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In vitro and in vivo hypoglycemic effects of brown algal fucoidans
Abstract
The inhibition of α-glucosidase is an effective therapeutic approach for type 2 diabetes mellitus that involves decreasing postprandial hyperglycemia. In the present study, the α-glucosidase and α-amylase inhibitory effects of 11 fucoidans extracted from different brown seaweeds were evaluated. Although no significant α-amylase inhibition was observed, fucoidan from Fucus vesiculosus (FvF) showed the highest α-glucosidase inhibitory activity, with an IC50 value of 67.9 μg/mL. In addition, FvF at a concentration of 200 μg/mL displayed very mild cytotoxicity to IEC-6 cells as indicated by the MTT assay. An in vivo study indicated that FvF decreased the fasting blood glucose and hemoglobin A1c (HbA1c) levels of db/db mice, with minimal effect on their weight. Therefore, our present in vitro and in vivo studies demonstrated that FvF could be a promising α-glucosidase inhibitor for the treatment of type 2 diabetes mellitus.
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“Algae are considered as a good source of dietary fibers because of the presence of non-digestible polysaccharides in the algal cell wall (Figure 3) [11]. It has been shown that they possess activities, like antioxidant [12], hypoglycemic [13], antiviral [14,15], antitumor [16], and anti-inflammatory due to the presence of fucoidan and laminarin [17].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [13]
Citations
Cites
The Emerging Risk Factors Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)60484-9 · Cited by 5,125
Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., & Hu, F. B. (2010) · Circulation · doi:10.1161/circulationaha.109.876185 · Cited by 1,641
Fucoidan: Structure and bioactivity
Li, B., Lu, F., Wei, X., & Zhao, R. (2008) · Molecules · doi:10.3390/molecules13081671 · Cited by 1,383
Chemical structures and bioactivities of sulfated polysaccharides from marine algae
Jiao, G., Yu, G., Zhang, J., & Ewart, H. S. (2011) · Marine Drugs · doi:10.3390/md9020196 · Cited by 1,054
Self-citationCumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026
Different Polyphenolic Components of Soft Fruits Inhibit α-Amylase and α-Glucosidase
McDougall, G. J., Shpiro, F., Dobson, P. P., Smith, P., Blake, A., & Stewart, D. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0489926 · Cited by 687
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531
The α-amylase and α-glucosidase inhibitory effects of Irish seaweed extracts
Lordan, S., Smyth, T. J., Soler‐Vila, A., Stanton, C., & Ross, R. P. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.04.123 · Cited by 443
Young, A. A., Gedulin, B. R., Bhavsar, S., Bodkin, N., Jodka, C., Hansen, B., & Denaro, M. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1026 · Cited by 440
Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00053-8 · Cited by 412
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Gurusaravanan, P., Sathasivam, V., Vasanthkumar, R., Arun, M., Muthukrishnan, S., Sivakumar, S., & Jayabalan, N. (2024) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-024-10444-x · Cited by 1
Li, F., Sun, H., Mei, J., Deng, Y., Hu, G., Zhu, C., & Xiang, X. G. (2024) · Frontiers in Marine Science · doi:10.3389/fmars.2024.1415341 · Cited by 1
Ferreira, A. E. A. (2018) · doi:10.14393/ufu.di.2018.1133 · Cited by 1
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Reys, L. L., Silva, S. S., Oliveira, C., López‐Cebral, R., Neves, N. M., Martins, A. M., Oliveira, J. M., Silva, T. H., & Reis, R. L. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch118 · Cited by 9
Ramakrishnan, V., Preetha, S. P., Arivuchelvan, A., Parthiban, M., & pandiyan, T. (2021) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2021.1001.305
Aitynova, A., Ibragimova, N. A., & Shalakhmetova, T. M. (2021) · REPORTS · doi:10.32014/2021.2518-1483.119
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Mabate, B., Daub, C. D., Malgas, S., & Pletschke, B. I. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4683460
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Metadata
- Authors
- Shan, X., Liu, X., Hao, J., Cai, C., Fan, F., Dun, Y., Zhao, X., Liu, X., Li, C., & Yu, G.
- Affiliations
- Ocean University of China (CN)
- Corresponding author
- Yu, Guangli
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 82
- Pages
- 249-255
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2181076115
- Cited by
- 166
- References
- 48
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 26 · 2023: 11 · 2022: 15 · 2021: 22 · 2020: 17 · 2019: 22 · 2018: 20 · 2017: 7 · 2016: 9
- FWCI
- 18.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Marine Science Research Centers (U1406402)
- Marine Scientific Research in the Public Interest (201005024)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, brown algae, Fucus vesiculosus, α-glucosidase inhibition, α-amylase inhibition, type 2 diabetes, hypoglycemic effect, postprandial hyperglycemia, db/db mice, fasting blood glucose, HbA1c, cytotoxicity, IEC-6 cells, dietary fiber
- MeSH terms
- Phaeophyceae, alpha-Amylases, alpha-Glucosidases, Animals, Blood Glucose, Cell Survival, Enzyme Inhibitors, Epithelial Cells, Hypoglycemic Agents, Male, Magnetic Resonance Spectroscopy, Polysaccharides, Seaweed, Mice, Rats
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