Cited by 730T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCancer Immunotherapy and Biomarkers

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Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

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Wing, James B., Tanaka, Atsushi, Sakaguchi, Shimon·2019·Immunity

DOI 10.1016/j.immuni.2019.01.020

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Abstract

Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in single cell analyses have revealed a range of Treg cell activation and differentiation states in different human pathologies. Here we review recent progress in the understanding of human Treg cell heterogeneity and function. We discuss these findings within the context of concepts in Treg cell development and function derived from preclinical models and insight from approaches targeting Treg cells in clinical settings. Distinguishing functional Treg cells from other T cells and understanding the context-dependent function(s) of different Treg subsets will be crucial to the development of strategies toward the selective therapeutic manipulation of Treg cells in autoimmunity and cancer.

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Additional file 1 of Characteristics and reference ranges of CD4+T cell subpopulations among healthy adult Han Chinese in Shanxi Province, North China
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Additional file 2 of Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry
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Additional file 4 of Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing
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Additional file 5 of Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing
Chen, Y., Yin, J., Zhao, L., Zhou, G., Dong, S., Zhang, Y., Niu, P., Ren, H., Zheng, T., Yan, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26550823
Additional file 2 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implications
Hayashi, Y., Ueyama, A., Funaki, S., Jinushi, K., Higuchi, N., Morihara, H., Hirata, M., Nagira, Y., Saito, T., Kawashima, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25893876
Additional file 3 of First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors
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Additional file 1 of Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing
Chen, Y., Yin, J., Zhao, L., Zhou, G., Dong, S., Zhang, Y., Niu, P., Ren, H., Zheng, T., Yan, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26550808
Additional file 4 of Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry
Li, B., Yang, C., Jia, G., Liu, Y., Wang, N., Yang, F., Su, R., Shang, Y., & Han, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20026327
Additional file 1 of Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry
Li, B., Yang, C., Jia, G., Liu, Y., Wang, N., Yang, F., Su, R., Shang, Y., & Han, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20026318
Additional file 1 of First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors
Cole, C. B., Morelli, M. P., Fantini, M. C., Miettinen, M., Fetsch, P. A., Peer, C., Figg, W. D., Yin, T., Houston, N. D., McCoy, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22623002
Additional file 2 of Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing
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Additional file 2 of First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors
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Additional file 2 of Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration
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Additional file 5 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implications
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Additional file 6 of Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing
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Additional file 3 of Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing
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Additional file 3 of Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry
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Additional file 1 of CD73 mediates the therapeutic effects of endometrial regenerative cells in concanavalin A-induced hepatitis by regulating CD4+ T cells
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Additional file 3 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implications
Hayashi, Y., Ueyama, A., Funaki, S., Jinushi, K., Higuchi, N., Morihara, H., Hirata, M., Nagira, Y., Saito, T., Kawashima, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26724584
Additional file 4 of In situ analysis of CCR8+ regulatory T cells in lung cancer: suppression of GzmB+ CD8+ T cells and prognostic marker implications
Hayashi, Y., Ueyama, A., Funaki, S., Jinushi, K., Higuchi, N., Morihara, H., Hirata, M., Nagira, Y., Saito, T., Kawashima, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26724587
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Authors: Wing, J. B., Tanaka, A., & Sakaguchi, S.
Affiliations: Immunology Frontier Research Center, The University of Osaka (JP)
Kyoto University (JP)
Corresponding author: Sakaguchi, Shimon
ORCID: Wing, James B.
Tanaka, Atsushi
Sakaguchi, Shimon
Venue: Immunity
Publisher: Elsevier BV
Published: 2019-02
Volume: 50
Issue: 2
Pages: 302-316
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2019.01.020
OpenAlex: W2917646500
Cited by: 726
References: 180
Citations by year: 2026: 55 · 2025: 95 · 2024: 117 · 2023: 120 · 2022: 114 · 2021: 105 · 2020: 87 · 2019: 33
FWCI: 7.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (16H06295, 18K07175)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: regulatory T cells, Foxp3, Treg differentiation, autoimmunity, tumor immunology, immune homeostasis, Treg therapy, single-cell analysis
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Neoplasms, Autoimmunity, T-Lymphocyte Subsets, Genetic Heterogeneity, T-Lymphocytes, Regulatory, Forkhead Transcription Factors

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Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

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