Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

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Control of Regulatory T Cell Development by the Transcription Factor Foxp3

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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The Immune Landscape of Cancer

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

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Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

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Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

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Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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Pathophysiology of Inflammatory Bowel Diseases

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Regulatory T Cells and Human Disease

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T cells in health and disease

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PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

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Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

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Chemokines and the immune response to cancer

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Regulatory mechanisms of PD-1/PD-L1 in cancers

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Cold and hot tumors: from molecular mechanisms to targeted therapy

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Pathogenesis of autoimmune disease

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NF‐κB signaling in inflammation and cancer

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Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets

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Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

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Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

Wang, H., Zhang, H., Wang, Y., Brown, Z. J., Xia, Y., Huang, Z., Shen, C., Hu, Z., Beane, J., Ansa-Addo, E. A., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.07.032 · Cited by 398

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

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Inducing immune tolerance with dendritic cell-targeting nanomedicines

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The functional crosstalk between myeloid-derived suppressor cells and regulatory T cells within the immunosuppressive tumor microenvironment

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B Cell Function in the Tumor Microenvironment

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The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer

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Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

Zhao, P., Wang, M., Chen, M., Chen, Z., Peng, X., Zhou, F., Song, J., & Qu, J. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120142 · Cited by 264

CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease

Gómez-Bris, R., Saéz, Á., Herrero‐Fernández, B., Rius, C., Sánchez-Martinez, H., & González, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032696 · Cited by 265

Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances

Bar‐Or, A., & Li, R. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00063-6 · Cited by 261

CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity

Moreno Ayala, M. A., Campbell, T. F., Zhang, C., Dahan, N., Bockman, A., Prakash, V., Feng, L., Sher, T., & DuPage, M. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.003 · Cited by 241

Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms

Moslehi, J., Lichtman, A. H., Sharpe, A. H., Galluzzi, L., & Kitsis, R. N. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145186 · Cited by 237

The Complex Role of Regulatory T Cells in Immunity and Aging

Rocamora‐Reverte, L., Melzer, F. L., Würzner, R., & Weinberger, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616949 · Cited by 239

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Kidani, Y., Nogami, W., Yasumizu, Y., Kawashima, A., Tanaka, A., Sonoda, Y., Tona, Y., Nashiki, K., Matsumoto, R., Hagiwara, M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114282119 · Cited by 212

Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation

Fueyo, A. S., Whitehouse, G. P., Grageda, N., Cramp, M., Lim, T. Y., Romano, M., Thirkell, S., Lowe, K., Fry, L., Heward, J., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15700 · Cited by 212

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Marangoni, F., Zhakyp, A., Corsini, M., Geels, S. N., Carrizosa, E., Thelen, M., Mani, V., Pruessmann, J. N., Warner, R. D., Ozga, A. J., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.027 · Cited by 209

Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics

Lu, Q., Yang, M.-F., Liang, Y.-J., Xu, J., Xu, H.-M., Nie, Y.-Q., Wang, L.-S., Yao, J., & Li, D.-F. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353038 · Cited by 222

Follicular regulatory T cells produce neuritin to regulate B cells

González-Figueroa, P., Roco, J. A., Papa, I., Núñez-Villacís, L., Stanley, M., Linterman, M. A., Dent, A. L., Cañete, P. F., & Vinuesa, C. G. (2021) · Cell · doi:10.1016/j.cell.2021.02.027 · Cited by 168

CD8+ T cell exhaustion and cancer immunotherapy

Wang, Q., Qin, Y., & Li, B. (2023) · Cancer Letters · doi:10.1016/j.canlet.2022.216043 · Cited by 155

Regulatory T cells in immune checkpoint blockade antitumor therapy

Zhang, A., Fan, T., Liu, Y., Yu, G., Li, C., & Jiang, Z. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02156-y · Cited by 174

Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity

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Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

Kotla, N. G., Bonam, S. R., Rasala, S., Wankar, J., Bohara, R. A., Bayry, J., Rochev, Y. A., & Pandit, A. S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.07.002 · Cited by 149

N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells

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Immune-Mediated Diseases Associated With Cancer Risks

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Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

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Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients

Bonam, S. R., Kaveri, S. V., Sakuntabhai, A., Gilardin, L., & Bayry, J. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100016 · Cited by 130

The gut ecosystem and immune tolerance

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Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients

Harden, P., Game, D. S., Sawitzki, B., van der Net, J. B., Hester, J., Bushell, A., Issa, F., Brook, M. O., Alzhrani, A., Schlickeiser, S., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16395 · Cited by 127

HIF-2α is indispensable for regulatory T cell function

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Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment

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Recent developments in immunotherapy for gastrointestinal tract cancers

Chong, X., Madeti, Y., Cai, J., Li, W., Cong, L., Lu, J., Mo, L., Liu, H., He, S., Yu, C., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01578-x · Cited by 132

Human FOXP3 and tumour microenvironment

Wang, J., Gong, R., Zhao, C., Lei, K., Sun, X., & Ren, H. (2022) · Immunology · doi:10.1111/imm.13520 · Cited by 131

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies

Muhammad, S., Fan, T. T., Hai, Y., Gao, Y., & He, J. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01826-7 · Cited by 130

The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy

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Tolerogenic nanoparticles suppress central nervous system inflammation

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Epithelial and stromal co-evolution and complicity in pancreatic cancer

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Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells

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Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases

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CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD

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Metabolic interplay: tumor macrophages and regulatory T cells

Vilbois, S., Xu, Y., & Ho, P. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.11.007 · Cited by 100

MHC Class II Presentation in Autoimmunity

Ishina, I. A., Zakharova, M. Y., Kurbatskaia, I. N., Mamedov, A. E., Belogurov, A. A., & Gabibov, A. G. (2023) · Cells · doi:10.3390/cells12020314 · Cited by 95

Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression

Quandt, J., Arnovitz, S., Haghi, L., Woehlk, J., Mohsin, A., Okoreeh, M. K., Mathur, P., Emmanuel, A. O., Osman, A., Krishnan, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00889-2 · Cited by 92

The Immune Privilege of Cancer Stem Cells: A Key to Understanding Tumor Immune Escape and Therapy Failure

Galassi, C., Musella, M., Manduca, N., Maccafeo, E., & Sistigu, A. (2021) · Cells · doi:10.3390/cells10092361 · Cited by 93

Potential of regulatory T-cell-based therapies in the management of severe COVID-19

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Tolerogenic Dendritic Cell-Based Approaches in Autoimmunity

Passeri, L., Fortunato, M., Bassi, V., & Gregori, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168415 · Cited by 100

Contribution of adaptive immunity to human COPD and experimental models of emphysema

Kheradmand, F., Zhang, Y., & Corry, D. B. (2022) · Physiological Reviews · doi:10.1152/physrev.00036.2021 · Cited by 87

Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus

Guo, C., Liu, Q., Zong, D., Zhang, W., Zuo, Z.-Q., Yu, Q., Sha, Q., Zhu, L., Gao, X., Fang, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111606 · Cited by 86

Temperature sensitive liposome based cancer nanomedicine enables tumour lymph node immune microenvironment remodelling

Fu, S., Chang, L., Liu, S., Gao, T., Sang, X., Zhang, Z., Mu, W., Liu, X., Liang, S., Yang, H. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38014-6 · Cited by 89

Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials

Zeng, L., Yang, T., Yang, K., Yu, G., Li, J., Wang, X., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.896476 · Cited by 89

T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer

Ni, H., Zhang, H., Li, L., Huang, H., Guo, H., Zhang, L., Li, C., Xu, J.-X., Nie, C.-P., Li, K., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005151 · Cited by 85

The progress and prospect of regulatory T cells in autoimmune diseases

Zhang, X., Olsen, N. J., & Zheng, S. G. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102461 · Cited by 87

Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma

Chen, J., Liu, K., Luo, Y., Kang, M., Wang, J., Chen, G., Qi, J., Wu, W., Wang, B., Han, Y., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.03.008 · Cited by 84

cGAS-STING signaling in the tumor microenvironment

Liu, Z., Wang, D., Zhang, J., Xiang, P., Zeng, Z., Xiong, W., & Shi, L. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216409 · Cited by 87

Proenkephalin + regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function

Shime, H., Odanaka, M., Tsuiji, M., Matoba, T., Imai, M., Yasumizu, Y., Uraki, R., Minohara, K., Watanabe, M., Bonito, A. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000372117 · Cited by 85

Striking a balance: new perspectives on homeostatic dendritic cell maturation

Bosteels, V., & Janssens, S. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01079-5 · Cited by 95

TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells

Tseng, W.-Y., Huang, Y.-S., Clanchy, F. I. L., McNamee, K., Perocheau, D. P. B., Ogbechi, J., Luo, S., Feldmann, M., McCann, F. E., & Williams, R. O. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909687116 · Cited by 82

Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species

Karakus, U., Şahin, D., Mittl, P. R. E., Mooij, P., Koopman, G., & Boyman, O. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abb9283 · Cited by 83

A perspective on HPK1 as a novel immuno-oncology drug target

Sawasdikosol, S., & Burakoff, S. J. (2020) · eLife · doi:10.7554/elife.55122 · Cited by 80

Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration

Li, J., Wang, S., Wang, N., Zheng, Y., Yang, B., Wang, X., Zhang, J., Pan, B., & Wang, Z. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00775-2 · Cited by 82

Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach

Kim, C.-G., Sang, Y. B., Lee, J. H., & Chon, H. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158035 · Cited by 78

Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application

Henschel, P., Landwehr-Kenzel, S., Engels, N., Schienke, A., Kremer, J., Riët, T., Redel, N., Iordanidis, K., Saetzler, V., John, K., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103057 · Cited by 76

Age-Related Changes in Thymic Central Tolerance

Srinivasan, J., Lancaster, J. N., Singarapu, N., Hale, L. P., Ehrlich, L. I. R., & Richie, E. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676236 · Cited by 67

Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

de Kivit, S., Mensink, M., Hoekstra, A. T., Berlin, I., Derks, R. J. E., Both, D., Aslam, M. A., Amsen, D., Berkers, C. R., & Borst, J. G. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00271-w · Cited by 69

Psoriasis: Recent progress in molecular‐targeted therapies

Honma, M., & Hayashi, K. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15727 · Cited by 72

Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy

Liu, K., Kong, L., Cui, H., Zhang, L., Xin, Q., Zhuang, Y., Guo, C., Yao, Y., Tao, J., Gu, X., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101751 · Cited by 72

Targeting adenosine and regulatory T cells in cancer immunotherapy

Churov, A. V., & Жулай, Г. А. (2021) · Human Immunology · doi:10.1016/j.humimm.2020.12.005 · Cited by 68

Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer

He, Z., Zhang, C., Zhao, Y., He, S., Li, Y., Shi, B., Hu, J., Qi, R., & Hua, B. (2023) · Discover Oncology · doi:10.1007/s12672-023-00793-1 · Cited by 66

Cellular Signaling Pathways in Medium and Large Vessel Vasculitis

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Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

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