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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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CpG motifs in bacterial DNA trigger direct B-cell activation

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

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Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

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DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivityPreprint

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Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging

Storci, G., Carolis, S. D., Olivieri, F., & Bonafè, M. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.08.003 · Cited by 37

Intracellular RNA Sensing in Mammalian Cells: Role in Stress Response and Cancer Therapies

Khodarev, N. N. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.08.005 · Cited by 34

RNA is taking its Toll: Impact of RNA‐specific Toll‐like receptors on health and disease

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Nucleic Acid Sensing in Mammals and Plants: Facts and Caveats

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Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration

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Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA

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Chromatin-Associated Molecular Patterns (CAMPs) in sepsis

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Investigations on the molecular mode of action of the novel immunostimulator ZelNate: Activation of the cGAS-STING pathway in mammalian cells

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Insights into the role of circular RNA in macrophage activation and fibrosis disease

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Stratum corneum as polymer sheet: concept and cornification processes

Murata, T., Honda, T., Mostafa, A., & Kabashima, K. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.02.008 · Cited by 35

PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry

Patel, A. J., Warda, S., Mååg, J. L. V., Misra, R., Miranda-Román, M. A., Pachai, M. R., Lee, C. J., Li, D., Wang, N., Bayshtok, G., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1671 · Cited by 36

Regulation of type I and type III interferon induction in response to pathogen sensing

Gewaid, H. E., & Bowie, A. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102424 · Cited by 36

Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA

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Systemic innate and adaptive immune responses to SARS-CoV-2 as it relates to other coronaviruses

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Intracellular calcium is a rheostat for the STING signaling pathway

Kwon, D., Sesaki, H., & Kang, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.117 · Cited by 32

Extracellular miRNAs as activators of innate immune receptors

Bosisio, D., Gianello, V., Salvi, V., & Sozzani, S. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.03.021 · Cited by 32

Cryo-electron Microscopic Analysis of Single-Pass Transmembrane Receptors

Cai, K., Zhang, X., & Bai, X. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01035 · Cited by 31

CNS disease associated with enhanced type I interferon signalling

Crow, Y. J. (2024) · The Lancet Neurology · doi:10.1016/s1474-4422(24)00263-1 · Cited by 32

The Conserved RNA Exonuclease Rexo5 Is Required for 3′ End Maturation of 28S rRNA, 5S rRNA, and snoRNAs

Gerstberger, S. C., Meyer, C., Benjamin, S., Rodriguez, J., Briskin, D., Bognanni, C., Bogardus, K. A., Steller, H., & Tuschl, T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.067 · Cited by 29

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia

Danilova, N., Wilkes, M. C., Бибикова, Е., Youn, M., Sakamoto, K. M., & Lin, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-23561-6 · Cited by 32

Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies

Shamseddine, A. A., Patel, S. H., Chavez, V. A., Moore, Z., Adnan, M., Bona, M. D., Li, J., Dang, C. T., Ramanathan, L. V., Oeffinger, K. C., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220809 · Cited by 33

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription

Chan, B., Magalhães, V. G., Lemmermann, N. A. W., Lisnić, V. J., Stempel, M., Bussey, K. A., Reimer, E., Podlech, J., Lienenklaus, S., Reddehase, M. J., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006382 · Cited by 29

Yin Yang 1 Dynamically Regulates Antiviral Innate Immune Responses During Viral Infection

Zan, J., Zhang, H., Gu, A.-P., Zhong, K.-L., Lu, M., Bai, X., Zhang, J., & Cai, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485116 · Cited by 30

Expanding Structural Space for Immunomodulatory Nucleic Acid Nanoparticles via Spatial Arrangement of Their Therapeutic Moieties

Chandler, M. R., Rolband, L. A., Johnson, M. B., Shi, D., Avila, Y. I., Cedrone, E., Beasock, D., Danai, L., Stassenko, E., Krueger, J. K., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205581 · Cited by 30

Extracellular nucleic acids in immunity and cardiovascular responses: between alert and disease

Preissner, K. T., & Herwald, H. (2017) · Thrombosis and Haemostasis · doi:10.1160/th-16-11-0858 · Cited by 33

SAMHD1 deficient human monocytes autonomously trigger type I interferon

Martínez‐López, A., Martín-Fernández, M., Buta, S., Kim, B., Bogunovic, D., & Diaz‐Griffero, F. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.08.005 · Cited by 30

Tiered DNA sensors for escalating responses

Emming, S., & Schroder, K. (2019) · Science · doi:10.1126/science.aay2701 · Cited by 30

Signaling Cascade through DC-ASGPR Induces Transcriptionally Active CREB for IL-10 Induction and Immune Regulation

Gu, C., Wang, L., Zurawski, S., & Oh, S. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900289 · Cited by 29

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Wang, H., Zang, C., Ren, M., Shang, M., Wang, Z., Peng, X., Zhang, Q., Wen, X., Xi, Z., & Zhou, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-72393-w · Cited by 29

SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist

Li, A., Zhao, K., Zhang, B., Hua, R.-H., Fang, Y., Jiang, W., Zhang, J., Hui, L., Zheng, Y., Li, Y., et al. (2021) · Journal of Virology · doi:10.1128/jvi.00747-21 · Cited by 30

ISG15: A link between innate immune signaling, DNA replication, and genome stability

Wardlaw, C. P., & Petrini, J. H. J. (2023) · BioEssays · doi:10.1002/bies.202300042 · Cited by 27

Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling

Liu, K., Zhao, X., Guo, M., Zhu, J., Li, D., Ding, J., Han, X., & Wu, J. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.01.003 · Cited by 28

Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles

Ohto, T., Konishi, M., Tanaka, H., Onomoto, K., Yoneyama, M., Nakai, Y., Tange, K., Yoshioka, H., & Akita, H. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00783 · Cited by 29

Relative Contributions of the cGAS-STING and TLR3 Signaling Pathways to Attenuation of Herpes Simplex Virus 1 Replication

Latif, M. B., Raja, R., Kessler, P., & Sen, G. C. (2020) · Journal of Virology · doi:10.1128/jvi.01717-19 · Cited by 27

Monogenic systemic lupus erythematosus: insights in pathophysiology

Batu, E. D. (2018) · Rheumatology International · doi:10.1007/s00296-018-4048-7 · Cited by 27

DNA‐Based Biomaterials for Immunoengineering

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DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy

Szymura, S. J., Bernal, G. M., Wu, L., Zhang, Z., Crawley, C. D., Voce, D. J., Campbell, P.-A., Rañoa, D. R. E., Weichselbaum, R. R., & Yamini, B. (2020) · BMC Biology · doi:10.1186/s12915-020-0764-z · Cited by 27

Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration

Wang, Z., Hu, X., Cui, P., Kong, C., Chen, X., Wang, W., & Lu, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01607-7 · Cited by 27

JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination

Zhang, W., Wang, Q., Yang, F., Zhu, Z., Duan, Y., Yang, Y., Cao, W., Zhang, K., Ma, J., Liu, X., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009366 · Cited by 25

Pharmacological Activation of cGAS for Cancer Immunotherapy

Garland, K. M., Rosch, J. C., Carson, C. S., Wang-Bishop, L., Hanna, A., Sevimli, S., Kaer, C. V., Balko, J. M., Ascano, M., & Wilson, J. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.753472 · Cited by 26

ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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Solid‐phase silica‐based extraction leads to underestimation of residual DNA in decellularized tissues

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Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS

Yang, B., Zhang, G., Qin, X., Huang, Y., Ren, X., Sun, J., Ma, S., Liu, Y., Song, D., Liu, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.730483 · Cited by 25

Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy

Zhang, Y., Wang, Y., Mu, P., Zhu, X. G., & Dong, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1470468 · Cited by 24

TLR9 and its signaling pathway in multiple sclerosis

Zhou, Y., Fang, L., Peng, L., & Qiu, W. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.12.027 · Cited by 24

Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation

Cho, K., Cha, J.-E., Kim, J.-W., Kim, Y., Ryu, K., & Woo, S. (2021) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-021-00395-4 · Cited by 24

CD72 is a Negative Regulator of B Cell Responses to Nuclear Lupus Self-antigens and Development of Systemic Lupus Erythematosus

Tsubata, T. (2019) · Immune Network · doi:10.4110/in.2019.19.e1 · Cited by 27

RNA Epigenetics: Fine-Tuning Chromatin Plasticity and Transcriptional Regulation, and the Implications in Human Diseases

Willbanks, A. R., Wood, S., & Cheng, J. X. (2021) · Genes · doi:10.3390/genes12050627 · Cited by 26

Ribosomal DNA instability: An evolutionary conserved fuel for inflammaging

Storci, G., Bacalini, M. G., Bonifazi, F., Garagnani, P., Carolis, S. D., Salvioli, S., Olivieri, F., & Bonafè, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101018 · Cited by 24

cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette

Cai, H., & Imler, J. (2021) · Faculty Reviews · doi:10.12703/r/10-54 · Cited by 27

Current concepts of photosensitivity in cutaneous lupus erythematosus

Klein, B., & Kunz, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.939594 · Cited by 24

Manganese enhances macrophage defense against Mycobacterium tuberculosis via the STING-TNF signaling pathway

Qian, K., Shan, L., Shang, S., Li, T., Wang, S., Wei, M., Tang, B., & Xi, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109471 · Cited by 22

VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation

Hu, Z., Xie, Y., Lu, J., Yang, J., Zhang, J., Jiang, H., Li, H., Zhang, Y., Wu, D., Zeng, K., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg2339 · Cited by 23

E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells

Song, X., Liu, S., Wang, W., Ma, Z., Cao, X., & Jiang, M. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0236-y · Cited by 23

Bridging innate and adaptive tumor immunity: cGAS–STING pathway activation to potentiate immune checkpoint blockade

Li, Z. Y., Zheng, W., Liu, Y., Cao, R., Wei, J., & Jia, H. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03555-9 · Cited by 22

STING dependent sensing – Does HIV actually care?

Krapp, C., Jønsson, K. L., & Jakobsen, M. R. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.03.002 · Cited by 20

The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors

Amagai, R., Takahashi, T., Terui, H., Fujimura, T., Yamasaki, K., Aiba, S., & Asano, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010875 · Cited by 26

Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA

Ye, Y., Qin, G., Yang, H., Hao, J., Zeng, Q., Zheng, D., Ye, S., Zhang, Z., Liu, T., Luo, K. Q., et al. (2024) · Advanced Science · doi:10.1002/advs.202400888 · Cited by 22

Mitochondrial dsRNA: A New DAMP for MDA5

Linder, A., & Hornung, V. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.019 · Cited by 22

Crosstalk Between Mammalian Antiviral Pathways

Watson, S., Knol, L. I., Witteveldt, J., & Macías, S. (2019) · Non-Coding RNA · doi:10.3390/ncrna5010029 · Cited by 21

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus

Payet, C. A., You, A., Fayet, O., Hemery, E., Truffault, F., Bondet, V., Duffy, D., Michel, F., Fadel, É., Guihaire, J., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26590 · Cited by 22

The m6A Reader YTHDF2 Modulates Antiviral and Antibacterial Activity by Suppressing METTL3 Methylation-Modified STING in Fish

Geng, S., Zheng, W., Wang, W., Lv, X., Xin, S., & Xu, T. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200618 · Cited by 19

Activation of viral defense signaling in cancer

González‐Cao, M., Karachaliou, N., Santarpía, M., Viteri, S., Meyerhans, A., & Rosell, R. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835918793105 · Cited by 21

Expression patterns of innate immunity-related genes in response to polyinosinic:polycytidylic acid (poly[I:C]) stimulation in DF-1 chicken fibroblast cells

Jang, H., & Song, K. (2020) · Journal of Animal Science and Technology · doi:10.5187/jast.2020.62.3.385 · Cited by 19

Metatranscriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites

Guo, L., Lu, X., Liu, X., Li, P., Wu, J., Xing, F., Peng, H., Xiao, X., Shī, M., Liu, Z., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01686-20 · Cited by 19

DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection

Zhang, R., Cheng, M., Liu, B., Yuan, M., Chen, D., Wang, Y., & Wu, Z. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.725392 · Cited by 19

GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation

Liu, Q., Gu, T., Su, L., Jiao, L., Qiao, X., Xu, M., Xie, T., Yang, L.-X., Yu, D., Xu, L., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102172 · Cited by 19

Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

Hwang, B.-J., Tsao, L.-C., Acharya, C. R., Trotter, T. N., Agarwal, P., Wei, J.-P., Wang, T., Yang, X., Lei, G., Osada, T., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003721 · Cited by 21

The second half of mitosis and its implications in cancer biology

Moreno-Andrés, D., Holl, K., & Antonin, W. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.11.013 · Cited by 22

Lamin A/C facilitates DNA damage response by modulating ATM signaling and homologous recombination pathways

Kim, S.-J., Park, S. H., Myung, K., & Lee, K. (2024) · Animal Cells and Systems · doi:10.1080/19768354.2024.2393820 · Cited by 21

Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis

Järver, P., Dondalska, A., Poux, C., Sandberg, A., Bergenstråhle, J., Sköld, A. E., Dereuddre‐Bosquet, N., Martinon, F., Pålsson, S. A., Zaghloul, E. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33960-4 · Cited by 20

Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis

Hamel, Y., Mauvais, F., Madrange, M., Renard, P., Lebreton, C., Nemazanyy, I., Pellé, O., Goudin, N., Tang, X., Rodero, M. P., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100370 · Cited by 20

DAMP signaling networks: from receptors to diverse pathophysiological functions

Chen, R., Zou, J., Zhong, X. Y., Liu, J., Kang, R., & Tang, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.047 · Cited by 26

RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

Yang, Z., Wang, J., He, B., Zhang, X., Li, X., & Kuang, E. (2021) · eLife · doi:10.7554/elife.68958 · Cited by 18

Identification of a small molecule that primes the type I interferon response to cytosolic DNA

Khiar, S., Lucas‐Hourani, M., Nisole, S., Smith, N., Helynck, O., Bourgine, M., Ruffié, C., Herbeuval, J., Munier‐Lehmann, H., Tangy, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02776-z · Cited by 18

Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection

Lum, K. K., & Cristea, I. M. (2021) · Current Issues in Molecular Biology · doi:10.21775/cimb.042.635 · Cited by 21

The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading

Schweibenz, B., Devarkar, S. C., Solotchi, M., Craig, C., Zheng, J., Pascal, B. D., Gokhale, S., Xie, P., Griffin, P. R., & Patel, S. S. (2022) · The EMBO Journal · doi:10.15252/embj.2021109782 · Cited by 18

Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses

Manils, J., Fischer, H., Climent, J., Casas, E., Garcia‐Martínez, C., Bas, J., Sukseree, S., Vavouri, T., Ciruela, F., de Anta, J. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12308-4 · Cited by 19

NLRC4-mediated activation of CD1c+ DC contributes to perpetuation of synovitis in rheumatoid arthritis

Delgado‐Arévalo, C., Calvet‐Mirabent, M., Triguero‐Martínez, A., Vázquez, E., Benguría, A., Largo, R., Calzada‐Fraile, D., Popova, O., Sánchez‐Cerrillo, I., Tsukalov, I., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.152886 · Cited by 18

An update on post‐transcriptional regulation of retrotransposons

Warkocki, Z. (2022) · FEBS Letters · doi:10.1002/1873-3468.14551 · Cited by 19

Therapeutic potential of DNases in immunothrombosis: promising succor or uncertain future?

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