Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

limma powers differential expression analyses for RNA-sequencing and microarray studies

Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219

Integrative genomics viewer

Robinson, J. T., Thorvaldsdóttir, H., Winckler, W., Guttman, M., Lander, E. S., Getz, G., & Mesirov, J. P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1754 · Cited by 15,390

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Law, C. W., Chen, Y., Shi, W., & Smyth, G. K. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r29 · Cited by 6,155

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493

deepTools: a flexible platform for exploring deep-sequencing data

Ramírez, F., Dündar, F., Diehl, S., Grüning, B. A., & Manke, T. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku365 · Cited by 3,738

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · cited 3×

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

Innate immune memory in the brain shapes neurological disease hallmarks

Wendeln, A.-C., Degenhardt, K., Kaurani, L., Gertig, M., Ulas, T., Jain, G., Wagner, J., Häsler, L. M., Wild, K., Skodras, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0023-4 · Cited by 956

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

Erny, D., Dokalis, N., Mezö, C., Castoldi, A., Mossad, O., Staszewski, O., Frosch, M., Villa, M., Fuchs, V., Mayer, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.010 · Cited by 478

Microglia and early brain development: An intimate journey

Thion, M. S., Ginhoux, F., & Garel, S. (2018) · Science · doi:10.1126/science.aat0474 · Cited by 465

Crosstalk Between Astrocytes and Microglia: An Overview

Matejuk, A., & Ransohoff, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01416 · Cited by 445

Microglia: Agents of the CNS Pro-Inflammatory Response

Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365

Trained Immunity: Reprogramming Innate Immunity in Health and Disease

Bekkering, S., Domínguez‐Andrés, J., Joosten, L. A. B., Riksen, N. P., & Netea, M. G. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102119-073855 · Cited by 360

Epigenetic regulation of macrophages: from homeostasis maintenance to host defense

Chen, S., Yang, J., Wei, Y., & Wei, X. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0315-0 · Cited by 331

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

Lauro, C., & Limatola, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00493 · Cited by 315

Priming Microglia for Innate Immune Memory in the Brain

Neher, J. J., & Cunningham, C. M. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.02.001 · Cited by 263

Cien Años de Microglía: Milestones in a Century of Microglial Research

Sierra, A., Paolicelli, R. C., & Kettenmann, H. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.004 · Cited by 244

Uncovering sex differences of rodent microglia

Han, J., Fan, Y., Zhou, K., Blomgren, K., & Harris, R. A. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02124-z · Cited by 224

Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

Kumar, V., Kundu, S., Singh, A., & Singh, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x19666210609160017 · Cited by 210

When encephalitogenic T cells collaborate with microglia in multiple sclerosis

Dong, Y., & Yong, V. W. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0253-6 · Cited by 169

Epigenetics Control Microglia Plasticity

Cheray, M., & Joseph, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00243 · Cited by 157

Analyzing microglial phenotypes across neuropathologies: a practical guide

Schwabenland, M., Brück, W., Priller, J., Stadelmann, C., Lassmann, H., & Prinz, M. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02370-8 · Cited by 149

Trained immunity: General and emerging concepts

Vuscan, P., Kischkel, B., Joosten, L. A. B., & Netea, M. G. (2024) · Immunological Reviews · doi:10.1111/imr.13326 · Cited by 162

The Epigenetics of Alzheimer’s Disease: Factors and Therapeutic Implications

Liu, X., Jiao, B., & Shen, L. H. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00579 · Cited by 153

Microglia in Alzheimer's Disease: Risk Factors and Inflammation

Katsumoto, A., Takeuchi, H., Takahashi, K., & Tanaka, F. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00978 · Cited by 140

The influence of environment and origin on brain resident macrophages and implications for therapy

Bennett, M. L., & Bennett, F. C. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0545-6 · Cited by 136

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

Mezö, C., Dokalis, N., Mossad, O., Staszewski, O., Neuber, J., Yilmaz, B., Schnepf, D., de Agüero, M. G., Ganal-Vonarburg, S. C., Macpherson, A. J., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00988-5 · Cited by 120

Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

He, X., Li, L., Xian, W., Li, M., Zhang, L., Xu, J., Pei, Z., Zheng, H., & Hu, X. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02199-8 · Cited by 116

IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease

Lau, S.-F., Chen, C., Fu, W.-Y., Qu, J. Y., Cheung, T. H., Fu, A. K. Y., & Ip, N. Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107530 · Cited by 114

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

Niranjan, R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.003 · Cited by 112

Microglia in brain development and regeneration

Mehl, L. C., Manjally, A. V., Bouadi, O., Gibson, E. M., & Tay, T. L. (2022) · Development · doi:10.1242/dev.200425 · Cited by 113

Microglia metabolism in health and disease

Borst, K., Schwabenland, M., & Prinz, M. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2018.11.006 · Cited by 95

The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings

Yang, J., Liang, J., Hu, N., He, N., Liu, B., Liu, G., & Qin, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70091 · Cited by 109

Noteworthy perspectives on microglia in neuropsychiatric disorders

Zhu, H., Guan, A., Liu, J., Li, P., Zhang, Z., & Wang, S. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02901-y · Cited by 91

Epigenetic regulation of microglial phosphatidylinositol 3‐kinase pathway involved in long‐term potentiation and synaptic plasticity in rats

Saw, G., Krishna, K., Gupta, N., Soong, T. W., Mallilankaraman, K., Sajikumar, S., & Dheen, S. T. (2020) · Glia · doi:10.1002/glia.23748 · Cited by 87

Behaviour Hallmarks in Alzheimer’s Disease 5xFAD Mouse Model

Pádua, M. S., Guil‐Guerrero, J. L., & Lopes, P. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126766 · Cited by 87

A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

Abdel-Haq, R., Schlachetzki, J. C., Boktor, J. C., Cantu-Jungles, T. M., Thron, T., Zhang, M., Bostick, J. W., Khazaei, T., Chilakala, S., Morais, L. H., et al. (2022) · eLife · doi:10.7554/elife.81453 · Cited by 82

Microglia and sexual differentiation of the developing brain: A focus on extrinsic factors

VanRyzin, J. W., Marquardt, A. E., Pickett, L. A., & McCarthy, M. M. (2019) · Glia · doi:10.1002/glia.23740 · Cited by 84

Therapeutic Epigenetic Reprogramming of Trained Immunity in Myeloid Cells

Rodríguez, R. M. A., Suárez-Álvarez, B., & López‐Larrea, C. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.11.006 · Cited by 76

Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease

Yang, Y., & Zhang, Z. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00110 · Cited by 76

Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117278 · Cited by 85

How microbiota shape microglial phenotypes and epigenetics

Erny, D., & Prinz, M. (2020) · Glia · doi:10.1002/glia.23822 · Cited by 80

The role of altered protein acetylation in neurodegenerative disease

Kabir, F., Atkinson, R., Cook, A. L., Phipps, A. J., & King, A. E. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1025473 · Cited by 75

Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer’s disease

Morabito, S., Miyoshi, E., Michael, N., & Swarup, V. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa182 · Cited by 74

Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood

Desplats, P., Gutierrez, A. M., Antonelli, M. C., & Frasch, M. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.013 · Cited by 74

Brain Parenchymal and Extraparenchymal Macrophages in Development, Homeostasis, and Disease

Brioschi, S., Zhou, Y., & Colonna, M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900821 · Cited by 67

NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease

He, X., Xu, J., Li, G., Li, M., Li, L., Pei, Z., Zhang, L., & Hu, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03072-x · Cited by 64

Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice

Reiss, D. J., Maduna, T., Maurin, H., Audouard, E., & Gavériaux‐Ruff, C. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24626 · Cited by 62

Physiology of Microglia

Tay, T. L., Carrier, M., & Tremblay, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9913-8_6 · Cited by 61

Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

Atlante, A., Amadoro, G., Bobba, A., & Latina, V. (2020) · Cells · doi:10.3390/cells9112347 · Cited by 67

The Microbiota–Gut–Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells

Giovannini, M. G., Lana, D., Traini, C., & Vannucchi, M. G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112358 · Cited by 64

Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system

Tiwari, V., Prajapati, B., Asare, Y., Damkou, A., Ji, H., Liu, L., Naser, N., Gouna, G., Leszczyńska, K. B., Mieczkowski, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.001 · Cited by 58

Region-Specific Phenotypes of Microglia: The Role of Local Regulatory Cues

Biase, L. M. D., & Bonci, A. (2018) · The Neuroscientist · doi:10.1177/1073858418800996 · Cited by 57

Combined exposure of lead and cadmium leads to the aggravated neurotoxicity through regulating the expression of histone deacetylase 2

Zhou, R., Zhao, J., Li, D., Chen, Y., Xiao, Y., Fan, A., Chen, X.-T., & Wang, H.-L. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126589 · Cited by 56

Omics-based biomarkers discovery for Alzheimer's disease

Aerqin, Q., Wang, Z.-T., Wu, K., He, X., Dong, Q., & Yu, J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04614-6 · Cited by 56

Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease

Haque, M. E., Kim, I., Jakaria, M., Akther, M., & Choi, D. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00258 · Cited by 55

Systematic Identification of Cell-Cell Communication Networks in the Developing Brain

Sheikh, B. N., Bondareva, O., Guhathakurta, S., Tsang, T. H., Sikora, K., Aizarani, N., Sagar, Holz, H., Grün, D., Hein, L., et al. (2019) · iScience · doi:10.1016/j.isci.2019.10.026 · Cited by 53

Microglial ontogeny, diversity and neurodevelopmental functions

Thion, M. S., & Garel, S. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.06.013 · Cited by 58

Role of primary aging hallmarks in Alzheimer´s disease

Zhao, J., & Huai, J. (2022) · Theranostics · doi:10.7150/thno.79535 · Cited by 55

Developmental roles of microglia: A window into mechanisms of disease

Anderson, S., & Vetter, M. L. (2018) · Developmental Dynamics · doi:10.1002/dvdy.1 · Cited by 53

The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

Osorio, C. P., Kanukuntla, T., Diaz, E. L., Jafri, N., Cummings, M., & Sfera, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00143 · Cited by 50

The heterogeneity of microglial activation and its epigenetic and non-coding RNA regulations in the immunopathogenesis of neurodegenerative diseases

Li, C., Ren, J., Zhang, M., Wang, H., Fang, Y., Wu, J., & Tang, Y. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04536-3 · Cited by 52

Epigenetic Regulations of Microglia/Macrophage Polarization in Ischemic Stroke

Qiu, M., Xu, E., & Zhan, L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.697416 · Cited by 48

Epigenetics: An opportunity to shape innate and adaptive immune responses

Liotti, A., Ferrara, A. L., Loffredo, S., Galdiero, M. R., Varricchi, G., Rella, F. D., Maniscalco, G. T., Belardo, M., Vastano, R., Prencipe, R., et al. (2022) · Immunology · doi:10.1111/imm.13571 · Cited by 50

Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell

Dermitzakis, I., Μanthou, M. E., Meditskou, S., Tremblay, M., Petratos, S., Zoupi, L., Boziki, M. K., Kesidou, E., Simeonidou, C., & Theotokis, P. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030171 · Cited by 55

Unique molecular characteristics and microglial origin of Kv1.3 channel–positive brain myeloid cells in Alzheimer’s disease

Ramesha, S., Rayaprolu, S., Bowen, C. A., Giver, C. R., Bitarafan, S., Nguyen, H. M., Gao, T., Chen, M. J., Nwabueze, N. V., Dammer, E. B., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2013545118 · Cited by 47

Little cells of the little brain: microglia in cerebellar development and function

Stoessel, M. B., & Majewska, A. K. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.04.001 · Cited by 49

Structure-activity relationships and mechanisms of natural polysaccharides in modulating neurological disorders via the microbiota-gut-brain axis

Song, Y., Deng, Q., Li, J., Chen, R., Li, D., Wang, S., Jing, B., & Zhou, X. Y. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123960 · Cited by 47

Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1

Haage, V. C., Elmadany, N., Roll, L., Faissner, A., Gutmann, D. H., Semtner, M., & Kettenmann, H. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.047 · Cited by 48

Transcriptional Networks of Microglia in Alzheimer’s Disease and Insights into Pathogenesis

Chew, G., & Petretto, E. G. (2019) · Genes · doi:10.3390/genes10100798 · Cited by 46

Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice

Ritzel, R. M., Li, Y., Lei, Z., Carter, J., He, J., Choi, H., Khan, N., Li, H., Allen, S., Lipinski, M. M., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00562-y · Cited by 46

Myeloid cell‐specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation

Zhu, K., Wang, Y., Sarlus, H., Geng, K., Nutma, E., Sun, J., Kung, S., Bay, C., Han, J., Min, J., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154499 · Cited by 43

The Epigenetics of Migraine

Zobdeh, F., Еременко, И. И., Akan, M. A., Tarasov, V. V., Chubarev, V. N., Schiöth, H. B., & Mwinyi, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119127 · Cited by 44

Maternal obesity and developmental programming of neuropsychiatric disorders: An inflammatory hypothesis

Davis, J. M., & Mire, E. (2021) · Brain and Neuroscience Advances · doi:10.1177/23982128211003484 · Cited by 40

Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease

Šimić, G., Španić, E., Horvat, L. L., & Hof, P. R. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.003 · Cited by 40

Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1 /2: Microglial heterogenization via the Nrf2/ HO1 pathway

Jiang, Z., Yang, H., Ni, W., Gao, X., Pei, X., Jiang, H., Su, J., Weng, R., Fei, Y., Gao, Y., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14646 · Cited by 38

Epigenetic control of microglial immune responses

Scholz, R., Brösamle, D., Yuan, X., Beyer, M., & Neher, J. J. (2024) · Immunological Reviews · doi:10.1111/imr.13317 · Cited by 39

Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases

Wang, L., Yu, C.-C., Liu, X., Deng, X., Tian, Q., & Du, Y. (2021) · Neural Plasticity · doi:10.1155/2021/9912686 · Cited by 41

Epigenetic basis of Alzheimer disease

Tecalco-Cruz, Á. C., Ramírez‐Jarquín, J. O., Álvarez-Sánchez, M. E., & Zepeda–Cervantes, J. (2020) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v11.i2.62 · Cited by 37

Targeting epigenetics: A novel promise for Alzheimer’s disease treatment

Jeremic, D., Jiménez‐Díaz, L., & Navarro‐López, J. D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102003 · Cited by 36

The Ambiguous Role of Microglia in Aβ Toxicity: Chances for Therapeutic Intervention

Merlo, S., Spampinato, S. F., Caruso, G. I., & Sortino, M. A. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200131105418 · Cited by 35

The serotonin 2B receptor is required in neonatal microglia to limit neuroinflammation and sickness behavior in adulthood

Béchade, C., D’Andrea, I., Etienne, F., Verdonk, F., Moutkine, I., Banas, S. M., Kolodziejczak, M., Diaz, S. L., Parkhurst, C. N., Gan, W., et al. (2020) · Glia · doi:10.1002/glia.23918 · Cited by 37

An overview of microglia ontogeny and maturation in the homeostatic and pathological brain

Mendes, M. S., & Majewska, A. K. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15225 · Cited by 35

Normalizing HDAC2 Levels in the Spinal Cord Alleviates Thermal and Mechanical Hyperalgesia After Peripheral Nerve Injury and Promotes GAD65 and KCC2 Expression

Ouyang, B., Chen, D., Hou, X., Wang, T., Wang, J., Zou, W., Song, Z., Huang, C., Guo, Q., & Weng, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00346 · Cited by 33

Unique microglia expression profile in developing white matter

Staszewski, O., & Hagemeyer, N. (2019) · BMC Research Notes · doi:10.1186/s13104-019-4410-1 · Cited by 33

Epigenetics and Communication Mechanisms in Microglia Activation with a View on Technological Approaches

Petralla, S., Chirico, F. D., Miti, A., Tartagni, O., Massenzio, F., Poeta, E., Virgili, M., Zuccheri, G., & Monti, B. (2021) · Biomolecules · doi:10.3390/biom11020306 · Cited by 37

Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation

Baek, S. Y., Lee, J., Kim, T., Lee, H., Choi, H., Park, H., Koh, M., Kim, E., Jung, M. E., Iliopoulos, D., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115312 · Cited by 32

Rusty Microglia: Trainers of Innate Immunity in Alzheimer's Disease

Sfera, A., Gradini, R., Cummings, M., Diaz, E. L., Price, A. I., & Osorio, C. P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01062 · Cited by 32

Prophylactic and therapeutic insights into trained immunity: A renewed concept of innate immune memory

Bindu, S., Dandapat, S., Manikandan, R., Dinesh, M., Anbazhagan, S., Pashupathi, M., Dhawan, M. K., Tiwari, R., Bilal, M., Emran, T. B., et al. (2022) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2022.2040238 · Cited by 32

Zingiberene, a non-zinc-binding class I HDAC inhibitor: A novel strategy for the management of neuropathic pain

Borgonetti, V., Governa, P., Manetti, F., & Galeotti, N. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154670 · Cited by 30

Nano‐Plumber Reshapes Glymphatic‐Lymphatic System to Sustain Microenvironment Homeostasis and Improve Long‐Term Prognosis after Traumatic Brain Injury

Tong, S., Xie, L., Xie, X., Xu, J., You, Y., Sun, Y., Zhou, S., Ma, C., Jiang, G., Ma, F., et al. (2023) · Advanced Science · doi:10.1002/advs.202304284 · Cited by 29

Gut Microbiota Mediates Neuroinflammation in Alzheimer’s Disease: Unraveling Key Factors and Mechanistic Insights

Junyi, L., Yueyang, W., Liu, B., Xiaohong, D., Wenhui, C., Zhang, N., & Zhang, H. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04513-w · Cited by 32

Histone deacetylase in neuropathology

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.09.004 · Cited by 28

Regulation of Central Nervous System Development by Class I Histone Deacetylases

D’Mello, S. R. (2019) · Developmental Neuroscience · doi:10.1159/000505535 · Cited by 28

A dynamic and multimodal framework to define microglial states

Sankowski, R., & Prinz, M. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01978-3 · Cited by 31

Metabolic regulation of immune memory and function of microglia

Nirakis, N., Dimothyra, S., Karadima, E., & Alexaki, V. I. (2025) · eLife · doi:10.7554/elife.107552 · Cited by 26

Histone deacetylases 1, 2 and 3 in nervous system development

D’Mello, S. R. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.11.007 · Cited by 27

HDACs in the Brain: From Chromatin Remodeling to Neurodegenerative Disease

Diniz, L. P., Pinheiro, P. D. S. M., Franco, L. S., & Gomes, F. C. A. (2025) · Cells · doi:10.3390/cells14171338 · Cited by 28

Transcriptional and epigenetic regulation of microglia in maintenance of brain homeostasis and neurodegeneration

Maurya, S. K., Gupta, S., & Mishra, R. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1072046 · Cited by 26

Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment

Schwabenland, M., Mossad, O., Sievert, A., Peres, A. G., Ringel, E., Baasch, S., Kolter, J., Cascone, G., Dokalis, N., Vlachos, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38373-0 · Cited by 26

The Two Faces of HDAC3: Neuroinflammation in Disease and Neuroprotection in Recovery

Rosete, C., & Ciernia, A. V. (2024) · Epigenomics · doi:10.1080/17501911.2024.2419357 · Cited by 24

Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain

Miao, J., Chen, Z., Wu, Y. Z., Hu, Q., & Ji, T. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00440 · Cited by 24

Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy

Sun, P., Zhang, S., Maksim, S., Yao, Y., Liu, H., & Du, J. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190619143706 · Cited by 24

Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications

Qin, Y., Yang, P. C., He, W., Li, D., Zeng, L., Li, J., Zhou, T., Peng, J., Cao, L., & Huang, W. G. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01650-w · Cited by 26

Histone deacetylase‑2: A potential regulator and therapeutic target in liver disease (Review)

Liu, Y.-R., Wang, J., Huang, Z., Chen, R.-N., Cao, X., Zhu, D., Yu, H., Wang, X., Zhou, H.-Y., Xia, Q., et al. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4964 · Cited by 23

A Developmental Switch in Microglial HDAC Function

Mathys, H., Penney, J., & Tsai, L. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.010 · Cited by 8

Die Histondeacetylasen 1 und 2 und das Mikrobiom beeinflussen die Epigenetik der Mikroglia im Verlauf ihrer Entwicklung und der Neurodegeneration

Frosch, M. (n.d.)

Ablation of Hdac1 and 2 in Microglia ameliorates Alzheimer’s disease progression

Staszewski, O., Datta, M., & Prinz, M. (2016) · German Medical Science (German Research Foundation) · doi:10.3205/16dgnn19

HDAC3 controls homeostasis of retina-resident microglia derived from embryonic precursors

Mi, X., Yao, Y., Liu, Q., Kumar, A., Gao, H., Zhou, L., & Mi, Q. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.198.supp.62.13

Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease

Casali, B. T., & Reed-Geaghan, E. G. (2021) · Cells · doi:10.3390/cells10040957 · Cited by 70