The DOI matches its Crossref record; 162 of the 164 references it cites were found in a registry or an index.
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Open accessAbstract
Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central element in the detection of microbial invaders by the innate immune system. However, the capacity of these sensors to discriminate between microbial and endogenous nucleic acids is limited. Over the past few years, evidence has accumulated to suggest that endogenous DNA or RNA species can engage nucleic-acid-sensing pattern-recognition receptors that can trigger or sustain detrimental pathology. Here, we review principles of how the activation of innate sensors by host nucleic acids is prevented in the steady state and discuss four important determinants of whether a nucleic-acid-driven innate response is mounted. These include structural features of the ligand being sensed, the subcellular location and quantity of pathogen-derived or endogenous nucleic acids, and the regulation of sensor-activation thresholds. Furthermore, we emphasize disease mechanisms initiated by failure to discriminate self from non-self in nucleic acid detection.
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“In summary, DAMPs from senescent, damaged, and dying cells trigger various cell death modalities, including necrosis, pyroptosis, necroptosis, PANoptosis, NETosis, and ferroptosis (Fig. 4).”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [279]
In the citing paper
“DAMPs bind to specific receptors, initiating inflammation and orchestrating a coordinated response involving immune cells.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [279]
In the citing paper
“This response includes the recruitment of neutrophils and monocytes, which play crucial roles in tissue repair and healing processes.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [279]
In the citing paper
“Endogenous DAMPs can activate PRRs and non-PRR transmembrane proteins, resulting in massive inflammation, cellular senescence, diseases of the organs, and aging.277–279”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [279]
In the citing paper
“When leukocytes fail to clear immunostimulatory molecules, inflammation persists, which further causes cancer and aging.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [279]
In the citing paper
“These degradation products are presumably produced by nucleases in the endosome shortly after the RNA is internalized (Roers et al. 2016).”
From RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo (2019) · cites this paper as Roers et al. 2016
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Cites
1 retracted
MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses
Zeng, M., Hu, Z., Shi, X., Li, X., Zhan, X., Li, X.-D., Wang, J., Choi, J. H., Wang, K.-W., Purrington, T., et al. (2014) · Science · doi:10.1126/science.346.6216.1486 · Cited by 112
RetractedRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627
Self-citationSmall anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,577
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2 of the 164 references couldn’t be matched to a known paper.
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Molecular mechanisms and cellular functions of cGAS–STING signalling
Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052
Self-citationcGAS surveillance of micronuclei links genome instability to innate immunity
Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
Gong, T., Liu, L., Jiang, W., & Zhou, R. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0215-7 · Cited by 1,672
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443
Mitochondrial DNA in innate immune responses and inflammatory pathology
West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115
Metadata
- Authors
- Roers, A., Hiller, B., & Hornung, V.
- Affiliations
- Technische Universität Dresden (DE)
- University Hospital Bonn (DE)
- Center for Integrated Protein Science Munich (DE)
- Corresponding author
- Hornung, Veit
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 44
- Issue
- 4
- Pages
- 739-754
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2340906209
- Cited by
- 541
- References
- 164
- Citations by year
- 2026: 32 · 2025: 42 · 2024: 64 · 2023: 43 · 2022: 57 · 2021: 65 · 2020: 66 · 2019: 72 · 2018: 53 · 2017: 35 · 2016: 12
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- innate immunity, pattern recognition receptors, autoinflammation, autoimmunity
- MeSH terms
- DNA, Humans, Immunity, Innate, RNA, Signal Transduction, Receptors, Pattern Recognition
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