Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745

The Immune Landscape of Cancer

Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1027 · Cited by 5,294

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., & Trajanoski, Z. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.019 · Cited by 5,041

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576

CCL5: An emerging key target and progress in the targeted therapy of hepatocellular carcinoma

Liu, X., Liang, J., Zhao, L., Li, W., Wang, L., Wang, X., Liu, Y., Zhou, M., Li, X., Jia, Z., et al. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.08.023 · Cited by 4

Targeting regulatory T cells for cancer immunotherapy: promises and pitfalls

Mirallas, O., Pretelli, G., Pena, M. B., Jiménez-Labaig, P., Hernando-Calvo, A., Tan, H. N., Selvadurai, P. N., de Lara, P. T., Vieito, M., Martín-Liberal, J., et al. (2026) · Annals of Oncology · doi:10.1016/j.annonc.2026.04.015 · Cited by 5

Longitudinal monitoring of circulating immune cell phenotypes in anti-neutrophil cytoplasmic antibody-associated vasculitis

Matsumoto, K., Suzuki, K., Yasuoka, H., Hirahashi, J., Yoshida, H., Magi, M., Noguchi‐Sasaki, M., Kaneko, Y., & Takeuchi, T. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103271 · Cited by 4

Modeling the Development of Cellular Exhaustion and Tumor-Immune Stalemate

Simmons, T., & Levy, D. (2023) · Bulletin of Mathematical Biology · doi:10.1007/s11538-023-01207-7 · Cited by 4

Biological insights into the role of TET2 in T cell lymphomas

Carty, S. A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1199108 · Cited by 4

Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD

Kim, W. D., & Sin, D. D. (2024) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412555.2023.2299104 · Cited by 4

Mannosylated Fluoropolypeptide Nanovaccines Remodeling Tumor Immunosuppressive Microenvironment to Achieve Highly Potent Cancer Immunotherapy

He, M., Xu, W., Dan, Y., Pan, Y., Li, Y., Chen, M.-S., & Dong, C. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401354 · Cited by 4

FOXP3/TLS; a prognostic marker in patients with bladder carcinoma without muscle invasion

Balçık, O. Y., & Yılmaz, F. (2024) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.11.017 · Cited by 4

The Progress of Immune Cells-induced Inflammatory Response in Gout

Liu, J., Liu, G., Chu, T., Wu, Y., Yang, L. Z., & Fang, W. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128369016250306050522 · Cited by 4

Humanized NOD/SCID/IL2rγnull mice exhibit functionally augmented human regulatory T cells associated with enzymatic up-regulation of H3K27me3 in comparison with humans

Takahashi, H., Tsuboi, H., Abe, S., Honda, F., Kondo, Y., Matsumoto, I., & Sumida, T. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13583 · Cited by 4

Sirtuins in hematopoiesis and blood malignancies

Vázquez, B. N., Fernández-Duran, I., & Vaquero, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00020-3 · Cited by 3

Multiplex immunohistochemistry and high-throughput image analysis for evaluation of spatial tumor immune cell markers in human breast cancer

Su, T., Wang, S., Huang, S., Cai, H., McKinley, E. T., Beeghly-Fadiel, A. C., Zheng, W., Shu, X., & Cai, Q. (2022) · Cancer Biomarkers · doi:10.3233/cbm-220071 · Cited by 4

Establishing the applicability of cancer vaccines in combination with chemotherapeutic entities: current aspect and achievable prospects

Kothari, N. R., Postwala, H. I., Pandya, A. J., Shah, A. C., Shah, Y. B., & Chorawala, M. R. (2023) · Medical Oncology · doi:10.1007/s12032-023-02003-y · Cited by 4

CD73 mediates the therapeutic effects of endometrial regenerative cells in concanavalin A-induced hepatitis by regulating CD4+ T cells

Qin, H., Sun, C., Kong, D., Zhu, Y., Shao, B., Ren, S., Wang, H., Zhang, J., Xu, Y., & Wang, H. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03505-2 · Cited by 4

Meta‐analysis of FOXP3 polymorphisms and recurrent spontaneous abortion susceptibility

Shuai, R., Li, D., Xu, X., Yang, X., & Liu, D. (2024) · American Journal of Reproductive Immunology · doi:10.1111/aji.13827 · Cited by 4

Nobel Prize for immune checkpoint inhibitors, understanding the immunological switching between immunosuppression and autoimmunity

Motofei, I. G. (2021) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2020243 · Cited by 5

Emerging Nanotechnology in Preclinical Pancreatic Cancer Immunotherapy: Driving Towards Clinical Applications

Pan, X., han, T., Zhao, Z., Wang, X. M., & Fang, X. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s466459 · Cited by 4

Shengqiyichang decoction regulates antitumor immunity in colorectal cancer by downregulating lymphocyte antigen 6 family member G6D via the protein kinase B/p38 mitogen-activated protein kinase signaling pathway

Luo, R. X., Li, H. L., Jia, Y. X., Gao, M., Gao, Z. Y., Ji, Y., Deng, S., Huo, J. G., Zhang, J., & Zhang, D. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39071 · Cited by 3

Yerba Mate (Ilex paraguariensis) Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Regulatory T Cell Function

Herrada, A. A., Rodríguez-Arriaza, F., Olate‐Briones, A., Albornoz-Muñoz, S., Faúndez-Acuña, J. Y., Rojas‐Henríquez, V., Retamal-Quinteros, L., Prado, C. E., & Escobedo, N. (2025) · Nutrients · doi:10.3390/nu17050897 · Cited by 3

Distinct T Cell Dysregulation Reflects Disease Severity and Progression in Infantile Epileptic Spasms Syndrome and Lennox-Gastaut Syndrome

Chang, L., Jeong, Y.-J., Chang, H., Sang, H. D., Kwon, K.-N., Lee, S.-B., Kim, S.-Y., Kang, Y. M., Ha, S., Kim, S. H., et al. (2025) · Immune Network · doi:10.4110/in.2025.25.e28 · Cited by 3

APE1 mediates chemoresistance in esophageal squamous cell carcinoma by remodeling the immunosuppressive microenvironment

Gao, H., Rao, J., Xiao, H., Kuang, X., Wang, Y., Yao, Y., Yang, Y., Li, M., Liao, X., & Wang, D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1689468 · Cited by 3

Advances in the application of PD-1/PD-L1 immunotherapy for prostate cancer: a review

Hu, G., Li, Z., Chen, Y., Liao, H., & Zhou, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1664587 · Cited by 3

Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

Yang, N., Yuan, H., Wang, W., Liu, X., Liu, C., Yao, Y., Li, Y., Gao, Y., Lin, X., Wang, M., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117230 · Cited by 3

CD4+CD25highCD226low/– cells: An innovative approach to identify human regulatory T cells

Liu, Y., Qi, G., Wang, J., Huang, F., Bellanti, J. A., & Zheng, S. G. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.06.029 · Cited by 3

Targeting Tumor Microenvironment-associated Immune Cells with Nanoparticles-based Strategies

Alotaibi, N. (2021) · Pharmacophore · doi:10.51847/pj1xcwaw3u · Cited by 3

Deciphering the factors determining the differentiation of autoreactive thymocytes into regulatory T cells

Benito‐Villalvilla, C., Angelina, A., & Martín‐Cruz, L. (2023) · Allergy · doi:10.1111/all.15993 · Cited by 3

Chimeric Antigen Receptor‐T (CAR‐T) Cells as “Living Drugs”: A Clinical Pharmacist Perspective

Murnane, C., Gardiner, N., Crehan, O., Bacon, C. L., McHugh, R., Gilmer, J. F., Mantalaris, A., & Panoskaltsis, N. (2024) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1155/2024/2239888 · Cited by 3

Chinese Medicines and Natural Medicine as Immunotherapeutic Agents for Gastric Cancer: Recent Advances

Zhang, Z., Chen, Z., Que, Z., Fang, Z., Zhu, H., & Tian, J. (2024) · Cancer Reports · doi:10.1002/cnr2.2134 · Cited by 4

OSU-T315 overcomes immunosuppression in triple-negative breast cancer by targeting the ILK/NF-κB signaling pathway to enhance immunotherapeutic efficacy

Wang, Y., Qin, Y., Wu, C., Chen, J., Zhang, Y., Chen, Y., Xie, X., Gao, X., Sun, C., & Liu, S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113530 · Cited by 3

Peripheral lymphocyte phenotypic characteristics in healthy populations across the lifespan, from infancy to older adults

Wang, T., Chen, R., Ouyang, R., Wang, Y., Wei, W., Wang, F. Y., Wu, S., & Hou, H. (2025) · Laboratory Medicine · doi:10.1093/labmed/lmae117 · Cited by 3

Isolation and Characterization of Both Human and Mouse Tfh/Tfr Cells

Tulyeu, J., Søndergaard, J. N., Sakaguchi, S., & Wing, J. B. (2021) · Current Protocols · doi:10.1002/cpz1.283 · Cited by 3

Distribution and chemotactic mechanism of CD4+ T cells in traumatic tracheal stenosis

Feng, T., Chen, Y., Wei, J., Tan, S., & Guangnan, L. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.916 · Cited by 3

Hematopoietic cell-based and non-hematopoietic cell-based strategies for immune tolerance induction in living-donor renal transplantation: A systematic review

Annamalai, C., Kute, V. B., Sheridan, C., & Halawa, A. M. (2023) · Transplantation Reviews · doi:10.1016/j.trre.2023.100792 · Cited by 3

PHLDA2 reshapes the immune microenvironment and induces drug resistance in hepatocellular carcinoma

Feng, K., PENG, H., Lv, Q., & ZHANG, Y. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.047078 · Cited by 3

Function of NEK2 in clear cell renal cell carcinoma and its effect on the tumor microenvironment

Tang, P., Zheng, G., Xu, C., Yu, N., Du, J., Hu, L., Zhou, Z. M., & Zheng, Y. (2024) · Medicine · doi:10.1097/md.0000000000037939 · Cited by 3

Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity

Lepore, M. T., Bruzzaniti, S., Rocca, C. L., Fusco, C., Carbone, F., Mottola, M., Zuccarelli, B., Lanzillo, R., Morra, V. B., Maniscalco, G. T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-68098-z · Cited by 3

FOXP3+ Tregs exhibit different infiltrating status and predict a distinct prognosis in primary lesions and hepatic metastases in stage III&IV advanced gastric cancer.

Liu, X., Guo, Y., Huang, C., Xu, D., Zhu, C., Xu, J., Zhang, Z., Shen, Y., Zhao, W., & Zhao, G. (2020) · PubMed Central · Cited by 3

New insights on the monitoring of solid-organ allografts based on immune cell signatures

Mardomi, A., Naderi, S. B., Vahed, S. Z., & Ardalan, M. (2021) · Transplant Immunology · doi:10.1016/j.trim.2021.101509 · Cited by 3

For antigen-specific effector or Foxp3+ regulatory T cell fate, cyclin-dependent kinases hold the trump card

Bonam, S. R., & Bayry, J. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0349-3 · Cited by 3

Bystander CD4 + T cells infiltrate human tumors and are phenotypically distinctPreprint

Simoni, Y., Li, S., Zhuang, S., Heit, A., Koo, S., Chow, I., Kwok, W. W., Tan, I. B., Tan, D. S. W., & Newell, E. W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.15.204172 · Cited by 3

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and gatekeeper featuresPreprint

Raeber, M. E., Caspar, D., Zurbuchen, Y., Guo, N., Schmid, J., Michler, J., Steiner, U. C., Moor, A. E., Koning, F., & Boyman, O. (2022) · medRxiv · doi:10.1101/2022.11.15.22282201 · Cited by 3

The double-edged sword of regulatory T cells in MASLD: from inflammation control to fibrosis promotion

Lee, S. E., Jo, M. G., Park, S. W., Kim, H. J., Yun, S. P., & Kim, J.-W. (2026) · Animal Cells and Systems · doi:10.1080/19768354.2026.2630463 · Cited by 2

Expanded Antigen-Specific Donor Regulatory T Cells for Gvhd Prevention

Pidala, J. A., Cieri, N., Schell, M. J., Song, X., Shao, Y., Cao, B., Du, D., Thapa, R., Betts, B. C., Janssen, W., et al. (2024) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2023.12.056 · Cited by 2

Dexamethasone-loaded fibroin nanoparticles promote retinal reattachment in rats by regulating the Th17/Treg balance

Han, L., Li, X., Ke, G., Dong, K., Wang, G., Sheng, Y., & Tao, L. (2024) · Nanotechnology · doi:10.1088/1361-6528/ad9df2 · Cited by 2

A causal link between circulating immune cells and erectile dysfunction: Two-sample bidirectional Mendelian randomization study

Wu, G., Wang, J., Zhu, W., Liu, H., Ding, W., Liu, Y., Wang, Z., & Tao, L. (2024) · Medicine · doi:10.1097/md.0000000000041124 · Cited by 2

Efficacy and safety of low-molecular-weight heparin or rivaroxaban combined with immunotherapy and chemotherapy in the treatment of advanced nonsmall cell lung cancer: a prospective, randomized, controlled clinical study

Zhang, H., Li, J., Yuan, G., Huang, S., & Li, X. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04227-5 · Cited by 2

LAG-3 at the crossroads: A context-dependent regulator of Tregs and autoimmunity inflammatory disorders

Yu, Z., Tang, X., Shi, Y., & Gong, Y. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124359 · Cited by 2

A stage-based framework to interpret regulatory T cell biology after heart transplantation

Wang, Y., Ni, M., Zheng, A., Peng, Y., Liu, J., Xiong, Q., Wang, X., Savković, V., & Kang, S. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1777360 · Cited by 2

In vivo engineering of immunosuppressive T cells to treat ocular autoimmune diseases

Wang, D., Ling, J., Liang, J.-J., Li, J. W., Hu, Q., Yang, L., Jin, J., Bai, X., Zheng, Y., Lin, B., et al. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111041 · Cited by 2

cGAS-STING Signalling in the tumour microenvironment: Implications for immune surveillance and therapeutic strategies

Al-Adayleh, T. Y. M., Ahmad, W., Rahiman, S. S. F., Murugaiyah, V., Mohamed, R., Afzal, S., Al-Ramamneh, R. S., & Attiq, A. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116832 · Cited by 3

Prognostic significance of immunoscore related markers in bladder cancer

Ariafar, A., Sanati, A., Ahmadvand, S., Shekarkhar, G., Safaei, A., Shayan, Z., & Faghih, Z. (2022) · BMC Urology · doi:10.1186/s12894-022-01085-6 · Cited by 2

Insight into the significance of Foxp3 + tumor-infiltrating lymphocytes in squamous cell lung cancer

Shiomi, K., Ichinoe, M., Ushiwata, A., Eshima, K., Nagashio, R., Hayashi, S., Sonoda, D., Kondo, Y., Maruyama, R., Mikubo, M., et al. (2024) · Clinical & Translational Oncology · doi:10.1007/s12094-024-03392-w · Cited by 2

Identifying cell type-specific transcription factor-mediated activity immune modules reveal implications for immunotherapy and molecular classification of pan-cancer

Li, F., Wang, J., Li, M., Zhang, X., Tang, Y., Song, X., Zhang, Y., Pei, L., Liu, J., Zhang, C., et al. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae368 · Cited by 2

Identification of ENTPD1 as a novel biomarker linking allergic rhinitis and systemic lupus erythematosus

Chen, M., Meng, Y., Shi, X., Zhu, C., Zhu, M., Tang, H., & Zheng, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-69228-3 · Cited by 2

Pan-cancer analysis reveals CCL5/CSF2 as potential predictive biomarkers for immune checkpoint inhibitors

Chen, Y.-C., Zheng, W.-Z., Liu, C., Zhao, Y.-Q., Li, J., Du, Z.-S., Zhai, T., Lin, H., Shi, W., Cai, S.-Q., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03496-x · Cited by 3

Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Activation and Cytokine Production

Oldak, M., Kurowska, W., Plebańczyk, M., Janicka, I., Radzikowska, A., Skalska, U., & Kuca‐Warnawin, E. (2024) · Medical Science Monitor · doi:10.12659/msm.945273 · Cited by 2

Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide

Hong, J., Pan, X., Xiong, Y., Wang, P., Yao, Y., Liu, Y., & Zhang, H. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70026 · Cited by 2

Differential impact of immune-mediated inflammatory diseases before versus after cancer on patient survival: a nationwide cohort study

Deng, G., Guo, Z., Le, J., Sun, Y., Chen, D., Zeng, F., & Shen, M. (2025) · Lara D. Veeken · doi:10.1093/rheumatology/keaf213 · Cited by 2

Identification and validation of prognostic models and tumor microenvironment infiltration characteristics for tRNA modification regulators in clear cell renal cell carcinoma

Zhu, X. C., Shen, C., Zhang, W., Ji, Y., Xu, S., Zheng, B., & Chen, Z. (2025) · Oncology Letters · doi:10.3892/ol.2025.15108 · Cited by 2

Cell Therapy for Type 1 Diabetes Mellitus: a Review of Clinical Trials

Danilevskiĭ, M. I., Захарова, О. В., Skaletskiy, N. N., Basok, Y. B., Roumiantsev, S. A., & Lyundup, A. V. (2025) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-025-06444-5 · Cited by 4

Regulatory T Cell Sub-Populations in Patients with Distinct Autoimmune/Inflammatory Diseases With or Without Inborn Errors of Immunity

Halaçlı, S. O., Inan, D., Esenboğa, S., Bildik, H. N., Bolat, A. B., Tezcan, İ., & Cağdaş, D. N. (2025) · Diagnostics · doi:10.3390/diagnostics15151879 · Cited by 2

Expression of FoxP3 in oral squamous cell carcinoma and its biological significance

Jiang, L., Zhang, Y., Zhu, C., Song, L., Ma, Z., Liu, H., Su, Z., Xia, M., & Li, J. (2025) · Discover Oncology · doi:10.1007/s12672-025-03661-2 · Cited by 2

Mechanisms of action of regulatory lymphocytes and a possibility to use them in the treatment of autoimmune diseases and GvH reactions

Buc, M. (2020) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2020_001 · Cited by 2

Progress of Actinidia chinensis Planch. root extract (acRoots) in cancer immunity

Wang, L., Li, Z., Zhang, M., Shen, Q., & Zhang, X. (2023) · Clinical and Translational Discovery · doi:10.1002/ctd2.171 · Cited by 2

Activated CD4+ T Cell Proportion in the Peripheral Blood Correlates with the Duration of Cytokine Release Syndrome and Predicts Clinical Outcome after Chimeric Antigen Receptor T Cell Therapy

Kitamura, W., Asada, N., Ikegawa, S., Fujiwara, H., Kamoi, C., Ennishi, D., Nishimori, H., Fujii, K., Fujii, N., Matsuoka, K., et al. (2024) · Internal Medicine · doi:10.2169/internalmedicine.2556-23 · Cited by 2

CXCR3 Expression in Regulatory T Cells Drives Interactions With Dendritic Cells in Tumors to Limit CD8 + T Cell Tumor ImmunityPreprint

Ayala, M. A. M., Campbell, T. F., Zhang, C., Dahan, N. E., Danford, A. K., Prakash, V., Feng, L., Sher, T., & DuPage, M. J. P. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4170185 · Cited by 2

Function and Therapeutic Intervention of Regulatory T Cells in Immune Regulation

Liu, Y., Hou, T., & Hao, H. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104914 · Cited by 1

CXCR3 + effector regulatory T cells associate with disease tolerance during lower respiratory pneumovirus infection

Sebina, I., Ngo, S., Rashid, R. B., Alorro, M., Namubiru, P., Howard, D. R., Ahmed, T., & Phipps, S. (2024) · Immunology · doi:10.1111/imm.13790 · Cited by 1

CRISPR/Cas9-mediated RELA and RELC knockout in human regulatory T cells abrogates FOXP3 expression and suppressive function

Sato, Y., Hanawa, Y., & Tsubota, A. (2024) · Clinical Immunology Communications · doi:10.1016/j.clicom.2024.10.002 · Cited by 1

The clinical potential of PDL-1 pathway and some related micro-RNAs as promising diagnostic markers for breast cancer

Al-Sharabass, E. A., El-Houseini, M. E., Effat, H., Ibrahim, S., & Abdellateif, M. S. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01137-1 · Cited by 1

Astilbin ameliorates intracerebral hemorrhage-induced secondary brain injury by upregulating Treg cells in mice

Qin, L., Ji, X., Zhu, S., Zhu, Z., Yang, S., Li, H., Bai, L., Yu, Z., & Li, X. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151805 · Cited by 1

Expansion of multiple CD4+ T-cell lineages in lymphocytic variant hypereosinophilic syndrome

Anderson, C. F., Makiya, M. A., Xiong, K., Penrod, L., Wetzler, L., Ware, J. M., Constantine, G. M., Khoury, P., & Klion, A. D. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.04.027 · Cited by 1

Increased STAT3 Phosphorylation in CD4+ T-Cells of Treated Patients with Chronic Lymphocytic Leukemia and Changes in Circulating Regulatory T-Cell Subsets Relative to Tumor Mass Distribution Value and Disease Duration

Dreisinger, M., Roškar, Z., Goropevšek, A., Zakelšek, A., Čurič, S., Živko, N., Bevc, S., & Homšak, E. (2025) · Biomedicines · doi:10.3390/biomedicines13051204 · Cited by 2

EZH2 in digestive system cancers: Epigenetic regulation, oncogenic interactions, and therapeutic potential

Hjazi, A. M., Hussn, A., Kareem, A. K., Alshahrani, M. Y., Malathi, H., Nayak, P. P., Chauhan, A. S., & Sharma, J. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114648 · Cited by 1

Plasma metabolites mediate the effects of circulating immune cell phenotypes on prostate cancer: A 2-step Mendelian randomization study

Zhou, W., Ding, J., Shen, Y., Huang, F., & Xu, D. (2025) · Medicine · doi:10.1097/md.0000000000044282 · Cited by 1

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Azari-Pour, A., Chamkalani, A., Rangan, S., MacDonald, K. N., Huynh, M., Levings, M. K., Schulze, H. G., Piret, J. M., & Gopaluni, R. B. (2025) · Scientific Reports · doi:10.1038/s41598-025-16002-8 · Cited by 1

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Wu, J., Cheng, Z., Liao, X., Yang, P., Wu, Q., Wang, T., Meng, W., Tang, Z., & Du, L. (2025) · Biomedicines · doi:10.3390/biomedicines13122962 · Cited by 1

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Sano, R., Nakamura, H., Suzuki, S., Inukai, D., Okamoto, H., Yamanaka, S., Takahara, T., Satou, A., Fujimoto, Y., Tsuzuki, T., et al. (2025) · Auris Nasus Larynx · doi:10.1016/j.anl.2025.12.004 · Cited by 1

Digestive System Toxicities of Immune Checkpoint Inhibitors: Mechanisms and Clinical Implications

Lin, A., Huang, Q., Zhang, J., & Luo, P. (2026) · BIO Integration · doi:10.15212/bioi-2025-0169 · Cited by 1

TDRD3, a Tudor domain-containing protein, regulates Klf2 -dependent T reg differentiation and function to modulate immune tolerance

Shi, Y., Tao, X., Shen, L., Yuan, Y.-C., Wang, G., Eurmsirilerd, E., Chang, R., Jia, Z., Shang, W., Yang, Y., et al. (2026) · Science Advances · doi:10.1126/sciadv.aea3960 · Cited by 1

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Donhauser, S., Salzmann‐Manrique, E., Lueck, L. M., Fekadu, J., Schubert, R., Huenecke, S., & Bakhtiar, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1697915 · Cited by 1

Regulatory T cells from concept to clinic: The 2025 Nobel Prize and its implications for immune-mediated diseases and cancer

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Cui, S., Wang, G., Sun, X., Wang, Z., Zhou, G., & Jiang, H. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04307-1 · Cited by 1

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Gong, Y., Huang, J., Li, Y., Chen, J., Liu, L., Chen, R., Guan, S., Wang, Y., & Sun, J. (2026) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2026.116830 · Cited by 1

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Xiao, J., Duan, L., Yang, J., Deng, Y., 庞舒尹, Wang, H., Yin, X., Wang, H., Qiu, Y., Li, X., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1755310 · Cited by 2

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Nová, Z., Zemánek, T., & Botek, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315122 · Cited by 1

Regulatory Immune Cells

Wing, J. B., & Sakaguchi, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8165-1.00013-7 · Cited by 1

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Xu, L., Liu, M., Lian, J., Li, E., Dongmin, C., Li, X., & Wang, W. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05187-y · Cited by 1

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Jiang, L., Shen, M., Zhang, S., Zhang, J., Shi, Y., Gu, Y., Yang, T., Fu, Q., Wang, B., Chen, Y., et al. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02389-9 · Cited by 2

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Understanding the Relationship between Bone-Remodeling T Cells and Microbiota in Breast Cancer Bone Metastases

Masset, M. E. G., Canto, F. B., & Monteiro, A. C. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1010215 · Cited by 1

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Sohrabi, M., Gholami, A., Kalali, B. A., Khoonsari, M., Sahraei, R., Toosi, M. N., Zamani, F., & Keyvani, H. (2021) · Middle East Journal of Digestive Diseases · doi:10.34172/mejdd.2021.247 · Cited by 1

Characterization of immune profile in an aging multiple sclerosis clinic population

Keegan, A. P., Joshi, U., Abdullah, L. I., Paris, D., Darcey, T. S., Niedospial, D., Davis, L. A., Crawford, F., & MULLAN, M. J. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103818 · Cited by 1

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Indonesia, U. K. W. M. S., Tjahjono, Y., Wijaya, H., Indonesia, U. K. W. M. S., Esar, S. Y., Indonesia, U. K. W. M. S., Caroline, C., Indonesia, U. K. W. M. S., Jafet, N., Indonesia, U. K. W. M. S., et al. (2022) · Jurnal Farmasi Sains dan Terapan · doi:10.33508/jfst.v9i2.4079 · Cited by 1

Human FOXP 3+ T regulatory cell heterogeneity

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The role of gp130-related cytokines in the modulation of human regulatory T cell function

Bartolucci, S. (2019) · doi:10.82308/7148

FOXP3+ regulatory T cells and their functional regulation

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The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases

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