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Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

Lagoumtzi, Sofia M., Chondrogianni, Niki·2021·Free Radical Biology and Medicine
DOI 10.1016/j.freeradbiomed.2021.05.003
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Abstract

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases. Senescent cells (SC) exhibit a specific senescence-associated secretory phenotype (SASP), mainly characterized by the production of proinflammatory and matrix-degrading molecules. When SC accumulate, a chronic, systemic, low-grade inflammation, known as inflammaging, is induced. In turn, this chronic immune system activation results in reduced SC clearance thus establishing a vicious circle that fuels inflammaging. SC accumulation represents a causal factor for various age-related pathologies. Targeting of several aging hallmarks has been suggested as a strategy to ameliorate healthspan and possibly lifespan. Consequently, SC and SASP are viewed as potential therapeutic targets either through the selective killing of SC or the selective SASP blockage, through natural or synthetic compounds. These compounds are members of a family of agents called senotherapeutics divided into senolytics and senomorphics. Few of them are already in clinical trials, possibly representing a future treatment of age-related pathologies including diseases such as atherosclerosis, osteoarthritis, osteoporosis, cancer, diabetes, neurodegenerative diseases such as Alzheimer's disease, cardiovascular diseases, hepatic steatosis, chronic obstructive pulmo…

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Metadata

Authors
Lagoumtzi, S. M., & Chondrogianni, N.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2021-08
Volume
171
Pages
169-190
ISSN
0891-5849
DOI
10.1016/j.freeradbiomed.2021.05.003
Cited by
279
References
111
Language
en
Licence

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