Isolation, structures and biological activities of polysaccharides from Chlorella: a review
Abstract
Chlorella, a green microalga, has been used as an important ingredient in food and medicine because of its excellent nutritive and functional properties. Polysaccharides, as major active ingredients of Chlorella, have attracted increasing attention due to their various health promotion activities, such as those associated with immunomodulation, antioxidation, anti-hyperlipidemia, antitumor, neuroprotection, and anti-asthmatic effect. The significance of polysaccharides from various species of the Chlorella genus has been extensively reported by the scientific community from the perspectives of extraction, structural features, biological activities, and potential uses, which need to be reviewed to improve the understanding, development and utilization of these species. Therefore, this review aims to comprehensively summarize previous and current references regarding the extraction, purification, structural characterization and biological activities of polysaccharides from Chlorella. Moreover, this review also highlights the challenges of investigation and future considerations for holistic utilization in food and medicine.
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Chlorella sp. is recognized by the Food and Agriculture Organization (FAO) as a "healthy green food".
“Chlorella sp., in turn, is recognized by the Food and Agriculture Organization (FAO) as a “healthy green food””
From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Yuan et al., 2020
Chlorella sp. has been consolidated as one of the most widely produced microalgae on a large scale in Europe, Asia, and the United States.
“and has been consolidated as one of the most widely produced microalgae on a large scale in Europe, Asia, and the United States.”
From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Yuan et al., 2020
Chlorella application is especially intended for the sector of dietary supplements, nutraceuticals, and pharmaceutical formulations.
“Its application is especially intended for the sector of dietary supplements, nutraceuticals, and pharmaceutical formulations (Saurav et al., 2019; Yuan et al., 2020; Sinetova et al., 2024).”
From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Yuan et al., 2020
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Tan, M., Zhao, Q., & Zhao, B. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.10.226 · Cited by 85 · see citing works
Gitau, M. M., Farkas, A., Balla, B., Ördög, V., Futó, Z., & Maróti, G. (2021) · Plants · doi:10.3390/plants10061060 · Cited by 60 · see citing works
Microalgae biotechnology and its role in sustainable and healthy food design
Schneider, A. T., Machado, R. L. S., Dutra, D. A., Machado, E. F., Dias, R. R., Deprá, M. C., Zepka, L. Q., & Jacob-Lopes, E. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1716473 · Cited by 15 · see citing works
“Its application is especially intended for the sector of dietary supplements, nutraceuticals, and pharmaceutical formulations (Saurav et al., 2019; Yuan et al., 2020; Sinetova et al., 2024).”
- Authors
- Yuan, Q., Li, H., Wei, Z., Lv, K., Gao, C., Liu, Y., & Zhao, L.
- Affiliations
- Guangxi University of Chinese Medicine (CN)
- Guangxi University (CN)
- Corresponding author
- Zhao, Longyan
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 163
- Pages
- 2199-2209
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W3087662759
- Cited by
- 104
- References
- 107
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 20 · 2023: 20 · 2022: 21 · 2021: 8
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- Chlorella, microalgae polysaccharides, polysaccharide extraction, polysaccharide purification, polysaccharide structure, immunomodulation, antioxidant activity, anticancer activity, neuroprotection, antiasthmatic effect, functional food ingredients, therapeutic applications
- MeSH terms
- Neuroprotection, Antineoplastic Agents, Antioxidants, Chlorella, Humans, Polysaccharides, Anti-Asthmatic Agents, Immunomodulation
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