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Cited by 270

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

Open access
Colom, Bartomeu, Bodkin, Jennifer V., Beyrau, Martina, Woodfin, Abigail, Ody, Christiane, Rourke, Claire, Chavakis, Triantafyllos, Brohi, Karim, Imhof, Beat A., Nourshargh, Sussan·2015·Immunity
DOI 10.1016/j.immuni.2015.05.010
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Abstract

Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the vascular lumen to the extravascular tissue, but fundamental aspects of this response remain largely unknown. We have previously shown that neutrophils can exhibit abluminal-to-luminal migration through EC junctions within mouse cremasteric venules and that this response is elicited following reduced expression and/or functionality of the EC junctional adhesion molecule-C (JAM-C). Here we demonstrate that the lipid chemoattractant leukotriene B4 (LTB4) was efficacious at causing loss of venular JAM-C and promoting neutrophil reverse transendothelial cell migration (rTEM) in vivo. Local proteolytic cleavage of EC JAM-C by neutrophil elastase (NE) drove this cascade of events as supported by presentation of NE to JAM-C via the neutrophil adhesion molecule Mac-1. The results identify local LTB4-NE axis as a promoter of neutrophil rTEM and provide evidence that this pathway can propagate a local sterile inflammatory response to become systemic.

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Metadata

Authors
Colom, B., Bodkin, J. V., Beyrau, M., Woodfin, A., Ody, C., Rourke, C., Chavakis, T., Brohi, K., Imhof, B. A., & Nourshargh, S.
Venue
Immunity
Publisher
Elsevier BV
Published
2015-06
Volume
42
Issue
6
Pages
1075-1086
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2015.05.010
OpenAlex
W1561928773
Cited by
270
References
49
FWCI
18.63
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. https://app.cochat.ai/papers/10.1016/j.immuni.2015.05.010
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Colom, B., Bodkin, J. V., Beyrau, M., Woodfin, A., Ody, C., Rourke, C., Chavakis, T., Brohi, K., Imhof, B. A., & Nourshargh, S. (2015). Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. Immunity. https://doi.org/10.1016/j.immuni.2015.05.010

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.