Cited by 188Seaweed-derived Bioactive CompoundsMarine and coastal plant biologyPhytochemistry and Biological Activities

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Valuable compounds in macroalgae extracts

Andrade, Paula B., Barbosa, Mariana, Matos, Rui Pedro, Lopes, Graciliana, Vinholes, Juliana, Mouga, Teresa, Valentão, Patrícia·2013·Food Chemistry

DOI 10.1016/j.foodchem.2012.11.081

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Abstract

Bioactive compounds present in ethanolic extracts from 18 macroalgae of the Portuguese coast were analysed by gas chromatography-mass spectrometry (GC-MS), leading to the characterization of 14 compounds: proline, phloroglucinol, mannitol, 8 fatty acids and 3 sterols. A dose-dependent response against enzymes with biological significance (α-glucosidase, acetylcholinesterase and butyrylcholinesterase) and free radicals (DPPH, nitric oxide, superoxide and hydroxyl) was found, Phaeophyta being the most promising group. A PCA analysis was performed and allowed the establishment of a correlation between the algae chemical composition and the biological activity. Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus are among the most active species, which is in accordance with their higher contents in phloroglucinol, mannitol, oleic, arachidonic and eicosapentaenoic acids, and fucosterol. The results point to the potential interest of the use of Phaeophyta species as food additives, due to their potent antiradical activities, and especially highlights the importance of F. spiralis in the food chain of Mediterranean countries. Moreover, the incorporation of the extracts of these species in food products, nutraceutical and pharmaceutical preparations for human health should also be instigated, since they can suppress hyperglycemia and inhibit cholinesterases.

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Authors: Andrade, P. B., Barbosa, M., Matos, R. P., Lopes, G., Vinholes, J., Mouga, T., & Valentão, P.
Affiliations: Universidade do Porto (PT)
Universidade de Leiria e Oeste (PT)
ORCID: Andrade, Paula B.
Barbosa, Mariana
Lopes, Graciliana
Vinholes, Juliana
Mouga, Teresa
Venue: Food Chemistry
Publisher: Elsevier BV
Published: 2013-06
Volume: 138
Issue: 2-3
Pages: 1819-1828
ISSN: 0308-8146 (ISSN-L)
DOI: 10.1016/j.foodchem.2012.11.081
OpenAlex: W2030477556
Cited by: 188
References: 53
Citations by year: 2026: 10 · 2025: 11 · 2024: 9 · 2023: 14 · 2022: 18 · 2021: 20 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 4 · 2013: 2
FWCI: 8.43
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Food Chemistry (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Funders: Fundação para a Ciência e a Tecnologia (FCT) (PEst-C/EQB/LA0006/2011)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords: macroalgae extracts, bioactive compounds, brown algae, Cystoseira, Fucus spiralis, phloroglucinol, mannitol, fatty acids, sterols, fucosterol, anticholinesterase activity, α-glucosidase inhibition, antioxidant activity, free radical scavenging, nutraceuticals, food additives, hyperglycemia
MeSH terms: Acetylcholinesterase, Antioxidants, Butyrylcholinesterase, Chromatography, High Pressure Liquid, Enzyme Inhibitors, Humans, Seaweed, Glycoside Hydrolase Inhibitors

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