The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Valuable compounds in macroalgae extracts
Abstract
Bioactive compounds present in ethanolic extracts from 18 macroalgae of the Portuguese coast were analysed by gas chromatography-mass spectrometry (GC-MS), leading to the characterization of 14 compounds: proline, phloroglucinol, mannitol, 8 fatty acids and 3 sterols. A dose-dependent response against enzymes with biological significance (α-glucosidase, acetylcholinesterase and butyrylcholinesterase) and free radicals (DPPH, nitric oxide, superoxide and hydroxyl) was found, Phaeophyta being the most promising group. A PCA analysis was performed and allowed the establishment of a correlation between the algae chemical composition and the biological activity. Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus are among the most active species, which is in accordance with their higher contents in phloroglucinol, mannitol, oleic, arachidonic and eicosapentaenoic acids, and fucosterol. The results point to the potential interest of the use of Phaeophyta species as food additives, due to their potent antiradical activities, and especially highlights the importance of F. spiralis in the food chain of Mediterranean countries. Moreover, the incorporation of the extracts of these species in food products, nutraceutical and pharmaceutical preparations for human health should also be instigated, since they can suppress hyperglycemia and inhibit cholinesterases.
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“macroalgae are responsible for the production of a large range of primary and secondary metabolites that can be used for different applications in food, cosmetic, pharmaceutical, and other industries [108].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [108]
In the citing paper
“Many of these compounds have well-established antiinflammatory, antimutagenic, antitumor, antidiabetic, hepatoprotective, free radical scavengers, anticoagulants, thrombolytic, and antihyperthensive properties [108,109].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [108]
In the citing paper
“Macroalgae contain larger amount of unsaturated fatty acids than saturated [23,24], and because of that, they exhibit acetylcholinesterase inhibition, which means that they can provide protection from neurodegenerative disorders [25].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [25]
Citations
Cites
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
The Value of Plants Used in Traditional Medicine for Drug Discovery
Fabricant, D. S., & Farnsworth, N. R. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s169 · Cited by 2,383
Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178
Plant metabolomics: large-scale phytochemistry in the functional genomics era
Sumner, L. W., Mendes, P., & Dixon, R. A. (2003) · Phytochemistry · doi:10.1016/s0031-9422(02)00708-2 · Cited by 1,132
Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960
Biological importance of marine algae
El‐Gamal, A. A. (2010) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2009.12.001 · Cited by 547
Chemical composition and functional properties of Ulva lactuca seaweed collected in Tunisia
Yaich, H., Garna, H., Besbes, S., Paquot, M., Blecker, C. S., & Attia, H. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.03.114 · Cited by 401
Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds
Bocanegra, A., Bastida, S., Benedı́, J., de la Rocha, S. R., & Sánchez-Muniz, F. J. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0151 · Cited by 377
Potent α-glucosidase inhibitors purified from the red alga Grateloupia elliptica
Kim, K. Y., Nam, K.-D., Kurihara, H., & Kim, S. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.09.007 · Cited by 328
Seaweed resources of the world
Critchley, A. T., & 大野, 正. (1998) · Medical Entomology and Zoology · Cited by 313
Nwosu, F., Morris, J., Lund, V. A., Stewart, D., Ross, H. A., & McDougall, G. J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2010.11.111 · Cited by 306
Meyer, E. H., Tomaz, T., Carroll, A. J., Estavillo, G. M., Delannoy, É., Tanz, S. K., Small, I., Pogson, B. J., & Millar, A. H. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.141770 · Cited by 293
Metabolite profiling and quantification of phenolic compounds in methanol extracts of tomato fruit
Gómez‐Romero, M., Segura‐Carretero, A., & Fernández‐Gutiérrez, A. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.08.002 · Cited by 261
Antioxidant and antitumoural activities of some Phaeophyta from Brittany coasts
Zubia, M., Fabre, M. S., Kerjean, V., Lann, K. L., Stiger‐Pouvreau, V., Fauchon, M., & Deslandes, É. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.03.025 · Cited by 252
Neuroprotective Effects of Marine Algae
Pangestuti, R., & Kim, S. (2011) · Marine Drugs · doi:10.3390/md9050803 · Cited by 248
Lopes, G., Sousa, C., Silva, L. R., Pinto, E., Andrade, P. B., Bernardo, J., Mouga, T., & Valentão, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031145 · Cited by 227
Self-citationChemoinformatics and Drug Discovery
Xu, J. C., & Hagler, A. T. (2002) · Molecules · doi:10.3390/70800566 · Cited by 225
Tabarsa, M., Rezaei, M., Ramezanpour, Z., & Waaland, J. R. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5659 · Cited by 208
Yoon, N. Y., Chung, H. Y., Kim, H. R., & Choi, J. S. (2008) · Fisheries Science · doi:10.1111/j.1444-2906.2007.01511.x · Cited by 173
Kang, K. A., Lee, K. H., Chae, S., Zhang, R., Jung, M. S., Ham, Y., Baik, J. S., Lee, N. H., & Hyun, J. W. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20668 · Cited by 168
Vergouw, C. G., Botros, L. L., Roos, P., Lens, J. W., Schats, R., Hompes, P. G. A., Burns, D. H., & Lambalk, C. B. (2008) · Human Reproduction · doi:10.1093/humrep/den111 · Cited by 165
Moon, H. E., Islam, M. N., Ahn, B. R., Chowdhury, S., Sohn, H. S., Jung, H. A., & Choi, J. S. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110137 · Cited by 151
Anti-Diabetic activities of fucosterol fromPelvetia siliquosa
Lee, Y. S., Shin, K. H., Kim, B., & Lee, S. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02975115 · Cited by 145
Salt-Regulated Mannitol Metabolism in Algae
Iwamoto, K., & Shiraiwa, Y. (2005) · Marine Biotechnology · doi:10.1007/s10126-005-0029-4 · Cited by 137
Seaweed : ecology, nutrient composition and medicinal uses
Pomin, V. H. (2012) · Cited by 130
Vinholes, J. R., Grosso, C., Andrade, P. B., Gil‐Izquierdo, Á., Valentão, P., de Pinho, P. G., & Ferreres, F. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.04.098 · Cited by 121
Self-citationZhang, J., Tiller, C., Shen, J., Wang, C., Girouard, G. S., Dennis, D. A., Barrow, C. J., Miao, M., & Ewart, H. S. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y07-105 · Cited by 114
STEROL PROFILES IN 18 MACROALGAE OF THE PORTUGUESE COAST1
Lopes, G., Sousa, C., Bernardo, J., Andrade, P. B., Valentão, P., Ferreres, F., & Mouga, T. (2011) · Journal of Phycology · doi:10.1111/j.1529-8817.2011.01028.x · Cited by 97
Self-citationLo, T. C. T., Jiang, Y. H., Chao, A. L. J., & Chang, C. A. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.10.051 · Cited by 96
FATTY ACIDS, AMINO ACIDS, MINERAL CONTENTS, AND PROXIMATE COMPOSITION OF SOME BROWN SEAWEEDS1
Tabarsa, M., Rezaei, M., Ramezanpour, Z., Waaland, J. R., & Rabiei, R. (2012) · Journal of Phycology · doi:10.1111/j.1529-8817.2012.01122.x · Cited by 91
GC-MS Analysis of Compounds Extracted from Buds of Populus balsamifera and Populus nigra
Isidorov, V. A., & Vinogorova, V. T. (2003) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2003-5-612 · Cited by 86
Current Therapeutic Options for Alzheimers Disease
Lleó, A. (2007) · Current Genomics · doi:10.2174/138920207783769549 · Cited by 77
A metabolite profiling approach to follow the sprouting process of mung beans (Vigna radiata)
Jom, K. N., Frank, T., & Engel, K. (2010) · Metabolomics · doi:10.1007/s11306-010-0236-5 · Cited by 76
Codium tomentosum and Plocamium cartilagineum: Chemistry and antioxidant potential
Valentão, P., Trindade, P., Gomes, D. F., de Pinho, P. G., Mouga, T., & Andrade, P. B. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.09.015 · Cited by 76
Self-citationPolyphenol contents and radical scavenging capacities of red maple (Acer rubrum L.) extracts
Royer, M., Diouf, P. N., & Stevanović, T. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.06.003 · Cited by 76
Seasonal Variation of Phenolic Antioxidant-mediated α-glucosidase Inhibition of Ascophyllum nodosum
Apostolidis, E., Karayannakidis, P. D., Kwon, Y., Lee, C. M., & Seeram, N. P. (2011) · Plant Foods for Human Nutrition · doi:10.1007/s11130-011-0250-4 · Cited by 74
Potato metabolomics by GC–MS: what are the limiting factors?
Shepherd, T., Dobson, G., Verrall, S. R., Conner, S. D., Griffiths, D. W., McNicol, J. W., Davies, H. V., & Stewart, D. (2007) · Metabolomics · doi:10.1007/s11306-007-0058-2 · Cited by 73
Extracellular secretion of phenolic substances from living brown algae
Shibata, T., Hama, Y., Miyasaki, T., Ito, M., & Nakamura, T. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9094-y · Cited by 72
Antioxidant and cytotoxic activities of some red algae (Rhodophyta) from Brittany coasts (France)
Zubia, M., Fabre, M.-S., Kerjean, V., & Deslandes, É. (2009) · Botanica Marina · doi:10.1515/bot.2009.037 · Cited by 68
Liu, Y., Chen, T., Qiu, Y., Cheng, Y., Cao, Y., Zhao, A., & Jia, W. P. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4880-z · Cited by 59
Inhibitory Compounds of .ALPHA.-Glucosidase Activity from Arctium lappa L.
Miyazawa, M., Yagi, N., & TAGUCHI, K. (2005) · Journal of Oleo Science · doi:10.5650/jos.54.589 · Cited by 57
Sánchez‐Machado, D. I., López‐Cervántes, J., López-Hernández, J., Paseiro‐Losada, P., & Simal‐Lozano, J. (2003) · Chromatographia · doi:10.1365/s10337-003-0031-9 · Cited by 52
Ren, Y., Houghton, P. J., & Hider, R. C. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.7.0015 · Cited by 51
AMINO ACID COMPOSITION OF SOME BRAZILIAN SEAWEED SPECIES
Ramos, M. V., MONTEIRO, A. C. O., Moreira, R. D. A., & CARVALHO, A. D. F. A. F. U. (2000) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2000.tb00041.x · Cited by 48
Pereira, D. M., Vinholes, J. R., de Pinho, P. G., Valentão, P., Mouga, T., Teixeira, N. A. A., & Andrade, P. B. (2012) · Talanta · doi:10.1016/j.talanta.2012.08.004 · Cited by 39
Self-citationAmino acid composition of some common seaweeds.
Qasim, R. (1991) · PubMed · Cited by 33
Toward a global analysis of metabolites in regulatory mutants of yeast
Humston, E. M., Dombek, K. M., Tu, B. P., Young, E. T., & Synovec, R. E. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4800-2 · Cited by 29
Steroids from Poison Hemlock (Conium maculatum L.): A GC-MS analysis
Radulović, N. S., & Djordjevic, N. (2011) · Journal of the Serbian Chemical Society · doi:10.2298/jsc110206128r · Cited by 27
Macroalage as a source of alpha-glucosidase inhibitors
Li, X., Rongli, N., Xiao, F. R., Han, L.-J., & Lixin, Z. (2005) · Chinese Journal of Oceanology and Limnology · doi:10.1007/bf02847160 · Cited by 26
Kim, S., Shin, M. H., Hossain, M. A., Yun, E. J., Lee, H., & Kim, K. H. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4693-0 · Cited by 17
Muralidhar, A. P., Syamala, K., Prakāsh, C., Kalidas, C., & Naik, R. (2010) · World Applied Sciences Journal · Cited by 15
Antioxidant activity of macroalgae from the Azores
Paiva, L. S., Patarra, R. F., Neto, A. I., Lima, E., & Baptista, J. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 14
Chemical composition and bioactivity of some benthic algae from Karachi Coast of Pakistan
Shameel, M., & Shahnaz, L. (2009) · International Journal on Algae · doi:10.1615/interjalgae.v11.i4.70 · Cited by 12
Research works printed but not linked: 4
- Awad, 2002, Volatile constituents, carbohydrate compositions and topical anti-inflammatory of the two green algae Caulerpa racemosa (O. Dargent) and Codium tomentosum (Stackhouse), Bulletin of the Faculty of Pharmacy (Cairo University), 20, 233
- Çokuğraş, 2003, Butyrylcholinesterase: Structure and physiological importance, Turkish Journal of Biochemistry, 28, 54
- Cui-xia, 2004, Effect of mannitol on the activity of serum cholinesterases in the mouse and rabbit, Herald of Medicine, 23, 716
- International Conference on Harmonization (ICH) of technical requirements for the registration of pharmaceuticals for human use, validation of analytical procedures. (1996). Text and methodology. ICH-Q2B, Geneva.
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An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications
Lomartire, S., & Gonçalves, A. M. M. (2022) · Marine Drugs · doi:10.3390/md20020141 · Cited by 304
The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value
Gomez-Zavaglia, A., Prieto Lage, M. A., Jimenez-Lopez, C., Mejuto, J. C., & Simal-Gandara, J. (2019) · Antioxidants · doi:10.3390/antiox8090406 · Cited by 280
Cikoš, A.-M., Jokić, S., Šubarić, D., & Jerković, I. (2018) · Marine Drugs · doi:10.3390/md16100348 · Cited by 225
Barbosa, M., Valentão, P., & Andrade, P. (2014) · Marine Drugs · doi:10.3390/md12094934 · Cited by 181
Self-citation
Metadata
- Authors
- Andrade, P. B., Barbosa, M., Matos, R. P., Lopes, G., Vinholes, J., Mouga, T., & Valentão, P.
- Affiliations
- Universidade do Porto (PT)
- Universidade de Leiria e Oeste (PT)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 138
- Issue
- 2-3
- Pages
- 1819-1828
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2030477556
- Cited by
- 188
- References
- 53
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 9 · 2023: 14 · 2022: 18 · 2021: 20 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 4 · 2013: 2
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia (FCT) (PEst-C/EQB/LA0006/2011)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- macroalgae extracts, bioactive compounds, brown algae, Cystoseira, Fucus spiralis, phloroglucinol, mannitol, fatty acids, sterols, fucosterol, anticholinesterase activity, α-glucosidase inhibition, antioxidant activity, free radical scavenging, nutraceuticals, food additives, hyperglycemia
- MeSH terms
- Acetylcholinesterase, Antioxidants, Butyrylcholinesterase, Chromatography, High Pressure Liquid, Enzyme Inhibitors, Humans, Seaweed, Glycoside Hydrolase Inhibitors
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