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In vitro and in vivo hypoglycemic effects of brown algal fucoidans
Abstract
The inhibition of α-glucosidase is an effective therapeutic approach for type 2 diabetes mellitus that involves decreasing postprandial hyperglycemia. In the present study, the α-glucosidase and α-amylase inhibitory effects of 11 fucoidans extracted from different brown seaweeds were evaluated. Although no significant α-amylase inhibition was observed, fucoidan from Fucus vesiculosus (FvF) showed the highest α-glucosidase inhibitory activity, with an IC50 value of 67.9 μg/mL. In addition, FvF at a concentration of 200 μg/mL displayed very mild cytotoxicity to IEC-6 cells as indicated by the MTT assay. An in vivo study indicated that FvF decreased the fasting blood glucose and hemoglobin A1c (HbA1c) levels of db/db mice, with minimal effect on their weight. Therefore, our present in vitro and in vivo studies demonstrated that FvF could be a promising α-glucosidase inhibitor for the treatment of type 2 diabetes mellitus.
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“Algae are considered as a good source of dietary fibers because of the presence of non-digestible polysaccharides in the algal cell wall (Figure 3) [11]. It has been shown that they possess activities, like antioxidant [12], hypoglycemic [13], antiviral [14,15], antitumor [16], and anti-inflammatory due to the presence of fucoidan and laminarin [17].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [13]
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Metadata
- Authors
- Shan, X., Liu, X., Hao, J., Cai, C., Fan, F., Dun, Y., Zhao, X., Liu, X., Li, C., & Yu, G.
- Affiliations
- Ocean University of China (CN)
- Corresponding author
- Yu, Guangli
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 82
- Pages
- 249-255
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2181076115
- Cited by
- 166
- References
- 48
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 26 · 2023: 11 · 2022: 15 · 2021: 22 · 2020: 17 · 2019: 22 · 2018: 20 · 2017: 7 · 2016: 9
- FWCI
- 18.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Marine Science Research Centers (U1406402)
- Marine Scientific Research in the Public Interest (201005024)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, brown algae, Fucus vesiculosus, α-glucosidase inhibition, α-amylase inhibition, type 2 diabetes, hypoglycemic effect, postprandial hyperglycemia, db/db mice, fasting blood glucose, HbA1c, cytotoxicity, IEC-6 cells, dietary fiber
- MeSH terms
- Phaeophyceae, alpha-Amylases, alpha-Glucosidases, Animals, Blood Glucose, Cell Survival, Enzyme Inhibitors, Epithelial Cells, Hypoglycemic Agents, Male, Magnetic Resonance Spectroscopy, Polysaccharides, Seaweed, Mice, Rats
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