Cited by 396T-cell and B-cell ImmunologyDevelopmental Biology and Gene RegulationPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Direct Regulation of Gata3 Expression Determines the T Helper Differentiation Potential of Notch

Open access

Amsen, Derk, Antov, Andrey, Jankovic, Dragana, Sher, Alan, Radtke, Freddy, Souabni, Abdallah, Busslinger, Meinrad, McCright, Brent, Gridley, Thomas, Flavell, Richard A.·2007·Immunity

DOI 10.1016/j.immuni.2007.05.021PMC PMC2062505

Open this paper in CoChat — free account Open PDF

Abstract

CD4(+) T helper cells differentiate into T helper 1 (Th1) or Th2 effector lineages, which orchestrate immunity to different types of microbes. Both Th1 and Th2 differentiation can be induced by Notch, but what dictates which of these programs is activated in response to Notch is not known. By using T cell-specific gene ablation of the Notch effector RBP-J or the Notch1 and 2 receptors, we showed here that Notch was required on CD4(+) T cells for physiological Th2 responses to parasite antigens. GATA-3 was necessary for Notch-induced Th2 differentiation, and we identified an upstream Gata3 promoter as a direct target for Notch signaling. Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2007.05.021

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Functional diversity of helper T lymphocytes
Abbas, A. K., MURPHY, K. M. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,431
Self-citation
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Self-citation
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
The lineage decisions of helper T cells
MURPHY, K. M. M., & Reiner, S. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri954 · Cited by 1,690
Dendritic-cell control of pathogen-driven T-cell polarization
Kapsenberg, M. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1246 · Cited by 1,495
Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1
Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J. P. M., MacDonald, H. R., & Aguet, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80054-0 · Cited by 1,393
Self-citation

Flagged first, then by citations

Show all 73 references

Sorted by citations

Items 101–200 of 396

Sending the right signal: Notch and stem cells
Perdigoto, C. N., & Bardin, A. J. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.009 · Cited by 91
Review series on helminths, immune modulation and the hygiene hypothesis: Mechanisms underlying helminth modulation of dendritic cell function
Carvalho, L., Sun, J., Kane, C., Marshall, F., Krawczyk, C., & Pearce, E. J. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.03008.x · Cited by 85
Therapeutic Targeting of Notch Signaling: From Cancer to Inflammatory Disorders
Allen, F., & Maillard, I. P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.649205 · Cited by 84
Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance
Sierra, R. A., Trillo-Tinoco, J., Mohamed, E. T., Yu, L. C., Achyut, B. R., Arbab, A. S., Bradford, J. W., Osborne, B. A., Miele, L., & Rodrı́guez, P. C. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0357 · Cited by 82
Rescue of Notch-1 Signaling in Antigen-Specific CD8+ T Cells Overcomes Tumor-Induced T-cell Suppression and Enhances Immunotherapy in Cancer
Sierra, R. A., Thevenot, P., Raber, P. L., Cui, Y. R., Parsons, C. H., Ochoa, A. C., Trillo-Tinoco, J., Valle, L. D., & Rodrı́guez, P. C. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0021 · Cited by 81
Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition
Ong, C., Šedý, J. R., MURPHY, K. M. M., & Kopan, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002823 · Cited by 81
STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway
Jin, L., Vu, T., Yuan, G., & Datta, P. K. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0286 · Cited by 82
TH2 adjuvants: Implications for food allergy
Berin, M. C., & Shreffler, W. G. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.023 · Cited by 80
Rapid In Vivo Conversion of Effector T Cells into Th2 Cells during Helminth Infection
Panzer, M., Sitte, S., Wirth, S., Drexler, I., Sparwasser, T. D., & Voehringer, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101164 · Cited by 83
Transcriptional drivers of the T-cell lineage program
Rothenberg, E. V. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.12.012 · Cited by 80
IL-9 and Th9 cells: progress and challenges
Zhao, P., Xiao, X., Ghobrial, R. M., & Li, X. C. (2013) · International Immunology · doi:10.1093/intimm/dxt039 · Cited by 82
TCR-Dependent Translational Control of GATA-3 Enhances Th2 Differentiation
Cook, K. D., & Miller, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902544 · Cited by 79
GATA3 Regulates the Development and Functions of Innate Lymphoid Cell Subsets at Multiple Stages
Zhu, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01571 · Cited by 79
E proteins and the regulation of early lymphocyte development
de Pooter, R. F., & Kee, B. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00957.x · Cited by 77
Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation
Cai, J., Lee, J., Kopan, R., & Ma, L. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.11.021 · Cited by 78
An insight into molecular mechanisms of human T helper cell differentiation
Rautajoki, K. J., Rautajoki, K. J., Kyläniemi, M. K., Raghav, S. K., Rao, K. V. S., & Lahesmaa, R. (2008) · Annals of Medicine · doi:10.1080/07853890802068582 · Cited by 78
Notch1 modulates mesenchymal stem cells mediated regulatory T ‐cell induction
Papa, B. D., Sportoletti, P., Cecchini, D., Rosati, E., Balucani, C., Baldoni, S., Fettucciari, K., Marconi, P., Martelli, M. F., Falzetti, F., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242643 · Cited by 82
Notch3 Inhibition in Myelin-Reactive T Cells Down-Regulates Protein Kinase Cθ and Attenuates Experimental Autoimmune Encephalomyelitis
Juryńczyk, M., Jurewicz, A., Raine, C. S., & Selmaj, K. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2634 · Cited by 76
Transcriptional regulation of Th2 cell differentiation
Zhu, J. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2009.114 · Cited by 82
Notch signaling in CD4 and CD8 T cell development
Laky, K., & Fowlkes, B. J. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.004 · Cited by 77
Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4+ T Cells
Dongre, A., Surampudi, L., Lawlor, R. G., Fauq, A. H., Miele, L., Golde, T. E., Minter, L. M., & Osborne, B. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00054 · Cited by 76
Initiation and maintenance of Th2 cell identity
Nakayama, T., & Yamashita, M. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.011 · Cited by 75
Transcriptional Repression of Gata3 Is Essential for Early B Cell Commitment
Banerjee, A., Northrup, D. L., Boukarabila, H., Jacobsen, S. E. W., & Allman, D. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.014 · Cited by 72
T helper 2 and T follicular helper cells: Regulation and function of interleukin-4
Sahoo, A., Wali, S., & Nurieva, R. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.03.011 · Cited by 79
Notch signaling: its roles and therapeutic potential in hematological malignancies
Gu, Y., Masiero, M., & Banham, A. H. (2016) · Oncotarget · doi:10.18632/oncotarget.7772 · Cited by 75
Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells
Krawczyk, C. M., Sun, J., & Pearce, E. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.7931 · Cited by 71
Th9 Cell Differentiation and Its Dual Effects in Tumor Development
Chen, T., Guo, J., Cai, Z., Li, B., Sun, L., Shen, Y., Wang, S., Wang, Z., Wang, Z., Wang, Y., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01026 · Cited by 76
Mechanisms of anti-carcinogenesis by indole-3-carbinol
Fong, A. T., Swanson, H. I., Dashwood, R. H., Williams, D. E., Hendricks, J. D., & Bailey, G. (1990) · Biochemical Pharmacology · doi:10.1016/0006-2952(90)90643-y · Cited by 68
Notch Signaling Regulates Follicular Helper T Cell Differentiation
Auderset, F., Schuster, S., Fasnacht, N., Coutaz, M., Charmoy, M., Koch, U., Favre, S., Wilson, A., Trottein, F., Alexander, J. K., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300643 · Cited by 68
Self-citation
Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2
Gentek, R., Munneke, J. M., Helbig, C., Blom, B., Hazenberg, M. D., Spits, H., & Amsen, D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00334 · Cited by 67
Self-citation
Transcriptional Regulatory Networks for CD4 T Cell Differentiation
Christie, D. A., & Zhu, J. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_372 · Cited by 69
Cellular and population plasticity of helper CD4+ T cell responses
Magombedze, G., Reddy, P. B. J., Eda, S., & Ganusov, V. V. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00206 · Cited by 72
Rbpj expression in regulatory T cells is critical for restraining TH2 responses
Delacher, M., Schmidl, C., Herzig, Y., Breloer, M., Hartmann, W., Brunk, F., Kägebein, D., Träger, U., Hofer, A.-C., Bittner, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09276-w · Cited by 63
CD4+ T helper 2 cells - microbial triggers, differentiation requirements and effector functions
Okoye, I., & Wilson, M. S. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03497.x · Cited by 65
Notch: A new player in MS mechanisms
Juryńczyk, M., & Selmaj, K. W. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.08.010 · Cited by 65
Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells
Debeb, B. G., Cohen, E. N., Boley, K. M., Freiter, E. M., Li, L., Robertson, F. M., Reuben, J. M., Cristofanilli, M., Buchholz, T. A., & Woodward, W. A. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2075-8 · Cited by 65
Critical role for mouse marginal zone B cells in PF4/heparin antibody production
Zheng, Y., Yu, M., Podd, A., Yuan, L., Newman, D. K., Wen, R., Arepally, G. M., & Wang, D. (2013) · Blood · doi:10.1182/blood-2013-01-477091 · Cited by 64
Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes
Chari, S., & Winandy, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6265 · Cited by 63
Regulation of dendritic cell differentiation and function by Notch and Wnt pathways
Cheng, P., Zhou, J. H. S., & Gabrilovich, D. I. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00871.x · Cited by 63
Essential role of Notch signaling in effector memory CD8+ T cell–mediated airway hyperresponsiveness and inflammation
Okamoto, M., Takeda, K., Joetham, A., Ohnishi, H., Matsuda, H., Swasey, C. H., Swanson, B. J., Yasutomo, K., Dakhama, A., & Gelfand, E. W. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072200 · Cited by 61
Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate
Sakata‐Yanagimoto, M., Nakagami‐Yamaguchi, E., Saito, T., Kumano, K., Yasutomo, K., Ogawa, S., Kurokawa, M., & Chiba, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801074105 · Cited by 63
M2-like macrophages transplantation protects against the doxorubicin-induced heart failure via mitochondrial transfer
Liu, Y., Wu, M., Zhong, C., Xu, B., & Kang, L. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00260-y · Cited by 64
Cellular networks controlling Th2 polarization in allergy and immunity
Kool, M., Hammad, H., & Lambrecht, B. N. (2012) · F1000 Biology Reports · doi:10.3410/b4-6 · Cited by 60
c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development
Nakata, Y., Brignier, A., Jin, S., Shen, Y., Rudnick, S. I., Sugita, M., & Gewirtz, A. M. (2010) · Blood · doi:10.1182/blood-2009-05-223255 · Cited by 60
Impaired CD4+ T‐cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis
Carson, W. F., Cavassani, K. A., Ito, T., Schaller, M. A., Ishii, M., Dou, Y., & Kunkel, S. L. (2010) · European Journal of Immunology · doi:10.1002/eji.200939739 · Cited by 59
Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy
Biktasova, A. K., Dudimah, D. F., Uzhachenko, R. V., Park, K., Akhter, A., Arasada, R. R., Evans, J. V., Novitskiy, S. V., Tchekneva, E. E., Carbone, D. P., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1154 · Cited by 59
Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors
Blander, J. M. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.097964 · Cited by 62
BCL6 Controls Th9 Cell Development by Repressing Il9 Transcription
Bassil, R., Orent, W., Olah, M., Kurdi, A. T., Frangieh, M., Buttrick, T., Khoury, S. J., & Elyaman, W. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303184 · Cited by 61
Notch signaling in the hematopoietic system
Sandy, A. R., & Maillard, I. P. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903260777 · Cited by 56
Liver sinusoidal endothelial cells induce immunosuppressive IL‐10‐producing Th1 cells via the Notch pathway
Neumann, K., Rudolph, C., Neumann, C., Janke, M., Amsen, D., & Scheffold, A. (2015) · European Journal of Immunology · doi:10.1002/eji.201445346 · Cited by 60
Self-citation
The osteoimmunology of alveolar bone loss
Tompkins, K. A. (2016) · Connective Tissue Research · doi:10.3109/03008207.2016.1140152 · Cited by 57
Notch Signaling in T Helper Cell Subsets: Instructor or Unbiased Amplifier?
Tindemans, I., Peeters, M. J. W., & Hendriks, R. W. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00419 · Cited by 57
Developmental plasticity of lymphocytes
Cobaleda, C., & Busslinger, M. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.017 · Cited by 57
Self-citation
Notch Signaling in Acute Inflammation and Sepsis
Gallenstein, N., Tichy, L., Weigand, M. A., & Schenz, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043458 · Cited by 60
Notch signaling is necessary for GATA3 function in the initiation of T cell development
Hozumi, K., Negishi, N., Tsuchiya, I., Abe, N., Hirano, K., Suzuki, D., Yamamoto, M. P., Engel, J. D., & Habu, S. (2008) · European Journal of Immunology · doi:10.1002/eji.200737688 · Cited by 56
Curdlan Induces DC-Mediated Th17 Polarization via Jagged1 Activation in Human Dendritic Cells
Higashi, T., Hashimoto, K., Takagi, R., Mizuno, Y., Okazaki, Y., Tanaka, Y., & Matsushita, S. (2010) · Allergology International · doi:10.2332/allergolint.09-oa-0103 · Cited by 55
CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid arthritis: evidence from a case–control study
Ye, H., Zhang, J., Wang, J., Gao, Y., Du, Y., Li, C., Deng, M., Guo, J., & Li, Z. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0590-9 · Cited by 57
T Cell–Specific Notch Inhibition Blocks Graft-versus-Host Disease by Inducing a Hyporesponsive Program in Alloreactive CD4+ and CD8+ T Cells
Sandy, A. R., Chung, J., Toubai, T., Shan, G. T., Tran, I., Friedman, A. D., Blackwell, T. S., Reddy, P. R., King, P. D., & Maillard, I. P. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203452 · Cited by 55
Group 2 innate lymphoid cells in lung inflammation
Li, B. W. S., & Hendriks, R. W. (2013) · Immunology · doi:10.1111/imm.12153 · Cited by 53
Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity
Tchekneva, E. E., Goruganthu, M., Uzhachenko, R. V., Thomas, P. L., Antonucci, A., Chekneva, I. S., Koenig, M. J., Piao, L., Akhter, A., de Aquino, M. T. P., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0566-4 · Cited by 54
Notch signaling in differentiation and function of dendritic cells
Cheng, P., & Gabrilovich, D. I. (2007) · Immunologic Research · doi:10.1007/s12026-007-8011-z · Cited by 53
A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury
Grigorieva, I. V., Oszwald, A., Grigorieva, E. F., Schachner, H., Neudert, B., Ostendorf, T., Floege, J., Lindenmeyer, M. T., Cohen, C. D., Panzer, U., et al. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018111143 · Cited by 52
Current understanding of Th2 cell differentiation and function
Li, Z., Zhang, Y., & Sun, B. (2011) · Protein & Cell · doi:10.1007/s13238-011-1083-5 · Cited by 57
Mouse and human Notch-1 regulate mucosal immune responses
Mathern, D. R., Laitman, L. E., Hovhannisyan, Z., Dunkin, D., Farsio, S., Malik, T. J., Roda, G., Chitre, A. S., Iuga, A. C., Yeretssian, G., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2013.118 · Cited by 49
Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells
Stanelle, J., Döring, C., Hansmann, M., & Küppers, R. (2010) · Blood · doi:10.1182/blood-2010-01-265827 · Cited by 50
Delta-Like Ligand 4 Regulates Central Nervous System T Cell Accumulation during Experimental Autoimmune Encephalomyelitis
Reynolds, N. D., Lukacs, N. W., Long, N. C., & Karpus, W. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100160 · Cited by 50
Targeting Notch Signaling for Cancer Therapeutic Intervention
Shao, H., Huang, Q., & Liu, Z. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-397927-8.00007-5 · Cited by 49
‘All things considered’: transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation
Zeng, W. (2013) · Immunology · doi:10.1111/imm.12121 · Cited by 49
Regulation of Th1/Th2 cells in asthma development: A mathematical model
Kim, Y., Lee, S., Kim, Y., Lawler, S. E., Gho, Y. S., Kim, Y., & Hwang, H. J. (2013) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2013.10.1095 · Cited by 48
Notch regulation of early thymocyte development
Yashiro–Ohtani, Y., Ohtani, T., & Pear, W. S. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2010.04.015 · Cited by 47
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis
Qian, Y., Arellano, G., Ifergan, I., Lin, J., Snowden, C. K., Kim, T., Thomas, J. J., Law, C., Guan, T., Balabanov, R. D., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109602 · Cited by 49
Control of IL‐4 expression in T helper 1 and 2 cells
Gilmour, J., & Lavender, P. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02845.x · Cited by 47
The Notch Signaling Pathway Controls Short-Lived Effector CD8+ T Cell Differentiation but Is Dispensable for Memory Generation
Mathieu, M., Duval, F., Daudelin, J., & Labrecque, N. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402837 · Cited by 45
An NK and T Cell Enhancer Lies 280 Kilobase Pairs 3′ to the Gata3 Structural Gene
Hosoya-Ohmura, S., Lin, Y.-H., Herrmann, M., Kuroha, T., Rao, A. U. K., Moriguchi, T., Lim, K.-C., Hosoya, T., & Engel, J. D. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05065-11 · Cited by 45
Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene
Watarai, H., Rybouchkin, A., Hongo, N., Nagata, Y., Sakata, S., Sekine-Kondo, E., Dashtsoodol, N., Tashiro, T., Fujii, S., Shimizu, K., et al. (2009) · Blood · doi:10.1182/blood-2009-04-217729 · Cited by 45
Mechanisms in allergic airway inflammation – lessons from studies in the mouse
Shum, B. O. V., Rolph, M. S., & Sewell, W. A. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000707 · Cited by 45
Memory CD4+ T Cells: fate determination, positive feedback and plasticity
Yamane, H., & Paul, W. E. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0966-9 · Cited by 45
Notch signaling pathway in infectious diseases: role in the regulation of immune response
Castro, R. C., Gonçales, R. A., Zambuzi, F. A., & Frantz, F. G. (2021) · Inflammation Research · doi:10.1007/s00011-021-01442-5 · Cited by 44
The Role of Notch in the Differentiation of CD4+ T Helper Cells
Auderset, F., Coutaz, M., & Tacchini‐Cottier, F. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_227 · Cited by 43
Notch system in the linkage of innate and adaptive immunity
Ito, T., Connett, J. M., Kunkel, S. L., & Matsukawa, A. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1011529 · Cited by 42
Canonical and Non-Canonical Notch Signaling in CD4+ T Cells
Minter, L. M., & Osborne, B. A. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_233 · Cited by 43
Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination
Rothenberg, E. V., & Scripture-Adams, D. D. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2008.07.006 · Cited by 43
Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 Signaling
Hu, C., Li, Z., Feng, J., Tang, Y., Qin, L., Hu, X., Zhang, Y., & He, R. (2018) · International Archives of Allergy and Immunology · doi:10.1159/000485890 · Cited by 42
IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation
Karrich, J. J., Jachimowski, L. C. M., Nagasawa, M., Kamp, A. M., Balzarolo, M., Wolkers, M. C., Uíttenbogaart, C. H., van Ham, S. M., & Blom, B. (2013) · Blood · doi:10.1182/blood-2012-08-452995 · Cited by 47
PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells
Yashiro, T., Kubo, M., Ogawa, H., Okumura, K., & Nishiyama, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137699 · Cited by 43
Transcriptional regulation of CD4+ TH cells that mediate tissue inflammation
Loo, T. T., Gao, Y., & Lazarevic, V. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ri0418-152rr · Cited by 43
Fbw7 Targets GATA3 through Cyclin-Dependent Kinase 2-Dependent Proteolysis and Contributes to Regulation of T-Cell Development
Kitagawa, K., Shibata, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H., & Kitagawa, M. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01549-13 · Cited by 40
Selective induction of the Notch ligand Jagged‐1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling
Goh, F., Irvine, K. M., Lovelace, E. S., Donnelly, S., Jones, M. K., Brion, K., Hume, D. A., Kotze, A. C., Dalton, J. P., Ingham, A. B., et al. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02979.x · Cited by 39
Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable
Tindemans, I., Lukkes, M. M., de Bruijn, M. J. W., Li, B. W. S., van Nimwegen, M., Amsen, D., KleinJan, A., & Hendriks, R. W. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.11.046 · Cited by 39
Self-citation
Group 2 innate lymphocytes at the interface between innate and adaptive immunity
Schuijs, M. J., & Halim, T. Y. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13604 · Cited by 40
Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate
Dell’Aringa, M., & Reinhardt, R. L. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0012-9 · Cited by 38
Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes
Kling, J. C., & Blumenthal, A. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1mr0616-272r · Cited by 36
Molecular pathways regulating CD4+ T cell differentiation, anergy and memory with implications for vaccines
Ahlers, J. D., & Belyakov, I. M. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.07.007 · Cited by 37
Genetic and epigenetic networks controlling T helper 1 cell differentiation
Placek, K., Coffre, M., Maiella, S., Bianchi, E., & Rogge, L. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03059.x · Cited by 36
Estradiol resolves pneumonia via ERβ in regulatory T cells
Xiong, Y., Zhong, Q., Palmer, T., Benner, A., Wang, L., Suresh, K. S., Damico, R. L., & D’Alessio, F. R. (2020) · JCI Insight · doi:10.1172/jci.insight.133251 · Cited by 38
Linking GATA-3 and interleukin-13: implications in asthma
Rayees, S., Malik, F. A., Bukhari, S. I., & Singh, G. (2013) · Inflammation Research · doi:10.1007/s00011-013-0700-6 · Cited by 36
Down-regulation of Notch signaling pathway reverses the Th1/Th2 imbalance in tuberculosis patients
Li, Q., Zhang, H., Yu, L., Wu, C., Luo, X., Sun, H., & Ding, J. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.10.026 · Cited by 36
Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress
Tindemans, I., van Schoonhoven, A., KleinJan, A., de Bruijn, M. J. W., Lukkes, M. M., van Nimwegen, M., van den Branden, A., Bergen, I. M., Corneth, O. B. J., van IJcken, W. F. J., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci128310 · Cited by 35
Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice
Jiang, S., Han, S., Chen, J., Xue-jiao, L., & Che, H. (2016) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2016.10.024 · Cited by 34
The intrathymic crossroads of T and NK cell differentiation
Wolterink, R. G. J. K., García‐Ojeda, M. E., Vosshenrich, C. A. J., Hendriks, R. W., & Santo, J. P. D. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00960.x · Cited by 34

Authors: Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A.
Affiliations: Yale University (US)
National Institutes of Health (US)
ISREC Foundation (CH)
Research Institute of Molecular Pathology (AT)
Jackson Laboratory (US)
Howard Hughes Medical Institute (US)
Corresponding author: Amsen, Derk
ORCID: Amsen, Derk
Jankovic, Dragana
Sher, Alan
Radtke, Freddy
Busslinger, Meinrad
McCright, Brent
Flavell, Richard A.
Venue: Immunity
Publisher: Elsevier BV
Published: 2007-07
Volume: 27
Issue: 1
Pages: 89-99
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2007.05.021
PMC: PMC2062505
OpenAlex: W2042784167
Cited by: 396
References: 73
Citations by year: 2026: 5 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 17 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 21 · 2013: 37 · 2012: 33
FWCI: 15.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
IRIS (submittedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: American Diabetes Association
National Institutes of Health (NS036437)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: GATA3, Notch signaling, T helper cell differentiation, Th1 differentiation, Th2 differentiation, CD4+ T cells, RBPJ, Notch1, Notch2, parasite antigens, transcriptional regulation
MeSH terms: Animals, Base Sequence, Cell Differentiation, Cells, Cultured, T-Lymphocytes, Helper-Inducer, Humans, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Signal Transduction, Mice, Knockout, Th1 Cells, Th2 Cells, GATA3 Transcription Factor, Mice, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Receptors, Notch

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Direct Regulation of Gata3 Expression Determines the T Helper Differentiation Potential of Notch

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks