Cited by 280Protein Hydrolysis and Bioactive PeptidesSeaweed-derived Bioactive CompoundsPeptidase Inhibition and Analysis

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Isolation and characterisation of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from the algae protein waste

Sheih, I.-Chuan, Fang, Tony J., Wu, Tung-Kung·2009·Food Chemistry

DOI 10.1016/j.foodchem.2008.12.019

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Abstract

A hendeca-peptide with angiotensin I-converting enzyme (ACE) inhibitory activity was isolated from the pepsin hydrolysate of algae protein waste, a mass-produced industrial by-product of an algae essence from microalgae, Chlorella vulgaris. Edman degradation revealed its amino acid sequence to be Val-Glu-Cys-Tyr-Gly-Pro-Asn-Arg-Pro-Gln-Phe. Inhibitory kinetics revealed a non-competitive binding mode with IC₅₀ value against ACE of 29.6μM, suggesting a potent amount of ACE inhibitory activity compared with other peptides from the microalgae protein hydrolysates which have a reported range between 11.4 and 315.3μM. In addition, the purified hendeca-peptide completely retained its ACE inhibitory activity at a pH range of 2-10, temperatures of 40-100°C, as well as after treatments in vitro by a gastrointestinal enzyme, thus indicating its heat- and pH-stability. The combination of the biochemical properties of this isolated hendeca-peptide and a cheap algae protein resource make an attractive alternative for producing a high value product for blood pressure regulation as well as water and fluid balance.

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Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
Cushman, D. W., & Cheung, H. S. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90292-9 · Cited by 2,633
Antioxidant Activity of Proteins and Peptides
Elias, R. J., Kellerby, S. S., & Decker, E. A. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701425615 · Cited by 1,389
[32] GOR method for predicting protein secondary structure from amino acid sequence
Garnier, J., Gibrat, J.-F., & Robson, B. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66034-0 · Cited by 1,291
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.
Cheung, H. S., Wang, F. L., Ondetti, M. A., Sabo, E. F., & Cushman, D. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86187-2 · Cited by 746
Angiotensin I–converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects
Li, G., Le, G., Shi, Y., & Shrestha, S. (2004) · Nutrition Research · doi:10.1016/j.nutres.2003.10.014 · Cited by 562
Classification and Antihypertensive Activity of Angiotensin I‐Converting Enzyme Inhibitory Peptides Derived from Food Proteins
Iroyukifujita, H., Eiichiyokoyama, K., & Yoshikawa, M. (2000) · Journal of Food Science · doi:10.1111/j.1365-2621.2000.tb16049.x · Cited by 550
Enzymes of the Renin-Angiotensin System and their Inhibitors
Ondetti, M. A., & Cushman, D. W. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.001435 · Cited by 467
Free radical scavenging activity of a novel antioxidative peptide purified from hydrolysate of bullfrog skin, Rana catesbeiana Shaw
Qian, Z., Jung, W., & Kim, S. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.04.005 · Cited by 412
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Wu, J., & Ding, X. (2002) · Food Research International · doi:10.1016/s0963-9969(01)00131-4 · Cited by 344
Angiotensin I-converting enzyme inhibitory peptide from yellowfin sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats
Jung, W., Mendis, E., Je, J., Park, P., Son, B. W., Kim, H. C., Choi, Y., & Kim, S. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2004.09.048 · Cited by 304

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Authors: Sheih, I.-C., Fang, T. J., & Wu, T.-K.
Affiliations: National Chung Hsing University (TW)
National Yang Ming Chiao Tung University (TW)
Corresponding author: Wu, Tung-Kung
ORCID: Fang, Tony J.
Wu, Tung-Kung
Venue: Food Chemistry
Publisher: Elsevier BV
Published: 2009-07
Volume: 115
Issue: 1
Pages: 279-284
ISSN: 0308-8146 (ISSN-L)
DOI: 10.1016/j.foodchem.2008.12.019
OpenAlex: W2075270505
Cited by: 280
References: 26
Citations by year: 2026: 4 · 2025: 17 · 2024: 11 · 2023: 16 · 2022: 17 · 2021: 17 · 2020: 19 · 2019: 24 · 2018: 15 · 2017: 19 · 2016: 20 · 2015: 17 · 2014: 17 · 2013: 23 · 2012: 12
FWCI: 4.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Food Chemistry (publishedVersion)
Funders: Ministry of Earth Sciences
National Science Council
Novo Nordisk
Ministry of Education, India
National Chiao Tung University
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Peptidase Inhibition and Analysis
Keywords: angiotensin I-converting enzyme inhibitory peptides, Chlorella vulgaris, pepsin hydrolysate, non-competitive inhibition, peptide stability, blood pressure regulation, bioactive peptides

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Isolation and characterisation of a novel angiotensin I-converting enzyme (ACE) inhibitory peptide from the algae protein waste

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