Long-term maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites
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Human naïve T cells are maintained in lymph nodes for decades and clonally expand in situ after cessation of thymopoiesis.
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Compartmentalization of naive and memory CD4+ and CD8+ T cells in spleen, lymph nodes, and blood changes over life.
“compartmentalization of naive and memory CD4+ and CD8+ T cells in spleen, lymph nodes, and blood changes over life”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Thome et al., 2016
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- Authors
- Thome, J. J. C., Grinshpun, B., Kumar, B. V., Kubota, M., Ohmura, Y., Lerner, H., Sempowski, G. D., Shen, Y., & Farber, D. L.
- Affiliations
- Columbia University Irving Medical Center (US)
- LiveOnNY, New York, NY 10001, USA.
- Duke University (US)
- Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
- Corresponding author
- Thome, Joseph J. C.
- Grinshpun, Boris
- Venue
- Science Immunology
- Published
- 2016-12-23
- Volume
- 1
- Issue
- 6
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC5367636
- OpenAlex
- W2560349103
- Cited by
- 162
- References
- 51
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 10 · 2023: 10 · 2022: 18 · 2021: 25 · 2020: 22 · 2019: 18 · 2018: 14 · 2017: 13
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (F31AG047003)
- National Institute of General Medical Sciences (T32GM007367)
- National Institute of Allergy and Infectious Diseases (U01AI100119, P01AI106697, R01AI100119, UC6AI058607)
- National Center for Research Resources (S10RR027050)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- naive T cells, T cell homeostasis, lymph nodes, thymopoiesis, lymphoid tissue
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