Efficacy of paroxetine in treating major depressive disorder in persons with multiple sclerosis

Ehde, Dawn M.; Kraft, George H.; Chwastiak, Lydia; Sullivan, Mark D.; Gibbons, Laura E.; Bombardier, Charles H.; Wadhwani, Rohini

doi:10.1016/j.genhosppsych.2007.08.002

Cited by 107Treatment of Major DepressionMultiple Sclerosis Research StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Efficacy of paroxetine in treating major depressive disorder in persons with multiple sclerosis

Ehde, Dawn M., Kraft, George H., Chwastiak, Lydia, Sullivan, Mark D., Gibbons, Laura E., Bombardier, Charles H., Wadhwani, Rohini·2008·General Hospital Psychiatry

DOI 10.1016/j.genhosppsych.2007.08.002

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Abstract

Objective The objective of this study was to evaluate the efficacy of paroxetine in treating major depressive disorder (MDD) in persons with multiple sclerosis (MS).Method In this double-blind trial, 42 participants with MS and MDD were randomly assigned to one of two parallel 12-week treatment arms: paroxetine or placebo. The participants started at an initial dose of 10 mg/day paroxetine or placebo, titrated up to 40 mg daily based on symptoms response and side effects. The primary outcome measure was the Hamilton Rating Scale for Depression (HAM-D). Secondary outcomes included fatigue, anxiety and self-reported quality of life.Results Intent-to-treat analyses revealed that both groups improved from pretreatment to posttreatment. Although the treatment group improved more than the control group on most measures, few differences were statistically significant. For the primary outcome, 57.1% of participants in the treatment arm had at least a 50% reduction in HAM-D score, compared with 40% in the control group (nonsignificant). Treatment effects were greater among the participants who completed the study; 78.6% of completers had a treatment response compared with 42.1% of controls (P=.073).Conclusion Although paroxetine may not be efficacious for all persons with MS and MDD, it appears to benefit some individuals.

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Two studies, one pharmacological and one psychological, reported the proportion of patients achieving a 50% reduction in symptoms.
“one pharmacological and one psychological, reported the proportion of patients achieving a 50% reduction in symptoms.”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Ehde et al., 2008
In two pharmacological trials, fatigue scores did not improve (SMD −0.70 [95%CI −1.17, −0.23]).
“), fatigue scores did not improve (SMD:−0.70[95%CI: −1.17, −0.23]).”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Ehde et al., 2008
All adverse events were more common in the paroxetine group relative to placebo, including nausea, headache, dry mouth, and sexual dysfunction.
“Ehde and colleagues found that all adverse events were more common in the paroxetine group, relative to placebo, including nausea, headache, dry mouth, and sexual dysfunction (Ehde et al., 2008”
From Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis (2016) · cites this paper as Ehde et al., 2008

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Authors: Ehde, D. M., Kraft, G. H., Chwastiak, L., Sullivan, M. D., Gibbons, L. E., Bombardier, C. H., & Wadhwani, R.
Affiliations: University of Washington (US)
Yale University (US)
Corresponding author: Ehde, Dawn M.
ORCID: Ehde, Dawn M.
Chwastiak, Lydia
Sullivan, Mark D.
Gibbons, Laura E.
Bombardier, Charles H.
Venue: General Hospital Psychiatry
Publisher: Elsevier BV
Published: 2008-01
Volume: 30
Issue: 1
Pages: 40-48
ISSN: 0163-8343 (ISSN-L)
DOI: 10.1016/j.genhosppsych.2007.08.002
OpenAlex: W2086423905
Cited by: 107
References: 47
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 11 · 2016: 7 · 2015: 10 · 2014: 9 · 2013: 7 · 2012: 11
FWCI: 5.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: General Hospital Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: GlaxoSmithKline
National Institute on Disability and Rehabilitation Research
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: paroxetine, major depressive disorder, multiple sclerosis, antidepressant efficacy, selective serotonin reuptake inhibitors, fatigue, anxiety, quality of life, treatment response
MeSH terms: Adult, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Middle Aged, Multiple Sclerosis, United States, Washington, Comorbidity, Treatment Outcome, Outcome Assessment, Health Care, Paroxetine, Antidepressive Agents, Second-Generation

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Efficacy of paroxetine in treating major depressive disorder in persons with multiple sclerosis

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