The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer
Abstract
Seaweeds, being abundant sources of bioactive components have much interest in recent times. The complex polysaccharides from the brown, red and green seaweeds possess broad spectrum therapeutic properties. The sulfated polysaccharides are routinely used in biomedical research and have known biological activities. Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed has various biological functions including anticancer effects. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, the mechanism of cell death depends on the magnitude of DNA damage following exposure to anticancer agents. Apoptosis is mainly regulated by cell growth signaling molecules. Number of research studies evidenced that fucoidan shown to induce cytotoxicity of various cancer cells, induces apoptosis, and inhibits invasion, metastasis and angiogenesis of cancer cells. There are few articles discussing on fucoidan biological activity but no specific review on cancer and its signaling mechanism. Hence, this review discusses the brown seaweed fucoidan structure and some biological function and role in apoptosis, invasion, metastasis, angiogenesis and growth signal mechanism on cancer.
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“Fucoidans are an integral part of the cell walls and intercellular spaces in brown macroalgae, playing a crucial role in the protection of the macroalgae against the effects of desiccation when the biomass is exposed at low tide”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Senthilkumar et al., 2013
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Cites
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118
AP-1 as a regulator of cell life and death
Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961
Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824
Journal of Food Science and Technology
(2013) · Journal of Food Science and Technology · doi:10.1007/13197.0975-8402 · Cited by 2,456
International Journal of Molecular Medicine
(2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm · Cited by 2,247
Bioactive compounds in seaweed: functional food applications and legislation
Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135
Kaufmann, S. H., Desnoyers, S., Ottaviano, Y. L., Davidson, N. E., & Poirier, G. G. (1993) · PubMed · Cited by 1,889
Research works printed but not linked: 8
- Riou, 1996, Anticancer Research, 16, 1213
- Yamamoto, 1984, Japanese Journal of Experimental Medicine, 54, 143
- Itoh, 1995, Anticancer Research, 15, 1937
- Makarenkova, 2010, Voprosy Virusologii, 55, 41
- Semenov, 1998, Voprosy medit sinskoĭ khimii, 44, 135
- Hayakawa, 2009, Anticancer Research, 29, 1211
- Kaufmann, 1993, Cancer Research, 53, 3976
- Rodriguez, 1999, Science Signaling, 13, 3179
Cited by
Sorted by citations
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications
Cunha, L., & Grenha, A. (2016) · Marine Drugs · doi:10.3390/md14030042 · Cited by 620
Garcia-Vaquero, M., Rajauria, G., O'Doherty, J. V., & Sweeney, T. (2017) · Food Research International · doi:10.1016/j.foodres.2016.11.016 · Cited by 364
Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms
van Weelden, G. H., Bobiński, M. S., Okła, K., van Weelden, W. J., Romano, A., & Pijnenborg, J. M. A. (2019) · Marine Drugs · doi:10.3390/md17010032 · Cited by 340
Salehi, B., Sharifi‐Rad, J., Seca, A. M. L., Pinto, D. C. G. A., Michalak, I., Trincone, A., Mishra, A. P., Nigam, M., Zam, W., & Martins, N. A. (2019) · Molecules · doi:10.3390/molecules24224182 · Cited by 324
The seasonal variation of fucoidan within three species of brown macroalgae
Fletcher, H. R., Biller, P., Ross, A. B., & Adams, J. M. M. (2016) · Algal Research · doi:10.1016/j.algal.2016.10.015 · Cited by 270
Metadata
- Authors
- Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K.
- Affiliations
- Pukyong National University (KR)
- Corresponding author
- Kim, Se-Kwon
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 60
- Pages
- 366-374
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2018692723
- Cited by
- 340
- References
- 123
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 26 · 2023: 18 · 2022: 28 · 2021: 32 · 2020: 24 · 2019: 40 · 2018: 33 · 2017: 25 · 2016: 26 · 2015: 22 · 2014: 20 · 2013: 4
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Oceans and Fisheries, Republic of Korea
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- fucoidan, brown algae, sulfated polysaccharides, apoptosis, tumor suppression, metastasis suppression, angiogenesis inhibition, cytotoxicity, DNA damage, anticancer activity
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Cell Cycle, Humans, Molecular Weight, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Polysaccharides, Seaweed, Signal Transduction, Apoptosis
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