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Direct Regulation of Gata3 Expression Determines the T Helper Differentiation Potential of Notch
Open accessAbstract
CD4(+) T helper cells differentiate into T helper 1 (Th1) or Th2 effector lineages, which orchestrate immunity to different types of microbes. Both Th1 and Th2 differentiation can be induced by Notch, but what dictates which of these programs is activated in response to Notch is not known. By using T cell-specific gene ablation of the Notch effector RBP-J or the Notch1 and 2 receptors, we showed here that Notch was required on CD4(+) T cells for physiological Th2 responses to parasite antigens. GATA-3 was necessary for Notch-induced Th2 differentiation, and we identified an upstream Gata3 promoter as a direct target for Notch signaling. Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch.
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“In fact, GATA3 expression can also be induced by T cell receptor (TCR) signaling [41] and other pathways, such as Notch [42] and WNT signaling [43].”
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Cites
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
Functional diversity of helper T lymphocytes
Abbas, A. K., MURPHY, K. M. M., & Sher, A. (1996) · Nature · doi:10.1038/383787a0 · Cited by 4,431
Self-citationA Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
Self-citationIL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
The lineage decisions of helper T cells
MURPHY, K. M. M., & Reiner, S. L. (2002) · Nature reviews. Immunology · doi:10.1038/nri954 · Cited by 1,690
Dendritic-cell control of pathogen-driven T-cell polarization
Kapsenberg, M. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1246 · Cited by 1,495
Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1
Radtke, F., Wilson, A., Stark, G., Bauer, M., van Meerwijk, J. P. M., MacDonald, H. R., & Aguet, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80054-0 · Cited by 1,393
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Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
How are TH2-type immune responses initiated and amplified?
Paul, W. E., & Zhu, J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2735 · Cited by 997
Epigenetic control of T-helper-cell differentiation
Wilson, C. B., Rowell, E. A., & Sekimata, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2487 · Cited by 691
The Notch signaling pathway: Transcriptional regulation at Notch target genes
Borggrefe, T., & Oswald, F. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8668-7 · Cited by 661
Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
Joffre, O. P., Nolte, M. A., Spörri, R., & Sousa, C. R. E. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00718.x · Cited by 620
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556
Notch Signaling in the Immune System
Radtke, F., Fasnacht, N., & MacDonald, H. R. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.004 · Cited by 561
Self-citationAn Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells
Wang, Y., Su, M. A., & Wan, Y. Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.012 · Cited by 461
Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment
Bouras, T., Pal, B., Vaillant, F., Harburg, G. C., Asselin-Labat, M.-L., Oakes, S. R., Lindeman, G. J., & Visvader, J. E. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.08.001 · Cited by 451
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
Ho, I., Tai, T.-S., & Pai, S. (2009) · Nature reviews. Immunology · doi:10.1038/nri2476 · Cited by 441
Regulation of innate and adaptive immunity by Notch
Radtke, F., MacDonald, H. R., & Tacchini‐Cottier, F. (2013) · Nature reviews. Immunology · doi:10.1038/nri3445 · Cited by 416
Self-citationTaylor, B. C., Zaph, C., Troy, A. E., Du, Y., Guild, K. J., Comeau, M. R., & Artis, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081499 · Cited by 340
Th17 cells: new players in asthma pathogenesis
Cosmi, L., Liotta, F., Maggi, E., Romagnani, S., & Annunziato, F. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02576.x · Cited by 339
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The differential expression of IL-4 and IL-13 and its impact on type-2 immunity
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GATA3 in development and cancer differentiation: Cells GATA have it!
Chou, J., Provot, S., & Werb, Z. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21943 · Cited by 309
Yamane, H., & Paul, W. E. (2013) · Immunological Reviews · doi:10.1111/imr.12032 · Cited by 319
Oyoshi, M. K., Larson, R. P., Ziegler, S. F., & Geha, R. S. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.041 · Cited by 302
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Huang, B., Yang, H., Cheng, X., Wang, D., Fu, S., Shen, W., Zhang, Q., Zhang, L., Xue, Z., Li, Y., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3146 · Cited by 295
Maekawa, Y., Minato, Y., Ishifune, C., Kurihara, T., Kitamura, A., Kojima, H., Yagita∥, H., Sakata‐Yanagimoto, M., Saito, T., Taniuchi, I., et al. (2008) · Nature Immunology · doi:10.1038/ni.1649 · Cited by 269
Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways
Hu, X., Chung, A. Y., Wu, I., Foldi, J., Chen, J., Ji, J. D., Tateya, T., Kang, Y. J., Han, J., Gessler, M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.016 · Cited by 261
GATA-3 Function in Innate and Adaptive Immunity
Tindemans, I., Serafini, N., Santo, J. P. D., & Hendriks, R. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.006 · Cited by 265
Cellular and molecular mechanisms of allergic asthma
Komlósi, Z. I., van de Veen, W., Kovács, N., Szűcs, G., Sokołowska, M., O’Mahony, L., Akdiş, M., & Akdiş, C. A. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100995 · Cited by 269
T helper cells plasticity in inflammation
Cosmi, L., Maggi, L., Santarlasci, V., Liotta, F., & Annunziato, F. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22348 · Cited by 265
GATA3: a master of many trades in immune regulation
Wan, Y. Y. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.002 · Cited by 248
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
Shang, Y., Smith, S. M., & Hu, X. (2016) · Protein & Cell · doi:10.1007/s13238-016-0250-0 · Cited by 250
Dendritic cells and other innate determinants of T helper cell polarisation
Walsh, K. P., & Mills, K. H. G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.07.006 · Cited by 251
Wolterink, R. G. J. K., Serafini, N., van Nimwegen, M., Vosshenrich, C. A. J., de Bruijn, M. J. W., Fonseca‐Pereira, D., Veiga‐Fernandes, H., Hendriks, R. W., & Santo, J. P. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217158110 · Cited by 226
NFAT pulls the strings during CD4+ T helper cell effector functions
Hermann-Kleiter, N., & Baier, G. (2010) · Blood · doi:10.1182/blood-2009-10-233585 · Cited by 218
Mechanistic Insights into Notch Receptor Signaling from Structural and Biochemical Studies
Kovall, R. A., & Blacklow, S. C. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92002-4 · Cited by 213
Bertrand, J. Y., Kim, A. D., Teng, S., & Traver, D. J. (2008) · Development · doi:10.1242/dev.015297 · Cited by 214
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma
Krishnamoorthy, N., Oriss, T. B., Paglia, M., Fei, M., Yarlagadda, M., Vanhaesebroeck, B., Ray, A., & Ray, P. (2008) · Nature Medicine · doi:10.1038/nm1766 · Cited by 212
Yu, Q., Sharma, A., Oh, S. Y., Moon, H.-G., Hossain, M. Z., Salay, T. M., Leeds, K. E., Du, H., Wu, B., Waterman, M. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1762 · Cited by 208
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Self-citationYang, Y., Ahn, Y., Gibbons, D. L., Zang, Y., Lin, W., Thilaganathan, N., Alvarez, C. A., Moreira, D. C., Creighton, C. J., Gregory, P. A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42579 · Cited by 198
Heterogeneity of human effector CD4+ T cells
Annunziato, F., & Romagnani, S. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2843 · Cited by 194
Samon, J. B., Champhekar, A. S., Minter, L. M., Telfer, J. C., Miele, L., Fauq, A. H., Das, P., Golde, T. E., & Osborne, B. A. (2008) · Blood · doi:10.1182/blood-2008-03-144980 · Cited by 191
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Functions of Notch Signaling in the Immune System: Consensus and Controversies
Yuan, J. S., Kousis, P. C., Suliman, S., Visan, I., & Guidos, C. J. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132719 · Cited by 180
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Self-citationSTAT6‐dependent and ‐independent mechanisms in T h2 polarization
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Neumann, C., Blume, J., Roy, U., Teh, P. P., Vasanthakumar, A., Beller, A. V., Liao, Y., Heinrich, F., Arenzana, T. L., Hackney, J. A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0316-2 · Cited by 179
Self-citationNotch signaling: Emerging molecular targets for cancer therapy
Yin, L., Velazquez, O. C., & Liu, Z. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.03.026 · Cited by 177
Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells
Elyaman, W., Bassil, R., Bradshaw, E. M., Orent, W., Lahoud, Y., Zhu, B., Radtke, F., Yagita∥, H., & Khoury, S. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.020 · Cited by 175
Self-citationTranscriptional control of T-cell development
Naito, T., Tanaka, H., Naoe, Y., & Taniuchi, I. (2011) · International Immunology · doi:10.1093/intimm/dxr078 · Cited by 168
GATA-3 and the regulation of the mammary luminal cell fate
Kouros‐Mehr, H., Kim, J., Bechis, S. K., & Werb, Z. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.02.003 · Cited by 169
Blockade of individual Notch ligands and receptors controls graft-versus-host disease
Tran, I., Sandy, A. R., Carulli, A. J., Ebens, C. L., Chung, J., Shan, G. T., Radojčić, V., Friedman, A. D., Gridley, T., Shelton, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65477 · Cited by 169
Self-citationNon-Canonical Notch Signaling in Cancer and Immunity
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Vijayanand, P., Seumois, G., Simpson, L. J., Abdul‐Wajid, S., Baumjohann, D., Panduro, M., Huang, X., Interlandi, J., Djuretic, I. M., Brown, D. R., et al. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.014 · Cited by 161
How are TH1 and TH2 effector cells made?
Amsen, D., Spilianakis, C. G., & Flavell, R. A. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.03.010 · Cited by 165
Self-citationFrom the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation
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GATA-3 is required for early T lineage progenitor development
Hosoya, T., Kuroha, T., Moriguchi, T., Cummings, D. R., Maillard, I. P., Lim, K.-C., & Engel, J. D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090934 · Cited by 154
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Nakano, K., Higashi, T., Hashimoto, K., Takagi, R., Tanaka, Y., & Matsushita, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.012 · Cited by 146
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Wen, Z., Shen, Y., Berry, G. J., Shahram, F., Li, Y., Watanabe, R., Liao, Y. J., Goronzy, J. J., & Weyand, C. M. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3322 · Cited by 138
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Foldi, J., Chung, A. Y., Xu, H., Zhu, J., Outtz, H. H., Kitajewski, J., Li, Y., Hu, X., & Ivashkiv, L. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001544 · Cited by 128
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Yamane, H., & Paul, W. E. (2012) · Nature Immunology · doi:10.1038/ni.2431 · Cited by 133
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Liu, T., Hu, B., Choi, Y. Y., Chung, M., Ullenbruch, M. R., Yu, H., Lowe, J. B., & Phan, S. H. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080618 · Cited by 126
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Zhang, Y., Sandy, A. R., Wang, J., Radojčić, V., Shan, G. T., Tran, I., Friedman, A. D., Kato, K., He, S., Cui, S., et al. (2010) · Blood · doi:10.1182/blood-2010-03-271940 · Cited by 120
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Backer, R. A., Helbig, C., Gentek, R., Kent, A., Laidlaw, B. J., Dominguez, C. X., de Souza, Y., Trierum, S. E. V.-V., van Beek, R., Rimmelzwaan, G. F., et al. (2014) · Nature Immunology · doi:10.1038/ni.3027 · Cited by 120
Self-citationNotch Signalling in Breast Development and Cancer
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Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo
Bertrand, J. Y., Schwedler, J. L., Stachura, D. L., & Traver, D. J. (2010) · Blood · doi:10.1182/blood-2009-09-244590 · Cited by 123
Transcriptional and epigenetic regulation of T‐helper lineage specification
Tripathi, S. K., & Lahesmaa, R. (2014) · Immunological Reviews · doi:10.1111/imr.12204 · Cited by 118
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Ulges, A., Klein, M., Reuter, S., Gerlitzki, B., Hoffmann, M., Grebe, N., Staudt, V., Stergiou, N., Bohn, T., Brühl, T.-J., et al. (2015) · Nature Immunology · doi:10.1038/ni.3083 · Cited by 112
Regulation of CD8+ T Cells and Antitumor Immunity by Notch Signaling
Tsukumo, S., & Yasutomo, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00101 · Cited by 111
On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites
Perrigoue, J., Marshall, F. A., & Artis, D. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01174.x · Cited by 112
Mercher, T., Raffel, G. D., Moore, S. A., Cornejo, M., Bluteau, D., Cagnard, N., Jesneck, J. L., Pikman, Y., Cullen, D. E., Williams, I. R., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35901 · Cited by 111
Dai, J., Megjugorac, N. J., Gallagher, G. E., Yu, R. Y.-L., & Gallagher, G. E. (2009) · Blood · doi:10.1182/blood-2008-09-179507 · Cited by 116
Wang, Y., Misumi, I., Gu, A.-D., Curtis, T. A., Su, L., Whitmire, J. K., & Wan, Y. Y. (2013) · Nature Immunology · doi:10.1038/ni.2623 · Cited by 109
ADAM10 is essential for proteolytic activation of Notch during thymocyte development
Tian, L., Wu, X., Chi, C., Han, M., Xu, T., & Zhuang, Y. (2008) · International Immunology · doi:10.1093/intimm/dxn076 · Cited by 108
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Suppression of Th2 Cell Development by Notch Ligands Delta1 and Delta4
Sun, J., Krawczyk, C. J., & Pearce, E. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1655 · Cited by 100
Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Kanai, A., Suzuki, Y., & Nakayama, T. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100760 · Cited by 100
Schaller, M. A., Neupane, R., Rudd, B. D., Kunkel, S. L., Kallal, L. E., Lincoln, P., Lowe, J. B., Man, Y., & Lukacs, N. W. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070661 · Cited by 100
What determines Th2 differentiation, in vitro and in vivo?
Paul, W. E. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.2 · Cited by 99
Bleck, B., Tse, D. B., Gordon, T., Ahsan, M. R., & Reibman, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000719 · Cited by 99
Chong, L., Zhang, W., Nie, Y., Yu, G., Liu, L., Lin, L., Wen, S., Zhu, L., & Li, C. (2014) · Inflammation · doi:10.1007/s10753-014-9873-6 · Cited by 99
An Intrinsic Mechanism Predisposes Foxp3-Expressing Regulatory T Cells to Th2 Conversion In Vivo
Wang, Y., Souabni, A., Flavell, R. A., & Wan, Y. Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001255 · Cited by 95
Self-citationγ-Secretase Inhibitor Reduces Allergic Pulmonary Inflammation by Modulating Th1 and Th2 Responses
Kang, J. H., Kim, B., Uhm, T. G., Lee, S., Lee, G. R., Park, C., & Chung, I. Y. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-893oc · Cited by 95
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Metadata
- Authors
- Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A.
- Affiliations
- Yale University (US)
- National Institutes of Health (US)
- ISREC Foundation (CH)
- Research Institute of Molecular Pathology (AT)
- Jackson Laboratory (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Amsen, Derk
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 27
- Issue
- 1
- Pages
- 89-99
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC2062505
- OpenAlex
- W2042784167
- Cited by
- 396
- References
- 73
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 17 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 19 · 2016: 25 · 2015: 22 · 2014: 21 · 2013: 37 · 2012: 33
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (NS036437)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- GATA3, Notch signaling, T helper cell differentiation, Th1 differentiation, Th2 differentiation, CD4+ T cells, RBPJ, Notch1, Notch2, parasite antigens, transcriptional regulation
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cells, Cultured, T-Lymphocytes, Helper-Inducer, Humans, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Signal Transduction, Mice, Knockout, Th1 Cells, Th2 Cells, GATA3 Transcription Factor, Mice, Immunoglobulin J Recombination Signal Sequence-Binding Protein, Receptors, Notch
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