Cited by 340Seaweed-derived Bioactive CompoundsEchinoderm biology and ecologyMarine and coastal plant biology

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Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer

Senthilkumar, Kalimuthu, Manivasagan, Panchanathan, Venkatesan, Jayachandran, Kim, Se-Kwon·2013·International Journal of Biological Macromolecules

DOI 10.1016/j.ijbiomac.2013.06.030

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Abstract

Seaweeds, being abundant sources of bioactive components have much interest in recent times. The complex polysaccharides from the brown, red and green seaweeds possess broad spectrum therapeutic properties. The sulfated polysaccharides are routinely used in biomedical research and have known biological activities. Fucoidan, a fucose-rich polysaccharide extracted from brown seaweed has various biological functions including anticancer effects. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, the mechanism of cell death depends on the magnitude of DNA damage following exposure to anticancer agents. Apoptosis is mainly regulated by cell growth signaling molecules. Number of research studies evidenced that fucoidan shown to induce cytotoxicity of various cancer cells, induces apoptosis, and inhibits invasion, metastasis and angiogenesis of cancer cells. There are few articles discussing on fucoidan biological activity but no specific review on cancer and its signaling mechanism. Hence, this review discusses the brown seaweed fucoidan structure and some biological function and role in apoptosis, invasion, metastasis, angiogenesis and growth signal mechanism on cancer.

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Authors: Senthilkumar, K., Manivasagan, P., Venkatesan, J., & Kim, S.-K.
Affiliations: Pukyong National University (KR)
Corresponding author: Kim, Se-Kwon
ORCID: Manivasagan, Panchanathan
Venkatesan, Jayachandran
Kim, Se-Kwon
Venue: International Journal of Biological Macromolecules
Publisher: Elsevier BV
Published: 2013-09
Volume: 60
Pages: 366-374
ISSN: 0141-8130 (ISSN-L)
DOI: 10.1016/j.ijbiomac.2013.06.030
OpenAlex: W2018692723
Cited by: 340
References: 123
Citations by year: 2026: 20 · 2025: 21 · 2024: 26 · 2023: 18 · 2022: 28 · 2021: 32 · 2020: 24 · 2019: 40 · 2018: 33 · 2017: 25 · 2016: 26 · 2015: 22 · 2014: 20 · 2013: 4
FWCI: 3.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: International Journal of Biological Macromolecules (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Oceans and Fisheries, Republic of Korea
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords: fucoidan, brown algae, sulfated polysaccharides, apoptosis, tumor suppression, metastasis suppression, angiogenesis inhibition, cytotoxicity, DNA damage, anticancer activity
MeSH terms: Animals, Antineoplastic Agents, Phytogenic, Cell Cycle, Humans, Molecular Weight, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Polysaccharides, Seaweed, Signal Transduction, Apoptosis

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Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer

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