The DOI matches its Crossref record; 251 of the 254 references it cites were found in a registry or an index.
Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: Bacteriocins and conjugated linoleic acid
Open accessAbstract
The mechanisms by which intestinal bacteria achieve their associated health benefits can be complex and multifaceted. In this respect, the diverse microbial composition of the human gastrointestinal tract (GIT) provides an almost unlimited potential source of bioactive substances (pharmabiotics) which can directly or indirectly affect human health. Bacteriocins and fatty acids are just two examples of pharmabiotic substances which may contribute to probiotic functionality within the mammalian GIT. Bacteriocin production is believed to confer producing strains with a competitive advantage within complex microbial environments as a consequence of their associated antimicrobial activity. This has the potential to enable the establishment and prevalence of producing strains as well as directly inhibiting pathogens within the GIT. Consequently, these antimicrobial peptides and the associated intestinal producing strains may be exploited to beneficially influence microbial populations. Intestinal bacteria are also known to produce a diverse array of health-promoting fatty acids. Indeed, certain strains of intestinal bifidobacteria have been shown to produce conjugated linoleic acid (CLA), a fatty acid which has been associated with a variety of systemic health-promoting effects. Recently, the ability to modulate the fatty acid composition of the liver and adipose tissue of the host upon oral administration of CLA-producing bifidobacteria and lactobacilli was demonstrated in a murine model. Importantly, this implies a potential therapeutic role for probiotics in the treatment of certain metabolic and immunoinflammatory disorders. Such examples serve to highlight the potential contribution of pharmabiotic production to probiotic functionality in relation to human health maintenance.
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“Several health benefits have been attributed to CLA, and there is increasing evidence that these effects are isomer-specific [257].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [257]
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Role of Probiotics and Prebiotics in the Dysbiosis of Gut Microbiota
Shad, E., Väkeväinen, K., & Gómez-Gallego, C. (2025) · Springer handbooks · doi:10.1007/978-3-032-01636-2_36
Metabolomics of probiotics: Impact on host metabolism
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Probiotics for skin health: Treating acne, eczema, and other skin conditions
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Metadata
- Authors
- O'Shea, E. F., Cotter, P. D., Stanton, C., Ross, R. P., & Hill, C.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Corresponding author
- Ross, R. Paul
- Venue
- International Journal of Food Microbiology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 152
- Issue
- 3
- Pages
- 189-205
- ISSN
- 0168-1605 (ISSN-L)
- OpenAlex
- W2051115786
- Cited by
- 305
- References
- 254
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 16 · 2023: 28 · 2022: 30 · 2021: 21 · 2020: 29 · 2019: 22 · 2018: 25 · 2017: 21 · 2016: 20 · 2015: 22 · 2014: 18 · 2013: 16 · 2012: 10
- FWCI
- 21.42
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- International Journal of Food Microbiology (publishedVersion)
- PubMed (publishedVersion)
- T-Stór (Teagasc) (acceptedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, bacteriocins, conjugated linoleic acid, intestinal bacteria, Bifidobacterium, lactobacilli, antimicrobial peptides, gut microbiota, fatty acid composition, pathogen inhibition
- MeSH terms
- Animals, Bacteriocins, Bifidobacterium, Fatty Acids, Humans, Lactobacillus, Mice, Inbred BALB C, Probiotics, Gastrointestinal Tract, Linoleic Acids, Conjugated, Mice
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