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Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer
Abstract
Seaweeds, being abundant sources of bioactive components have much interest in recent times. The complex polysaccharides from the brown, red and green seaweeds possess broad spectrum therapeutic properties. The sulfated polysaccharides are routinely used in biomedical research and have known biological activities. Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed has various biological functions including anticancer effects. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, the mechanism of cell death depends on the magnitude of DNA damage following exposure to anticancer agents. Apoptosis is mainly regulated by cell growth signaling molecules. Number of research studies evidenced that fucoidan shown to induce cytotoxicity of various cancer cells, induces apoptosis, and inhibits invasion, metastasis and angiogenesis of cancer cells. There are few articles discussing on fucoidan biological activity but no specific review on cancer and its signaling mechanism. Hence, this review discusses the brown seaweed fucoidan structure and some biological function and role in apoptosis, invasion, metastasis, angiogenesis and growth signal mechanism on cancer.
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“Fucoidans are an integral part of the cell walls and intercellular spaces in brown macroalgae, playing a crucial role in the protection of the macroalgae against the effects of desiccation when the biomass is exposed at low tide”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Senthilkumar et al., 2013
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Metadata
- Authors
- Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K.
- Affiliations
- Pukyong National University (KR)
- Corresponding author
- Kim, Se-Kwon
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 60
- Pages
- 366-374
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2018692723
- Cited by
- 340
- References
- 123
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 26 · 2023: 18 · 2022: 28 · 2021: 32 · 2020: 24 · 2019: 40 · 2018: 33 · 2017: 25 · 2016: 26 · 2015: 22 · 2014: 20 · 2013: 4
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Oceans and Fisheries, Republic of Korea
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- fucoidan, brown algae, sulfated polysaccharides, apoptosis, tumor suppression, metastasis suppression, angiogenesis inhibition, cytotoxicity, DNA damage, anticancer activity
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Cell Cycle, Humans, Molecular Weight, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Polysaccharides, Seaweed, Signal Transduction, Apoptosis
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