Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680

Origin and physiological roles of inflammation

Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474

Understanding the tumor immune microenvironment (TIME) for effective therapy

Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145

The future of immune checkpoint therapy

Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · cited 2×

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

Bindea, G., Mlecnik, B., Tosolini, M., Kirilovsky, A., Waldner, M. J., Obenauf, A. C., Angell, H. K., Fredriksen, T., Lafontaine, L., Berger, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.003 · Cited by 4,455

STATs in cancer inflammation and immunity: a leading role for STAT3

Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

Topalian, S. L., Drake, C. G., & Pardoll, D. M. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.03.001 · Cited by 4,229

The Three Es of Cancer Immunoediting

Dunn, G. P., Old, L. J., & Schreiber, R. D. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104803 · Cited by 3,235

NF-κB: linking inflammation and immunity to cancer development and progression

Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175

Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment

Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer

Puram, S. V., Tirosh, I., Parikh, A. S., Patel, A. P., Yizhak, K., Gillespie, S., Rodman, C., Luo, C. L., Mroz, E. A., Emerick, K. S., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.044 · Cited by 2,557

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

Aceto, N., Bardia, A., Miyamoto, D. T., Collier, M. D., Wittner, B. S., Spencer, J. A., Yu, M., Pely, A., Engstrom, A., Zhu, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.07.013 · Cited by 2,516

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

Riaz, N., Havel, J. J., Makarov, V., Desrichard, A., Urba, W. J., Sims, J. S., Hodi, F. S., Martín-Algarra, S., Mandal, R., Sharfman, W. H., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.028 · Cited by 2,401

Intestinal inflammation targets cancer-inducing activity of the microbiota

Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263

Crypt stem cells as the cells-of-origin of intestinal cancer

Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A. R., Sansom, O. J., & Clevers, H. C. (2008) · Nature · doi:10.1038/nature07602 · Cited by 2,232

Natural Innate and Adaptive Immunity to Cancer

Vesely, M. D., Kershaw, M. H., Schreiber, R. D., & Smyth, M. J. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101324 · Cited by 2,225

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.008 · Cited by 2,198

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

Grivennikov, S., Karin, E., Terzic, J., Mucida, D., Yu, G.-Y., Vallabhapurapu, S., Scheller, J., Rose-John, S., Cheroutre, H., Eckmann, L., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.001 · Cited by 2,155

Targeting macrophages: therapeutic approaches in cancer

Cassetta, L., & Pollard, J. W. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.169 · Cited by 2,101

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Azizi, E., Carr, A. J., Plitas, G., Cornish, A. E., Konopacki, C., Prabhakaran, S., Nainys, J., Wu, K., Kiseliovas, V., Setty, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.060 · Cited by 1,976

Myeloid-Derived Suppressor Cells

Gabrilovich, D. I. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0297 · Cited by 1,935

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898

Myeloid-derived suppressor cells coming of age

Veglia, F., Perego, M., & Gabrilovich, D. I. (2018) · Nature Immunology · doi:10.1038/s41590-017-0022-x · Cited by 1,818

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

Coffelt, S. B., Kersten, K., Doornebal, C. W., Weiden, J., Vrijland, K., Hau, C.-S., Verstegen, N. J. M., Ciampricotti, M., Hawinkels, L. J. A. C., Jonkers, J., et al. (2015) · Nature · doi:10.1038/nature14282 · Cited by 1,703

Radical causes of cancer

Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer

Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574

Identification of the tumour transition states occurring during EMT

Pastushenko, I., Brisebarre, A., Sifrim, A., Fioramonti, M., Revenco, T., Boumahdi, S., Keymeulen, A. V., Brown, D. V., Moers, V., Lemaire, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0040-3 · Cited by 1,556

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

Erez, N., Truitt, M., Olson, P., & Hanahan, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.041 · Cited by 1,515

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

Rothwell, P. M., Fowkes, F. G. R., Belch, J. F., Ogawa, H., Warlow, C. P., & Meade, T. W. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62110-1 · Cited by 1,497

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

Žilionis, R., Engblom, C., Pfirschke, C., Savova, V., Zemmour, D., Saatcioglu, H. D., Krishnan, I., Maroni, G., Meyerovitz, C. V., Kerwin, C. M., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.009 · Cited by 1,486

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E., Upadhyay, P., Uyeminami, D. L., Pommier, A., Küttner, V., et al. (2018) · Science · doi:10.1126/science.aao4227 · Cited by 1,476

Adaptive immunity maintains occult cancer in an equilibrium state

Koebel, C. M., Vermi, W., Swann, J. B., Zerafa, N., Rodig, S. J., Old, L. J., Smyth, M. J., & Schreiber, R. D. (2007) · Nature · doi:10.1038/nature06309 · Cited by 1,438

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Jerby-Arnon, L., Shah, P., Cuoco, M. S., Rodman, C., Su, M.-J., Melms, J. C., Leeson, R., Kanodia, A., Mei, S., Lin, J.-R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.006 · Cited by 1,429

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,395

IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma

Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., & Tuveson, D. A. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0710 · Cited by 1,360

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

Ridker, P. M., MacFadyen, J. G., Thuren, T., Everett, B. M., Libby, P., Glynn, R. J., Ridker, P., Lorenzatti, A., Krum, H., Varigos, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32247-x · Cited by 1,344

Interactions between cancer stem cells and their niche govern metastatic colonization

Malanchi, I., Santamaria-Martínez, A., Susanto, E., Peng, H., Lehr, H.-A., Delaloye, J.-F., & Huelsken, J. (2012) · Nature · doi:10.1038/nature10694 · Cited by 1,339

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327

Macrophage polarization in tumour progression

Sica, A., Larghi, P., Mancino, A., Rubino, L., Porta, C., Totaro, M. G., Rimoldi, M., Biswas, S. K., Allavena, P., & Mantovani, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.03.004 · Cited by 1,241

Neutrophils escort circulating tumour cells to enable cell cycle progression

Szczerba, B. M., Castro-Giner, F., Vetter, M. H. F., Krol, I., Gkountela, S., Landin, J., Scheidmann, M. C., Donato, C., Scherrer, R., Singer, J., et al. (2019) · Nature · doi:10.1038/s41586-019-0915-y · Cited by 1,225

Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer

Tosolini, M., Kirilovsky, A., Mlecnik, B., Fredriksen, T., Mauger, S., Bindea, G., Berger, A., Bruneval, P., Fridman, W.-H., Pagès, F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2907 · Cited by 1,146

Intestinal Inflammation and Cancer

Ullman, T. A., & Itzkowitz, S. H. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.057 · Cited by 1,127

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., et al. (2018) · Science · doi:10.1126/science.aah3648 · Cited by 1,105 · cited 1×

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

Schwitalla, S., Fingerle, A. A., Cammareri, P., Nebelsiek, T., Göktuna, S. İ., Ziegler, P. K., Canli, Ö., Heijmans, J., Huels, D. J., Moreaux, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.12.012 · Cited by 1,098

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

Calon, A., Lonardo, E., Berenguer-Llergo, A., Espinet, E., Hernando-Momblona, X., Iglesias, M., Sevillano, M., Palomo-Ponce, S., Tauriello, D. V. F., Byrom, D., et al. (2015) · Nature Genetics · doi:10.1038/ng.3225 · Cited by 1,070

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

Calon, A., Espinet, E., Palomo-Ponce, S., Tauriello, D. V. F., Iglesias, M., Céspedes, M. V., Sevillano, M., Nadal, C., Jung, P., Zhang, X. H.-F., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.013 · Cited by 1,060

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

Mlecnik, B., Bindea, G., Angell, H. K., Maby, P., Angelova, M., Tougeron, D., Church, S. E., Lafontaine, L., Fischer, M., Fredriksen, T., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.025 · Cited by 1,034

Necroptosis in development, inflammation and disease

Weinlich, R., Oberst, A., Beere, H. M., & Green, D. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.149 · Cited by 1,016

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

Rothwell, P. M., Wilson, M., Price, J. F., Belch, J. F., Meade, T. W., & Mehta, Z. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60209-8 · Cited by 984

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells

Jin, C., Lagoudas, G. K., Zhao, C., Bullman, S., Bhutkar, A., Hu, B., Ameh, S., Sandel, D., Liang, X. S., Mazzilli, S., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.040 · Cited by 964

Neoantigen-directed immune escape in lung cancer evolution

The TRACERx consortium, Rosenthal, R., Cadieux, E. L., Salgado, R., Bakir, M. A., Moore, D. A., Hiley, C. T., Lund, T., Tanić, M., Reading, J. L., et al. (2019) · Nature · doi:10.1038/s41586-019-1032-7 · Cited by 946

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Cassetta, L., Fragkogianni, S., Sims, A. H., Swierczak, A., Forrester, L. M., Zhang, H., Soong, D. Y. H., Cotechini, T., Anur, P., Lin, E. Y., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.02.009 · Cited by 946

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

Yang, L., Huang, J., Ren, X., Gorska, A. E., Chytil, A., Aakre, M., Carbone, D. P., Matrisian, L. M., Richmond, A., Lin, P. C., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.004 · Cited by 918

IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway

Wang, L., Yi, T., Kortylewski, M., Pardoll, D. M., Zeng, D., & Yu, H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090207 · Cited by 868

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

Popivanova, B. K., Kitamura, K., Wu, Y., Kondo, T., Kagaya, T., Kaneko, S., Oshima, M., Fujii, C., & Mukaida, N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32453 · Cited by 845

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J. R., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.014 · Cited by 834

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

Melo, F. D. S. E., Kurtova, A. V., Harnoss, J. M., Kljavin, N. M., Hoeck, J. D., Hung, J., Anderson, J. E., Storm, E. E., Modrusan, Z. D., Koeppen, H., et al. (2017) · Nature · doi:10.1038/nature21713 · Cited by 812

Fatty acid transport protein 2 reprograms neutrophils in cancer

Veglia, F., Tyurin, V. A., Blasi, M., Leo, A. D., Kossenkov, A. V., Donthireddy, L., To, T. K. J., Schug, Z. T., Basu, S., Wang, F., et al. (2019) · Nature · doi:10.1038/s41586-019-1118-2 · Cited by 771

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Johnson, M. O., Wolf, M. M., Madden, M. Z., Andrejeva, G., Sugiura, A., Contreras, D. C., Maseda, D., Liberti, M. V., Paz, K. G., Kishton, R. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.001 · Cited by 729

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.020 · Cited by 726

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Huber, S., Gagliani, N., Zenewicz, L. A., Huber, F. J., Bosurgi, L., Hu, B., Hedl, M., Zhang, W. K., O’Connor, W., Murphy, A. J., et al. (2012) · Nature · doi:10.1038/nature11535 · Cited by 713

Ionic immune suppression within the tumour microenvironment limits T cell effector function

Eil, R. L., Vodnala, S. K., Clever, D. C., Klebanoff, C. A., Sukumar, M., Pan, J. H., Palmer, D. C., Gros, A., Yamamoto, T. N., Patel, S. J., et al. (2016) · Nature · doi:10.1038/nature19364 · Cited by 689

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

Eruslanov, E. B., Bhojnagarwala, P. S., Quatromoni, J. G., Stephen, T. L., Ranganathan, A., Deshpande, C. G., Akimova, T., Vachani, A., Litzky, L. A., Hancock, W. W., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci77053 · Cited by 653

Tissue biology perspective on macrophages

Okabe, Y., & Medzhitov, R. M. (2015) · Nature Immunology · doi:10.1038/ni.3320 · Cited by 651

Senescent cells as a source of inflammatory factors for tumor progression

Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9220-9 · Cited by 636

The Human Gut Bacterial Genotoxin Colibactin Alkylates DNA

Wilson, M. R., Jiang, Y., Villalta, P. W., Stornetta, A., Boudreau, P. D., Carrá, A., Brennan, C. A., Chun, E., Ngo, L., Samson, L. D., et al. (2019) · Science · doi:10.1126/science.aar7785 · Cited by 635

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

Seifert, L., Werba, G., Tiwari, S., Ly, N. N. G., Alothman, S., Alqunaibit, D., Avanzi, A., Barilla, R., Daley, D., Greco, S. H., et al. (2016) · Nature · doi:10.1038/nature17403 · Cited by 617

KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer

Liao, W., Overman, M. J., Boutin, A. T., Shang, X., Zhao, D., Dey, P., Li, J., Wang, G., Lan, Z., Li, J., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.02.008 · Cited by 617 · cited 1×

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

Gupta, P. B., Pastushenko, I., Skibinski, A., Blanpain, C., & Kuperwasser, C. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.11.011 · Cited by 616

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

Marusyk, A., Tabassum, D. P., Altrock, P. M., Almendro, V., Michor, F., & Polyák, K. (2014) · Nature · doi:10.1038/nature13556 · Cited by 606

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

Andreu, P., Johansson, M., Affara, N. I., Pucci, F., Tan, T., Junankar, S. R., Korets, L. V., Lam, J., Tawfik, D., DeNardo, D. G., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.019 · Cited by 604

Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

Luo, J., Maeda, S., Hsu, L.-C., Yagita∥, H., & Karin, M. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.012 · Cited by 598

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Shalapour, S., Lin, X.-J., Bastian, I. N., Brain, J., Burt, A. D., Aksenov, A. A., Vrbanac, A. F., Li, W., Perkins, A., Matsutani, T., et al. (2017) · Nature · doi:10.1038/nature24302 · Cited by 589

EMT and inflammation: inseparable actors of cancer progression

Suarez‐Carmona, M., Lesage, J., Cataldo, D. D., & Gilles, C. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12095 · Cited by 588

Innate Immune Recognition of Cancer

Woo, S., Corrales, L. P., & Gajewski, T. F. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112043 · Cited by 587

Inflammation and colorectal cancer: colitis-associated neoplasia

Grivennikov, S. I. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0352-6 · Cited by 574

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression

Kortlever, R. M., Sodir, N. M., Wilson, C. H., Burkhart, D. L., Pellegrinet, L., Brown Swigart, L., Littlewood, T. D., & Evan, G. I. (2017) · Cell · doi:10.1016/j.cell.2017.11.013 · Cited by 553

DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

Meira, L. B., Bugni, J. M., Green, S. L., Lee, C., Pang, B., Borenshtein, D., Rickman, B. H., Rogers, A. B., Moroski-Erkul, C. A., McFaline‐Figueroa, J. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35073 · Cited by 542

The obese adipose tissue microenvironment in cancer development and progression

Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542

Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts

Trinchieri, G. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075008 · Cited by 522

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

Nywening, T. M., Belt, B. A., Cullinan, D. R., Panni, R. Z., Han, B. J., Sanford, D. E., Jacobs, R. C., Ye, J., Patel, A. A., Gillanders, W. E., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-313738 · Cited by 506

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

Ruhland, M. K., Loza, A. J., Capietto, A.-H., Luo, X., Knolhoff, B. L., Flanagan, K. C., Belt, B. A., Alspach, E., Leahy, K., Luo, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11762 · Cited by 496

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

Sakurai, T., He, G., Matsuzawa, A., Yu, G.-Y., Maeda, S., Hardiman, G., & Karin, M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.06.016 · Cited by 487

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

Jinushi, M., Chiba, S., Yoshiyama, H., Masutomi, K., Kinoshita, I., Dosaka-Akita, H., Yagita, H., Takaoka, A., & Tahara, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106645108 · Cited by 479

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

Schulz, M. D., Atay, Ç., Heringer, J., Romrig, F., Schwitalla, S., Aydın, B., Ziegler, P. K., Varga, J., Reindl, W., Pommerenke, C., et al. (2014) · Nature · doi:10.1038/nature13398 · Cited by 458

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy

Krall, J. A., Reinhardt, F., Mercury, O. A., Pattabiraman, D. R., Brooks, M. W., Dougan, M. L., Lambert, A. W., Bierie, B., Ploegh, H. L., Dougan, S. K., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan3464 · Cited by 452

Interaction between the microbiome and TP53 in human lung cancer

Greathouse, K. L., White, J. R., Vargas, A. J., Bliskovsky, V. V., Beck, J. A., von Muhlinen, N., Polley, E. C., Bowman, E. D., Khan, M. A., Robles, A. I., et al. (2018) · Genome Biology · doi:10.1186/s13059-018-1501-6 · Cited by 446

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

Takahashi, H., Ogata, H., Nishigaki, R., Broide, D. H., & Karin, M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.008 · Cited by 445

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

Chihara, N., Madi, A., Kondo, T., Zhang, H., Acharya, N., Singer, M., Nyman, J., Marjanovic, N. D., Kowalczyk, M. S., Wang, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0206-z · Cited by 438

Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically

Putoczki, T. L., Thiem, S., Loving, A., Busuttil, R. A., Wilson, N. J., Ziegler, P. K., Nguyen, P. M., Preaudet, A., Farid, R., Edwards, K. M., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.017 · Cited by 431

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Shi, Y., Gao, W., Lytle, N. K., Huang, P., Yuan, X., Dann, A. M., Ridinger-Saison, M., DelGiorno, K. E., Antal, C. E., Liang, G., et al. (2019) · Nature · doi:10.1038/s41586-019-1130-6 · Cited by 431

Circuit Design Features of a Stable Two-Cell System

Zhou, X., Franklin, R. A., Adler, M., Jacox, J. B., Bailis, W., Shyer, J. A., Flavell, R. A., Mayo, A., Alon, U., & Medzhitov, R. (2018) · Cell · doi:10.1016/j.cell.2018.01.015 · Cited by 430

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

Halbrook, C. J., Pontious, C., Kovalenko, I., Lapienyte, L., Dreyer, S., Lee, H.-J., Thurston, G., Zhang, Y., Lazarus, J., Sajjakulnukit, P., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.001 · Cited by 419

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Meisel, M., Hinterleitner, R., Pacis, A., Chen, L., Earley, Z. M., Mayassi, T., Pierre, J. F., Ernest, J. D., Galipeau, H. J., Thuille, N., et al. (2018) · Nature · doi:10.1038/s41586-018-0125-z · Cited by 406

Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

McAllister, F., Bailey, J. M., Alsina, J., Nirschl, C. J., Sharma, R., Fan, H., Rattigan, Y., Roeser, J. C., Lankapalli, R. H., Zhang, H., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.014 · Cited by 405

IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L

Kryczek, I., Lin, Y., Nagarsheth, N., Peng, D., Zhao, L., Zhao, E., Vatan, L., Szeliga, W., Dou, Y., Owens, S. R., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.010 · Cited by 401

Diverse Functions of Macrophages in Different Tumor Microenvironments

Yang, M., McKay, D., Pollard, J. W., & Lewis, C. E. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1367 · Cited by 398

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Sevenich, L., Bowman, R. L., Mason, S. D., Quail, D. F., Rapaport, F., Elie, B. T., Brogi, E., Brastianos, P. K., Hahn, W. C., Holsinger, L. J., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3011 · Cited by 389

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity

Snyder, A. G., Hubbard, N., Messmer, M. N., Kofman, S. B., Hagan, C. E., Orozco, S. L., Chiang, K., Daniels, B. P., Baker, D. A., & Oberst, A. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw2004 · Cited by 382

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis

Canli, Ö., Nicolas, A. M., Gupta, J. R. P., Finkelmeier, F., Goncharova, O., Pesic, M. H., Neumann, T., Horst, D. A., Löwer, M., Şahin, U., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.004 · Cited by 375

Interleukin-22 protects intestinal stem cells against genotoxic stress

Gronke, K., Hernández, P. P., Zimmermann, J., Klose, C. S. N., Kofoed-Branzk, M., Guendel, F., Witkowski, M., Tizian, C., Amann, L., Schumacher, F., et al. (2019) · Nature · doi:10.1038/s41586-019-0899-7 · Cited by 373

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

Pylayeva‐Gupta, Y., Das, S., Handler, J. S., Hajdu, C. H., Coffre, M., Koralov, S. B., & Bar‐Sagi, D. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0843 · Cited by 367

Immune-mediated dormancy: an equilibrium with cancer

Teng, M. W. L., Swann, J. B., Koebel, C. M., Schreiber, R. D., & Smyth, M. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107774 · Cited by 360

Molecular Drivers of the Non–T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer

Sweis, R. F., Spranger, S., Bao, R., Paner, G. P., Stadler, W. M., Steinberg, G. D., & Gajewski, T. F. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0274 · Cited by 356

Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis

Wang, K., Kim, M. K., Caro, G. D., Wong, J., Shalapour, S., Wan, J., Zhang, W., Zhong, Z., Sánchez‐López, E., Wu, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.11.009 · Cited by 353

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

Daley, D., Zambirinis, C. P., Seifert, L., Akkad, N., Mohan, N., Werba, G., Barilla, R., Torres-Hernandez, A., Hundeyin, M., Mani, V. R. K., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.046 · Cited by 329

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

Affara, N. I., Ruffell, B., Medler, T. R., Gunderson, A. J., Johansson, M., Bornstein, S., Bergsland, E. K., Steinhoff, M. S., Li, Y., Gong, Q., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.026 · Cited by 314

Macrophages of distinct origins contribute to tumor development in the lung

Loyher, P.-L., Hamon, P., Laviron, M., Meghraoui, A., Gonçalves, E., Deng, Z., Torstensson, S., Bercovici, N., de Chanville, C. B., Combadière, B., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180534 · Cited by 306

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

Bos, P. D., Plitas, G., Rudra, D., Lee, S. Y., & Rudensky, A. Y. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130762 · Cited by 305

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

Wolf, M. J., Hoos, A., Bauer, J., Boettcher, S., Knust, M., Weber, A., Simonavicius, N., Schneider, C., Lang, M., Stürzl, M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.023 · Cited by 300

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

Schwitalla, S., Ziegler, P. K., Horst, D., Becker, V., Kerle, I., Begus-Nahrmann, Y., Lechel, A., Rudolph, K. L., Langer, R., Slotta-Huspenina, J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.014 · Cited by 296

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease−Associated Colorectal Cancers

Robles, A. I., Traverso, G., Zhang, M., Roberts, N. J., Ma, K., Joseph, C. G., Lauwers, G. Y., Selaru, F. M., Popoli, M., Pittman, M. E., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.036 · Cited by 282

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

Quail, D. F., Olson, O. C., Bhardwaj, P., Walsh, L. A., Akkari, L., Quick, M. L., Chen, I.-C., Wendel, N., Ben-Chetrit, N., Walker, J., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3578 · Cited by 277

Tumor Promotion via Injury- and Death-Induced Inflammation

Kuraishy, A. I., Karin, M., & Grivennikov, S. I. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.006 · Cited by 270

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

Ponzetta, A., Carriero, R., Carnevale, S., Barbagallo, M., Molgora, M., Perucchini, C., Magrini, E. I., Gianni, F., Kunderfranco, P., Polentarutti, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.047 · Cited by 258

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization

Martín, Y. D. P., Park, D., Ramachandran, A., Ombrato, L., Calvo, F., Chakravarty, P., Spencer‐Dene, B., Derzsi, S., Hill, C. S., Sahai, E. A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.025 · Cited by 250

HIV persists throughout deep tissues with repopulation from multiple anatomical sources

Chaillon, A., Gianella, S., Dellicour, S., Rawlings, S. A., Schlub, T. E., De Oliveira, M. F., Ignacio, C., Porrachia, M., Vrancken, B., & Smith, D. M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134815 · Cited by 250

p53 is a suppressor of inflammatory response in mice

Komarova, E. A., Krivokrysenko, V. I., Wang, K., Neznanov, N., Chernov, M. V., Komarov, P. G., Brennan, M., Golovkina, T. V., Rokhlin, O. W., Kuprash, D. V., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3213fje · Cited by 247

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

Clever, D. C., Roychoudhuri, R., Constantinides, M. G., Askenase, M. H., Sukumar, M., Klebanoff, C. A., Eil, R. L., Hickman, H. D., Yu, Z., Pan, J. H., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.032 · Cited by 246

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy

Jiang, H., Hegde, S., & DeNardo, D. G. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-2003-1 · Cited by 246

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.11.002 · Cited by 245

Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation

Shalapour, S., & Karin, M. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.021 · Cited by 240

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.005 · Cited by 239

Unique pattern of neutrophil migration and function during tumor progression

Patel, S., Fu, S., Mastio, J., Dominguez, G. A., Purohit, A., Kossenkov, A. V., Lin, C., Alicea-Torres, K. M., Sehgal, M., Nefedova, Y., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0229-5 · Cited by 222

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D. M., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004566 · Cited by 220

Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

Ammirante, M., Shalapour, S., Kang, Y., Jamieson, C., & Karin, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416498111 · Cited by 209

Cell plasticity in epithelial homeostasis and tumorigenesis

Varga, J., & Greten, F. R. (2017) · Nature Cell Biology · doi:10.1038/ncb3611 · Cited by 209

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic

Tomkovich, S., Dejea, C. M., Winglee, K., Drewes, J. L., Chung, L., Housseau, F., Pope, J. L., Gauthier, J., Sun, X., Mühlbauer, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124196 · Cited by 209 · cited 1×

CKIα ablation highlights a critical role for p53 in invasiveness control

Elyada, E., Pribluda, A., Goldstein, R. E., Morgenstern, Y., Brachya, G., Cojocaru, G., Snir-Alkalay, I., Burstain, I., Haffner‐Krausz, R., Jung, S., et al. (2011) · Nature · doi:10.1038/nature09673 · Cited by 202

Agonism of CD11b reprograms innate immunity to sensitize pancreatic cancer to immunotherapies

Panni, R. Z., Herndon, J. M., Zuo, C., Hegde, S., Hogg, G. D., Knolhoff, B. L., Breden, M. A., Li, X., Krisnawan, V. E., Khan, S. Q., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau9240 · Cited by 202

NK cell self tolerance, responsiveness and missing self recognition

Shifrin, N. T., Raulet, D. H., & Ardolino, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.02.007 · Cited by 200

Mesenchymal Cells in Colon Cancer

Koliaraki, V., Pallangyo, C. K., Greten, F. R., & Kollias, G. A. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.11.049 · Cited by 200

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer

Dmitrieva-Posocco, O., Dzutsev, A., Posocco, D. F., Hou, V., Yuan, W., Thovarai, V., Mufazalov, I. A., Gunzer, M., Shilovskiy, I. P., Khaitov, M. R., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.11.015 · Cited by 196

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

Medler, T. R., Murugan, D., Horton, W. R., Kumar, S., Cotechini, T., Forsyth, A. M., Leyshock, P., Leitenberger, J. J., Kulesz-Martin, M. F., Margolin, A. A., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.09.003 · Cited by 190

RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma

Lam, A. R., Bert, N. L., Ho, S. S. W., Shen, Y. J., Tang, M. L. F., Xiong, G. M., Croxford, J. L., Koo, C. X., Ishii, K. J., Akira, S., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1703 · Cited by 179

Epithelial-mesenchymal transition and inflammation at the site of the primary tumor

Dominguez, C. L., David, J. M., & Palena, C. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.002 · Cited by 163

Whole Chromosome Instability induces senescence and promotes SASP

Andriani, G. A., Almeida, V. P., Faggioli, F., Mauro, M., Tsai, W. L., Santambrogio, L., Maslov, A. Y., Gadina, M., Campisi, J., Vijg, J., et al. (2016) · Scientific Reports · doi:10.1038/srep35218 · Cited by 154

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

Ziegler, P. K., Bollrath, J., Pallangyo, C. K., Matsutani, T., Canli, Ö., Oliveira, T. D., Diamanti, M. A., Müller, N., Gamrekelashvili, J., Putoczki, T. L., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.028 · Cited by 152

Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions

Alexander, J. I., & Cukierman, E. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.05.002 · Cited by 149

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

Henry, C. J., Casás-Selves, M., Kim, J., Zaberezhnyy, V., Aghili, L., Daniel, A. E., Jimenez, L., Azam, T., McNamee, E. N., Clambey, E. T., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83024 · Cited by 148

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

Pallangyo, C. K., Ziegler, P. K., & Greten, F. R. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150576 · Cited by 142

A new paradigm for tumor immune escape: β-catenin-driven immune exclusion

Spranger, S., & Gajewski, T. F. (2015) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-015-0089-6 · Cited by 141

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy

Sánchez-Danés, A., Larsimont, J.-C., Liagre, M., Muñoz-Couselo, E., Lapouge, G., Brisebarre, A., Dubois, C., Suppa, M., Sukumaran, V., del Marmol, V., et al. (2018) · Nature · doi:10.1038/s41586-018-0603-3 · Cited by 139

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases

Panigrahy, D., Gartung, A., Yang, J., Yang, H., Gilligan, M. M., Sulciner, M. L., Bhasin, S. S., Bielenberg, D. R., Chang, J., Schmidt, B. A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127282 · Cited by 132

Targeting tumor associated macrophages: The new challenge for nanomedicine

Andón, F. T., Digifico, E., Maeda, A., Erreni, M., Mantovani, A., Alonso, M. J., & Allavena, P. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.09.004 · Cited by 131

Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes

Marusyk, A., Tabassum, D. P., Janiszewska, M., Place, A. E., Trinh, A. C., Rozhok, A. I., Pyne, S., Guerriero, J. L., Shu, S., Ekram, M. B., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1457 · Cited by 129

Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrixPreprint

Akkari, L., Gocheva, V., Kester, J. C., Hunter, K. E., Quick, M. L., Sevenich, L., Wang, H., Peters, C., Tang, L. H., Klimstra, D. S., et al. (2014) · Genes & Development · doi:10.1101/gad.249599.114 · Cited by 126

Tumor-associated macrophages and response to 5-fluorouracil adjuvant therapy in stage III colorectal cancer

Malesci, A., Bianchi, P., Celesti, G., Basso, G., Marchesi, F., Grizzi, F., Di Caro, G., Cavalleri, T., Rimassa, L., Palmqvist, R., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1342918 · Cited by 124

Epithelial–mesenchymal plasticity and circulating tumor cells: Travel companions to metastases

Francart, M., Lambert, J., Vanwynsberghe, A. M., Thompson, E. W., Bourcy, M., Polette, M., & Gilles, C. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24506 · Cited by 118

Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

Kersten, K., Coffelt, S. B., Hoogstraat, M., Verstegen, N. J. M., Vrijland, K., Ciampricotti, M., Doornebal, C. W., Hau, C.-S., Wellenstein, M. D., Salvagno, C., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1334744 · Cited by 109

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

Ciampricotti, M., Hau, C., Doornebal, C. W., Jonkers, J., & de Visser, K. E. (2012) · Nature Medicine · doi:10.1038/nm.2652 · Cited by 108

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Khambu, B., Huda, N., Chen, X., Antoine, D. J., Li, Y., Dai, G., Köhler, U. A., Zong, W., Waguri, S., Werner, S., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91814 · Cited by 106

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival

Majumder, S., Amatya, N., Revu, S. K., Jawale, C. V., Wu, D., Rittenhouse, N., Menk, A. V., Kupul, S., Du, F., Raphael, I., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0367-4 · Cited by 106

Widespread parainflammation in human cancer

Aran, D., Lasry, A., Zinger, A., Biton, M., Pikarsky, E., Hellman, A., Butte, A. J., & Ben‐Neriah, Y. (2016) · Genome biology · doi:10.1186/s13059-016-0995-z · Cited by 104

Innate immunity, inflammation and tumour progression: double‐edged swords

Mantovani, A., Ponzetta, A., Inforzato, A., & Jaillon, S. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12886 · Cited by 102

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

Srivatsa, S., Paul, M. C., Cardone, C., Holcmann, M., Amberg, N., Pathria, P., Diamanti, M. A., Linder, M., Timelthaler, G., Dienes, H. P., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.053 · Cited by 98

Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma

Kadariya, Y., Menges, C. W., Talarchek, J. N., Cai, K. Q., Klein–Szanto, A. J., Pietrofesa, R. A., Christofidou‐Solomidou, M., Cheung, M., Mossman, B. T., Shukla, A., et al. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0347 · Cited by 89

BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis

Das, S., & Bar‐Sagi, D. (2019) · Oncogene · doi:10.1038/s41388-018-0668-3 · Cited by 87

Cancer Evolution Constrained by the Immune Microenvironment

McGranahan, N., & Swanton, C. (2017) · Cell · doi:10.1016/j.cell.2017.08.012 · Cited by 79

A generalized theory of age-dependent carcinogenesis

Rozhok, A. I., & DeGregori, J. V. (2019) · eLife · doi:10.7554/elife.39950 · Cited by 74

Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium

Chang, W., Coudry, R. A., Clapper, M. L., Zhang, X., Williams, K.-L., Spittle, C., Li, T., & Cooper, H. S. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm134 · Cited by 65

Immunosuppressive cell death in cancer

Hou, J., Greten, T. F., & Xia, Q. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.46 · Cited by 50

Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments

DeGregori, J. V. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1207 · Cited by 48

Immunosurveillance of senescent cancer cells by natural killer cells

Iannello, A., & Raulet, D. H. (2014) · OncoImmunology · doi:10.4161/onci.27616 · Cited by 41

Macrophage-mediated immunoediting drives ductal carcinoma evolution: Space is the game changerPreprint

Gatenbee, C., West, J., Baker, A. M., Guljar, N., Jones, J. L., Graham, T. A., Robertson‐Tessi, M., & Anderson, A. R. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/594598 · Cited by 9

Tumors Exploit Dedicated Intracellular Vesicles to Program T cell ResponsesPreprint

Roberts, E. W., Ruhland, M. K., Cai, E., Mujal, A. M., Marchuk, K., Beppler, C., Nam, D., Serwas, N. K., Binnewies, M., & Krummel, M. F. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/691873 · Cited by 5

Macrophages in immunoregulation and therapeutics

Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., Xiao, G. G., Rao, L., & Duo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01452-1 · Cited by 2,477

Pattern recognition receptors in health and diseases

Li, D., & Wu, M. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00687-0 · Cited by 1,961

The updated landscape of tumor microenvironment and drug repurposing

Jin, M.-Z., & Jin, W.-L. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00280-x · Cited by 1,262

Targeting tumor-associated macrophages to synergize tumor immunotherapy

Xiang, X., Wang, J., Lu, D., & Xu, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00484-9 · Cited by 1,014

Role of Glutathione in Cancer: From Mechanisms to Therapies

Kennedy, L., Sandhu, J. K., Harper, M.-E., & Cuperlovic-Culf, M. (2020) · Biomolecules · doi:10.3390/biom10101429 · Cited by 880

Inflammation and tumors

Ribatti, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21798-2.00006-3

Inflammation in Cancer Development

Muñoz‐Pérez, V. M., Cariño‐Cortés, R., Santillán, I. C. L., & Salas‐Casas, A. (2022) · Mexican Journal of Medical Research ICSA · doi:10.29057/mjmr.v10i19.8112 · Cited by 5

Inflammation: the incubator of the tumor microenvironment

Denk, D., & Greten, F. R. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.07.002 · Cited by 287

Inflammation and cancer

Mackenzie, G. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823397-9.00003-x · Cited by 4

Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms

Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000