Cited by 104Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

Isolation, structures and biological activities of polysaccharides from Chlorella: a review

Yuan, Qingxia, Li, Hong, Wei, Ziyi, Lv, Kunling, Gao, Chenghai, Liu, Yonghong, Zhao, Longyan·2020·International Journal of Biological Macromolecules

Abstract

Chlorella, a green microalga, has been used as an important ingredient in food and medicine because of its excellent nutritive and functional properties. Polysaccharides, as major active ingredients of Chlorella, have attracted increasing attention due to their various health promotion activities, such as those associated with immunomodulation, antioxidation, anti-hyperlipidemia, antitumor, neuroprotection, and anti-asthmatic effect. The significance of polysaccharides from various species of the Chlorella genus has been extensively reported by the scientific community from the perspectives of extraction, structural features, biological activities, and potential uses, which need to be reviewed to improve the understanding, development and utilization of these species. Therefore, this review aims to comprehensively summarize previous and current references regarding the extraction, purification, structural characterization and biological activities of polysaccharides from Chlorella. Moreover, this review also highlights the challenges of investigation and future considerations for holistic utilization in food and medicine.

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Crossref · 10.1016/j.ijbiomac.2020.09.080

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107 of 107 references verified0 citation errors · 0 not checkable

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  • Chlorella sp. is recognized by the Food and Agriculture Organization (FAO) as a "healthy green food".

    “Chlorella sp., in turn, is recognized by the Food and Agriculture Organization (FAO) as a “healthy green food””

    From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Yuan et al., 2020

  • Chlorella sp. has been consolidated as one of the most widely produced microalgae on a large scale in Europe, Asia, and the United States.

    “and has been consolidated as one of the most widely produced microalgae on a large scale in Europe, Asia, and the United States.”

    From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Yuan et al., 2020

  • Chlorella application is especially intended for the sector of dietary supplements, nutraceuticals, and pharmaceutical formulations.

    “Its application is especially intended for the sector of dietary supplements, nutraceuticals, and pharmaceutical formulations (Saurav et al., 2019; Yuan et al., 2020; Sinetova et al., 2024).”

    From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Yuan et al., 2020

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Authors
Yuan, Q., Li, H., Wei, Z., Lv, K., Gao, C., Liu, Y., & Zhao, L.
Affiliations
  • Guangxi University of Chinese Medicine (CN)
  • Guangxi University (CN)
Corresponding author
Zhao, Longyan
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2020-11
Volume
163
Pages
2199-2209
ISSN
0141-8130 (ISSN-L)
OpenAlex
W3087662759
Cited by
104
References
107
Citations by year
2026: 12 · 2025: 23 · 2024: 20 · 2023: 20 · 2022: 21 · 2021: 8
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Guangxi Zhuang Autonomous Region
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords
Chlorella, microalgae polysaccharides, polysaccharide extraction, polysaccharide purification, polysaccharide structure, immunomodulation, antioxidant activity, anticancer activity, neuroprotection, antiasthmatic effect, functional food ingredients, therapeutic applications
MeSH terms
Neuroprotection, Antineoplastic Agents, Antioxidants, Chlorella, Humans, Polysaccharides, Anti-Asthmatic Agents, Immunomodulation

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