The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation
Open accessAbstract
SUMMARY T follicular helper (Tfh) cells promote T-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC) formation and long-lived antibody responses. However, the cellular and molecular mechanisms that control Tfh differentiation in vivo are incompletely understood. Here we show that interleukin-2 (IL-2) administration impaired influenza-specific GCs, long-lived IgG responses and Tfh cells. IL-2 did not directly inhibit GC formation, but instead suppressed the differentiation of Tfh cells, thereby hindering the maintenance of influenza-specific GC B cells. Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses in vivo and regulates Tfh cell development.
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Cites
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., & Horak, I. (1993) · Cell · doi:10.1016/0092-8674(93)80067-o · Cited by 1,744
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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
Sharpe, A. H., Wherry, E. J., Ahmed, R., & Freeman, G. J. (2007) · Nature Immunology · doi:10.1038/ni1443 · Cited by 1,528
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
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Bcl6 mediates the development of T follicular helper cells
Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506
Foxp3+ follicular regulatory T cells control the germinal center response
Linterman, M. A., Pierson, W., Lee, S. K., Kallies, A., Kawamoto, S., Rayner, T. F., Srivastava, M., Divekar, D. P., Beaton, L., Hogan, J. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2425 · Cited by 1,292
The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
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Cited by
T follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
T follicular helper cell biology: a decade of discovery and diseases
Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591
Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy
Liao, W., Lin, J.-X., & Leonard, W. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.004 · Cited by 1,075
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,014
Metadata
- Authors
- Ballesteros-Tato, A., León, B., Graf, B. A., Moquin, A., Adams, P. S., Lund, F. E., & Randall, T. D.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 36
- Issue
- 5
- Pages
- 847-856
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1981597823
- Cited by
- 542
- References
- 64
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ballesteros-Tato, A., León, B., Graf, B. A., Moquin, A., Adams, P. S., Lund, F. E., & Randall, T. D. (2012). Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation. Immunity. https://doi.org/10.1016/j.immuni.2012.02.012
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