The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Valuable compounds in macroalgae extracts
Abstract
Bioactive compounds present in ethanolic extracts from 18 macroalgae of the Portuguese coast were analysed by gas chromatography-mass spectrometry (GC-MS), leading to the characterization of 14 compounds: proline, phloroglucinol, mannitol, 8 fatty acids and 3 sterols. A dose-dependent response against enzymes with biological significance (α-glucosidase, acetylcholinesterase and butyrylcholinesterase) and free radicals (DPPH, nitric oxide, superoxide and hydroxyl) was found, Phaeophyta being the most promising group. A PCA analysis was performed and allowed the establishment of a correlation between the algae chemical composition and the biological activity. Cystoseira tamariscifolia (Hudson) Papenfuss, Cystoseira nodicaulis (Withering) M. Roberts, Cystoseira usneoides (Linnaeus) M. Roberts and Fucus spiralis Linnaeus are among the most active species, which is in accordance with their higher contents in phloroglucinol, mannitol, oleic, arachidonic and eicosapentaenoic acids, and fucosterol. The results point to the potential interest of the use of Phaeophyta species as food additives, due to their potent antiradical activities, and especially highlights the importance of F. spiralis in the food chain of Mediterranean countries. Moreover, the incorporation of the extracts of these species in food products, nutraceutical and pharmaceutical preparations for human health should also be instigated, since they can suppress hyperglycemia and inhibit cholinesterases.
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In the citing paper
“macroalgae are responsible for the production of a large range of primary and secondary metabolites that can be used for different applications in food, cosmetic, pharmaceutical, and other industries [108].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [108]
In the citing paper
“Many of these compounds have well-established antiinflammatory, antimutagenic, antitumor, antidiabetic, hepatoprotective, free radical scavengers, anticoagulants, thrombolytic, and antihyperthensive properties [108,109].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [108]
In the citing paper
“Macroalgae contain larger amount of unsaturated fatty acids than saturated [23,24], and because of that, they exhibit acetylcholinesterase inhibition, which means that they can provide protection from neurodegenerative disorders [25].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [25]
Citations
Cites
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
The Value of Plants Used in Traditional Medicine for Drug Discovery
Fabricant, D. S., & Farnsworth, N. R. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s169 · Cited by 2,383
Kohen, R., & Nyska, A. (2002) · Toxicologic Pathology · doi:10.1080/01926230290166724 · Cited by 2,178
Plant metabolomics: large-scale phytochemistry in the functional genomics era
Sumner, L. W., Mendes, P., & Dixon, R. A. (2003) · Phytochemistry · doi:10.1016/s0031-9422(02)00708-2 · Cited by 1,132
Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960
Biological importance of marine algae
El‐Gamal, A. A. (2010) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2009.12.001 · Cited by 547
Chemical composition and functional properties of Ulva lactuca seaweed collected in Tunisia
Yaich, H., Garna, H., Besbes, S., Paquot, M., Blecker, C. S., & Attia, H. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.03.114 · Cited by 401
Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds
Bocanegra, A., Bastida, S., Benedı́, J., de la Rocha, S. R., & Sánchez-Muniz, F. J. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0151 · Cited by 377
Potent α-glucosidase inhibitors purified from the red alga Grateloupia elliptica
Kim, K. Y., Nam, K.-D., Kurihara, H., & Kim, S. (2008) · Phytochemistry · doi:10.1016/j.phytochem.2008.09.007 · Cited by 328
Seaweed resources of the world
Critchley, A. T., & 大野, 正. (1998) · Medical Entomology and Zoology · Cited by 313
Research works printed but not linked: 4
- Awad, 2002, Volatile constituents, carbohydrate compositions and topical anti-inflammatory of the two green algae Caulerpa racemosa (O. Dargent) and Codium tomentosum (Stackhouse), Bulletin of the Faculty of Pharmacy (Cairo University), 20, 233
- Çokuğraş, 2003, Butyrylcholinesterase: Structure and physiological importance, Turkish Journal of Biochemistry, 28, 54
- Cui-xia, 2004, Effect of mannitol on the activity of serum cholinesterases in the mouse and rabbit, Herald of Medicine, 23, 716
- International Conference on Harmonization (ICH) of technical requirements for the registration of pharmaceuticals for human use, validation of analytical procedures. (1996). Text and methodology. ICH-Q2B, Geneva.
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Roohinejad, S., Koubaa, M., Barba, F. J., Saljoughian, S., Amid, M., & Greiner, R. (2017) · Food Research International · doi:10.1016/j.foodres.2016.08.016 · Cited by 360
An Overview of Potential Seaweed-Derived Bioactive Compounds for Pharmaceutical Applications
Lomartire, S., & Gonçalves, A. M. M. (2022) · Marine Drugs · doi:10.3390/md20020141 · Cited by 304
The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value
Gomez-Zavaglia, A., Prieto Lage, M. A., Jimenez-Lopez, C., Mejuto, J. C., & Simal-Gandara, J. (2019) · Antioxidants · doi:10.3390/antiox8090406 · Cited by 280
Cikoš, A.-M., Jokić, S., Šubarić, D., & Jerković, I. (2018) · Marine Drugs · doi:10.3390/md16100348 · Cited by 225
Barbosa, M., Valentão, P., & Andrade, P. (2014) · Marine Drugs · doi:10.3390/md12094934 · Cited by 181
Self-citation
Metadata
- Authors
- Andrade, P. B., Barbosa, M., Matos, R. P., Lopes, G., Vinholes, J., Mouga, T., & Valentão, P.
- Affiliations
- Universidade do Porto (PT)
- Universidade de Leiria e Oeste (PT)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 138
- Issue
- 2-3
- Pages
- 1819-1828
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2030477556
- Cited by
- 188
- References
- 53
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 9 · 2023: 14 · 2022: 18 · 2021: 20 · 2020: 21 · 2019: 19 · 2018: 18 · 2017: 13 · 2016: 16 · 2015: 12 · 2014: 4 · 2013: 2
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia (FCT) (PEst-C/EQB/LA0006/2011)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- macroalgae extracts, bioactive compounds, brown algae, Cystoseira, Fucus spiralis, phloroglucinol, mannitol, fatty acids, sterols, fucosterol, anticholinesterase activity, α-glucosidase inhibition, antioxidant activity, free radical scavenging, nutraceuticals, food additives, hyperglycemia
- MeSH terms
- Acetylcholinesterase, Antioxidants, Butyrylcholinesterase, Chromatography, High Pressure Liquid, Enzyme Inhibitors, Humans, Seaweed, Glycoside Hydrolase Inhibitors
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