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The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner
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The transcription factor PU.1 plays multiple context and concentration dependent roles in lymphoid and myeloid cell development. Here we showed that PU.1 (encoded by Sfpi1) was essential for dendritic cell (DC) development in vivo and that conditional ablation of PU.1 in defined precursors, including the common DC progenitor, blocked Flt3 ligand-induced DC generation in vitro. PU.1 was also required for the parallel granulocyte-macrophage colony stimulating factor-induced DC pathway from early hematopoietic progenitors. Molecular studies demonstrated that PU.1 directly regulated Flt3 in a concentration-dependent manner, as Sfpi1(+/-) cells displayed reduced expression of Flt3 and impaired DC formation. These studies identify PU.1 as a critical regulator of both conventional and plasmacytoid DC development and provide one mechanism how altered PU.1 concentration can have profound functional consequences for hematopoietic cell development.
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“PU.1 is directly required to maintain the expression of the cytokine receptor Flt3 that is indispensable for progenitors with B and T cell potentials (73).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [73]
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Cites
Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1693 · Cited by 3,741
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
Hayashi, S., & McMahon, A. P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0597 · Cited by 1,351
Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential
Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C. T., Bryder, D., Yang, L., Borge, O. J., Thorén, L., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.013 · Cited by 1,323
Steady-state and inflammatory dendritic-cell development
Shortman, K., & Naik, S. H. (2006) · Nature reviews. Immunology · doi:10.1038/nri1996 · Cited by 1,212
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
Nutt, S. L., Heavey, B., Rolink, A. G., & Busslinger, M. (1999) · Nature · doi:10.1038/44076 · Cited by 1,179
Self-citationTargeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130
Maraskovsky, E., Brasel, K., Teepe, M., Roux, E. R., Lyman, S. D., Shortman, K., & McKenna, H. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.1953 · Cited by 1,117
In Vivo Analysis of Dendritic Cell Development and Homeostasis
Liu, K., Victora, G. D., Schwickert, T. A., Guermonprez, P., Meredith, M. M., Yao, K.-H., Chu, F.-F., Randolph, G. J., Rudensky, A. Y., & Nussenzweig, M. C. (2009) · Science · doi:10.1126/science.1170540 · Cited by 1,001
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Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Human dendritic cell subsets: an update
Collin, M., & Bigley, V. (2018) · Immunology · doi:10.1111/imm.12888 · Cited by 1,301
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Wang, P., Xue, Y., Han, Y., Li, L., Wu, C., Xu, S., Jiang, Z., Xu, J., Liu, Q., & Cao, X. (2014) · Science · doi:10.1126/science.1251456 · Cited by 1,108
Deciphering the transcriptional network of the dendritic cell lineage
Miller, J. C., Brown, B. D., Shay, T., Gautier, E. L., Jojic, V., Cohain, A. T., Pandey, G. S., Leboeuf, M., Elpek, K. G., Helft, J., et al. (2012) · Nature Immunology · doi:10.1038/ni.2370 · Cited by 802
Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740
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Reizis, B. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.027 · Cited by 702
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Dickinson, R. E., Griffin, H. R., Bigley, V., Reynard, L. N., Hussain, R., Haniffa, M. A., Lakey, J. H., Rahman, T., Wang, X.-N., McGovern, N. N., et al. (2011) · Blood · doi:10.1182/blood-2011-06-360313 · Cited by 444
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Balan, S., Saxena, M., & Bhardwaj, N. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.07.004 · Cited by 370
The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency
Bigley, V., Haniffa, M. A., Doulatov, S. R., Wang, X., Dickinson, R. E., McGovern, N. N., Jardine, L., Pagan, S., Dimmick, I., Chua, I. C., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101459 · Cited by 304
Menezes, S., Melandri, D., Anselmi, G., Perchet, T., Loschko, J., Dubrot, J., Patel, R., Gautier, E. L., Hugues, S., Longhi, M. P., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.12.001 · Cited by 288
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Belz, G. T., & Nutt, S. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3149 · Cited by 282
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Self-citationHou, P.-P., Luo, L.-J., Chen, H., Chen, Q.-T., Bian, X., Wu, S.-F., Zhou, J.-X., Zhao, W., Liu, J., Wang, X., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.004 · Cited by 256
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Yu, Y., Wang, J., Khaled, W. T., Burke, S., Li, P., Chen, X., Yang, W., Jenkins, N. A., Copeland, N. G., Zhang, S., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20121846 · Cited by 223
Sichien, D., Lambrecht, B. N., Guilliams, M., & Scott, C. L. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.8 · Cited by 181
Bresnick, E. H., Katsumura, K. R., Lee, H., Johnson, K. D., & Perkins, A. S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks281 · Cited by 189
Staber, P. B., Zhang, P., Ye, M., Welner, R. S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B. A., Zhang, H., Alberich-Jordà, M., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.007 · Cited by 158
Niche signals and transcription factors involved in tissue-resident macrophage development
T’Jonck, W., Guilliams, M., & Bonnardel, J. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.02.005 · Cited by 173
Transcriptional Networks Driving Dendritic Cell Differentiation and Function
Nutt, S. L., & Chopin, M. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.005 · Cited by 168
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Carotta, S., Willis, S. N., Hasbold, J., Inouye, M., Pang, S. H. M., Emslie, D., Light, A., Chopin, M., Shi, W., Wang, H., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140425 · Cited by 163
Self-citationMechanisms regulating dendritic cell specification and development
Watowich, S. S., & Liu, Y. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00949.x · Cited by 157
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Somasundaram, R., Prasad, M. A. J., Ungerbäck, J., & Sigvardsson, M. (2015) · Blood · doi:10.1182/blood-2014-12-575688 · Cited by 135
Jackson, J. T., Hu, Y., Liu, R., Masson, F., D’Amico, A., Carotta, S., Xin, A., Camilleri, M., Mount, A. M., Kallies, A., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.163 · Cited by 142
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Reynolds, G., & Haniffa, M. A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00330 · Cited by 138
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Leddin, M., Perrod, C., Hoogenkamp, M., Ghani, S., Assi, S., Heinz, S., Wilson, N. K., Follows, G., Schönheit, J., Vockentanz, L., et al. (2011) · Blood · doi:10.1182/blood-2010-08-302976 · Cited by 131
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Seillet, C., Huntington, N. D., Gangatirkar, P., Axelsson, E., Minnich, M., Brady, H. J. M., Busslinger, M., Smyth, M. J., Belz, G. T., & Carotta, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302605 · Cited by 128
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Lee, J., Zhou, Y. J., Ma, W., Zhang, W., Aljoufi, A., Luh, T., Lucero, K., Liang, D., Thomsen, M., Bhagat, G., et al. (2017) · Nature Immunology · doi:10.1038/ni.3789 · Cited by 139
Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks
Chopin, M., Seillet, C., Chevrier, S., Wu, L., Wang, H., Morse, H. C., Belz, G. T., & Nutt, S. L. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130930 · Cited by 122
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Delconte, R. B., Shi, W., Sathe, P., Ushiki, T., Seillet, C., Minnich, M., Kolesnik, T. B., Rankin, L. C., Mielke, L. A., Zhang, J., et al. (2016) · Immunity · doi:10.1016/j.immuni.2015.12.007 · Cited by 124
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Rosa, F. A., Pires, C. F., Kurochkin, I., Ferreira, A. G., Gomes, A. M., Palma, L. G., Shaiv, K., Solanas, L., Azenha, C. D. J., Papatsenko, D., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aau4292 · Cited by 119
Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T., & Rothenberg, E. V. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.024 · Cited by 116
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Luan, X., Zhou, X. C., Naqvi, A. R., Francis, M., Foyle, D., Nares, S., & Diekwisch, T. G. H. (2018) · International Journal of Oral Science · doi:10.1038/s41368-018-0025-y · Cited by 121
Schlitzer, A., Loschko, J., Mair, K., Vogelmann, R., Henkel, L., Einwächter, H., Schiemann, M., Niess, J. H., Reindl, W., & Krug, A. (2011) · Blood · doi:10.1182/blood-2010-12-326678 · Cited by 113
CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3
Seillet, C., Jackson, J. T., Markey, K. A., Brady, H. J. M., Hill, G. R., MacDonald, K. P. A., Nutt, S. L., & Belz, G. T. (2013) · Blood · doi:10.1182/blood-2012-07-445650 · Cited by 108
Self-citationEnvironmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB
Willis, S. N., Tellier, J., Liao, Y., Trezise, S., Light, A., O’Donnell, K., Garrett-Sinha, L. A., Shi, W., Tarlinton, D. M., & Nutt, S. L. (2017) · Nature Communications · doi:10.1038/s41467-017-01605-1 · Cited by 112
Self-citationZhou, H., Xiao, J., Wu, N., Liu, C., Xu, J., Liu, F., & Wu, L. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.073 · Cited by 107
Self-citationQu, C., Brinck-Jensen, N.-S., Zang, M., & Chen, K. (2013) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2013.09.023 · Cited by 112
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MURPHY, K. M. M. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00009-0 · Cited by 108
Chopin, M., Lun, A. T., Zhan, Y., Schreuder, J., Coughlan, H., D’Amico, A., Mielke, L. A., Almeida, F. F., Kueh, A. J., Dickins, R. A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.11.010 · Cited by 104
Self-citationThe Transcription Factor PU.1 is a Critical Regulator of Cellular Communication in the Immune System
Turkistany, S. A., & DeKoter, R. P. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-011-0147-9 · Cited by 96
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Sasaki, I., Hoshino, K., Sugiyama, T., Yamazaki, C., Yano, T., Iizuka, A., Hemmi, H., Tanaka, T., Saito, M., Sugiyama, M., et al. (2012) · Blood · doi:10.1182/blood-2012-06-436527 · Cited by 106
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Rothenberg, E. V., Hosokawa, H., & Ungerbäck, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00228 · Cited by 99
“1 is directly required to maintain the expression of the cytokine receptor Flt3 that is indispensable for progenitors with B and T cell potentials (73).”
BackgroundTranscription factor PU.1 and immune cell differentiation (Review)
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Kim, S. K., Bagadia, P., Anderson, D. A., Liu, T., Huang, X., Theisen, D. J., O’Connor, K., Ohara, R. A., Iwata, A., Murphy, T. L., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.018 · Cited by 86
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de Pooter, R. F., & Kee, B. L. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00957.x · Cited by 77
Ungerbäck, J., Hosokawa, H., Wang, X., Strid, T., Williams, B. A., Sigvardsson, M., & Rothenberg, E. V. (2018) · Genome Research · doi:10.1101/gr.231423.117 · Cited by 77
Champhekar, A., Damle, S. S., Freedman, G., Carotta, S., Nutt, S. L., & Rothenberg, E. V. (2015) · Genes & Development · doi:10.1101/gad.259879.115 · Cited by 74
Self-citationConstrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients
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Bornstein, C., Winter, D. R., Barnett‐Itzhaki, Z., David, E., Kadri, S., Garber, M. G., & Amit, I. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.014 · Cited by 69
Epigenetic program and transcription factor circuitry of dendritic cell development
Lin, Q., Chauvistré, H., Costa, I. G., Gusmao, E. G., Mitzka, S., Hänzelmann, S., Baying, B., Klisch, T., Moriggl, R., Hennuy, B., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1056 · Cited by 67
Plasmacytoid Dendritic Cells: No Longer an Enigma and Now Key to Transplant Tolerance?
Rogers, N. M., Isenberg, J. S., & Thomson, A. W. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12229 · Cited by 66
Transcriptional determination and functional specificity of myeloid cells: making sense of diversity
Monticelli, S., & Natoli, G. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.51 · Cited by 63
Wu, X., Satpathy, A. T., Wumesh, K. C., Liu, P., Murphy, T. L., & MURPHY, K. M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064800 · Cited by 66
Plazolles, N., Humbert, J.-M., Vachot, L., Verrier, B., Hocké, C., & Halary, F. A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710386 · Cited by 65
Smith, M. A., Wright, G. M., Wu, J., Tailor, P. B., Ozato, K., Chen, X., Wei, S., Piskurich, J. F., Ting, J. P. ‐., & Wright, K. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.165431 · Cited by 63
Won, H., Nandakumar, V., Yates, P., Sanchez, S., Jones, L. E., Huang, X. F., & Chen, S. (2014) · Blood · doi:10.1182/blood-2013-10-534313 · Cited by 62
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Pang, S. H. M., de Graaf, C. A., Hilton, D. J., Huntington, N. D., Carotta, S., Wu, L., & Nutt, S. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01264 · Cited by 60
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Thompson, P. K., & Zúñiga‐Pflücker, J. C. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.007 · Cited by 59
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Chrisikos, T. T., Zhou, Y., Slone, N., Babcock, R. L., Watowich, S. S., & Li, H. S. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.01.014 · Cited by 61
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You, Z., Wang, Q., Bian, Z., Liu, Y., Han, X., Peng, Y., Shen, L., Chen, X., Qiu, D., Selmi, C., et al. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.05.022 · Cited by 57
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Puhr, S., Lee, J., Zvezdova, E., Zhou, Y. J., & Liu, K. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2016.03.012 · Cited by 71
Kitamura, N., Yokoyama, H., Yashiro, T., Nakano, N., Nishiyama, M., Kanada, S., Fukai, T., Hara, M., Ikeda, S., Ogawa, H., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.10.019 · Cited by 55
Transcriptional Control of Macrophage Identity, Self-Renewal, and Function
Molawi, K., & Sieweke, M. H. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00010-7 · Cited by 58
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Metadata
- Authors
- Carotta, S., Dakic, A., D'Amico, A., Pang, S. H. M., Greig, K. T., Nutt, S. L., & Wu, L.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- The University of Melbourne (AU)
- Corresponding author
- Nutt, Stephen L.
- Wu, Li
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 32
- Issue
- 5
- Pages
- 628-641
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1963617750
- Cited by
- 279
- References
- 53
- Citations by year
- 2026: 12 · 2025: 4 · 2024: 14 · 2023: 8 · 2022: 10 · 2021: 13 · 2020: 19 · 2019: 15 · 2018: 16 · 2017: 18 · 2016: 15 · 2015: 23 · 2014: 22 · 2013: 29 · 2012: 27
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1209 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Leukaemia Foundation
- University of Melbourne
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- PU.1, dendritic cell development, FLT3, Flt3 ligand, plasmacytoid dendritic cells, myeloid dendritic cells, GM-CSF, transcriptional regulation, dose-dependent gene expression, conditional gene deletion, hematopoietic progenitor cells
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Base Sequence, Cell Differentiation, Cells, Cultured, Dendritic Cells, Dose-Response Relationship, Drug, Flow Cytometry, Membrane Proteins, Mice, Transgenic, Molecular Sequence Data, Promoter Regions, Genetic, Proto-Oncogene Proteins, Trans-Activators, Polymerase Chain Reaction, Models, Immunological, Mice
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