The DOI matches its Crossref record; 115 of the 116 references it cites were found in a registry or an index.
Origin and Functions of Tissue Macrophages
Open accessAbstract
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own composition of embryonically derived and adult-derived macrophages, but it is unclear whether macrophages of distinct origins are functionally interchangeable or have unique roles at steady state. This new understanding also prompts reconsideration of the function of circulating monocytes. Classical Ly6c(hi) monocytes patrol the extravascular space in resting organs, and Ly6c(lo) nonclassical monocytes patrol the vasculature. Inflammation triggers monocytes to differentiate into macrophages, but whether resident and newly recruited macrophages possess similar functions during inflammation is unclear. Here, we define the tools used for identifying the complex origin of tissue macrophages and discuss the relative contributions of tissue niche versus ontological origin to the regulation of macrophage functions during steady state and inflammation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Macrophages often are the first immune cells that encounter invading pathogens [219,220,221].”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [220]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1×
“Several detailed review articles describing different aspects of macrophage ontogeny and function have been published (Sieweke and Allen, 2013; Davies et al., 2013a; Wynn et al., 2013).”
BackgroundSynaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599
Flagged first, then by citations
1 of the 116 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 801–900 of 1,003
Spalinger, M. R., Crawford, M. S., Bobardt, S. D., Li, J., Sayoc-Becerra, A., Santos, A. N., Shawki, A., Chatterjee, P., Nair, M. G., & McCole, D. F. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00441-3 · Cited by 17
P-Selectin Expressed by a Human SELP Transgene Is Atherogenic in Apolipoprotein E–Deficient Mice
Zhang, N., Liu, Z., Yao, L., Mehta-D’souza, P., & McEver, R. P. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307437 · Cited by 18
McCubbrey, A. L., Barthel, L., Mould, K. J., Mohning, M. P., Redente, E. F., & Janssen, W. J. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00141.2016 · Cited by 17
Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis
Wang, Q., Ji, J., Huang, D., & Gao, C. (2025) · BME Frontiers · doi:10.34133/bmef.0102 · Cited by 18
Macrophage Metabolic Reprogramming in Inflammatory Bowel Diseases: From Pathogenesis to Therapy
Zhang, Y.-F., Shi, T. T., Lin, Y., Zhu, Y., Lin, S., & Fang, T. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s534447 · Cited by 19
Bone marrow-independent adventitial macrophage progenitor cells contribute to angiogenesis
Kleefeldt, F., Upcin, B., Bömmel, H. M., Schulz, C., Eckner, G., Allmanritter, J., Bauer, J., Braunger, B. M., Rueckschloss, U., & Ergün, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04605-2 · Cited by 17
Xu, Y., Schrank, P. R., & Williams, J. W. (2022) · Current Protocols · doi:10.1002/cpz1.456 · Cited by 16
Giryes, S., & McGonagle, D. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103240 · Cited by 17
Cell-targeted vaccines: implications for adaptive immunity
Ung, T. W.-M., Rutledge, N. S., Weiss, A. M., Esser-Kahn, A. P., & Deak, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1221008 · Cited by 19
Endothelial Cell Dysfunction Due to Molecules Secreted by Macrophages in Sepsis
He, H., Zhang, W., Jiang, L., Tong, X., Zheng, Y., & Xia, Z. (2024) · Biomolecules · doi:10.3390/biom14080980 · Cited by 19
Calvier, L., Manouchehri, N., Sacharidou, A., Mineo, C., Shaul, P. W., Hui, D. Y., Kounnas, M. Z., Stüve, O., & Herz, J. (2021) · Science Immunology · doi:10.1126/sciimmunol.abd0931 · Cited by 17
Rasaei, R., Tyagi, A., Rasaei, S., Lee, S., Yang, S., Kim, K.-S., Ramakrishna, S., & Hong, S. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03136-z · Cited by 18
Kamei, A., Gao, G., Neale, G. A. M., Loh, L. N., Vogel, P., Thomas, P. G., TUOMANEN, E. I., & Murray, P. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607787113 · Cited by 17
Fallon, E. A., Chun, T. T., Young, W. A., Gray, C. C., Ayala, A., & Heffernan, D. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01469 · Cited by 17
Wu, C., Zhao, X., Babu, V. S., Yuan, G., Wang, W., Su, J., Liu, X., & Lin, L. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.03.049 · Cited by 17
Petrescu, A. D., Grant, S. M., Frampton, G. A., McMillin, M., Kain, J., Kodali, M., Shetty, A. K., & DeMorrow, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31599-9 · Cited by 18
Pascual‐Gil, S., Abizanda, G., Iglesias, E., Garbayo, E., Prósper, F., & Blanco‐Prieto, M. J. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1531417 · Cited by 17
Ghosh, J., Koussa, R. E., Mohamad, S., Liu, J., Kacena, M. A., & Srour, E. F. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000656 · Cited by 17
Role of macrophage polarization in heart failure and traditional Chinese medicine treatment
Zhu, Z., Wang, M., Lu, S., Dai, S., & Liu, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1434654 · Cited by 16
The interplay between lymphatic vessels and macrophages in inflammation response
Zhou, C., Sun, T., Dong, Z., Lu, F., & Li, B. (2024) · The FASEB Journal · doi:10.1096/fj.202400160rr · Cited by 16
Ispirjan, M., Marx, S., Freund, E., Fleck, S. K., Baldauf, J., Rössler, K., Schroeder, H. W. S., & Bekeschus, S. (2024) · OncoImmunology · doi:10.1080/2162402x.2024.2425124 · Cited by 16
Challenges in Gaucher disease: Perspectives from an expert panel
Grabowski, G. A., Kishnani, P. S., Alcalay, R. N., Prakalapakorn, S. G., Rosenbloom, B. E., Tuason, D. A., & Weinreb, N. J. (2025) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2025.109074 · Cited by 17
Lee‐Rueckert, M., Jauhiainen, M., Kovanen, P. T., & Escolá‐Gil, J. C. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.008 · Cited by 16
Central Versus Peripheral Nervous System Regeneration: Is There An Exception for Cranial Nerves?
Echternacht, S. R., Chacon, M. A., & Leckenby, J. I. (2021) · Regenerative Medicine · doi:10.2217/rme-2020-0096 · Cited by 16
Immune modulations of the tumor microenvironment in response to phototherapy
Valerio, T. I., Furrer, C. L., Sadeghipour, N., Patrock, S.-J. X., Tillery, S. A., Hoover, A. R., Liu, K., & Chen, W. R. (2023) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545823300070 · Cited by 16
Protein O-GlcNAcylation in multiple immune cells and its therapeutic potential
Cai, H., Xiong, W., Zhu, H., Wang, Q., Liu, S., & Lu, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1209970 · Cited by 16
Sun, C., Shen, Y., Liu, P., Shen, Y., Hu, Y., Li, P., Zhang, Y., Miao, F., & Zhang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713265 · Cited by 16
Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation
Jha, A., & Moore, E. (2024) · Matrix Biology Plus · doi:10.1016/j.mbplus.2024.100143 · Cited by 17
Circadian Biology and the Neurovascular Unit
Li, W., Tiedt, S., Lawrence, J. H., Harrington, M. E., Musiek, E. S., & Lo, E. H. (2024) · Circulation Research · doi:10.1161/circresaha.124.323514 · Cited by 17
Fan, Z., Karakone, M., Nagarajan, S., Nagy, N., Mildenberger, W., Petrova, E. S., Hinte, L. C., Bijnen, M., Häne, P., Nelius, E., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114395 · Cited by 17
The Brain–Intestinal Mucosa–Appendix– Microbiome–Brain Loop
Vitetta, L., Vitetta, G., & Hall, S. (2018) · Diseases · doi:10.3390/diseases6020023 · Cited by 16
Škuljec, J., Jirmo, A. C., Habener, A., Talbot, S. R., Pul, R., Grychtol, R. M., Aydin, M., Kleinschnitz, C., Happle, C., & Hansen, G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02458 · Cited by 16
Role of bone marrow-derived macrophages (BMDMs) in neurovascular interactions during stroke
Srivastava, A., Srivastava, P., & Verma, R. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104480 · Cited by 16
The significance of CD163-expressing macrophages in asthma
Tokunaga, Y., Imaoka, H., Kaku, Y., Kawayama, T., & Hoshino, T. (2019) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2019.05.019 · Cited by 16
Interaction between γδTCR signaling and the E protein‐Id axis in γδ T cell development
Anderson, M. K., & Selvaratnam, J. S. (2020) · Immunological Reviews · doi:10.1111/imr.12924 · Cited by 16
Macrophages and RhoA Pathway in Transplanted Organs
Liu, Y., Kubiak, J. Z., Li, X. C., Ghobrial, R. M., & Kloc, M. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_15 · Cited by 16
The M2 Macrophages Importance Role in Psoriasis
Alshihmani, A. H. H., Mahmoudi, M., Kheder, R. K., Fadaee, A., & Esmaeili, S. (2025) · Immunity, Inflammation and Disease · doi:10.1002/iid3.70211 · Cited by 16
Functional blood cell analysis by label-free biosensors and single-cell technologies
Szittner, Z., Péter, B., Kurunczi, S., Székács, I., & Horváth, R. (2022) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2022.102727 · Cited by 16
Peritoneal resident macrophages in tumor metastasis and immunotherapy
Zhang, Y., Ouyang, D., Chen, Y. H., & Xia, H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.948952 · Cited by 16
Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation
Kalliara, E., Kardyńska, M., Bagnall, J., Spiller, D. G., Müller, W., Rückerl, D., Biswas, S. K., Śmieja, J., & Paszek, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947213 · Cited by 15
Preteroti, M., Traboulsi, H., Greiss, P. M., Lapohos, O., Fonseca, G. J., Eidelman, D. H., & Baglole, C. J. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12614 · Cited by 15
Raps, S., Bahr, L. L., Karkossa, I., Rossol, M., von Bergen�, M., & Schubert, K. A. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169650 · Cited by 15
Liao, Y., Peng, X., Yang, Y., Zhou, G., Chen, L., Yang, Y., Li, H., Chen, X., Guo, S., Zuo, Q., et al. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2409352 · Cited by 15
Tet2 modulates M2 macrophage polarization via mRNA 5-methylcytosine in allergic rhinitis
Fan, W., Liu, P., Tan, L., Lv, H., Zhou, H., Tao, Z., & Xu, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113495 · Cited by 15
Qin, R.-X., Ma, X., Han, Z., Ma, S., Shen, Z., Lu, Z.-H., Sun, Y., & Yu, W. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s490655 · Cited by 15
Qi, Y., Sun, D., Yang, W., Xu, B., Lv, D., Han, Y., Sun, M., Jiang, S., Hu, W., & Yang, Y. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.03.010 · Cited by 15
Novel mineralocorticoid receptor mechanisms regulate cardiac tissue inflammation in male mice
Ong, G. S. Y., Cole, T. J., Tesch, G. H., Morgan, J., Dowling, J. K., Mansell, A. S., Fuller, P. J., & Young, M. J. (2020) · Journal of Endocrinology · doi:10.1530/joe-20-0161 · Cited by 15
Stothert, A. R., & Kaur, T. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.694292 · Cited by 15
Koda, S., Zhang, B., Zhou, Q.-Y., Xu, N., Li, J., Liu, J., Liu, M., Lv, Z., Wang, J.-L., Shi, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.754208 · Cited by 15
Role of Macrophage Polarization in Acute Respiratory Distress Syndrome
Mishra, P., Pandey, N., Pandey, R., & Tripathi, Y. B. (2021) · Journal of Respiration · doi:10.3390/jor1040024 · Cited by 14
Deng, Y., Zhang, Y., Chen, X., & Li, C. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114960 · Cited by 15
Deshpande, K., Liu, S., McCracken, J. M., Jiang, L., Gaw, T., Kaydo, L., Richard, Z., O’Neil, M. F., & Pritchard, M. T. (2016) · Biomolecules · doi:10.3390/biom6010005 · Cited by 15
Different phenotypes of monocytes in patients with new-onset mild acute pancreatitis
Zhang, M., Jiang, Y., Wang, X., Ding, L., Wang, H., Meng, Q., & Gao, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i8.1477 · Cited by 15
Inmunopatología de la enfermedad pulmonar obstructiva crónica
Martínez-Aguilar, N. E., Vargas-Camaño, M. E., Hernández-Pliego, R. R., Chaia-Semerena, G. M., & Perez-Chavira, M. R. (2017) · Revista Alergia México · doi:10.29262/ram.v64i3.263 · Cited by 17
Phenotypic characterization of macrophages in the BMB sample of human acute leukemia
Jian-xin, S., Wen, Y., Li, R.-W., Dong, T., Tang, Y., Zhang, J., & Sa, Y.-L. (2020) · Annals of Hematology · doi:10.1007/s00277-020-03912-y · Cited by 15
Schmitz, T., Jannasch, M., Weigel, T., Moseke, C., Gbureck, U., Gröll, J., Walles, H., & Hansmann, J. (2020) · Materials · doi:10.3390/ma13051142 · Cited by 16
Resident macrophages as potential therapeutic targets for cardiac ageing and injury
Zhang, S., Chen, R., Chakrabarti, S., & Su, Z. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1167 · Cited by 15
Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons
Gao, Y., Shi, Y., Wei, M., Yang, X., Yang, H., Liu, H., Zhang, Y., Zhou, L., Hu, G., & Yang, R. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.91389 · Cited by 14
Ho, M. F. S., Farkas, O., Faria, A. V., Plemel, J. R., & Kerr, B. J. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.05.004 · Cited by 15
Macrophages: friend or foe in diabetes pathogenesis and therapy
Grimes, R. N., Orecchioni, M., & Quesada‐Masachs, E. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1625391 · Cited by 15
Li, Y., & Wang, L. (2026) · Immunology · doi:10.1111/imm.70103 · Cited by 18
Medina-Buelvas, D. M., Estrada‐Muñiz, E., Rodríguez‐Sosa, M., Shibayama, M., & Vega, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-54218-7 · Cited by 14
Tumor-Associated Macrophages: Reasons to Be Cheerful, Reasons to Be Fearful
Szulc-Kiełbik, I., & Kiełbik, M. (2022) · Experientia supplementum · doi:10.1007/978-3-030-91311-3_4 · Cited by 14
Wang, W., Wu, Y., Wang, Y., Wang, R., Deng, C., Yi, L., Wang, L., He, M., Zhou, W., Xie, Y., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202202420 · Cited by 14
Domokos, A., Varga, Z., Jambrovics, K., Caballero-Sánchez, N., Szabó, E. V., Nagy, G., Scholtz, B., Halász, L., Váradi, E., Bene, K., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1168635 · Cited by 14
ZHANG, Y., TANG, S., GAO, Y., LU, Z., Yang, Y., Chen, J., & Li, T. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.043481 · Cited by 14
Macrophage biology in the pathogenesis of Helicobacter pylori infection
Xiao, F., Li, N., Xu, X., & Zhu, Y. (2024) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2024.2366944 · Cited by 14
ten Hoeve, A. L., Rodríguez, M. E., Säflund, M., Michel, V., Magimel, L., Ripoll, A., Yu, T., Hakimi, M., Saeij, J. P. J., Özata, D. M., et al. (2024) · mBio · doi:10.1128/mbio.02140-24 · Cited by 15
Mitochondrial metabolism regulated macrophage phenotype in myocardial infarction
Kong, Y., Zhang, Q., Wang, S., Li, R., Fu, C., & Wei, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117494 · Cited by 14
Zhang, M., Ding, L., Wang, X., Hou, J., Li, M., Jiang, Y., He, X., Cui, M., Hu, F., Zhang, X., et al. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.02.018 · Cited by 14
Rzeczycki, P., Woldemichael, T., Willmer, A. R., Murashov, M. D., Baik, J., Keswani, R. K., Yoon, G. S., Stringer, K. A., Rodríguez‐Hornedo, N., & Rosania, G. R. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2539-6 · Cited by 14
Liu, W., Bi, S., Li, C., Zheng, H., Guo, Z., Luo, Y., Ou, X., Song, L., Zhu, J., & Yu, R. (2020) · Marine Drugs · doi:10.3390/md18060299 · Cited by 14
Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis
Bartneck, M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.009 · Cited by 14
Varier, K. M., Dhandapani, H., Liu, W., Song, J., Wang, C., Hu, A., Ben‐David, Y., Shen, X., Li, Y., & Gajendran, B. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01997-5 · Cited by 13
Bredemeyer, A. L., Amrute, J., Koenig, A. L., Idol, R. A., He, L. N., Luff, S. A., Dege, C., Leid, J. M., Schilling, J. D., Hinson, J. T., et al. (2022) · Development · doi:10.1242/dev.200016 · Cited by 13
Self-citationThe role of macrophages in thermal injury.
Penatzer, J. A., Srinivas, S., & Thakkar, R. K. (2022) · PubMed Central · Cited by 15
Dirty Jobs: Macrophages at the Heart of Cardiovascular Disease
Stevens, T. W., Khalaf, F. K., Soehnlen, S. M., Hegde, P., Storm, K., Meenakshisundaram, C., Dworkin, L. D., Malhotra, D. K., Haller, S. T., Kennedy, D. J., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10071579 · Cited by 13
Yang, F., Zong, H., Li, F., Luo, S., Zhang, X., Xu, Y., & Zhang, X. (2022) · Platelets · doi:10.1080/09537104.2022.2135694 · Cited by 16
The duality of macrophage function in chronic lymphocytic leukaemia
Chen, Y.-C. E., Mapp, S., Blumenthal, A., Burgess, M. L., Mazzieri, R., Mattarollo, S. R., Mollee, P. N., Gill, D. S., & Saunders, N. A. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.03.006 · Cited by 14
Generating tissue-resident macrophages from pluripotent stem cells: Lessons learned from microglia
Claes, C., Daele, J. V. D., & Verfaillie, C. M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.019 · Cited by 13
Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation
Pascual‐Gil, S., & Epelman, S. (2018) · Immunity · doi:10.1016/j.immuni.2018.11.005 · Cited by 14
Self-citationCopple, B. L. (2019) · doi:10.31531/edwiser.jcegh.1000106 · Cited by 14
Cooper, D. M., & Radom‐Aizik, S. (2019) · Pediatric Research · doi:10.1038/s41390-019-0581-7 · Cited by 17
Macrophage Long Non-Coding RNAs in Pathogenesis of Cardiovascular Disease
Wysoczynski, M., Kim, J. I., Moore, J. B., & Uchida, S. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030028 · Cited by 14
Manipulating Macrophage Polarization to Fix the Broken Heart
Giannarelli, C., & Fernandez, D. M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.06.019 · Cited by 15
Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
Lin, Z., Zheng, Y., Zhong, Y., & Wang, H. (2026) · Advanced Science · doi:10.1002/advs.202510758 · Cited by 13
Force-bearing phagocytic adhesion rings mediate the phagocytosis of surface-bound particles
Kundu, S., Pal, K., Pyne, A., & Wang, X. (2025) · Nature Communications · doi:10.1038/s41467-025-56404-w · Cited by 17
Wu, W., Tong, M., Wang, Y., Chen, J., & Liang, C. Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114332 · Cited by 13
Interferons in Autoimmunity: From Loss of Tolerance to Chronic Inflammation
Mihăescu, G., Pîrcălăbioru, G. G., Roznovan, C. N., Diţu, L.-M., Comanici, M. M., & Savu, O. (2025) · Biomedicines · doi:10.3390/biomedicines13102472 · Cited by 13
Wang, L., Wang, K., & Zheng, H. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s546817 · Cited by 14
Macrophage-derived chemokines in T cell regulation: implications for cancer immunotherapy
Zhang, K., Liu, J., Liu, Q., Zhu, N., & Ye, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1739154 · Cited by 14
Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis
Codo, A. C., Romero-Pichardo, J. E., Wang, Z., Aufiero, M. A., Lazarov, T., Rojas, W. S., Walker, N. S., Nair, A., Cole, R. F., Adkins, S., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.01.009 · Cited by 14
Hong, C., Lu, H., Huang, X., Chen, M., Jin, R., Dai, X., Gong, F., Dong, H., Wang, H., & Gao, X. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.05.021 · Cited by 13
Wang, C., Yu, R., Zhang, S., Zhao, Y., Qi, C., Zhu, Z., Chen, X., Bi, J., Xu, P., Cheng, L., et al. (2022) · Briefings in Functional Genomics · doi:10.1093/bfgp/elac033 · Cited by 13
Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease
Cheng, Z., Hou, G., & Shen, N. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102948 · Cited by 15
Kang, H., Lee, G. K. C., Bienzle, D., Arroyo, L. G., Sears, W., Lillie, B. N., & Beeler‐Marfisi, J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282738 · Cited by 15
Control of myeloid cell functions by nociceptors
Hanč, P., Messou, M.-A., Wang, Y., & von Andrian, U. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127571 · Cited by 14
Wang, Z., Ma, X., Shi, S., He, S., Li, J., Wilson, G., Cai, W., & Liu, L. (2023) · Polymers · doi:10.3390/polym15092081 · Cited by 13
Xu, X., Zhou, R., Duan, Q., Miao, Y., Zhang, T., Wang, M., Jones, O. D., & Xu, M. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01075-7 · Cited by 14
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Zhang, W., Zhou, R., Liu, X., You, L., Chen, C., Ye, X., Liu, J., & Liang, Y. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5574 · Cited by 14
Metadata
- Authors
- Epelman, S., Lavine, K. J., & Randolph, G. J.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Epelman, Slava
- Randolph, Gwendalyn J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 41
- Issue
- 1
- Pages
- 21-35
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4470379
- OpenAlex
- W2054540776
- Cited by
- 1,585
- References
- 116
- Citations by year
- 2026: 95 · 2025: 127 · 2024: 152 · 2023: 127 · 2022: 197 · 2021: 168 · 2020: 140 · 2019: 143 · 2018: 138 · 2017: 102 · 2016: 94 · 2015: 89 · 2014: 13
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI049653)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- tissue macrophages, macrophage origin, embryonic development, monocyte-derived macrophages, Ly6C+ monocytes, non-classical monocytes, tissue niche, macrophage function, inflammation, macrophage heterogeneity
- MeSH terms
- Animals, Antigens, Ly, Cell Differentiation, Central Nervous System, Humans, Inflammation, Lung, Macrophages, Monocytes, Myocardium, Cell Lineage, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review