Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745

The Immune Landscape of Cancer

Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1027 · Cited by 5,294

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., & Trajanoski, Z. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.019 · Cited by 5,041

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576

Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential

Han, Q., Wang, M., Dong, X., Wei, F., Luo, Y., & Sun, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.985815 · Cited by 31

Autoreactive T-Cells in Psoriasis: Are They Spoiled Tregs and Can Therapies Restore Their Functions?

Pietraforte, I., & Frasca, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054348 · Cited by 30

Unveiling the role of regulatory T cells in the tumor microenvironment of pancreatic cancer through single-cell transcriptomics and in vitro experiments

Xu, W., Zhang, W., Zhao, D., Wang, Q., Zhang, M., Li, Q., Zhu, W., & Xu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1242909 · Cited by 31

Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma

Spasevska, I., Sharma, A., Steen, C. B., Josefsson, S. E., Blaker, Y. N., Kolstad, A., Rustad, E. H., Meyer, S., Isaksen, K. T., Chellappa, S., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2023010158 · Cited by 33

N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma

Xu, W., Zhou, B., Wang, P., Ma, Y., Yu, J., Mo, D., Wu, J., Ma, J., Wang, X., Miao, Y., et al. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101197 · Cited by 30

CCR8 + decidual regulatory T cells maintain maternal-fetal immune tolerance during early pregnancy

Li, Z., Si, P., Meng, T., Zhao, X., Zhu, C., Zhang, D., Meng, S., Li, N., Liu, R., Ni, T., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.ado2463 · Cited by 35

Lung Cancer Survival in Patients With Autoimmune Disease

Jacob, S. L., Rahbari, K. J., Tegtmeyer, K., Zhao, J. W., Tran, S., Helenowski, I., Zhang, H., Walunas, T. L., Varga, J., Dematte, J. E., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.29917 · Cited by 30

Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-α non-selective blockers

Degen, A., Krynytska, І., & Kamyshnyi, O. (2020) · Endocrine Regulations · doi:10.2478/enr-2020-0019 · Cited by 29

T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38

Wang, H., Fang, K., Yan, W., & Chang, X. (2021) · Journal of Innate Immunity · doi:10.1159/000516642 · Cited by 29

The tumor immune microenvironments of HPV + and HPV − head and neck cancers

Gameiro, S. F., Evans, A. M., & Mymryk, J. S. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1539 · Cited by 32

MiR-146a regulates regulatory T cells to suppress heart transplant rejection in mice

Lu, J., Wang, W., Li, P., Wang, X., Gao, C., Zhang, B., Du, X., Liu, Y., Yang, Y., & Qi, F. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00534-9 · Cited by 28

Fragile Treg cells: Traitors in immune homeostasis?

Song, X., Chen, R., Li, J., Zhu, Y., Jiao, J., Liu, H., Chen, Z., & Geng, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107297 · Cited by 29

Type 1 diabetes linked PTPN22 gene polymorphism is associated with the frequency of circulating regulatory T cells

Valta, M., Gazali, A. M., Viisanen, T., Ihantola, E., Ekman, I., Toppari, J., Knip, M., Veijola, R., Ilonen, J., Lempainen, J., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201948378 · Cited by 34

Evaluation of immune‑biomarker expression in high‑grade soft‑tissue sarcoma: HLA‑DQA1 expression as a prognostic marker

Bae, J. Y., Choi, K. U., Kim, A., Lee, S. J., Kim, K., Kim, J. Y., Lee, I. S., Chung, S. H., & Kim, J. I. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9225 · Cited by 28

Single-Cell Sequencing Reveals the Transcriptome and TCR Characteristics of pTregs and in vitro Expanded iTregs

Hui, Z., Zhang, J., Zheng, Y., Yang, L., Yu, W., An, Y., Wei, F., & Ren, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.619932 · Cited by 28

Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities

Serr, I., Drost, F., Schubert, B., & Daniel, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.712870 · Cited by 31

SUMOylation Pattern Predicts Prognosis and Indicates Tumor Microenvironment Infiltration Characterization in Bladder Cancer

Xia, Q., Sun, J., Xun, Y., Xiao, J., Liu, C., Xu, J., An, Y., Xu, M., Liu, Z., Wang, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864156 · Cited by 28

Impact of disease-modifying therapy on dendritic cells and exploring their immunotherapeutic potential in multiple sclerosis

Liu, C., Zhu, J., Mi, Y., & Jin, T. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02663-z · Cited by 29

Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing

Chen, Y., Yin, J., Zhao, L., Zhou, G., Dong, S., Zhang, Y., Niu, P., Ren, H., Zheng, T., Yan, J., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03792-y · Cited by 29

Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients

Hoffmann, A. D., Weinberg, S. E., Swaminathan, S., Chaudhuri, S. M., Almubarak, H. F., Schipma, M. J., Mao, C., Wang, X., El-Shennawy, L., Dashzeveg, N. K., et al. (2022) · Clinical Immunology · doi:10.1016/j.clim.2023.109634 · Cited by 30

ZFP91 is required for the maintenance of regulatory T cell homeostasis and function

Wang, A., Ding, L., Wu, Z., Ding, R., Teng, X.-L., Wang, F., Hu, Z., Chen, L., Yu, X., & Zou, Q. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201217 · Cited by 28

Monocarboxylate transporter upregulation in induced regulatory T cells promotes resistance to anti-PD-1 therapy in hepatocellular carcinoma patients

Zhou, J., Shao, Q., Lu, Y., Li, Y., Xu, Z., Zhou, B., Chen, Q., Li, X., Xu, X., Pan, Y., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.960066 · Cited by 27

Selective Depletion of CCR8+Treg Cells Enhances the Antitumor Immunity of Cytotoxic T Cells in Lung Cancer by Dendritic Cells

Chen, P., Wang, H., Tang, Z., Shi, J., Cheng, L., Zhao, C., Li, X., & Zhou, C. (2025) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2025.02.029 · Cited by 32

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

Li, Y., Liu, Q., Jing, X., Wang, Y., Jia, X., Yang, X., & Chen, K. (2025) · MedComm · doi:10.1002/mco2.70292 · Cited by 32

DAPT reverses the Th17/Treg imbalance in experimental autoimmune uveitis in vitro via inhibiting Notch signaling pathway

Yin, X., Wei, H., Wu, S., Wang, Z., Liu, B., Guo, L., Bi, H., & Guo, D. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106107 · Cited by 27

Application of double-negative T cells in haematological malignancies: recent progress and future directions

Chen, X., Wang, D., & Zhu, X. (2022) · Biomarker Research · doi:10.1186/s40364-022-00360-w · Cited by 27

The dual role of regulatory T cells in hepatitis B virus infection and related hepatocellular carcinoma

He, J., Miao, R., Yao, C., Wang, H., & Liu, M. (2023) · Immunology · doi:10.1111/imm.13738 · Cited by 30

Lactate acid promotes PD-1+ Tregs accumulation in the bone marrow with high tumor burden of Acute myeloid leukemia

Zhang, Y., Huang, Y., Hong, Y., Lin, Z., Zha, J., Zhu, Y., Li, Z., Wang, C., Fang, Z., Zhou, Z., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111765 · Cited by 30

Characteristics and reference ranges of CD4+T cell subpopulations among healthy adult Han Chinese in Shanxi Province, North China

Niu, H.-Q., Zhao, X., Li, W., Xie, J.-F., Liu, X., Luo, J., Zhao, W., & Li, X. (2020) · BMC Immunology · doi:10.1186/s12865-020-00374-9 · Cited by 26

Prognostic impact of regulatory T cell in head and neck squamous cell carcinoma: A systematic review and meta-analysis

Cho, J. H., & Lim, Y. C. (2021) · Oral Oncology · doi:10.1016/j.oraloncology.2020.105084 · Cited by 27

Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model

Huaux, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.690375 · Cited by 26

Improved Tumor Infiltration and Immunomodulation for Tumor Therapy: A Pathway Based on Tetrahedral Framework Nucleic Acids Coupled Bacterial Nanocells

Zhan, Y., Zhang, Y., Mao, C., Li, J., Zhao, Y., Chen, Y., Liu, Z., & Lin, Y. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c03943 · Cited by 26

A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients

Søndergaard, J. N., Tulyeu, J., Edahiro, R., Shirai, Y., Yamaguchi, Y., Murakami, T., Morita, T., Kato, Y., Hirata, H., Takeda, Y., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217902120 · Cited by 24

Role of heterogeneous regulatory T cells in the tumor microenvironment

Wei, T., Zhong, W., & Li, Q. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104659 · Cited by 26

The role of the adaptive immune system in the initiation and persistence of multiple sclerosis

Afzali, A. M., & Korn, T. (2025) · Seminars in Immunology · doi:10.1016/j.smim.2025.101947 · Cited by 25

Immunomodulation of Myocardial Fibrosis

Sikking, M. A., Stroeks, S. L. V. M., Marelli‐Berg, F. M., Heymans, S. R. B., Ludewig, B., & Verdonschot, J. A. J. (2023) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2023.03.015 · Cited by 28

Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism

Qin, T., Jiang, T., Zhou, Z., Wu, M., Zhang, Y., Yang, Z., Zheng, Z., Jiang, Y., Wang, X., Luo, M., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.09.001 · Cited by 26

Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer

Andric, F., Al-Fairouzi, A., Wettergren, Y., Szeponik, L., Lindskog, E. B., Cusack, J. C., Tumusiime, G., Quiding‐Järbrink, M., & Ljungman, D. (2023) · Cancers · doi:10.3390/cancers15051457 · Cited by 25

Distinct PLZF+CD8αα+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity

Sheng, H., Marrero, I., Maricic, I., Fanchiang, S. S., Zhang, S., Sant’Angelo, D. B., & Kumar, V. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900832 · Cited by 26

Epstein–Barr Virus Reactivation-Induced Immunoglobulin Production: Significance on Autoimmunity

Nagata, K., & Hayashi, K. (2020) · Microorganisms · doi:10.3390/microorganisms8121875 · Cited by 25

Applications of pyroptosis activators in tumor immunotherapy

Bao, X., Sun, M., Meng, L., Zhang, H., Yi, X., & Zhang, P. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101191 · Cited by 24

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy

Jamison, B. L., Lawrance, M. F., Wang, C. J., DeBerg, H. A., Ziegler, L., Sansom, D. M., Gavin, M. A., Walker, L. S. K., & Campbell, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114938 · Cited by 24

Current landscape of the immunoproteasome: implications for disease and therapy

Zou, Z., Hao, Y., Tao, Z., Ye, W., Luo, Z., Li, X., Li, R., Zheng, K., Xia, J., Guo, C., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02698-0 · Cited by 31

An open-space microfluidic chip with fluid walls for online detection of VEGF via rolling circle amplification

Feng, S., Mao, S., Dou, J., Li, W., Li, H., & Lin, J. (2019) · Chemical Science · doi:10.1039/c9sc02974e · Cited by 25

The functions of EZH2 in immune cells: Principles for novel immunotherapies

Shao, F.-F., Chen, B.-J., & Wu, G. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ru0520-311r · Cited by 23

TIGIT+ A2Ar-Dependent anti-uveitic Treg cells are a novel subset of Tregs associated with resolution of autoimmune uveitis

Muhammad, F., Wang, D., McDonald, T., Walsh, M., Drenen, K., Montieth, A., Foster, C. S., & Lee, D. J. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102441 · Cited by 24

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Zhu, S., Zhang, X., Liu, W., Zhou, Z. G., Xiong, S., Li, J., Chen, X., & Peng, C. (2025) · 癌症：英文版 · doi:10.1002/cac2.70044 · Cited by 25

Galunisertib Drives Treg Fragility and Promotes Dendritic Cell-Mediated Immunity against Experimental Lymphoma

Hira, S. K., Rej, A., Paladhi, A., Singh, R. K., Saha, J., Mondal, I., Bhattacharyya, S., & Manna, P. P. (2020) · iScience · doi:10.1016/j.isci.2020.101623 · Cited by 23

The role and research progress of the balance and interaction between regulatory T cells and other immune cells in obesity with insulin resistance

Liu, L., Hu, J., Wang, Y., Lei, H. C., & Xu, D. (2021) · Adipocyte · doi:10.1080/21623945.2021.1876375 · Cited by 26

Characteristics of T‐cell responses in COVID‐19 patients with prolonged SARS‐CoV‐2 positivity – a cohort study

Yang, J., Zhong, M., Hong, K., Yang, Q., Zhang, E., Zhou, D., Xia, J., Chen, Y., Sun, M., Zhao, B., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1259 · Cited by 24

Tissue Nutrient Environments and Their Effect on Regulatory T Cell Biology

Blagih, J., Hennequart, M., & Zani, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.637960 · Cited by 25

Tertiary lymphoid structure patterns aid in identification of tumor microenvironment infiltration and selection of therapeutic agents in bladder cancer

An, Y., Sun, J., Xu, M., Xu, J., Ma, S.-Y., Liu, C., Liu, Z., Wang, S., & Xia, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1049884 · Cited by 24

Cell and biomaterial delivery strategies to induce immune tolerance

Scotland, B. L., Shaw, J. R., Dharmaraj, S., Caprio, N., Cottingham, A. L., Lasola, J. J., Sung, J. J., & Pearson, R. M. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115141 · Cited by 26

Short-term cold exposure supports human Treg induction in vivo

Becker, M., Serr, I., Salb, V. K., Ott, V. B., Mengel, L. A., Blüher, M., Weigmann, B., Hauner, H., Tschöp, M. H., & Daniel, C. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.002 · Cited by 24

Role of CD4+ T cells in cancer immunity: a single-cell sequencing exploration of tumor microenvironment

An, Q., Duan, L., Wang, Y., Wang, F., Liu, X., Liu, C., & Hu, Q. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06167-1 · Cited by 28

Regulatory T cells and their role in inflammatory bowel disease: molecular targets, therapeutic strategies and translational advances

Lee, C., Park, Y. W., Park, M. H., Lee, Y. J., & Rhee, I. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117087 · Cited by 22

Glucose Metabolism Reprogramming of Regulatory T Cells in Concanavalin A-Induced Hepatitis

Huang, C., Shen, Y., Shen, M., Fan, X., Men, R., Ye, T., & Yang, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.726128 · Cited by 22

Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation

Louis, K., Fadakar, P. K., Macedo, C., Yamada, M., Lucas, M., Gu, X., Zeevi, A., Randhawa, P. S., Lefaucheur, C., & Metes, D. (2022) · Kidney International · doi:10.1016/j.kint.2021.12.027 · Cited by 22

First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors

Cole, C. B., Morelli, M. P., Fantini, M. C., Miettinen, M., Fetsch, P. A., Peer, C. J., Figg, W. D., Yin, T., Houston, N. D., McCoy, A., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02649-6 · Cited by 22

Expansion of CD4+ cytotoxic T lymphocytes with specific gene expression patterns may contribute to suppression of tumor immunity in oral squamous cell carcinoma: single-cell analysis and in vitro experiments

Hu, C., Sameshima, J., Yokomizo, S., Sueyoshi, T., Nagano, H., Miyahara, Y., Sakamoto, T., Fujii, S., Kiyoshima, T., Guy, T. V., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1305783 · Cited by 23

TNFR2-expressing CD4+Foxp3+ regulatory T cells in cancer immunology and immunotherapy

He, J., Li, R., Chen, Y., Yuanjia, H., & Chen, X. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.03.010 · Cited by 22

Combined Anti-Cancer Strategies Based on Anti-Checkpoint Inhibitor Antibodies

Golay, J., & Andrea, A. E. (2020) · Antibodies · doi:10.3390/antib9020017 · Cited by 24

Autoimmune Responses in Oncology: Causes and Significance

Bareke, H., Juanes‐Velasco, P., Landeira‐Viñuela, A., Hernández, Á., Cruz, J. J., Bellido, L., Fonseca, E., Cárdenas, A. N., Montalvillo, E., Góngora, R., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158030 · Cited by 24

Treatment strategies and molecular mechanism of radiotherapy combined with immunotherapy in colorectal cancer

Jin, Y., Jiang, J. F., Mao, W. B., Bai, M., Chen, Q., & Zhu, J. Y. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216858 · Cited by 24

Unraveling Th subsets: insights into their role in immune checkpoint inhibitor therapy

Ryba-Stanisławowska, M. E. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00992-0 · Cited by 23

Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality

Bakker, N. A. M., Garner, H., van Dyk, E., Champanhet, E., Klaver, C., Duijst, M., Voorwerk, L., Nederlof, I., Voorthuis, R. A. B., Liefaard, M. C., et al. (2025) · npj Breast Cancer · doi:10.1038/s41523-025-00721-2 · Cited by 27

AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

An, J., Ding, Y., Yu, C., Li, J., You, S., Liu, Z., Song, P., & Zou, M. (2021) · iScience · doi:10.1016/j.isci.2021.103570 · Cited by 21

Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients

Hynne, H., Aqrawi, L. A., Jensen, J. L., Thiede, B., Palm, Ø., Amdal, C. D., Westgaard, K. L., Herlofson, B. B., Utheim, T. P., & Galtung, H. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073714 · Cited by 22

CD4+CD25+ T regulatory cells in renal transplantation

Cheung, J., Zahorowska, B., SURANYI, M. G., Wong, J. K. W., Diep, J., Spicer, S. T., Verma, N. D., Hodgkinson, S. J., & Hall, B. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1017683 · Cited by 21

The prognostic values of FOXP3+ tumor-infiltrating T cells in breast cancer: a systematic review and meta-analysis

Sun, Y., Wang, Y., Lu, F. Y., Zhao, X., Nie, Z., & He, B. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03080-1 · Cited by 21

Biomaterial-enabled therapeutic modulation of cGAS-STING signaling for enhancing antitumor immunity

Liu, Y., Yang, F., Wang, X., Yang, B., Li, M., & Luo, Z. Y. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.03.026 · Cited by 24

Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling

Mendu, S. K., Stremska, M. E., Schappe, M. S., Moser, E. K., Krupa, J. K., Rogers, J. S., Stipes, E. J., Parker, C. A., Braciale, T. J., Perry, J. S. A., et al. (2020) · Science Signaling · doi:10.1126/scisignal.abb0619 · Cited by 22

The Role of Regulatory T Cells in Allergic Diseases: Collegium Internationale Allergologicum (CIA) Update 2024

Martín‐Cruz, L., Benito‐Villalvilla, C., Sirvent, S., Angelina, A., & Palomares, Ó. (2024) · International Archives of Allergy and Immunology · doi:10.1159/000536335 · Cited by 21

Immunosuppressive JAG2 + tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

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The impact of ICOS+ regulatory T cells and Helicobacter pylori infection on the prognosis of patients with gastric and colorectal cancer: potential prognostic benefit of pre-operative eradication therapy

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