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The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression
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“GO term analysis further confirmed that the identified miR-132 core targetome is enriched for biological pathways that have been previously functionally linked to miR-132, like FOXO and Akt signaling [75, 76, 80, 81] (Fig. 5G).”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [76]
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“Anti-inflammatory properties of miR-132 have been demonstrated in multiple independent in vitro and in vivo studies, including its direct targeting of acetylcholinesterase (which leads to increased levels of acetylcholine and, thereby, inhibits the release of pro-inflammatory cytokines), and its regulation over key inflammatory pathways, like TLR4 and NF-kB, which we also observed in our study [41”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [76]
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“Additionally, multiple of these core miR-132 targets (e.g. FOXO1, DPYSL3, SPRY1, BMI1, and CITED2 via P300) have previously been identified as miR-132 targets in other cell types, supporting the notion that they represent true miR-132 targets [2, 72–79].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [76]
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Citations
Cites
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Self-citation
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Cited by
Sorted by citations
MicroRNAs as regulatory elements in immune system logic
Mehta, A., & Baltimore, D. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.40 · Cited by 704
Self-citationMetabolic regulation of stem cell function in tissue homeostasis and organismal ageing
Chandel, N. S., Jasper, H., Ho, T. T., & Passegué, E. (2016) · Nature Cell Biology · doi:10.1038/ncb3385 · Cited by 326
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age
Mann, M., Mehta, A., de Boer, C. G., Kowalczyk, M. S., Lee, K., Haldeman, P., Rogel, N., Knecht, A. R., Farouq, D., Regev, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.056 · Cited by 188
Self-citationSparsely-connected autoencoder (SCA) for single cell RNAseq data mining
Alessandri, L., Cordero, F., Beccuti, M., Licheri, N., Arigoni, M., Olivero, M., Di Renzo, M. F., Sapino, A., & Calogero, R. (2021) · npj Systems Biology and Applications · doi:10.1038/s41540-020-00162-6 · Cited by 40
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Metadata
- Authors
- Mehta, A., Zhao, J. L., Sinha, N., Marinov, G. K., Mann, M., Kowalczyk, M. S., Galimidi, R. P., Du, X., Erikci, E., Regev, A., Chowdhury, K., & Baltimore, D.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 42
- Issue
- 6
- Pages
- 1021-1032
- ISSN
- 1074-7613
- PMC
- PMC4471877
- Cited by
- 95
- References
- 8
- Language
- en
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