Cited by 305Probiotics and Fermented FoodsGut microbiota and healthInfant Nutrition and Health

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Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: Bacteriocins and conjugated linoleic acid

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O'Shea, Eileen F., Cotter, Paul D., Stanton, Catherine, Ross, R. Paul, Hill, Colin·2012·International Journal of Food Microbiology

DOI 10.1016/j.ijfoodmicro.2011.05.025

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Abstract

The mechanisms by which intestinal bacteria achieve their associated health benefits can be complex and multifaceted. In this respect, the diverse microbial composition of the human gastrointestinal tract (GIT) provides an almost unlimited potential source of bioactive substances (pharmabiotics) which can directly or indirectly affect human health. Bacteriocins and fatty acids are just two examples of pharmabiotic substances which may contribute to probiotic functionality within the mammalian GIT. Bacteriocin production is believed to confer producing strains with a competitive advantage within complex microbial environments as a consequence of their associated antimicrobial activity. This has the potential to enable the establishment and prevalence of producing strains as well as directly inhibiting pathogens within the GIT. Consequently, these antimicrobial peptides and the associated intestinal producing strains may be exploited to beneficially influence microbial populations. Intestinal bacteria are also known to produce a diverse array of health-promoting fatty acids. Indeed, certain strains of intestinal bifidobacteria have been shown to produce conjugated linoleic acid (CLA), a fatty acid which has been associated with a variety of systemic health-promoting effects. Recently, the ability to modulate the fatty acid composition of the liver and adipose tissue of the host upon oral administration of CLA-producing bifidobacteria and lactobacilli was demonstrated in a murine model. Importantly, this implies a potential therapeutic role for probiotics in the treatment of certain metabolic and immunoinflammatory disorders. Such examples serve to highlight the potential contribution of pharmabiotic production to probiotic functionality in relation to human health maintenance.

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Authors: O'Shea, E. F., Cotter, P. D., Stanton, C., Ross, R. P., & Hill, C.
Affiliations: Teagasc - The Irish Agriculture and Food Development Authority (IE)
University College Cork (IE)
Corresponding author: Ross, R. Paul
ORCID: O'Shea, Eileen F.
Cotter, Paul D.
Stanton, Catherine
Ross, R. Paul
Hill, Colin
Venue: International Journal of Food Microbiology
Publisher: Elsevier BV
Published: 2012-01
Volume: 152
Issue: 3
Pages: 189-205
ISSN: 0168-1605 (ISSN-L)
DOI: 10.1016/j.ijfoodmicro.2011.05.025
OpenAlex: W2051115786
Cited by: 305
References: 254
Citations by year: 2026: 9 · 2025: 15 · 2024: 16 · 2023: 28 · 2022: 30 · 2021: 21 · 2020: 29 · 2019: 22 · 2018: 25 · 2017: 21 · 2016: 20 · 2015: 22 · 2014: 18 · 2013: 16 · 2012: 10
FWCI: 21.42
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: International Journal of Food Microbiology (publishedVersion)
PubMed (publishedVersion)
T-Stór (Teagasc) (acceptedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, bacteriocins, conjugated linoleic acid, intestinal bacteria, Bifidobacterium, lactobacilli, antimicrobial peptides, gut microbiota, fatty acid composition, pathogen inhibition
MeSH terms: Animals, Bacteriocins, Bifidobacterium, Fatty Acids, Humans, Lactobacillus, Mice, Inbred BALB C, Probiotics, Gastrointestinal Tract, Linoleic Acids, Conjugated, Mice

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Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: Bacteriocins and conjugated linoleic acid

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