Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing

The Hallmarks of Aging

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mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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The genetics of ageing

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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Stem Cells

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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

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Serine, glycine and one-carbon units: cancer metabolism in full circle

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

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NAD+ and sirtuins in aging and disease

Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.002 · Cited by 1,481 · see citing works

Metabolic pathways promoting cancer cell survival and growth

Boroughs, L. K., & DeBerardinis, R. J. (2015) · Nature Cell Biology · doi:10.1038/ncb3124 · Cited by 1,459 · see citing works

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362 · see citing works

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

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Direct measurement of local oxygen concentration in the bone marrow of live animals

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Molecular regulation of stem cell quiescence

Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148 · see citing works

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122 · see citing works

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101 · see citing works

The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity

Ramirez, J. L., Garver, L. S., Brayner, F. A., Alves, L. C., Rodrigues, J., Molina-Cruz, A., & Barillas-Mury, C. V. (2013) · Journal of Innate Immunity · doi:10.1159/000353765 · Cited by 1,085 · see citing works

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez‐Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Pérez-Terzic, C. M., & Terzic, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.011 · Cited by 980 · see citing works

The Free Radical Theory of Aging

Harman, D. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310202 · Cited by 926 · see citing works

Influence of Metabolism on Epigenetics and Disease

Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920 · see citing works

Stems Cells and the Pathways to Aging and Cancer

Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.036 · Cited by 895 · see citing works

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

Jang, Y.-Y., & Sharkis, S. J. (2007) · Blood · doi:10.1182/blood-2007-05-087759 · Cited by 894 · see citing works

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.020 · Cited by 891 · see citing works

Foxo3a is essential for maintenance of the hematopoietic stem cell pool

Miyamoto, K., Kazuhito, N., & Atsushi, H. (2009) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 858 · see citing works

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

Beyaz, S., Mana, M., Roper, J., Kedrin, D., Saadatpour, A., Hong, S., Bauer-Rowe, K. E., Xifaras, M. E., Akkad, A., Arias, E., et al. (2016) · Nature · doi:10.1038/nature17173 · Cited by 840 · see citing works

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura‐Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.10.011 · Cited by 810 · see citing works

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

Chambers, S. M., Shaw, C. A., Gatza, C. E., Fisk, C. J., Donehower, L. A., & Goodell, M. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050201 · Cited by 799 · see citing works

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

Le Belle, J. E., Orozco, N. M., Paucar, A. A., Saxe, J. P., Mottahedeh, J., Pyle, A. D., Wu, H., & Kornblum, H. I. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.028 · Cited by 789 · see citing works

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781 · see citing works

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert

Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., et al. (2014) · Nature · doi:10.1038/nature13255 · Cited by 776 · see citing works

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Yilmaz, Ö. H., Katajisto, P., Lamming, D. W., Gültekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., et al. (2012) · Nature · doi:10.1038/nature11163 · Cited by 753 · see citing works

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

Owusu-Ansah, E., & Banerjee, U. (2009) · Nature · doi:10.1038/nature08313 · Cited by 742 · see citing works

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2882 · Cited by 731 · see citing works

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in DrosophilaPreprint

Buchon, N., Broderick, N. A., Chakrabarti, S., & Lemaître, B. (2009) · Genes & Development · doi:10.1101/gad.1827009 · Cited by 722 · see citing works

Coordinated Changes of Mitochondrial Biogenesis and Antioxidant Enzymes During Osteogenic Differentiation of Human Mesenchymal Stem Cells

Chen, C.-T., Shih, Y.-R. V., Kuo, T. K., Lee, O. K., & Wei, Y. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0509 · Cited by 709 · see citing works

Distinct bone marrow blood vessels differentially regulate haematopoiesis

Itkin, T., Gur‐Cohen, S., Spencer, J. A., Schajnovitz, A., Ramasamy, S. K., Kusumbe, A. P., Ledergor, G., Jung, Y., Milo, I., Poulos, M. G., et al. (2016) · Nature · doi:10.1038/nature17624 · Cited by 709 · see citing works

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510452103 · Cited by 699 · see citing works

Metabolic Regulation of Epigenetics

Lu, C., & Thompson, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.001 · Cited by 699 · see citing works

Stem cells, ageing and the quest for immortality

Rando, T. A. (2006) · Nature · doi:10.1038/nature04958 · Cited by 695 · see citing works

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.03.002 · Cited by 686 · see citing works

Rapamycin slows aging in mice

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N. L., Strong, R., Wood, L. K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00832.x · Cited by 682 · see citing works

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K.-L., Liu, Y., & Zheng, P. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081297 · Cited by 682 · see citing works

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

Sykiotis, G. P., & Bohmann, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.002 · Cited by 675 · see citing works

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

Folmes, C. D. L., Dzeja, P. P., Nelson, T. J., & Terzic, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.002 · Cited by 664 · see citing works

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 663 · see citing works

Mitochondrial Complex III ROS Regulate Adipocyte Differentiation

Tormos, K. V., Ansó, E., Hamanaka, R. B., Eisenbart, J. D., Joseph, J., Kalyanaraman, B., & Chandel, N. S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.007 · Cited by 662 · see citing works

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660 · see citing works

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

Mortensen, M., Soilleux, E. J., Djordjevic, G., Tripp, R., Lutteropp, M., Sadighi-Akha, E., Stranks, A. J., Glanville, J., Knight, S., W. Jacobsen, S.-E., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101145 · Cited by 657 · see citing works

Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

Passegué, E., Wagers, A. J., Giuriato, S., Anderson, W. C., & Weissman, I. L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050967 · Cited by 646 · see citing works

FOXO3A directs a protective autophagy program in haematopoietic stem cells

Warr, M. R., Binnewies, M., Flach, J., Reynaud, D., Garg, T., Malhotra, R., Debnath, J., & Passegué, E. (2013) · Nature · doi:10.1038/nature11895 · Cited by 625 · see citing works

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

Rera, M., Clark, R. I., & Walker, D. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215849110 · Cited by 619 · see citing works

Taking a good look at free radicals in the aging process

Hekimi, S., Lapointe, J., & Wen, Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.008 · Cited by 606 · see citing works

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

Biteau, B., Hochmuth, C. E., & Jasper, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.024 · Cited by 583 · see citing works

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

Ryall, J. G., Dell’Orso, S., Derfoul, A., Juan, A., Zare, H., Feng, X., Clermont, D., Koulnis, M., Gutierrez-Cruz, G., Fulco, M., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.12.004 · Cited by 575 · see citing works

Stem cell metabolism in tissue development and aging

Shyh‐Chang, N., Daley, G. Q., & Cantley, L. C. (2013) · Development · doi:10.1242/dev.091777 · Cited by 573 · see citing works

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

Florian, M. C., Dörr, K., Niebel, A., Daria, D., Schrezenmeier, H., Rojewski, M., Filippi, M.-D., Hasenberg, A., Gunzer, M., Scharffetter-Kochanek, K., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.04.007 · Cited by 564 · see citing works

Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila

Amcheslavsky, A., Jiang, J., & Ip, Y. T. (2009) · Cell stem cell · doi:10.1016/j.stem.2008.10.016 · Cited by 563 · see citing works

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Katajisto, P., Döhla, J., Chaffer, C. L., Pentinmikko, N., Marjanovic, N. D., Iqbal, S., Zoncu, R., Chen, W. W., Weinberg, R. A., & Sabatini, D. M. (2015) · Science · doi:10.1126/science.1260384 · Cited by 542 · see citing works

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Nakada, D., Saunders, T. L., & Morrison, S. J. (2010) · Nature · doi:10.1038/nature09571 · Cited by 524 · see citing works

Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates

Koivunen, P., Hirsilä, M., Remes, A. M., Hassinen, I. E., Kivirikko, K. I., & Myllyharju, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610415200 · Cited by 521 · see citing works

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Knobloch, M., Braun, S., Zurkirchen, L., Schoultz, C., Zamboni, N., Araúzo-Bravo, M., Kovacs, W. J., Karalay, Ö., Suter, U., Machado, R. A. C., et al. (2012) · Nature · doi:10.1038/nature11689 · Cited by 503 · see citing works

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

Zhang, J., Khvorostov, I., Hong, J. S., Oktay, Y., Vergnes, L., Nuebel, E., Wahjudi, P. N., Setoguchi, K., Wang, G., Do, A., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.401 · Cited by 499 · see citing works

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Mohrin, M., Shin, J., Liu, Y., Brown, K., Luo, H., Xi, Y., Haynes, C. M., & Chen, D. (2015) · Science · doi:10.1126/science.aaa2361 · Cited by 490 · see citing works

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging

Beerman, I., Bock, C., Garrison, B. S., Smith, Z. D., Gu, H., Meissner, A., & Rossi, D. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.017 · Cited by 485 · see citing works

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

Cheng, C., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., Sacco, S. D., Mirisola, M. G., Quinn, D. I., Dorff, T. B., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.04.014 · Cited by 484 · see citing works

Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog

Rera, M., Bahadorani, S., Cho, J., Koehler, C. L., Ulgherait, M., Hur, J. H., Ansari, W. S., Lo, T., Jones, D. L., & Walker, D. W. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.013 · Cited by 472 · see citing works

Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells

Cho, Y. M., Kwon, S., Pak, Y. K., Seol, H. W., Choi, Y. M., Park, D. J., Park, K. S., & Lee, H. K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.020 · Cited by 465 · see citing works

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

Zhang, J., Nuebel, E., Daley, G. Q., Koehler, C. M., & Teitell, M. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.005 · Cited by 465 · see citing works

O2 regulates stem cells through Wnt/β-catenin signalling

Mazumdar, J., O'Brien, W. T., Johnson, R. S., LaManna, J. C., Chavez, J. C., Klein, P. S., & Simon, M. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2102 · Cited by 456 · see citing works

Cell cycle regulation in hematopoietic stem cells

Pietras, E. M., Warr, M. R., & Passegué, E. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102131 · Cited by 447 · see citing works

Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth

O’Brien, L. E., Soliman, S. S., Li, X., & Bilder, D. H. (2011) · Cell · doi:10.1016/j.cell.2011.08.048 · Cited by 444 · see citing works

SIRT3 Reverses Aging-Associated Degeneration

Brown, K., Xie, S., Qiu, X., Mohrin, M., Shin, J., Liu, Y., Zhang, D., Scadden, D. T., & Chen, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.005 · Cited by 436 · see citing works

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

Sperber, H., Mathieu, J., Wang, Y., Ferreccio, A., Hesson, J., Xu, Z., Fischer, K. A., Devi, A., Detraux, D., Gu, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3264 · Cited by 421 · see citing works

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

Cerletti, M., Jang, Y. C., Finley, L. W. S., Haigis, M. C., & Wagers, A. J. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.04.002 · Cited by 397 · see citing works

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegansPreprint

Lum, D. H., Kuwabara, P. E., Zarkower, D. A., & Spence, A. M. (2000) · Genes & Development · doi:10.1101/gad.853700 · Cited by 392 · see citing works

Mitochondrial Regulation in Pluripotent Stem Cells

Xu, X., Duan, S., Yi, F., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.005 · Cited by 370 · see citing works

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P. B., Wu, L. C., Hammer, R. E., Cleaver, O. B., & McKnight, S. L. (2009) · Science · doi:10.1126/science.1173288 · Cited by 365 · see citing works

Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila

Hochmuth, C. E., Biteau, B., Bohmann, D., & Jasper, H. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.006 · Cited by 364 · see citing works

Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling

Kasahara, A., Cipolat, S., Chen, Y., Dorn, G. W., & Scorrano, L. (2013) · Science · doi:10.1126/science.1241359 · Cited by 354 · see citing works

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

Biteau, B., Karpac, J., Supoyo, S., DeGennaro, M., Lehmann, R., & Jasper, H. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001159 · Cited by 351 · see citing works

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

Yu, W., Liu, X., Shen, J., Jovanović, O., Pohl, E. E., Gerson, S. L., Finkel, T., Broxmeyer, H. E., & Qu, C. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.022 · Cited by 341 · see citing works

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C., O’Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S. H., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina‐Graham, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.054 · Cited by 335 · see citing works

Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment

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Mitochondrial DNA mutations in disease and aging

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