Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism
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Age-related changes at the cellular level include the dysregulation of metabolic and signaling pathways. Analyses of blood leukocytes have revealed a set of alterations that collectively lower their ability to fight infections and resolve inflammation later in life. We studied the transcriptomic, epigenetic, and metabolomic profiles of monocytes extracted from younger adults and individuals over the age of 65 years to map major age-dependent changes in their cellular physiology. We found that the monocytes from older persons displayed a decrease in the expression of ribosomal and mitochondrial protein genes and exhibited hypomethylation at the HLA class I locus. Additionally, we found elevated gene expression associated with cell motility, including the CX3CR1 and ARID5B genes, which have been associated with the development of atherosclerosis. Furthermore, the downregulation of two genes, PLA2G4B and ALOX15B, which belong to the arachidonic acid metabolism pathway involved in phosphatidylcholine conversion to anti-inflammatory lipoxins, correlated with increased phosphatidylcholine content in monocytes from older individuals. We found age-related changes in monocyte metabolic fitness, including reduced mitochondrial function and increased glycose consumption without the capacity to upregulate it during increased metabolic needs, and signs of increased oxidative stress and DNA damage. In conclusion, our results complement existing findings and elucidate the metabolic alterations that occur in monocytes during aging.
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Mitochondria in aged classical monocytes have lower membrane potential and therefore function less well than mitochondria in young monocytes.
“Mitochondria from aged classical monocytes have reduced membrane potential as thus do not work as well as mitochondria from young monocytes (145).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [145]
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Plasma Lipidomics and Proteomics Analyses Pre- and Post-5000 m Race in Yili Horses
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- Authors
- Saare, M., Tserel, L., Haljasmägi, L., Taalberg, E., Peet, N., Eimre, M., Vetik, R., Kingo, K., Saks, K., Tamm, R., Milani, L., Kisand, K., & Peterson, P.
- Affiliations
- University of Tartu (EE)
- Tartu University Hospital (EE)
- Corresponding author
- Saare, Mario
- Kisand, Kai
- Peterson, Pärt
- ORCID
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2020-02-27
- Volume
- 19
- Issue
- 4
- Pages
- e13127-e13127
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC7189998
- OpenAlex
- W3006785559
- Cited by
- 79
- References
- 72
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 12 · 2023: 9 · 2022: 8 · 2021: 18 · 2020: 7
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Center of Translational Genomics, University of Tartu (SP1GVARENG)
- Eesti Teadusagentuur (IUT2‐2, PRG377, PUT1367)
- European Molecular Biology Organization (ASTF540‐2016)
- European Regional Development Fund (EXCEGEN, 2014‐2020.4.01.15‐0012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- monocytes, aging, phospholipid metabolism, phosphatidylcholine, energy metabolism, mitochondrial dysfunction, oxidative stress, DNA damage, epigenetics, arachidonic acid metabolism, lipoxins, CX3CR1, ARID5B, atherosclerosis, glycolysis, transcriptomics, metabolomics
- MeSH terms
- Adult, Aged, Aged, 80 and over, Energy Metabolism, Humans, Monocytes, Phospholipids, Cellular Senescence
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