Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474

Understanding the tumor immune microenvironment (TIME) for effective therapy

Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145

The future of immune checkpoint therapy

Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · cited 2×

Opportunities and challenges of targeting cGAS–STING in cancer

Lu, C., Wang, W., & Fu, Y. (2026) · Nature reviews. Cancer · doi:10.1038/s41568-025-00894-9 · Cited by 73

MUC1-C drives stemness in progression of colitis to colorectal cancer

Li, W., Zhang, N., Jin, C., Long, M. D., Rajabi, H. N., Yasumizu, Y., Fushimi, A., Yamashita, N., Hagiwara, M., Zheng, R., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137112 · Cited by 65

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway

Prabhu, K. S., Bhat, A. A., Siveen, K. S., Kuttikrishnan, S., Raza, S. S., Raheed, T., Jochebeth, A., Khan, A. Q., Chawdhery, M. Z., Haris, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112358 · Cited by 62

Interleukin 13 receptor alpha 2 (IL13Rα2): Expression, signaling pathways and therapeutic applications in cancer

Jaén, M., Martín‐Regalado, Á., Bartolomé, R. A., Robles, J., & Casal, J. I. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188802 · Cited by 65

Metabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer

Clemente‐Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., Ruisoto, P., Navarro-Jiménez, E., Ramos‐Campo, D. J., & Tornero-Aguilera, J. F. (2023) · Cancers · doi:10.3390/cancers15030814 · Cited by 71

Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways

Rahmani, A. H., Almatroudi, A., Allemailem, K. S., Alwanian, W. M., Alharbi, B. F., Alrumaihi, F., Khan, A. A., & Almatroodi, S. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119665 · Cited by 67

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Li, G., Wan, Y., Jiao, A., Jiang, K., Cui, G., Tang, J., Yu, S., Hu, Z., Zhao, S., Yi, Z., et al. (2025) · Med Research · doi:10.1002/mdr2.70007 · Cited by 63

Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma

Fukuda, Y., Bustos, M. A., Cho, S.-N., Roszik, J., Ryu, S., López, V., Burks, J. K., Lee, J. E., Grimm, E. A., Hoon, D. S. �., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04552-y · Cited by 61

Post-Translational Modifications of STING: A Potential Therapeutic Target

Kang, J., Wu, J., Liu, Q., Wu, X., Zhao, Y., & Ren, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.888147 · Cited by 62

Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization

Ren, W., Ban, J., Xia, Y., Zhou, F., Yuan, C., Jia, H., Huang, H., Jiang, M., Liang, M., Li, Z., et al. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100391 · Cited by 62

Intratumoral Microbiota Changes with Tumor Stage and Influences the Immune Signature of Oral Squamous Cell Carcinoma

Singh, R. P., Kumari, N., Gupta, S., Jaiswal, R., Mehrotra, D., Singh, S. K., Mukherjee, S., & Kumar, R. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04596-22 · Cited by 61

Extraction, purification, structural characterization and pharmacological activities of polysaccharides from sea buckthorn (Hippophae rhamnoides L.): A review

Teng, H., He, Z., Hong, C.-Z., Xie, S.-Z., & Zha, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117809 · Cited by 62

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Araujo, A. M., Abaurrea, A., Azcoaga, P., López-Velazco, J. I., Manzano, S., Rodríguez, J., Rezola, R., Egia‐Mendikute, L., Valdés‐Mora, F., Flores, J. M., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148667 · Cited by 62

Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease

Wooddell, C. I., Blomenkamp, K., Peterson, R. M., Subbotin, V. M., Schwabe, C., Hamilton, J., Chu, Q., Christianson, D. R., Hegge, J., Kolbe, J., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135348 · Cited by 60

B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy

Zhao, Y. C., Cao, Y., Chen, Y., Wu, L., Hang, H., Jiang, C., & Zhou, X. (2021) · Immunology · doi:10.1111/imm.13384 · Cited by 58

Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches

Conte, E. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108031 · Cited by 61

SIRT6 Widely Regulates Aging, Immunity, and Cancer

Li, Y., Jin, J., & Wang, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.861334 · Cited by 61

Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche

Luo, X., Li, Y., Hua, Z., Xue, X., Wang, X., Pang, M., Xiao, C., Zhao, H., Lü, A., & Liu, Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.050 · Cited by 63

Inflammatory bowel disease, colitis, and cancer: unmasking the chronic inflammation link

Khaze, V., Noorolyai, S., Youshanlui, M. A., Hossein, S., Nasiri, H., Mansoori, B., Holmskov, U., & Baradaran, B. (2024) · International Journal of Colorectal Disease · doi:10.1007/s00384-024-04748-y · Cited by 69

Cytotoxic activity of poly-ɛ-caprolactone lipid-core nanocapsules loaded with lycopene-rich extract from red guava (Psidium guajava L.) on breast cancer cells

Vasconcelos, A. G., Valim, M. O., Amorim, A. D. G. N., do Amaral, C. P., de Almeida, M. P., Borges, T. K. D. S., Socodato, R., Portugal, C. C., Brand, G. D., Mattos, J. S. D. C., et al. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109548 · Cited by 58

The cross talk between gastric cancer stem cells and the immune microenvironment: a tumor-promoting factor

Becerril-Rico, J., Alvarado-Ortiz, E., Toledo-Guzmán, M. E., Pelayo, R., & Ortíz-Sánchez, E. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02562-9 · Cited by 58

Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

Costa, P. A. C., da Silva, W. N., Prazeres, P. H. D. M., Picoli, C. C., Guardia, G. D. A., Costa, A. C., Oliveira, M. D. A., Guimarães, P. P. G., Gonçalves, R., Pinto, M. C. X., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01273-9 · Cited by 59

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

Pagadala, M. S., Sears, T. J., Wu, V. H., Pérez‐Guijarro, E., Kim, H., Castro, A., Talwar, J. V., González-Colín, C., Cao, S., Schmiedel, B. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38271-5 · Cited by 54

Use of Poly Lactic-co-glycolic Acid Nano and Micro Particles in the Delivery of Drugs Modulating Different Phases of Inflammation

Puricelli, C., Gigliotti, C. L., Stoppa, I., Sacchetti, S., Pantham, D., Scomparin, A., Rolla, R., Pizzimenti, S., Dianzani, U., Boggio, E. M., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061772 · Cited by 62

Natural antisense transcripts in the biological hallmarks of cancer: powerful regulators hidden in the dark

Zhao, S., Zhang, X., Chen, S., & Zhang, S. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01700-0 · Cited by 59

Clinical perspectives on the age-related increase of immunosuppressive activity

Salminen, A. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02193-4 · Cited by 57

Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?

Morales, P., Lago-Fernandez, A., Hurst, D. P., Sotudeh, N., Brailoiu, E., Reggio, P. H., Abood, M. E., & Jagerovic, N. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00926 · Cited by 57

Radiation-activated secretory proteins of Scgb1a1+ club cells increase the efficacy of immune checkpoint blockade in lung cancer

Ban, Y., Markowitz, G. J., Zou, Y., Ramchandani, D., Kraynak, J., Sheng, J., Lee, S. B., Wong, S. T. C., Altorki, N. K., Gao, D., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00245-1 · Cited by 57

Cell Membrane Vesicles with Enriched CXCR4 Display Enhances Their Targeted Delivery as Drug Carriers to Inflammatory Sites

Wang, D., Jiang, S., Zhang, F., Ma, S., Heng, B. C., Wang, Y., Zhu, J., Xu, M., He, Y., Wei, Y. Q., et al. (2021) · Advanced Science · doi:10.1002/advs.202101562 · Cited by 56

The regulatory role of PDE4B in the progression of inflammatory function study

Su, Y., Ding, J., Yang, F., He, C., Xu, Y., Zhu, X., Zhou, H., & Li, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.982130 · Cited by 58

The tumor microenvironment in the postsurgical liver: Mechanisms and potential targets of postoperative recurrence in human hepatocellular carcinoma

Wu, J., Chan, Y.-T., Lu, Y., Wang, N., & Feng, Y. (2023) · Medicinal Research Reviews · doi:10.1002/med.21967 · Cited by 56

C-Reactive Protein Signaling Pathways in Tumor Progression

Kim, E., Kim, S. Y., & Moon, A. (2023) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.132 · Cited by 58

Fumarate hydratase as a metabolic regulator of immunity

Peace, C. G., O’Carroll, S. M., & O'Neill, L. A. J. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.10.005 · Cited by 61

Integrated Safety Update of Abrocitinib in 3802 Patients with Moderate-to-Severe Atopic Dermatitis: Data from More than 5200 Patient-Years with Up to 4 Years of Exposure

Simpson, E. L., Silverberg, J. I., Nosbaum, A., Winthrop, K. L., Guttman‐Yassky, E., Hoffmeister, K. M., Egeberg, A., Valdez, H., Fan, H., Farooqui, S. A., et al. (2024) · American Journal of Clinical Dermatology · doi:10.1007/s40257-024-00869-w · Cited by 57

PANoptosis in cancer: bridging molecular mechanisms to therapeutic innovations

Lin, J., Wang, T., Huang, R., Tan, Y., Chen, D., & Ju, H. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01329-z · Cited by 63

Single-cell transcriptomic analysis of eutopic endometrium and ectopic lesions of adenomyosis

Liu, Z., Sun, Z., Liu, H., Niu, W., Wang, X., Liang, N., Wang, X., Wang, Y., Shi, Y., Xu, L., et al. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00562-z · Cited by 57

Inflammation-Driven Breast Tumor Cell Plasticity: Stemness/EMT, Therapy Resistance and Dormancy

Baram, T., Rubinstein-Achiasaf, L., Ben-Yaakov, H., & Ben‐Baruch, A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.614468 · Cited by 61

Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model

Ho, Y.-T., Shimbo, T., Wijaya, E., Kitayama, T., Takaki, S., Ikegami, K., Miyashita, K., Ouchi, Y., Takaki, E., Yamamoto, R., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.04.004 · Cited by 56

Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance

Capula, M., Perán, M., Xu, G., Donati, V. L., Yee, D., Gregori, A., Assaraf, Y. G., Giovannetti, E., & Deng, D. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100864 · Cited by 55

Balancing functional and health benefits of food products formulated with palm oil as oil sources

Sulaiman, N. S., Sintang, M. D. B., Mantihal, S., Zaini, H. M., Munsu, E., Mamat, H., Kanagaratnam, S., Jahurul, M. H. A., & Pindi, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11041 · Cited by 56

Effect of Cancer-Related Cachexia and Associated Changes in Nutritional Status, Inflammatory Status, and Muscle Mass on Immunotherapy Efficacy and Survival in Patients with Advanced Non-Small Cell Lung Cancer

Madeddu, C., Busquets, S., Donisi, C., Lai, E., Pretta, A., López-Soriano, F. J., Argilés, J. M. A., Scartozzi, M., & Macciò, A. (2023) · Cancers · doi:10.3390/cancers15041076 · Cited by 60

Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions

Ryan, S. T., Beheshti, E. H., Afrose, D., Ding, X., Xia, B., Grau, G. E., Little, C. B., McClements, L., & Li, J. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063023 · Cited by 54

KDM6 Demethylases and Their Roles in Human Cancers

Hua, C., Chen, J., Li, S., Zhou, J., Fu, J., Sun, W., & Wang, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.779918 · Cited by 57

Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer

Pérez, P. E., Riquelme, I., García, P., Brebi, P., & Roa, J. C. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020234 · Cited by 58

Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

Chen, C., Zhou, Y., Ning, X., Li, S., Xue, D., Wei, C., Zhu, Z., Sheng, L., Lu, B., Li, Y., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02682-w · Cited by 59

Periodontopathogens Porphyromonas gingivalis and Fusobacterium nucleatum and Their Roles in the Progression of Respiratory Diseases

Shi, T., Wang, J., Dong, J., Hu, P., & Guo, Q. (2023) · Pathogens · doi:10.3390/pathogens12091110 · Cited by 55

Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives

Gouda, N. A., Alshammari, S. O., Abourehab, M. A. S., Alshammari, Q. A., & Elkamhawy, A. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01366-y · Cited by 59

Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation

Zhou, H., Wang, L., Lin, Z., Jiang, C., Chen, X., Wang, K., Liu, L., Shao, L., Pan, J., Li, J., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007840 · Cited by 55

Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance

Sabit, H., Arneth, B. M., Pawlik, T. M., Abdel-Ghany, S. E., Ghazy, A., Abdelazeem, R. M., Alqosaibi, A. I., Al-Dhuayan, I. S., Almulhim, J., Alrabiah, N. A., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18010075 · Cited by 59

Bone marrow inflammation in haematological malignancies

de Jong, M. M. E., Chen, L., Raaijmakers, M. H. G. P., & Cupedo, T. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01003-x · Cited by 54

Creating and Validating a DNA Methylation-Based Proxy for Interleukin-6

Stevenson, A. J., Gadd, D. A., Hillary, R. F., McCartney, D. L., Campbell, A., Walker, R. M., Evans, K. L., Harris, S. E., Spires‐Jones, T. L., McRae, A. F., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab046 · Cited by 50

Insulin/IGF Axis and the Receptor for Advanced Glycation End Products: Role in Meta-inflammation and Potential in Cancer Therapy

Vella, V., Lappano, R., Bonavita, E., Maggiolini, M., Clarke, R. B., Belfiore, A., & Francesco, E. M. D. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad005 · Cited by 59

Inflammatory Networks in Renal Cell Carcinoma

Kruk, L., Mamtimin, M., Braun, A., Anders, H., Andrassy, J., Gudermann, T. W., & Mammadova‐Bach, E. (2023) · Cancers · doi:10.3390/cancers15082212 · Cited by 59

Interactions between diet and gut microbiota in cancer

Nakatsu, G., Andreeva, N., MacDonald, M. H., & Garrett, W. S. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01736-4 · Cited by 58

Microbe-material hybrids for therapeutic applications

Chen, M., Xia, L., Wu, C., Wang, Z., Ding, L. S., Xie, Y., Feng, W., & Chen, Y. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00655g · Cited by 56

Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin

Jafari, A., Rezaei–Tavirani, M., Farhadihosseinabadi, B., Zali, H., & Niknejad, H. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02196-x · Cited by 54

Drug resistance mechanisms in cancers: Execution of pro-survival strategies

Dhanyamraju, P. K. (2023) · Journal of Biomedical Research · doi:10.7555/jbr.37.20230248 · Cited by 56

Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease

Hyun, J., Abo, M. A., Dutta, R. K., Oh, S., Xiang, K., Zhou, X., Maeso‐Díaz, R., Caffrey, R., Sanyal, A. J., Freedman, J. A., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.04.033 · Cited by 53

Local Anesthetic Lidocaine and Cancer: Insight Into Tumor Progression and Recurrence

Zhang, C., Xie, C., & Lu, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.669746 · Cited by 53

Role of Lipids and Lipid Metabolism in Prostate Cancer Progression and the Tumor’s Immune Environment

Siltari, A., Syvälä, H., Lou, Y., Gao, Y., & Murtola, T. J. (2022) · Cancers · doi:10.3390/cancers14174293 · Cited by 53

Intratumoral bacteria are an important “accomplice” in tumor development and metastasis

Wang, G., He, X., & Wang, Q. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188846 · Cited by 51

The Pan-Cancer Multi-Omics Landscape of FOXO Family Relevant to Clinical Outcome and Drug Resistance

Xie, J., Zhang, J., Tian, W., Zou, Y., Tang, Y., Zheng, S., Wong, C., Deng, X., Wu, S., Chen, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415647 · Cited by 51

The role of myokines in cancer: crosstalk between skeletal muscle and tumor

Park, S.-Y., Hwang, B.-O., & Song, N. (2023) · BMB Reports · doi:10.5483/bmbrep.2023-0064 · Cited by 52

Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells

Rabas, N., Ferreira, R. M. M., Blasio, S. D., & Malanchi, I. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00752-0 · Cited by 58

Non-coding RNAs: emerging biomarkers and therapeutic targets in cancer and inflammatory diseases

Abdelmonem, B. H., Kamal, L. T., Wardy, L. W., Ragheb, M., Hanna, M. M., Elsharkawy, M., & Abdelnaser, A. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1534862 · Cited by 55

Targeting inflammation in cancer therapy: from mechanistic insights to emerging therapeutic approaches

Bakrim, S., Fessikh, M. E., Elhrech, H., Omari, N. E., Amanullah, M. R., Ming, L. C., Moshawih, S., & Bouyahya, A. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06583-3 · Cited by 58

Regulation of the Low-Density Lipoprotein Receptor-Related Protein LRP6 and Its Association With Disease: Wnt/β-Catenin Signaling and Beyond

Jeong, W., & Jho, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714330 · Cited by 54

HIF1, HSF1, and NRF2: Oxidant-Responsive Trio Raising Cellular Defenses and Engaging Immune System

Cyran, A. M., & Zhitkovich, A. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00131 · Cited by 55

Bioresponsive Immunotherapeutic Materials

Han, J., Sheng, T., Zhang, Y., Cheng, H., Gao, J., Yu, J., & Gu, Z. (2023) · Advanced Materials · doi:10.1002/adma.202209778 · Cited by 52

Neutrophils in Cancer and Potential Therapeutic Strategies Using Neutrophil-Derived Exosomes

Dutta, A., Bhagat, S., Paul, S., Katz, J. P., Sengupta, D., & Bhargava, D. K. (2023) · Vaccines · doi:10.3390/vaccines11061028 · Cited by 55

Inflammation and cancer: molecular mechanisms and clinical consequences

Akkız, H., Şimşek, H., Balcı, D., Ülger, Y., Onan, E., Ozturk, N. A., & Delik, A. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1564572 · Cited by 59

Gut Microbiota and Cardiovascular Diseases: Unraveling the Role of Dysbiosis and Microbial Metabolites

Barathan, M., & Hanafiah, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094264 · Cited by 56

c‐Fos separation from Lamin A/C by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment

Ding, Y., Hao, K., Li, Z., Ma, R., Zhou, Y. L., Zhou, Z., Wei, M., Liao, Y., Dai, Y., Yang, Y., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29317 · Cited by 52

In-depth analysis of lupeol: delving into the diverse pharmacological profile

Dalimunthe, A., Carensia Gunawan, M., Dhiya Utari, Z., Dinata, M. R., Halim, P., Estherina S. Pakpahan, N., Sitohang, A. I., Sukarno, M. A., Yuandani, Harahap, Y., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1461478 · Cited by 50

Arctigenin, an anti-tumor agent; a cutting-edge topic and up-to-the-minute approach in cancer treatment

Shabgah, A. G., Suksatan, W., Achmad, M. H., Bokov, D. O., Abdelbasset, W. K., Ezzatifar, F., Hemmati, S., Mohammadi, H., Soleimani, D., Jadidi‐Niaragh, F., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174419 · Cited by 51

Thyroid hormones act as modulators of inflammation through their nuclear receptors

Lasa, M., & Contreras‐Jurado, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.937099 · Cited by 56

CircRNAs regulate the crosstalk between inflammation and tumorigenesis: The bilateral association and molecular mechanisms

Qadir, J., Wen, S.-Y., Yuan, H., & Yang, B. B. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.12.005 · Cited by 52

Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers

Li, Y., Sui, S., & Goel, A. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.02.001 · Cited by 51

The Multifaceted Roles of MSCs in the Tumor Microenvironment: Interactions With Immune Cells and Exploitation for Therapy

Papait, A., Stefani, F. R., Cargnoni, A., Magatti, M., Parolini, O., & Silini, A. R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00447 · Cited by 52

Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

D’Orazi, G., Cordani, M., & Cirone, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03677-7 · Cited by 51

Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers

Masi, M., Racchi, M., Travelli, C., Corsini, E., & Buoso, E. (2021) · Cells · doi:10.3390/cells10112999 · Cited by 49

Roles of RNA-binding proteins in immune diseases and cancer

Hashimoto, S., & Kishimoto, T. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.03.017 · Cited by 49

A Comprehensive Update on the Bioactive Compounds from Seagrasses

Gono, C. M. P., Ahmadi, P., Hertiani, T., Septiana, E., Putra, M. Y., & Chianese, G. (2022) · Marine Drugs · doi:10.3390/md20070406 · Cited by 52

Ferroptosis interaction with inflammatory microenvironments: Mechanism, biology, and treatment

Dou, J., Liu, X., Yang, L., Huang, D., & Tan, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113711 · Cited by 52

Pathogenesis of (smoking-related) non-communicable diseases—Evidence for a common underlying pathophysiological pattern

Kopp, W. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1037750 · Cited by 60

The role of macrophages-mediated communications among cell compositions of tumor microenvironment in cancer progression

Li, M., Jiang, P., Wei, S., Wang, J., & Li, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1113312 · Cited by 52

Tumour extracellular vesicles induce neutrophil extracellular traps to promote lymph node metastasis

Su, X., Brassard, A., Bartolomucci, A., Dhoparee‐Doomah, I., Qiu, Q., Tsering, T., Rohanizadeh, R., Koufos, O., Giannias, B., Bourdeau, F., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12341 · Cited by 49

Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment

Horvat, N. K., Chocarro, S., Marques, O., Bauer, T. A., Qiu, R., Diaz-Jimenez, A., Helm, B., Chen, Y., Sawall, S., Sparla, R., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c08335 · Cited by 51

Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities

Li, B., Yang, Z., Li, Y., Zhang, J., Li, C., & Lv, N. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1352671 · Cited by 55

Inflammation and cancer: friend or foe?

Smith, A. D. T., Córdoba-Hernandez, S., Mejía-Guarnizo, L. V., Monroy-Camacho, P. S., & Rodríguez-García, J. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1385479 · Cited by 53

Regulatory T cells: masterminds of immune equilibrium and future therapeutic innovations

Ge, J., Yin, X., & Chen, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1457189 · Cited by 52

Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer

Li, K., Chen, Y., Zhang, Z., Wang, K., Sulayman, S., Zeng, X., Ababaike, S., Guan, J., & Zhao, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-96592-5 · Cited by 49

A Review of the Effects of Natural Compounds, Medicinal Plants, and Mushrooms on the Gut Microbiota in Colitis and Cancer

Cheung, M. K., Yue, G. G., Chiu, P. W. Y., & Lau, C. B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00744 · Cited by 49

Emerging Roles of Long non-coding RNAs in The Tumor Microenvironment

Zhou, L., Zhu, Y., Sun, D., & Zhang, Q. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.44420 · Cited by 49

Systemic Inflammation Response Index Is a Predictor of Poor Survival in Locally Advanced Nasopharyngeal Carcinoma: A Propensity Score Matching Study

Feng, Y., Zhang, N., Wang, S., Zou, W., He, Y., Ma, J., Liu, P., Liu, X., Hu, C., & Hou, T. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.575417 · Cited by 49

In silico approaches in carcinogenicity hazard assessment: Current status and future needs

Tice, R. R., Bassan, A., Amberg, A., Anger, L. T., Beal, M. A., Bellion, P., Benigni, R., Birmingham, J. M., Brigo, A., Bringezu, F., et al. (2021) · Computational Toxicology · doi:10.1016/j.comtox.2021.100191 · Cited by 50

Eosinophils and Lung Cancer: From Bench to Bedside

Sibille, A., Corhay, J.-L., Louis, R. E., Ninane, V., Jérusalem, G., & Duysinx, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095066 · Cited by 48

Cysteine cathepsins: A long and winding road towards clinics

Biasizzo, M., Javoršek, U., Vidak, E., Zarić, M., & Turk, B. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101150 · Cited by 50

Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice

Wang, G., Gao, H., Dai, S., Li, M., Gao, Y., Yin, L., Zhang, K., Zhang, J., Jiang, K., Miao, Y., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216155 · Cited by 47

Anticancer Potential of the Plant‐Derived Saponin Gracillin: A Comprehensive Review of Mechanistic Approaches

Bhuia, M. S., Chowdhury, R., Sonia, F. A., Kamli, H. M., Shaikh, A. A., El‐Nashar, H. A. S., El‐Shazly, M., & Islam, M. T. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202300847 · Cited by 49

Inflammation and tumors

Ribatti, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21798-2.00006-3

Inflammation in Cancer Development

Muñoz‐Pérez, V. M., Cariño‐Cortés, R., Santillán, I. C. L., & Salas‐Casas, A. (2022) · Mexican Journal of Medical Research ICSA · doi:10.29057/mjmr.v10i19.8112 · Cited by 5

Inflammation: the incubator of the tumor microenvironment

Denk, D., & Greten, F. R. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.07.002 · Cited by 287

Inflammation and cancer

Mackenzie, G. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823397-9.00003-x · Cited by 4

Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms

Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000