Cited by 543Immune Response and Inflammationinterferon and immune responsesInflammasome and immune disorders

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Recognition of Endogenous Nucleic Acids by the Innate Immune System

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Roers, Axel, Hiller, Björn, Hornung, Veit·2016·Immunity

DOI 10.1016/j.immuni.2016.04.002

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Abstract

Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central element in the detection of microbial invaders by the innate immune system. However, the capacity of these sensors to discriminate between microbial and endogenous nucleic acids is limited. Over the past few years, evidence has accumulated to suggest that endogenous DNA or RNA species can engage nucleic-acid-sensing pattern-recognition receptors that can trigger or sustain detrimental pathology. Here, we review principles of how the activation of innate sensors by host nucleic acids is prevented in the steady state and discuss four important determinants of whether a nucleic-acid-driven innate response is mounted. These include structural features of the ligand being sensed, the subcellular location and quantity of pathogen-derived or endogenous nucleic acids, and the regulation of sensor-activation thresholds. Furthermore, we emphasize disease mechanisms initiated by failure to discriminate self from non-self in nucleic acid detection.

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Authors: Roers, A., Hiller, B., & Hornung, V.
Affiliations: Technische Universität Dresden (DE)
University Hospital Bonn (DE)
Center for Integrated Protein Science Munich (DE)
Corresponding author: Hornung, Veit
ORCID: Roers, Axel
Hiller, Björn
Hornung, Veit
Venue: Immunity
Publisher: Elsevier BV
Published: 2016-04
Volume: 44
Issue: 4
Pages: 739-754
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2016.04.002
OpenAlex: W2340906209
Cited by: 541
References: 164
Citations by year: 2026: 32 · 2025: 42 · 2024: 64 · 2023: 43 · 2022: 57 · 2021: 65 · 2020: 66 · 2019: 72 · 2018: 53 · 2017: 35 · 2016: 12
FWCI: 5.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: innate immunity, pattern recognition receptors, autoinflammation, autoimmunity
MeSH terms: DNA, Humans, Immunity, Innate, RNA, Signal Transduction, Receptors, Pattern Recognition

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Recognition of Endogenous Nucleic Acids by the Innate Immune System

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