radibratović, M., Mihailović, J. M., Vasović, T. D., Nikolic, M. R., Milčić, M. K., Stanić-Vučinić, D., & Veličković, T. Ć. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.06.138 · Cited by 17 · see citing works

Nutraceutical induction and mimicry of heme oxygenase activity as a strategy for controlling excitotoxicity in brain trauma and ischemic stroke: focus on oxidative stress

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Analytical Protocols in Phycobiliproteins Analysis

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The Cyanobacterial “Nutraceutical” Phycocyanobilin Inhibits Cysteine Protease Legumain

Wilkinson, I. V. L., Castro‐Falcón, G., Roda‐Serrat, M. C., Purdy, T. N., Straetener, J., Brauny, M., Maier, L., Brötz‐Oesterhelt, H., Christensen, L. P., Sieber, S. A., et al. (2022) · ChemBioChem · doi:10.1002/cbic.202200455 · Cited by 13 · see citing works

The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome

Marín‐Prida, J., Rodríguez‐Ulloa, A., Besada, V., Llopiz, A., Batista, N. V., Hernández-González, I., Fuentes, N. P., Vieira, É. L. M., Falcón‐Cama, V., Acosta, E. F., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1227268 · Cited by 13 · see citing works

Spirulina as a Food of the Future

Amin, M., Haq, A. U., Shahid, A., Boopathy, R., & Syafiuddin, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-45523-0_3 · Cited by 13 · see citing works

Phycocyanin diminishes the viability of non-small cell lung cancer cells via induction of autophagy

Hao, S., Li, F., Liu, Y., Yang, Q., Li, Q., Zhang, W., & Wang, C. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105145 · Cited by 13 · see citing works

Stalling the Course of Neurodegenerative Diseases: Could Cyanobacteria Constitute a New Approach toward Therapy?

Ramos, V., Reis, M. A., Ferreira, L., Silva, A. M., Ferraz, R., Vieira, M., Vasconcelos, V. M., & Martins, R. F. (2023) · Biomolecules · doi:10.3390/biom13101444 · Cited by 12 · see citing works

Nutraceutical phycocyanobilin binding to catalase protects the pigment from oxidation without affecting catalytic activity

Gligorijević, N., Minic, S. L., Radibratović, M., Papadimitriou, V., Nedić, O., Sotiroudis, T. G., & Nikolic, M. R. (2021) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2021.119483 · Cited by 12 · see citing works

Anti-inflammatory compounds from cyanobacteria

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Extraction, Purification, Bioactivity and Pharmacological Effects of Phycobiliproteins (PBPs): A Review

Madji, S., Antih, J., Tabib, M., Silvestre, C., Ghennai, A., Warnery, A., Vaillant, F. E., Bichon, F., Echalier, A., & Poucheret, P. (2025) · Analytica—A Journal of Analytical Chemistry and Chemical Analysis · doi:10.3390/analytica6040044 · Cited by 12 · see citing works

Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases

Jayanti, S. D., Vı́tek, L., Verde, C. D., Llido, J. P., Sukowati, C. H. C., Tiribelli, C., & Gazzin, S. (2024) · Biomolecules · doi:10.3390/biom14010063 · Cited by 9 · see citing works

Effect of supercritical CO2 extraction as pretreatment to obtain C-phycocyanin from spirulina (Arthrospira maxima)

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Phycocyanobilin is a new binding partner of human alpha-2-macroglobulin that protects the protein against oxidative stress

Šunderić, M., Gligorijević, N., Milčić, M. K., Minic, S. L., Nedić, O., & Nikolic, M. R. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2248273 · Cited by 7 · see citing works

Algal Elixirs: Unraveling the multifaceted impact of Spirulina in human health

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Effects of spirulina (Arthrospira) platensis supplementation on inflammation, physical and mental quality of life, and anthropometric measures in patients with relapsing-remitting multiple sclerosis (RRMS): a triple-blinded, randomized, placebo-controlled trial

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Photodynamic anticancer activity of Arthrospira phycocyanobilin enhanced by metal cobalt ion coordination

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Probing the potential of mercury removal by covalently immobilized phycobiliproteins onto the surface of chitosan beads

Radović, J., Popović, D., Ćurčić, T., Veličković, L., Lević, S., Pavlović, V. B., Minic, S. L., Nikolic, M. R., & Gligorijević, N. (2024) · Algal Research · doi:10.1016/j.algal.2024.103543 · Cited by 4 · see citing works

Bioactive Compounds of the Genus Spirulina Can Prevent the Progression of Neurological Diseases

Elkader, H. A. E. A., Essawy, A. E., & Al‐Shami, A. S. (2024) · Neurochemical Journal · doi:10.1134/s1819712424010057 · Cited by 4 · see citing works

C-Phycocyanin and Phycocyanobilin for neuroprotection: a deep dive into the biological processes involved

Pentón‐Rol, G., Marín‐Prida, J., Sarduy-Chávez, R. D. L. C., & Hernández-González, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00016-6 · Cited by 3 · see citing works

Advances in Phycobiliproteins Research: Nutraceutical and Pharmaceutical Applications

Fernández-Rojas, B., Hernández-Juárez, J., & Pedraza‐Chaverrí, J. (2026) · Springer eBooks · doi:10.1007/978-3-032-05253-7_9 · Cited by 2 · see citing works

Arthrospira platensis phycocyanins: a perspective for use in foods for special dietary uses (brief review)

Александровна, Б. Н., Mazo, V. K., & Bagryantseva, O. V. (2022) · Voprosy Pitaniya · doi:10.33029/0042-8833-2022-91-6-30-36 · Cited by 2 · see citing works

Metabolic Materials from Cyanobacteria and Microalgae: Biotechnology, Biochemistry and Biotherapeutics

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Phycocyanin a nutraceutical with antioxidant activity

Fernández-Rojas, B., Hernández‐Juárez, J., & Pedraza‐Chaverrí, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21873-6.00004-x · Cited by 2 · see citing works

Spirulina: Morphology, Cultivation, Harvesting as a Supplement and Its Therapeutic Properties

Khushala, A., Bobby, M. N., & Balasubramaniyan, M. (2025) · Springer eBooks · doi:10.1007/978-981-96-1844-6_9 · Cited by 2 · see citing works

Neuroprotective potential of phycocyanobilin and C-phycocyanin: from molecular targets to translational applications

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Metabolic pathways and omics approaches in Nostoc sphaeroides: a roadmap for enhancing functional foods and health-related applications

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Therapeutic applications of Arthrospira sp. in human health: An overview

da Silva, M. R. O. B., da Silva, R. O. B., do Nascimento, B. E. G., Ramos, D. G., Mendes, M. E. M., da Silva, S. D. F. F., Costa, R. M. P. B., & Marques, D. D. A. V. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.07.041 · Cited by 3 · see citing works

Pharmaceutical and Nutraceutical Applications of Marine Microalgae

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Technological Bottlenecks for Industrial Production and Extraction of Microalgal Pigments

Poorniammal, R., Somasundaram, P., Jernisha, J., Rathinasamy, S. A., & Dufossé, L. (2026) · Springer eBooks · doi:10.1007/978-3-032-05438-8_9

Microalgae in functional food development: Bioactive compounds, food applications, and future prospects

Gengatharan, A., & Tiwari, B. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34082-6.00018-0

Charting Marine Bioactive Landscapes by Proteomics: Mass Spectrometry-Based Target Discovery and Molecular Mechanism Characterization

Spinelli, L., Giugliano, M., Morretta, E., Zampella, A., & Monti, M. C. (2026) · MarineMedicine · doi:10.64187/mm.2026.v2.i2.001

Phycocyanin: Biomedical Activities and Related Mechanisms of Action

Huang, H., & Wang, L. (2026) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x26500308

Algae as a Sustainable Source of High-Value Nutritional Ingredients: Regulatory Framework and Health Benefits

El‐Saadony, M. T., Saad, A. M., Sitohy, M. Z., Mohammed, D. M., Salem, H. M., Alkafaas, S. S., Choudhary, M., Ghosh, S., Fahmy, M. A., Mosa, W. F. A., et al. (2026) · Springer eBooks · doi:10.1007/978-3-032-22521-4_19

Neuroprotective effects of C-phycocyanin and allophycocyanin from Spirulina purified using a newly developed method: in vitro barrier permeability, antioxidant and anti-inflammatory activities

Girgenti, A., Picone, P., Palumbo, L., Lauceri, R., & Nuzzo, D. (2026) · Journal of Biological Engineering · doi:10.1186/s13036-026-00720-2

A genome-resolved cyanobacterial consortium from the Atacama Desert reveals novel bacterial diversity, stress-resilience potential, chromatic flexibility, and photoprotection

Galetović, A., Ortiz, J., Peña, G., Arros, P., Guerra-Leal, N., Berríos-Pastén, C., Silva, M., Acosta, J., Varas, M. A., Allende, M. L., et al. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1939861

Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis

Marín‐Prida, J., Fuentes, N. P., Lagumersindez-Denis, N., Camacho, H., García-Soca, A. M., Sarduy-Chávez, R. D. L. C., Vieira, É. L. M., Tavares, J. C., Falcón‐Cama, V., Fernández, J. R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1036200 · Cited by 18 · see citing works

Comparative Neuroregenerative Effects of C-Phycocyanin and IFN-Beta in a Model of Multiple Sclerosis in Mice

Pentón-Rol, G., Lagumersindez-Denis, N., Muzio, L., Bergami, A., Furlan, R., Fernández-Massó, J. R., Nazabal-Galvez, M., Llópiz-Arzuaga, A., Herrera-Rolo, T., Veliz-Rodriguez, T., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9642-9 · Cited by 36 · see citing works

Evaluación de la ficocianobilina y sus combinaciones en un modelo animal de esclerosis múltiple

Fuentes, N. P., Rol, G. P., Marín‐Prida, J., Pedré, L. L., Almaguer‐Melian, W., & Lezcano, L. B. (2016) · Revista cubana de neurología y neurocirugía

Cytoprotection in Multiple Sclerosis and Ischemic Stroke with C-Phycocyanin and Phycocyanobilin

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C-Phycocyanin ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells

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